CY1108866T1 - Βελτιωμενη μεθοδος για την παρασκευη ενωσεων 3-υδροξυ-4-υδροξυμεθυλ-πυρρολιδινης - Google Patents
Βελτιωμενη μεθοδος για την παρασκευη ενωσεων 3-υδροξυ-4-υδροξυμεθυλ-πυρρολιδινηςInfo
- Publication number
- CY1108866T1 CY1108866T1 CY20091100263T CY091100263T CY1108866T1 CY 1108866 T1 CY1108866 T1 CY 1108866T1 CY 20091100263 T CY20091100263 T CY 20091100263T CY 091100263 T CY091100263 T CY 091100263T CY 1108866 T1 CY1108866 T1 CY 1108866T1
- Authority
- CY
- Cyprus
- Prior art keywords
- hydroxy
- hydroxymethyl
- production
- improved method
- pyrrolidine compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Μέθοδος για την παρασκευή 3-υδροξυ-4-υδροξυμεθυλ-πυρρολιδίνης της ένωσης του τύπου (I) ή (3S,4S)-3-υδροξυ-4-υδροξυμεθυλπυρρολιδίνης της ένωσης του τύπου (la) που αφορά, ως στάδιο κλειδί, την εναντιοεκλεκτική υδρόλυση που καταλύεται από ένζυμο μιας ρακεμικής ένωσης 3,4-trans-διυποκατεστημένης πυρρολιδινόνης του τύπου (II).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NZ533360A NZ533360A (en) | 2004-06-04 | 2004-06-04 | Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds |
EP05757531A EP1756052B1 (en) | 2004-06-04 | 2005-06-03 | Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1108866T1 true CY1108866T1 (el) | 2014-07-02 |
Family
ID=35462865
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20091100263T CY1108866T1 (el) | 2004-06-04 | 2009-03-10 | Βελτιωμενη μεθοδος για την παρασκευη ενωσεων 3-υδροξυ-4-υδροξυμεθυλ-πυρρολιδινης |
Country Status (20)
Country | Link |
---|---|
US (1) | US8183019B2 (el) |
EP (1) | EP1756052B1 (el) |
JP (2) | JP5219506B2 (el) |
KR (1) | KR101294732B1 (el) |
CN (1) | CN101018768B (el) |
AT (1) | ATE417036T1 (el) |
AU (1) | AU2005250308B2 (el) |
CA (1) | CA2568836C (el) |
CY (1) | CY1108866T1 (el) |
DE (1) | DE602005011609D1 (el) |
DK (1) | DK1756052T3 (el) |
ES (1) | ES2318504T3 (el) |
HK (1) | HK1106518A1 (el) |
IL (1) | IL179749A (el) |
MX (1) | MXPA06014139A (el) |
NZ (1) | NZ533360A (el) |
PL (1) | PL1756052T3 (el) |
PT (1) | PT1756052E (el) |
SI (1) | SI1756052T1 (el) |
WO (1) | WO2005118532A1 (el) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5985848A (en) | 1997-10-14 | 1999-11-16 | Albert Einstein College Of Medicine Of Yeshiva University | Inhibitors of nucleoside metabolism |
CN1196704C (zh) | 1999-04-08 | 2005-04-13 | 工业研究有限公司 | 制备核苷代谢抑制剂的方法及中间体化合物 |
RU2330042C2 (ru) * | 2002-08-21 | 2008-07-27 | Альберт Эйнштейн Колледж Оф Медсин Оф Йешива Юниверсити | Ингибиторы нуклеозидфосфорилаз и нуклеозидаз |
NZ523970A (en) * | 2003-02-04 | 2005-02-25 | Ind Res Ltd | Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases |
CN1329374C (zh) * | 2004-06-09 | 2007-08-01 | 上海靶点药物有限公司 | 作为ccr5拮抗剂的化合物 |
EP1924684A4 (en) * | 2005-07-27 | 2009-02-11 | Einstein Coll Med | STRUCTURE OF TRANSITION STATUS OF 5'-METHYLTHIOADENOSINE / S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASES |
NZ544187A (en) * | 2005-12-15 | 2008-07-31 | Ind Res Ltd | Deazapurine analogs of 1'-aza-l-nucleosides |
