CY1108808T1 - Ενωσεις μοτιλιδης - Google Patents
Ενωσεις μοτιλιδηςInfo
- Publication number
- CY1108808T1 CY1108808T1 CY20091100165T CY091100165T CY1108808T1 CY 1108808 T1 CY1108808 T1 CY 1108808T1 CY 20091100165 T CY20091100165 T CY 20091100165T CY 091100165 T CY091100165 T CY 091100165T CY 1108808 T1 CY1108808 T1 CY 1108808T1
- Authority
- CY
- Cyprus
- Prior art keywords
- sup
- motorcycle
- units
- diseases
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nutrition Science (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyrrole Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
Ενώσεις μοτιλίδης που έχουν τον τύπο (I), στον οποίο τα R1, R2, R3 και R4 είναι όπως ορίστηκαν στο παρόν, και μέθοδοι για την παρασκευή και χρήση στη θεραπεία νόσων ή παθήσεων οι οποίες χαρακτηρίζονται από εξασθενημένη γαστρική κινητικότητα.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40734502P | 2002-08-29 | 2002-08-29 | |
EP03755757A EP1532131B1 (en) | 2002-08-29 | 2003-08-26 | Motilide compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1108808T1 true CY1108808T1 (el) | 2014-04-09 |
Family
ID=31978464
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20091100165T CY1108808T1 (el) | 2002-08-29 | 2009-02-13 | Ενωσεις μοτιλιδης |
Country Status (15)
Country | Link |
---|---|
US (1) | US6946482B2 (el) |
EP (1) | EP1532131B1 (el) |
JP (1) | JP4796300B2 (el) |
KR (1) | KR101051613B1 (el) |
CN (1) | CN100363359C (el) |
AT (1) | ATE417856T1 (el) |
AU (1) | AU2003273254B2 (el) |
CA (1) | CA2492846C (el) |
CY (1) | CY1108808T1 (el) |
DE (1) | DE60325377D1 (el) |
DK (1) | DK1532131T3 (el) |
ES (1) | ES2316805T3 (el) |
PT (1) | PT1532131E (el) |
SI (1) | SI1532131T1 (el) |
WO (1) | WO2004019879A2 (el) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8063021B2 (en) | 2002-01-17 | 2011-11-22 | Kosan Biosciences Incorporated | Ketolide anti-infective compounds |
US7407941B2 (en) * | 2003-08-26 | 2008-08-05 | Pfizer, Inc. | N-desmethyl-N-substituted-11-deoxyerythromycin compounds |
GB0327720D0 (en) * | 2003-11-28 | 2003-12-31 | Biotica Tech Ltd | Erythromycins and process for their preparation |
US7211568B2 (en) * | 2003-12-18 | 2007-05-01 | Kosan Biosciences Incorporated | 9-Desoxoerythromycin compounds as prokinetic agents |
US7468428B2 (en) * | 2004-03-17 | 2008-12-23 | App Pharmaceuticals, Llc | Lyophilized azithromycin formulation |
US20060116336A1 (en) * | 2004-03-17 | 2006-06-01 | American Pharmaceutical Partners, Inc. | Lyophilized azithromycin formulation |
US7582611B2 (en) * | 2005-05-24 | 2009-09-01 | Pfizer Inc. | Motilide compounds |
UA87569C2 (ru) * | 2005-05-24 | 2009-07-27 | Пфайзер Инк. | Соединения для лечения расстройств желудочно-кишечной моторики |
NZ568763A (en) * | 2005-12-08 | 2010-04-30 | Pfizer | Method for demethylating the 3'-dimethylamino group of erythromycin compounds |
CA2662897C (en) | 2006-09-11 | 2017-11-07 | Tranzyme Pharma, Inc. | Macrocyclic antagonists of the motilin receptor for treatment of gastrointestinal dysmotility disorders |
CA2670482C (en) * | 2006-12-05 | 2011-10-11 | Pfizer Inc. | Motilide polymorphs |
US20080287371A1 (en) * | 2007-05-17 | 2008-11-20 | Tranzyme Pharma Inc. | Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex |
CN106138038B (zh) * | 2015-04-28 | 2021-04-20 | 天津国际生物医药联合研究院 | 大环内酯类衍生物及其用途 |
CN106478541A (zh) * | 2016-10-17 | 2017-03-08 | 南开大学 | 大环内酯类衍生物及其用途 |
CN106478542A (zh) * | 2016-10-17 | 2017-03-08 | 南开大学 | 一种大环内脂类衍生物盐、其制备方法及用途 |
