CU24316B1 - Nuevos derivados fosfatos de 1,2,3,4-tetraisoquinolina amida fenilo, métodos de preparación de los mismos y composiciones farmacéuticas que los contienen - Google Patents

Nuevos derivados fosfatos de 1,2,3,4-tetraisoquinolina amida fenilo, métodos de preparación de los mismos y composiciones farmacéuticas que los contienen

Info

Publication number: CU24316B1
Authority: CU; Cuba
Prior art keywords: formula; compounds; preparation; tetraisoquinolina; phyphate
Prior art date: 2013-07-23

Application number

CUP2014000095A

Other languages

English (en)

Spanish (es)

Other versions

CU20140095A7 (es

Inventor

I Jen Chen

James Edward Paul Davidson

Nanteuil Guillaume De

Olivier Geneste

Anne Françoise Guillouzic

Jean Michel Henlin

Diguarher Thierry Le

Tiran Arnaud Le

James Brooke Murray

Jerome Benoît Starck

Original Assignee

Servier Lab

Vernalis R&D Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-07-23

Filing date

2014-07-23

Publication date

2018-02-08

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50288170&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU24316(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2014-07-23 Application filed by Servier Lab, Vernalis R&D Ltd filed Critical Servier Lab

2016-02-29 Publication of CU20140095A7 publication Critical patent/CU20140095A7/es

2018-02-08 Publication of CU24316B1 publication Critical patent/CU24316B1/xx

Links

238000002360 preparation method Methods 0.000 title abstract 2
241000670727 Amida Species 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 7
206010028980 Neoplasm Diseases 0.000 abstract 1
229910019142 PO4 Inorganic materials 0.000 abstract 1
108010090931 Proto-Oncogene Proteins c-bcl-2 Proteins 0.000 abstract 1
102000013535 Proto-Oncogene Proteins c-bcl-2 Human genes 0.000 abstract 1
206010041067 Small cell lung cancer Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
230000006909 anti-apoptosis Effects 0.000 abstract 1
150000007942 carboxylates Chemical class 0.000 abstract 1
150000001735 carboxylic acids Chemical class 0.000 abstract 1
238000002512 chemotherapy Methods 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
230000003211 malignant effect Effects 0.000 abstract 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
239000010452 phosphate Substances 0.000 abstract 1
150000003013 phosphoric acid derivatives Chemical class 0.000 abstract 1
208000000587 small cell lung carcinoma Diseases 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1092—Details
- A61N2005/1098—Enhancing the effect of the particle by an injected agent or implanted device

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Pathology (AREA)
Radiology & Medical Imaging (AREA)
Hematology (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

CUP2014000095A 2013-07-23 2014-07-23 Nuevos derivados fosfatos de 1,2,3,4-tetraisoquinolina amida fenilo, métodos de preparación de los mismos y composiciones farmacéuticas que los contienen CU24316B1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR1357259A FR3008979B1 (fr)	2013-07-23	2013-07-23	Nouveaux derives phosphates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number	Publication Date
CU20140095A7 CU20140095A7 (es)	2016-02-29
CU24316B1 true CU24316B1 (es)	2018-02-08

Family

ID=50288170

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CUP2014000095A CU24316B1 (es)	2013-07-23	2014-07-23	Nuevos derivados fosfatos de 1,2,3,4-tetraisoquinolina amida fenilo, métodos de preparación de los mismos y composiciones farmacéuticas que los contienen

Country Status (48)

Country	Link
US (3)	US9115159B2 (xx)
EP (1)	EP2829545B1 (xx)
JP (1)	JP5894638B2 (xx)
KR (2)	KR101713103B1 (xx)
CN (1)	CN104341451B (xx)
AP (1)	AP2014007773A0 (xx)
AR (1)	AR097008A1 (xx)
AU (1)	AU2014203808B2 (xx)
BR (1)	BR102014017997B1 (xx)
CA (1)	CA2856886C (xx)
CL (1)	CL2014001865A1 (xx)
CR (1)	CR20140336A (xx)
CU (1)	CU24316B1 (xx)
CY (1)	CY1117834T1 (xx)
DK (1)	DK2829545T3 (xx)
DO (1)	DOP2014000163A (xx)
EA (1)	EA027444B1 (xx)
EC (1)	ECSP14008757A (xx)
ES (1)	ES2593417T3 (xx)
FR (1)	FR3008979B1 (xx)
GE (1)	GEP201706704B (xx)
HK (2)	HK1201536A1 (xx)
HR (1)	HRP20161202T8 (xx)
HU (1)	HUE029616T2 (xx)
IL (1)	IL233580B (xx)
JO (1)	JO3160B1 (xx)
MA (1)	MA37213B1 (xx)
MD (1)	MD4551C1 (xx)
ME (1)	ME02641B (xx)
MX (1)	MX351467B (xx)
MY (1)	MY173258A (xx)
NI (1)	NI201400080A (xx)
PE (1)	PE20150218A1 (xx)
PH (1)	PH12014000194A1 (xx)
PL (1)	PL2829545T3 (xx)
PT (1)	PT2829545T (xx)
RS (1)	RS55098B1 (xx)
RU (1)	RU2617682C2 (xx)
SA (1)	SA114350669B1 (xx)
SG (1)	SG10201403939WA (xx)
SI (1)	SI2829545T1 (xx)
SV (1)	SV2014004771A (xx)
TN (1)	TN2014000301A1 (xx)
TW (1)	TWI527824B (xx)
UA (1)	UA119738C2 (xx)
UY (1)	UY35661A (xx)
WO (1)	WO2015011399A1 (xx)
ZA (1)	ZA201405418B (xx)

