CY1106420T1 - Νανοσωματιδιακα σκευασματα ινσουλινης - Google Patents
Νανοσωματιδιακα σκευασματα ινσουλινηςInfo
- Publication number
- CY1106420T1 CY1106420T1 CY20071100434T CY071100434T CY1106420T1 CY 1106420 T1 CY1106420 T1 CY 1106420T1 CY 20071100434 T CY20071100434 T CY 20071100434T CY 071100434 T CY071100434 T CY 071100434T CY 1106420 T1 CY1106420 T1 CY 1106420T1
- Authority
- CY
- Cyprus
- Prior art keywords
- insulin
- compositions
- nanoparticle formulations
- nanoparticulate
- insulin nanoparticle
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 12
- 102000004877 Insulin Human genes 0.000 title abstract 6
- 108090001061 Insulin Proteins 0.000 title abstract 6
- 229940125396 insulin Drugs 0.000 title abstract 6
- 239000000203 mixture Substances 0.000 title abstract 6
- 239000002105 nanoparticle Substances 0.000 title 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 238000004321 preservation Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Περιγράφονται νανοσωματιδιακές συνθέσεις ινσουλίνης που έχουν αποτελεσματικό μέγεθος σωματιδίου των λιγότερο από 5 μικρά. Οι συνθέσεις επιδεικνύουν διατήρηση της βιοενεργότητας της ινσουλίνης, αυξημένη βιοδιαθεσιμότητα και αυξημένη συνεκτικότητα της βιοδιαθεσιμότητας σε σύγκριση με πρότερες μακροσωματιδιακές σε μέγεθος συνθέσεις ινσουλίνης. Περιγράφονται επίσης μέθοδοι για τη κατασκευή νανοσωματιδιακών συνθέσεων ινσουλίνης, μορφές δοσολογίας που τις περιέχουν και η χρήση αυτών των σκευασμάτων στη θεραπεία με ινσουλίνη.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32345901P | 2001-09-19 | 2001-09-19 | |
PCT/US2002/029679 WO2003024425A1 (en) | 2001-09-19 | 2002-09-19 | Nanoparticulate insulin formulations |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1106420T1 true CY1106420T1 (el) | 2011-10-12 |
Family
ID=23259284
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20071100434T CY1106420T1 (el) | 2001-09-19 | 2007-03-29 | Νανοσωματιδιακα σκευασματα ινσουλινης |
Country Status (11)
Country | Link |
---|---|
US (2) | US20030095928A1 (el) |
EP (1) | EP1429731B1 (el) |
JP (2) | JP4464129B2 (el) |
AT (1) | ATE350013T1 (el) |
CA (1) | CA2460867C (el) |
CY (1) | CY1106420T1 (el) |
DE (1) | DE60217367T2 (el) |
DK (1) | DK1429731T3 (el) |
ES (1) | ES2280582T3 (el) |
PT (1) | PT1429731E (el) |
WO (1) | WO2003024425A1 (el) |
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-
2002
- 2002-09-19 US US10/246,751 patent/US20030095928A1/en not_active Abandoned
- 2002-09-19 CA CA2460867A patent/CA2460867C/en not_active Expired - Fee Related
- 2002-09-19 PT PT02775863T patent/PT1429731E/pt unknown
- 2002-09-19 WO PCT/US2002/029679 patent/WO2003024425A1/en active IP Right Grant
- 2002-09-19 JP JP2003528522A patent/JP4464129B2/ja not_active Expired - Fee Related
- 2002-09-19 DE DE60217367T patent/DE60217367T2/de not_active Expired - Lifetime
- 2002-09-19 ES ES02775863T patent/ES2280582T3/es not_active Expired - Lifetime
- 2002-09-19 EP EP02775863A patent/EP1429731B1/en not_active Expired - Lifetime
- 2002-09-19 AT AT02775863T patent/ATE350013T1/de active
- 2002-09-19 DK DK02775863T patent/DK1429731T3/da active
-
2007
- 2007-01-26 US US11/698,151 patent/US20070122486A1/en not_active Abandoned
- 2007-03-29 CY CY20071100434T patent/CY1106420T1/el unknown
-
2009
- 2009-08-24 JP JP2009193163A patent/JP2010006826A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
US20070122486A1 (en) | 2007-05-31 |
CA2460867C (en) | 2011-04-12 |
US20030095928A1 (en) | 2003-05-22 |
EP1429731A1 (en) | 2004-06-23 |
CA2460867A1 (en) | 2003-03-27 |
JP2010006826A (ja) | 2010-01-14 |
DE60217367T2 (de) | 2007-10-18 |
DE60217367D1 (de) | 2007-02-15 |
ES2280582T3 (es) | 2007-09-16 |
PT1429731E (pt) | 2007-04-30 |
JP4464129B2 (ja) | 2010-05-19 |
DK1429731T3 (da) | 2007-05-14 |
ATE350013T1 (de) | 2007-01-15 |
WO2003024425A1 (en) | 2003-03-27 |
JP2005511507A (ja) | 2005-04-28 |
EP1429731B1 (en) | 2007-01-03 |
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