WO2007097643A1 (en) | 2006-02-22 | 2007-08-30 | Industrial Research Limited | Analogues of coformycin and their use for treating protozoan parasite infections |
US8916571B2 (en) | 2006-02-24 | 2014-12-23 | Albert Einstein College Of Medicine Of Yeshiva University | Methods of treating cancer using inhibitors of 5′-methylthioadenosine phosphorylase |
AU2007218334A1 (en) * | 2006-02-24 | 2007-08-30 | Albert Einstein College Of Medicine Of Yeshiva University | Methods of treating diseases using inhibitors of nucleoside phosphorylases and nucleosidases |
CN101094080B (zh) * | 2006-06-22 | 2012-06-20 | 华为技术有限公司 | 一种即按即通***中的计费方法 |
AU2007293774C1 (en) | 2006-09-07 | 2014-12-18 | Albert Einstein College Of Medicine, Inc. | Acyclic amine inhibitors of nucleoside phosphorylases and hydrolases |
US8383636B2 (en) * | 2006-09-07 | 2013-02-26 | Industrial Research Limited | Acyclic amine inhibitors of 5-methytioadenosine phosphorylase and nucleosidase |
CN101600711A (zh) | 2006-12-22 | 2009-12-09 | 工业研究有限公司 | 核苷酶和磷酸化酶抑制剂的氮杂环丁烷类似物 |
JP5291123B2 (ja) * | 2008-01-25 | 2013-09-18 | ゼノポート,インコーポレイティド | (3s)−アミノメチル−5−ヘキサン酸プロドラッグの結晶形態及びその使用 |
US20110190265A1 (en) * | 2008-09-22 | 2011-08-04 | Schramm Vern L | Methods and compositions for treating bacterial infections by inhibiting quorum sensing |
CA2768291C (en) | 2009-07-17 | 2018-03-27 | Albert Einstein College Of Medicine Of Yeshiva University | 3-hydroxypyrrolidine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase |
WO2012074912A1 (en) | 2010-11-29 | 2012-06-07 | Albert Einstein College Of Medicine Of Yeshiva University | Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase |
US11186575B2 (en) | 2012-08-07 | 2021-11-30 | Alber Einslein College of Medicine | Treatment of helicobacter pylori infections |
EP2920179A4 (en) | 2012-11-12 | 2016-03-30 | Victoria Link Ltd | SALT FORMS AND POLYMORPHIC FORMS OF (3R, 4S) -1 - ((4-AMINO-5H-PYRROLO [3,2-D] PYRIMIDIN-7-YL) METHYL) -4- (METHYLTHIOMETHYL) PYRROLIDIN-3-OL (MTDIA) |
WO2015123101A1 (en) | 2014-02-12 | 2015-08-20 | Albert Einstein College Of Medicine Of Yeshiva University | Treatment of h. pylori infections using mtan inhibitors |
CN104529814A (zh) * | 2014-12-15 | 2015-04-22 | 上海同昌生物医药科技有限公司 | 一种合成n-苄基羟胺盐酸盐的方法 |
CN111793017B (zh) * | 2019-04-04 | 2024-01-16 | 广东东阳光药业股份有限公司 | 一种内酰胺化合物的制备方法 |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3504026B2 (ja) | 1995-06-16 | 2004-03-08 | 株式会社トクヤマ | ピロリジン誘導体の製造方法 |
US6379911B2 (en) | 1996-02-23 | 2002-04-30 | Albert Einstein College Of Medicine Of Yeshiva University | Enzyme detection/assay method and substrates |
US5985848A (en) | 1997-10-14 | 1999-11-16 | Albert Einstein College Of Medicine Of Yeshiva University | Inhibitors of nucleoside metabolism |
AU3147900A (en) | 1999-03-15 | 2000-10-04 | Novo Nordisk A/S | New salt of (2r,3r,4r)-3,4-dihydroxy-2-hydroxymethylpyrrolidine |
US6239163B1 (en) | 1999-03-15 | 2001-05-29 | Novo Nordisk A/S | Salt of (2R,3R,4R)-3,4-dihydroxy-2-hydroxymethylpyrrolidine |
CN1196704C (zh) | 1999-04-08 | 2005-04-13 | 工业研究有限公司 | 制备核苷代谢抑制剂的方法及中间体化合物 |
