CY1111650T1 - Ανασυνδυαστικα τροποποιημενη πλασμινη - Google Patents
Ανασυνδυαστικα τροποποιημενη πλασμινηInfo
- Publication number
- CY1111650T1 CY1111650T1 CY20101100930T CY101100930T CY1111650T1 CY 1111650 T1 CY1111650 T1 CY 1111650T1 CY 20101100930 T CY20101100930 T CY 20101100930T CY 101100930 T CY101100930 T CY 101100930T CY 1111650 T1 CY1111650 T1 CY 1111650T1
- Authority
- CY
- Cyprus
- Prior art keywords
- modified plastic
- domain
- terminal
- human plasminogen
- polypeptide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Παρέχονται πολυνουκλεοτίδια και πολυπεπτίδια που συνδέονται με ανασυνδυαστικά τροποποιημένο μόριο πλασμιν(ογόνου). Το μόριο του πλασμιν(ογόνου) έχει μια και μόνο περιοχή kringle στη θέση ενεργοποίησης του Ν-τελικού που είναι παρούσα στο μητρικό μόριο ανθρώπινου πλασμινογόνου και παρουσιάζει σύνδεση με τη λυσίνη και σημαντικά ενζυματικά χαρακτηριστικά που συνδέονται με το μητρικό ένζυμο.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56447204P | 2004-04-22 | 2004-04-22 | |
EP05737862A EP1740698B1 (en) | 2004-04-22 | 2005-04-21 | Recombinantly modified plasmin |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1111650T1 true CY1111650T1 (el) | 2015-10-07 |
Family
ID=34982338
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20101100930T CY1111650T1 (el) | 2004-04-22 | 2010-10-18 | Ανασυνδυαστικα τροποποιημενη πλασμινη |
Country Status (28)
Country | Link |
---|---|
US (2) | US8034913B2 (el) |
EP (2) | EP1740698B1 (el) |
JP (1) | JP5026254B2 (el) |
KR (1) | KR101161819B1 (el) |
CN (2) | CN1961070A (el) |
AT (1) | ATE476502T1 (el) |
AU (1) | AU2005238464B2 (el) |
BR (1) | BRPI0510063B8 (el) |
CA (1) | CA2563675C (el) |
CY (1) | CY1111650T1 (el) |
DE (1) | DE602005022692D1 (el) |
DK (1) | DK1740698T3 (el) |
EA (1) | EA010784B1 (el) |
ES (2) | ES2349555T3 (el) |
HK (3) | HK1099341A1 (el) |
HR (1) | HRP20100568T1 (el) |
IL (1) | IL178343A (el) |
MA (1) | MA28590B1 (el) |
MX (1) | MXPA06012236A (el) |
NO (1) | NO338542B1 (el) |
NZ (1) | NZ550250A (el) |
PL (2) | PL2246417T3 (el) |
PT (2) | PT1740698E (el) |
RS (1) | RS51623B (el) |
SI (1) | SI1740698T1 (el) |
TN (1) | TNSN06332A1 (el) |
WO (1) | WO2005105990A2 (el) |
ZA (1) | ZA200608498B (el) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1938427A (zh) | 2004-02-11 | 2007-03-28 | 比奥莱克斯公司 | 纤溶酶原和微纤溶酶原在浮萍中的表达 |
SI1740698T1 (sl) | 2004-04-22 | 2010-11-30 | Talecris Biotherapeutics Inc | Rekombinantno modificiran plazmin |
WO2007047874A2 (en) * | 2005-10-20 | 2007-04-26 | Talecris Biotherapeutics, Inc. | Recombinantly modified plasmin |
KR100888022B1 (ko) * | 2006-12-21 | 2009-03-09 | 재단법인 목암생명공학연구소 | 면역글로불린 Fc와 인간 아포리포단백질(a)크링글절편의 융합단백질 LK8Fc |
PT2220221E (pt) * | 2007-11-29 | 2015-04-16 | Grifols Therapeutics Inc | Plasmina modificada de forma recombinante |
KR20160110544A (ko) | 2008-06-04 | 2016-09-21 | 그리폴스 테라퓨틱스 인코포레이티드 | 플라스민의 제조를 위한 조성물, 방법 및 키트 |
PT2403865E (pt) | 2009-03-03 | 2015-11-18 | Grifols Therapeutics Inc | Métodos de preparação de plasminogénio |
CN102482338B (zh) | 2009-07-10 | 2016-09-28 | 斯路姆基因公司 | 纤溶酶原和纤溶酶的变体 |
WO2011023805A1 (en) | 2009-08-28 | 2011-03-03 | Thrombogenics N.V. | Use of plasmin for the treatment of filtration failure after trabeculectomy |
KR20140015289A (ko) | 2011-01-05 | 2014-02-06 | 쓰롬보제닉스 엔.브이. | 플라스미노겐 및 플라스민 변이체 |
CN103764163A (zh) | 2011-08-12 | 2014-04-30 | 斯路姆基因公司 | 纤溶酶原和纤溶酶变体 |
CA3008691A1 (en) * | 2015-12-18 | 2017-06-22 | Talengen International Limited | Method for preventing or treating diabetic retinopathy |
CN110114079A (zh) | 2016-12-15 | 2019-08-09 | 泰伦基国际有限公司 | 一种预防和治疗肥胖症的方法和药物 |
