CU24343B1 - FORMULATION OF DELAYED RELEASE DRUG - Google Patents
FORMULATION OF DELAYED RELEASE DRUGInfo
- Publication number
- CU24343B1 CU24343B1 CUP2016000026A CU20160026A CU24343B1 CU 24343 B1 CU24343 B1 CU 24343B1 CU P2016000026 A CUP2016000026 A CU P2016000026A CU 20160026 A CU20160026 A CU 20160026A CU 24343 B1 CU24343 B1 CU 24343B1
- Authority
- CU
- Cuba
- Prior art keywords
- delayed release
- drug
- core
- inner layer
- formulation
- Prior art date
Links
Landscapes
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
<p>La liberación retardada de un fármaco al colon se logra de una formulación de liberación retardada que comprende un núcleo y un recubrimiento para el núcleo. El núcleo comprende un fármaco y un recubrimiento que comprende una capa interior y una capa exterior. La capa interior comprende un tercer material polimérico que es soluble en el fluido intestinal o en el fluido gastrointestinal, el tercer material polimérico es un polímero no iónico, la capa interior comprende al menos un agente amortiguador y una base. Las ventajas de las formulaciones de acuerdo con la presente invención incluyen la liberación acelerada del fármaco cuando se expone a condiciones colónicas y la reducción o eliminación del efecto de los alimentos y/o alcohol en la liberación del fármaco después de la administración.</p><p> Delayed release of a drug to the colon is achieved from a delayed release formulation comprising a core and a coating for the core. The core comprises a drug and a coating comprising an inner layer and an outer layer. The inner layer comprises a third polymeric material that is soluble in the intestinal fluid or in the gastrointestinal fluid, the third polymeric material is a non-ionic polymer, the inner layer comprises at least one buffering agent and a base. Advantages of the formulations according to the present invention include accelerated drug release when exposed to colonic conditions and reduction or elimination of the effect of food and / or alcohol on drug release after administration. </ P >
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261640217P | 2012-04-30 | 2012-04-30 | |
| EP12166110.2A EP2659881B1 (en) | 2012-04-30 | 2012-04-30 | A delayed release drug formulation |
| PCT/EP2013/058921 WO2013164315A1 (en) | 2012-04-30 | 2013-04-29 | A delayed release drug formulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CU20160026A7 CU20160026A7 (en) | 2016-05-30 |
| CU24343B1 true CU24343B1 (en) | 2018-05-08 |
Family
ID=54196716
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CUP2016000014A CU24342B1 (en) | 2012-04-30 | 2013-04-29 | FORMULATION OF DELAYED RELEASE DRUG |
| CUP2016000026A CU24343B1 (en) | 2012-04-30 | 2013-04-29 | FORMULATION OF DELAYED RELEASE DRUG |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CUP2016000014A CU24342B1 (en) | 2012-04-30 | 2013-04-29 | FORMULATION OF DELAYED RELEASE DRUG |
Country Status (10)
| Country | Link |
|---|---|
| JP (2) | JP6700220B2 (en) |
| CL (2) | CL2017001990A1 (en) |
| CU (2) | CU24342B1 (en) |
| CY (1) | CY1121470T1 (en) |
| EC (2) | ECSP14028077A (en) |
| HK (3) | HK1202266A1 (en) |
| HR (3) | HRP20190470T1 (en) |
| IL (2) | IL235283A (en) |
| PH (3) | PH12017502369A1 (en) |