US6448799B1 (en) * | 1999-09-30 | 2002-09-10 | Hitachi Electronics Engineering Co., Ltd. | Timing adjustment method and apparatus for semiconductor IC tester |
WO2002018371A1 (en) | 2000-08-29 | 2002-03-07 | Industrial Research Limited | Nucleoside metabolism inhibitors |
US6458799B1 (en) | 2000-08-31 | 2002-10-01 | Biocryst Pharmaceuticals, Inc. | Deazaguanine analog, preparation thereof and use thereof |
MXPA04009026A (es) | 2002-03-18 | 2005-01-25 | Kyorin Seiyaku Kk | Derivados de acido 10- (3- ciclopropilaminometil -1-pirrolidinil) piridobenzoxazin- carboxilico efectivos contra bacterias resistentes a farmacos. |
US7098334B2 (en) | 2002-03-25 | 2006-08-29 | Industrial Research Limited | 4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases |
RU2330042C2 (ru) | 2002-08-21 | 2008-07-27 | Альберт Эйнштейн Колледж Оф Медсин Оф Йешива Юниверсити | Ингибиторы нуклеозидфосфорилаз и нуклеозидаз |
NZ523970A (en) * | 2003-02-04 | 2005-02-25 | Ind Res Ltd | Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases |
WO2005003307A2 (en) | 2003-06-17 | 2005-01-13 | The Regents Of The University Of California | Compositions and methods for analysis and manipulation of enzymes in biosynthetic proteomes |
WO2005023203A2 (en) * | 2003-09-09 | 2005-03-17 | Albert Einstein College Of Medicine Of Yeshiva University | Transition state analog inhibitors of ricin a-chain |
CN1329374C (zh) | 2004-06-09 | 2007-08-01 | 上海靶点药物有限公司 | 作为ccr5拮抗剂的化合物 |
AU2005269541A1 (en) | 2004-07-27 | 2006-02-09 | Biocryst Pharmaceuticals, Inc. | Inhibitors of 5'-methylthioadenosine phosphorylase and 5'methylthioadenosine/s-adenosylhomocysteine nucleosidase |
NZ540160A (en) | 2005-05-20 | 2008-03-28 | Einstein Coll Med | Inhibitors of nucleoside phosphorylases |
EP1924684A4 (en) | 2005-07-27 | 2009-02-11 | Einstein Coll Med | STRUCTURE OF TRANSITION STATUS OF 5'-METHYLTHIOADENOSINE / S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASES |
NZ544187A (en) | 2005-12-15 | 2008-07-31 | Ind Res Ltd | Deazapurine analogs of 1'-aza-l-nucleosides |
AU2007218334A1 (en) | 2006-02-24 | 2007-08-30 | Albert Einstein College Of Medicine Of Yeshiva University | Methods of treating diseases using inhibitors of nucleoside phosphorylases and nucleosidases |
US8916571B2 (en) | 2006-02-24 | 2014-12-23 | Albert Einstein College Of Medicine Of Yeshiva University | Methods of treating cancer using inhibitors of 5′-methylthioadenosine phosphorylase |
AR060216A1 (es) * | 2006-03-29 | 2008-06-04 | Medichem Sa | Procesos para preparar ezetimibe y compuestos intermediarios utiles para su preparacion |
US8383636B2 (en) | 2006-09-07 | 2013-02-26 | Industrial Research Limited | Acyclic amine inhibitors of 5-methytioadenosine phosphorylase and nucleosidase |
AU2007293774C1 (en) | 2006-09-07 | 2014-12-18 | Albert Einstein College Of Medicine, Inc. | Acyclic amine inhibitors of nucleoside phosphorylases and hydrolases |
WO2008039324A1 (en) | 2006-09-26 | 2008-04-03 | Albert Einstein College Of Medicine Of Yeshiva University | Transition state structure of human 5'-methylthioadenosine phosphorylase |
CN101600711A (zh) | 2006-12-22 | 2009-12-09 | 工业研究有限公司 | 核苷酶和磷酸化酶抑制剂的氮杂环丁烷类似物 |