WO2018107687A1 (zh) | 2016-12-15 | 2018-06-21 | 深圳瑞健生命科学研究院有限公司 | 一种预防和治疗高脂血症的方法 |
EP3556384B1 (en) | 2016-12-15 | 2024-04-10 | Talengen International Limited | Plasminogen for use in treating diabetes |
CN108210902A (zh) * | 2016-12-15 | 2018-06-29 | 深圳瑞健生命科学研究院有限公司 | 预防和治疗脂肪肝的药物及其用途 |
WO2021210198A1 (ja) | 2020-04-13 | 2021-10-21 | 株式会社エフ・シー・シー | 動力伝達装置 |
EP4140498A4 (en) * | 2020-05-11 | 2023-11-01 | Talengen International Limited | METHOD AND MEDICINE FOR THE TREATMENT OF SPINAL AMYOTROPHY |
EP4251195A1 (en) | 2020-11-25 | 2023-10-04 | Grifols Worldwide Operations Limited | Wound healing |
US11964004B2 (en) * | 2021-03-31 | 2024-04-23 | Shenzhen Bay Laboratory | Short in vivo half-life and in vivo unstable recombinant microplasmin, pharmaceutical composition comprising thereof and method of treating thromboembolism related diseases including administration thereof |
WO2024018051A1 (en) | 2022-07-22 | 2024-01-25 | Grifols Worldwide Operations Limited | Stable plasmin compositions for organ preservation and reconditioning |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4652639A (en) | 1982-05-06 | 1987-03-24 | Amgen | Manufacture and expression of structural genes |
US4631211A (en) | 1985-03-25 | 1986-12-23 | Scripps Clinic & Research Foundation | Means for sequential solid phase organic synthesis and methods using the same |
US5149533A (en) * | 1987-06-04 | 1992-09-22 | Zymogenetics, Inc. | Modified t-PA with kringle-/replaced by another kringle |
US4774087A (en) * | 1987-08-14 | 1988-09-27 | Northwestern University | Micro-size fibrinolytic plasmin |
ES2251009T3 (es) | 1990-06-28 | 2006-04-16 | Sanofi-Aventis Deutschland Gmbh | Proteinas de fusion con partes de inmunoglobulinas, su preparacion y uso. |
US7253264B1 (en) * | 1990-06-28 | 2007-08-07 | Sanofi-Arentideutschland GmbH | Immunoglobulin fusion proteins, their production and use |
US6312893B1 (en) | 1996-01-23 | 2001-11-06 | Qiagen Genomics, Inc. | Methods and compositions for determining the sequence of nucleic acid molecules |
ATE191750T1 (de) | 1996-01-23 | 2000-04-15 | Rapigene Inc | Verfahren und zusammenstellungen zur sequenzbestimmung von nukleinsäuremolekulen |
US6613508B1 (en) * | 1996-01-23 | 2003-09-02 | Qiagen Genomics, Inc. | Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques |
JPH10158300A (ja) | 1996-11-28 | 1998-06-16 | Suzuki Motor Corp | 血管新生抑制効果を有するタンパク質とその製造方法及びアンギオスタチンの製造方法 |
EP1000176A1 (en) | 1997-07-22 | 2000-05-17 | Rapigene, Inc. | Computer method and system for correlating sequencing data by ms |
CA2337231A1 (en) | 1998-07-14 | 2000-01-27 | Bristol-Myers Squibb Company | Lysine binding fragments of angiostatin |
WO2000018436A1 (en) * | 1998-09-29 | 2000-04-06 | Leuven Research & Development Vzw | Use of compounds that reduce alpha2-antiplasmin in vivo for the preparation of a composition for the treatment of ischemic stroke |
US6969515B2 (en) | 1999-11-13 | 2005-11-29 | Talecris Biotherapeutics, Inc. | Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin |
US6355243B1 (en) * | 1999-11-13 | 2002-03-12 | Bayer Corporation | Method of thrombolysis by local delivery of active plasmin |
US6964764B2 (en) * | 1999-11-13 | 2005-11-15 | Talecris Biotherapeutics, Inc. | Method of thrombolysis by local delivery of reversibly inactivated acidified plasmin |
EP1287010A1 (en) * | 2000-06-02 | 2003-03-05 | Blue Heron Biotechnology, Inc. | Methods for improving the sequence fidelity of synthetic double-stranded oligonucleotides |
JP4047170B2 (ja) * | 2000-12-21 | 2008-02-13 | トロム−イクス・ナムローゼ・フエンノートシャップ | 酵母発現ベクターおよび酵母細胞における発現による組換えタンパク質の製造方法 |
