CY1106420T1 - Νανοσωματιδιακα σκευασματα ινσουλινης - Google Patents

Νανοσωματιδιακα σκευασματα ινσουλινης

Info

Publication number
CY1106420T1
CY1106420T1 CY20071100434T CY071100434T CY1106420T1 CY 1106420 T1 CY1106420 T1 CY 1106420T1 CY 20071100434 T CY20071100434 T CY 20071100434T CY 071100434 T CY071100434 T CY 071100434T CY 1106420 T1 CY1106420 T1 CY 1106420T1
Authority
CY
Cyprus
Prior art keywords
insulin
compositions
nanoparticle formulations
nanoparticulate
insulin nanoparticle
Prior art date
Application number
CY20071100434T
Other languages
English (en)
Inventor
Simon L. Mcgurk
Elaine Merisko-Liversidge
Daniel O'mahoney
Amy Weiderhold
Araz Raoof
Original Assignee
Elan Pharma International Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharma International Limited filed Critical Elan Pharma International Limited
Publication of CY1106420T1 publication Critical patent/CY1106420T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Περιγράφονται νανοσωματιδιακές συνθέσεις ινσουλίνης που έχουν αποτελεσματικό μέγεθος σωματιδίου των λιγότερο από 5 μικρά. Οι συνθέσεις επιδεικνύουν διατήρηση της βιοενεργότητας της ινσουλίνης, αυξημένη βιοδιαθεσιμότητα και αυξημένη συνεκτικότητα της βιοδιαθεσιμότητας σε σύγκριση με πρότερες μακροσωματιδιακές σε μέγεθος συνθέσεις ινσουλίνης. Περιγράφονται επίσης μέθοδοι για τη κατασκευή νανοσωματιδιακών συνθέσεων ινσουλίνης, μορφές δοσολογίας που τις περιέχουν και η χρήση αυτών των σκευασμάτων στη θεραπεία με ινσουλίνη.
CY20071100434T 2001-09-19 2007-03-29 Νανοσωματιδιακα σκευασματα ινσουλινης CY1106420T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32345901P 2001-09-19 2001-09-19
PCT/US2002/029679 WO2003024425A1 (en) 2001-09-19 2002-09-19 Nanoparticulate insulin formulations

Publications (1)

Publication Number Publication Date
CY1106420T1 true CY1106420T1 (el) 2011-10-12

Family

ID=23259284

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071100434T CY1106420T1 (el) 2001-09-19 2007-03-29 Νανοσωματιδιακα σκευασματα ινσουλινης

Country Status (11)

Country Link
US (2) US20030095928A1 (el)
EP (1) EP1429731B1 (el)
JP (2) JP4464129B2 (el)
AT (1) ATE350013T1 (el)
CA (1) CA2460867C (el)
CY (1) CY1106420T1 (el)
DE (1) DE60217367T2 (el)
DK (1) DK1429731T3 (el)
ES (1) ES2280582T3 (el)
PT (1) PT1429731E (el)
WO (1) WO2003024425A1 (el)

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CA2460867C (en) 2011-04-12
US20030095928A1 (en) 2003-05-22
EP1429731A1 (en) 2004-06-23
CA2460867A1 (en) 2003-03-27
JP2010006826A (ja) 2010-01-14
DE60217367T2 (de) 2007-10-18
DE60217367D1 (de) 2007-02-15
ES2280582T3 (es) 2007-09-16
PT1429731E (pt) 2007-04-30
JP4464129B2 (ja) 2010-05-19
DK1429731T3 (da) 2007-05-14
ATE350013T1 (de) 2007-01-15
WO2003024425A1 (en) 2003-03-27
JP2005511507A (ja) 2005-04-28
EP1429731B1 (en) 2007-01-03

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