Family Cites Families (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US391594A (en) * | 1888-10-23 | Arc-extinguisher for electric switches or cut-outs | ||
US4382085A (en) * | 1982-03-01 | 1983-05-03 | Pfizer Inc. | 4"-Epi erythromycin A and derivatives thereof as useful antibacterial agents |
US4382086A (en) * | 1982-03-01 | 1983-05-03 | Pfizer Inc. | 9-Dihydro-11,12-ketal derivatives of erythromycin A and epi-erythromycin A |
PL136968B1 (en) | 1983-02-10 | 1986-04-30 | Tarchominskie Zaklad Farma | Process for preparing cyclic 11,12-carbonate of erythromycin a |
JPS60218321A (ja) * | 1984-04-13 | 1985-11-01 | Satoshi Omura | 消化管収縮運動促進剤 |
EP0184921A3 (en) * | 1984-12-08 | 1986-10-29 | Beecham Group Plc | Erythromycin derivatives |
GB8608080D0 (en) * | 1986-04-02 | 1986-05-08 | Fujisawa Pharmaceutical Co | Solid dispersion composition |
US4742049A (en) * | 1986-06-04 | 1988-05-03 | Abbott Laboratories | Semisynthetic erythromycin antibiotics |
US4857641A (en) * | 1987-08-14 | 1989-08-15 | Pfizer Inc. | C.12 modified erythromycin A derivatives |
IL93936A (en) * | 1989-03-28 | 1994-06-24 | Abbott Lab | History of 9-dioxo-21,9-epoxy - erythromycin, method of preparation History of 11-oxo and 11-hydroxy, and pharmaceutical preparations containing them |
US5190871A (en) * | 1989-06-12 | 1993-03-02 | Eli Lilly And Company | Use of the site-specific integrating function of phage φC31 |
US5824513A (en) * | 1991-01-17 | 1998-10-20 | Abbott Laboratories | Recombinant DNA method for producing erythromycin analogs |
US5523401A (en) * | 1991-04-09 | 1996-06-04 | Abbott Laboratories | Macrocyclic lactam prokinetic agents |
DE69211845T2 (de) * | 1991-04-09 | 1997-01-23 | Abbott Lab | Macrozyklische laktam-prokinetika |
MX9300278A (es) * | 1992-01-21 | 1993-12-31 | Abbott Lab | Compuestos de arilalcoxifenoxi-imidazolina. |
MY113693A (en) * | 1992-05-26 | 2002-05-31 | Chugai Pharmaceutical Co Ltd | Erythromycin derivatives having an enterokinesis stimulating action |
US6066721A (en) * | 1995-07-06 | 2000-05-23 | Stanford University | Method to produce novel polyketides |
US5712146A (en) * | 1993-09-20 | 1998-01-27 | The Leland Stanford Junior University | Recombinant combinatorial genetic library for the production of novel polyketides |
ATE286133T1 (de) * | 1995-07-06 | 2005-01-15 | Univ Leland Stanford Junior | Zellfreie synthese von polyketiden |
US6077943A (en) * | 1996-03-01 | 2000-06-20 | Takeda Chemical Industries, Ltd. | Method of producing erythromycin derivative |
WO1997035590A1 (en) * | 1996-03-25 | 1997-10-02 | Platt Chris E | 10-aza-9-deoxo-11-deoxy-erythromycin a and derivatives combined with sulfisoxazole |
US5712253A (en) * | 1996-06-18 | 1998-01-27 | Abbott Laboratories | Macrocyclic 13-membered ring derivatives of erythromycins A and B |
US6271255B1 (en) * | 1996-07-05 | 2001-08-07 | Biotica Technology Limited | Erythromycins and process for their preparation |
US5922849A (en) * | 1996-11-22 | 1999-07-13 | Abbott Laboratories | Process for preparation of N-demethyl-4"-deoxy-erthromycins A and B |
US6165986A (en) * | 1997-03-10 | 2000-12-26 | Taisho Pharmaceutical Co., Ltd. | Erythromycin a derivatives |
WO1999021867A1 (fr) | 1997-10-29 | 1999-05-06 | Taisho Pharmaceutical Co., Ltd. | Derives d'erythromycine a |
US6169168B1 (en) * | 1997-10-29 | 2001-01-02 | Taisho Pharmaceuticals Co., Ltd. | Erythromycin A derivatives |
US6084079A (en) * | 1998-05-15 | 2000-07-04 | Keyes; Robert F. | Process for preparing N-demethyl-N-alkyl erythromycin derivatives |