AU2002357249A1 (en) | 2001-12-13 | 2003-07-09 | Blue Heron Biotechnology, Inc. | Methods for removal of double-stranded oligonucleotides containing sequence errors using mismatch recognition proteins |
DE10390418D2 (de) * | 2002-02-06 | 2005-01-13 | N Zyme Biotec Gmbh | Verfahren zur Herstellung von rekombinanten Proteinen in Mikroorganismen |
US7776026B2 (en) * | 2002-02-06 | 2010-08-17 | Nuvue Technologies, Inc. | Method for vitreous liquefaction |
GB0228409D0 (en) * | 2002-12-06 | 2003-01-08 | Thromb X Nv | Pharmacological vitreolysis |
SI1740698T1 (sl) | 2004-04-22 | 2010-11-30 | Talecris Biotherapeutics Inc | Rekombinantno modificiran plazmin |
WO2007047874A2 (en) | 2005-10-20 | 2007-04-26 | Talecris Biotherapeutics, Inc. | Recombinantly modified plasmin |
PT2220221E (pt) * | 2007-11-29 | 2015-04-16 | Grifols Therapeutics Inc | Plasmina modificada de forma recombinante |
-
2005
- 2005-04-21 SI SI200531131T patent/SI1740698T1/sl unknown
- 2005-04-21 KR KR1020067024427A patent/KR101161819B1/ko active IP Right Grant
- 2005-04-21 US US11/568,023 patent/US8034913B2/en not_active Expired - Fee Related
- 2005-04-21 CN CNA2005800155389A patent/CN1961070A/zh active Pending
- 2005-04-21 ES ES05737862T patent/ES2349555T3/es active Active
- 2005-04-21 PL PL10166134T patent/PL2246417T3/pl unknown
- 2005-04-21 MX MXPA06012236A patent/MXPA06012236A/es active IP Right Grant
- 2005-04-21 PT PT05737862T patent/PT1740698E/pt unknown
- 2005-04-21 PT PT101661346T patent/PT2246417E/pt unknown
- 2005-04-21 AU AU2005238464A patent/AU2005238464B2/en not_active Ceased
- 2005-04-21 JP JP2007509616A patent/JP5026254B2/ja not_active Expired - Fee Related
- 2005-04-21 EP EP05737862A patent/EP1740698B1/en active Active
- 2005-04-21 CA CA2563675A patent/CA2563675C/en active Active
- 2005-04-21 DK DK05737862.2T patent/DK1740698T3/da active
- 2005-04-21 NZ NZ550250A patent/NZ550250A/en not_active IP Right Cessation
- 2005-04-21 BR BRPI0510063A patent/BRPI0510063B8/pt not_active IP Right Cessation
- 2005-04-21 CN CN2012101142890A patent/CN102660564B/zh not_active Expired - Fee Related
- 2005-04-21 DE DE602005022692T patent/DE602005022692D1/de active Active
- 2005-04-21 PL PL05737862T patent/PL1740698T3/pl unknown
- 2005-04-21 ES ES10166134.6T patent/ES2534744T3/es active Active
- 2005-04-21 EA EA200601950A patent/EA010784B1/ru not_active IP Right Cessation
- 2005-04-21 RS RS20100473A patent/RS51623B/en unknown
- 2005-04-21 WO PCT/US2005/013562 patent/WO2005105990A2/en active Application Filing
- 2005-04-21 EP EP10166134.6A patent/EP2246417B1/en active Active
- 2005-04-21 AT AT05737862T patent/ATE476502T1/de active
-
2006
- 2006-09-27 IL IL178343A patent/IL178343A/en active IP Right Grant
- 2006-10-11 ZA ZA200608498A patent/ZA200608498B/en unknown
- 2006-10-13 TN TNP2006000332A patent/TNSN06332A1/en unknown
- 2006-11-03 NO NO20065050A patent/NO338542B1/no not_active IP Right Cessation
- 2006-11-20 MA MA29466A patent/MA28590B1/fr unknown
-
2007
- 2007-06-15 HK HK07106503.0A patent/HK1099341A1/xx not_active IP Right Cessation
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2010
- 2010-10-18 CY CY20101100930T patent/CY1111650T1/el unknown
- 2010-10-19 HR HR20100568T patent/HRP20100568T1/hr unknown
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2011
- 2011-04-28 HK HK11104278.2A patent/HK1150242A1/xx not_active IP Right Cessation
- 2011-09-01 US US13/223,373 patent/US8420079B2/en active Active
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2013
- 2013-03-12 HK HK13103040.9A patent/HK1175812A1/xx not_active IP Right Cessation
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