| ZA (1) | ZA201407675B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3662902A1 (en) * | 2018-12-07 | 2020-06-10 | Tillotts Pharma AG | Colonic drug delivery formulation |
| EP3662900A1 (en) * | 2018-12-07 | 2020-06-10 | Tillotts Pharma AG | Colonic drug delivery formulation |
| CN113493220A (en) * | 2020-04-02 | 2021-10-12 | 杨洋 | Hollow metal oxide microsphere, preparation method thereof and drug sustained-release application |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5422121A (en) * | 1990-11-14 | 1995-06-06 | Rohm Gmbh | Oral dosage unit form |
| JP5167345B2 (en) * | 2007-05-07 | 2013-03-21 | エボニック レーム ゲゼルシャフト ミット ベシュレンクテル ハフツング | Solid dosage form with enteric coating for accelerated drug release |
| JOP20200144A1 (en) * | 2012-04-30 | 2017-06-16 | Tillotts Pharma Ag | A delayed release drug formulation |
-
2013
- 2013-04-29 CU CUP2016000014A patent/CU24342B1/en unknown
- 2013-04-29 CU CUP2016000026A patent/CU24343B1/en unknown
-
2014
- 2014-10-22 IL IL235283A patent/IL235283A/en active IP Right Grant
- 2014-10-22 ZA ZA2014/07675A patent/ZA201407675B/en unknown
- 2014-10-22 IL IL235282A patent/IL235282A/en active IP Right Grant
- 2014-11-25 EC ECIEPI201428077A patent/ECSP14028077A/en unknown
- 2014-11-25 EC ECIEPI201428079A patent/ECSP14028079A/en unknown
-
2015
- 2015-03-19 HK HK15102823.2A patent/HK1202266A1/en unknown
- 2015-03-19 HK HK15102824.1A patent/HK1202267A1/en unknown
- 2015-03-19 HK HK18103919.2A patent/HK1244435B/en not_active IP Right Cessation
-
2017
- 2017-06-06 JP JP2017112044A patent/JP6700220B2/en not_active Expired - Fee Related
- 2017-06-06 JP JP2017112035A patent/JP6626470B2/en active Active
- 2017-08-03 CL CL2017001990A patent/CL2017001990A1/en unknown
- 2017-08-03 CL CL2017001989A patent/CL2017001989A1/en unknown
- 2017-12-20 PH PH12017502369A patent/PH12017502369A1/en unknown
-
2018
- 2018-02-12 PH PH12018500304A patent/PH12018500304B1/en unknown
- 2018-06-19 PH PH12018501311A patent/PH12018501311A1/en unknown
-
2019
- 2019-03-11 HR HRP20190470TT patent/HRP20190470T1/en unknown
- 2019-03-15 CY CY20191100312T patent/CY1121470T1/en unknown
- 2019-04-17 HR HRP20190727TT patent/HRP20190727T1/en unknown
- 2019-12-09 HR HRP20192210TT patent/HRP20192210T1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP6700220B2 (en) | 2020-05-27 |
| PH12017502369A1 (en) | 2020-09-28 |
| HRP20190727T1 (en) | 2019-06-14 |
| HK1202267A1 (en) | 2015-09-25 |
| CU24342B1 (en) | 2018-05-08 |
| CU20160014A7 (en) | 2016-04-25 |
| PH12018500304A1 (en) | 2018-09-24 |
| HRP20192210T1 (en) | 2020-02-21 |
| PH12018500304B1 (en) | 2018-09-24 |
| ZA201407675B (en) | 2016-05-25 |
| CY1121470T1 (en) | 2020-05-29 |
| HK1202266A1 (en) | 2015-09-25 |
| ECSP14028077A (en) | 2015-12-31 |
| PH12018501311A1 (en) | 2020-09-14 |
| CL2017001989A1 (en) | 2018-03-16 |
| JP2017145268A (en) | 2017-08-24 |
| CL2017001990A1 (en) | 2018-03-16 |
| HK1244435B (en) | 2019-10-25 |
| ECSP14028079A (en) | 2015-12-31 |
| HRP20190470T1 (en) | 2019-05-17 |
| JP6626470B2 (en) | 2019-12-25 |
| IL235282A (en) | 2017-09-28 |
| IL235283A (en) | 2017-09-28 |
| JP2017145267A (en) | 2017-08-24 |
| CU20160026A7 (en) | 2016-05-30 |
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