WO2000024907A2 (en) * | 1998-10-28 | 2000-05-04 | Kosan Biosciences, Inc. | Library of novel "unnatural" natural products |
AU758421B2 (en) * | 1998-10-29 | 2003-03-20 | Kosan Biosciences, Inc. | Recombinant oleandolide polyketide synthase |
EP1144375A2 (en) | 1999-01-27 | 2001-10-17 | Kosan Biosciences | Synthesis of oligoketides |
WO2000063224A2 (en) * | 1999-04-16 | 2000-10-26 | Kosan Biosciences, Inc. | Macrolide antiinfective agents |
US6524841B1 (en) | 1999-10-08 | 2003-02-25 | Kosan Biosciences, Inc. | Recombinant megalomicin biosynthetic genes and uses thereof |
US7011959B1 (en) | 1999-10-27 | 2006-03-14 | Kosan Biosciences, Inc. | Heterologous production of polyketides |
EP1255763A2 (en) * | 2000-02-18 | 2002-11-13 | Kosan Biosciences, Inc. | Motilide compounds |
US6838265B2 (en) * | 2000-05-02 | 2005-01-04 | Kosan Biosciences, Inc. | Overproduction hosts for biosynthesis of polyketides |
US20020094962A1 (en) * | 2000-12-01 | 2002-07-18 | Gary Ashley | Motilide compounds |
JP2004522726A (ja) * | 2000-12-01 | 2004-07-29 | コーサン バイオサイエンシーズ, インコーポレイテッド | モチリド化合物 |
US6875576B2 (en) * | 2001-02-15 | 2005-04-05 | Kosan Biosciences, Inc. | Method for evaluating therapeutic efficacy |
CA2451391A1 (en) * | 2001-07-03 | 2003-01-16 | Chiron Corporation | C12 modified erythromycin macrolides and ketolides having antibacterial activity |
ITMI20021726A1 (it) | 2002-08-01 | 2004-02-02 | Zambon Spa | Macrolidi ad attivita' antiinfiammatoria. |
-
2003
- 2003-08-26 CA CA2492846A patent/CA2492846C/en not_active Expired - Fee Related
- 2003-08-26 KR KR1020047021161A patent/KR101051613B1/ko not_active IP Right Cessation
- 2003-08-26 JP JP2004531645A patent/JP4796300B2/ja not_active Expired - Fee Related
- 2003-08-26 AU AU2003273254A patent/AU2003273254B2/en not_active Ceased
- 2003-08-26 ES ES03755757T patent/ES2316805T3/es not_active Expired - Lifetime
- 2003-08-26 US US10/648,946 patent/US6946482B2/en not_active Expired - Lifetime
- 2003-08-26 DE DE60325377T patent/DE60325377D1/de not_active Expired - Lifetime
- 2003-08-26 AT AT03755757T patent/ATE417856T1/de active
- 2003-08-26 PT PT03755757T patent/PT1532131E/pt unknown
- 2003-08-26 DK DK03755757T patent/DK1532131T3/da active
- 2003-08-26 EP EP03755757A patent/EP1532131B1/en not_active Expired - Lifetime
- 2003-08-26 SI SI200331492T patent/SI1532131T1/sl unknown
- 2003-08-26 CN CNB038150530A patent/CN100363359C/zh not_active Expired - Fee Related
- 2003-08-26 WO PCT/US2003/026991 patent/WO2004019879A2/en active Application Filing
-
2009
- 2009-02-13 CY CY20091100165T patent/CY1108808T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
US20040138150A1 (en) | 2004-07-15 |
EP1532131A4 (en) | 2007-05-30 |
AU2003273254A1 (en) | 2004-03-19 |
KR20050038594A (ko) | 2005-04-27 |
SI1532131T1 (sl) | 2009-04-30 |
CN100363359C (zh) | 2008-01-23 |
AU2003273254B2 (en) | 2008-10-30 |
CN1665799A (zh) | 2005-09-07 |
EP1532131A2 (en) | 2005-05-25 |
ES2316805T3 (es) | 2009-04-16 |
CA2492846A1 (en) | 2004-03-11 |
US6946482B2 (en) | 2005-09-20 |
CA2492846C (en) | 2012-09-25 |
DK1532131T3 (da) | 2009-02-09 |
PT1532131E (pt) | 2009-02-18 |
KR101051613B1 (ko) | 2011-07-25 |
WO2004019879A2 (en) | 2004-03-11 |
JP2005537317A (ja) | 2005-12-08 |
ATE417856T1 (de) | 2009-01-15 |
WO2004019879A8 (en) | 2004-07-29 |
DE60325377D1 (de) | 2009-01-29 |
WO2004019879A3 (en) | 2004-06-03 |
EP1532131B1 (en) | 2008-12-17 |
JP4796300B2 (ja) | 2011-10-19 |
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