WO2009082247A1 (en) | 2007-12-21 | 2009-07-02 | Industrial Research Limited | Process for preparing immucillins having a methylene link |
US20110190265A1 (en) | 2008-09-22 | 2011-08-04 | Schramm Vern L | Methods and compositions for treating bacterial infections by inhibiting quorum sensing |
CA2768291C (en) | 2009-07-17 | 2018-03-27 | Albert Einstein College Of Medicine Of Yeshiva University | 3-hydroxypyrrolidine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase |
-
2004
- 2004-06-04 NZ NZ533360A patent/NZ533360A/en not_active IP Right Cessation
-
2005
- 2005-06-03 CN CN2005800234431A patent/CN101018768B/zh not_active Expired - Fee Related
- 2005-06-03 MX MXPA06014139A patent/MXPA06014139A/es active IP Right Grant
- 2005-06-03 KR KR1020077000157A patent/KR101294732B1/ko not_active IP Right Cessation
- 2005-06-03 WO PCT/NZ2005/000114 patent/WO2005118532A1/en active Application Filing
- 2005-06-03 ES ES05757531T patent/ES2318504T3/es active Active
- 2005-06-03 US US11/628,427 patent/US8183019B2/en active Active
- 2005-06-03 DE DE602005011609T patent/DE602005011609D1/de active Active
- 2005-06-03 JP JP2007514966A patent/JP5219506B2/ja not_active Expired - Fee Related
- 2005-06-03 DK DK05757531T patent/DK1756052T3/da active
- 2005-06-03 AT AT05757531T patent/ATE417036T1/de active
- 2005-06-03 PT PT05757531T patent/PT1756052E/pt unknown
- 2005-06-03 CA CA2568836A patent/CA2568836C/en not_active Expired - Fee Related
- 2005-06-03 PL PL05757531T patent/PL1756052T3/pl unknown
- 2005-06-03 EP EP05757531A patent/EP1756052B1/en not_active Not-in-force
- 2005-06-03 AU AU2005250308A patent/AU2005250308B2/en not_active Ceased
- 2005-06-03 SI SI200530574T patent/SI1756052T1/sl unknown
-
2006
- 2006-11-30 IL IL179749A patent/IL179749A/en not_active IP Right Cessation
-
2007
- 2007-11-02 HK HK07111895.6A patent/HK1106518A1/xx not_active IP Right Cessation
-
2009
- 2009-03-10 CY CY20091100263T patent/CY1108866T1/el unknown
-
2012
- 2012-05-10 JP JP2012108801A patent/JP2012211136A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
KR20070050037A (ko) | 2007-05-14 |
IL179749A0 (en) | 2007-05-15 |
DK1756052T3 (da) | 2009-03-09 |
JP2008501682A (ja) | 2008-01-24 |
PL1756052T3 (pl) | 2009-05-29 |
CA2568836C (en) | 2013-04-16 |
EP1756052A1 (en) | 2007-02-28 |
ATE417036T1 (de) | 2008-12-15 |
US8183019B2 (en) | 2012-05-22 |
CA2568836A1 (en) | 2005-12-15 |
NZ533360A (en) | 2007-02-23 |
CN101018768B (zh) | 2012-11-21 |
PT1756052E (pt) | 2009-02-11 |
SI1756052T1 (sl) | 2009-04-30 |
JP2012211136A (ja) | 2012-11-01 |
KR101294732B1 (ko) | 2013-08-12 |
EP1756052B1 (en) | 2008-12-10 |
AU2005250308A1 (en) | 2005-12-15 |
MXPA06014139A (es) | 2007-05-09 |
US20080280334A1 (en) | 2008-11-13 |
JP5219506B2 (ja) | 2013-06-26 |
ES2318504T3 (es) | 2009-05-01 |
EP1756052A4 (en) | 2007-08-22 |
AU2005250308B2 (en) | 2012-04-26 |
CN101018768A (zh) | 2007-08-15 |
IL179749A (en) | 2011-07-31 |
HK1106518A1 (en) | 2008-03-14 |
WO2005118532A1 (en) | 2005-12-15 |
DE602005011609D1 (de) | 2009-01-22 |
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