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FR3008976A1 (fr) *	2013-07-23	2015-01-30	Servier Lab	"nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent"
FR3008977A1 (fr) *	2013-07-23	2015-01-30	Servier Lab	Nouveaux derives d'isoindoline ou d'isoquinoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
UY37316A (es) *	2016-07-07	2018-01-31	Servier Lab	Dispersión sólida farmacéutica de un inhibidor de bcl-2, composiciones farmacéuticas de ésta, y usos para el tratamiento de cáncer
AU2017300738A1 (en) *	2016-07-22	2019-02-07	Les Laboratoires Servier	Combination of a BCL-2 inhibitor and a MCL-1 inhibitor, uses and pharmaceutical compositions thereof
CU20190002A7 (es) *	2016-07-22	2019-09-04	Servier Lab	Combinación de un inhibidor de bcl-2 y un inhibidor de mcl1 para el tratamiento del cáncer y composiciones farmacéuticas que los comprenden
WO2018158225A1 (en)	2017-02-28	2018-09-07	Les Laboratoires Servier	Combination of a bcl-2 inhibitor and a mdm2 inhibitor, uses and pharmaceutical compositions thereof
EA039621B1 (ru) *	2017-06-09	2022-02-17	Ле Лаборатуар Сервье	Комбинация bcl-2 ингибитора и mcl-1 ингибитора, их применения и фармацевтические композиции
TWI672302B (zh) *	2017-07-06	2019-09-21	法商施維雅藥廠	Bcl-2抑制劑之新結晶型、其製備方法及含其之醫藥組合物
FR3072679B1 (fr) *	2017-10-25	2020-10-30	Servier Lab	Nouveaux derives macrocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CA3089566A1 (en)	2018-01-31	2019-08-08	Deciphera Pharmaceuticals, Llc	Combination therapy for the treatment of gastrointestinal stromal tumors
CN114615982A (zh)	2019-08-12	2022-06-10	德西费拉制药有限责任公司	用于治疗胃肠道间质瘤的瑞普替尼
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CN110606860B (zh) *	2019-09-29	2021-12-10	上海勋和医药科技有限公司	一种吡啶磺酰胺磷酸酯类化合物、其制备方法及其用途
LT4084778T (lt)	2019-12-30	2024-01-25	Deciphera Pharmaceuticals, Llc	Amorfinės kinazės inhibitoriaus vaistinės formos ir jų panaudojimo būdai
CN115243681A (zh)	2019-12-30	2022-10-25	德西费拉制药有限责任公司	1-(4-溴-5-(1-乙基-7-(甲氨基)-2-侧氧基-1,2-二氢-1,6-萘啶-3-基)-2-氟苯基)-3-苯基脲的组合物
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WO2023057394A1 (en)	2021-10-04	2023-04-13	Forx Therapeutics Ag	N,n-dimethyl-4-(7-(n-(1-methylcyclopropyl)sulfamoyl)-imidazo[1,5-a]pyridin-5-yl)piperazine-1-carboxamide derivatives and the corresponding pyrazolo[1,5-a]pyridine derivatives as parg inhibitors for the treatment of cancer
WO2023225359A1 (en)	2022-05-20	2023-11-23	Novartis Ag	Antibody-drug conjugates of antineoplastic compounds and methods of use thereof
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CN103177906A (zh)	2011-12-26	2013-06-26	西门子公司	用于中压开关设备的断路器
ITPR20110103A1 (it)	2011-12-27	2013-06-28	G E A F S R L	Metodo e apparato per la sterilizzazione di una soluzione liquida mediante radio frequenza
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IN2012DE00210A (xx)	2012-01-24	2015-06-19	Danfoss As

2013
- 2013-07-23 FR FR1357259A patent/FR3008979B1/fr active Active
2014
- 2014-07-08 PH PH12014000194A patent/PH12014000194A1/en unknown
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- 2014-07-09 SG SG10201403939WA patent/SG10201403939WA/en unknown
- 2014-07-10 IL IL233580A patent/IL233580B/en active IP Right Grant
- 2014-07-10 EC ECIEPI20148757A patent/ECSP14008757A/es unknown
- 2014-07-10 PE PE2014001093A patent/PE20150218A1/es active IP Right Grant
- 2014-07-10 MY MYPI2014701887A patent/MY173258A/en unknown
- 2014-07-11 UY UY35661A patent/UY35661A/es unknown
- 2014-07-11 TN TNP2014000301A patent/TN2014000301A1/fr unknown
- 2014-07-11 CR CR20140336A patent/CR20140336A/es unknown
- 2014-07-11 AU AU2014203808A patent/AU2014203808B2/en active Active
- 2014-07-14 CA CA2856886A patent/CA2856886C/fr active Active
- 2014-07-15 MA MA37213A patent/MA37213B1/fr unknown
- 2014-07-15 CL CL2014001865A patent/CL2014001865A1/es unknown
- 2014-07-15 MD MDA20140073A patent/MD4551C1/ro not_active IP Right Cessation
- 2014-07-15 DO DO2014000163A patent/DOP2014000163A/es unknown
- 2014-07-17 UA UAA201408109A patent/UA119738C2/uk unknown
- 2014-07-17 SV SV2014004771A patent/SV2014004771A/es unknown
- 2014-07-21 GE GEAP201413528A patent/GEP201706704B/en unknown
- 2014-07-22 WO PCT/FR2014/051887 patent/WO2015011399A1/fr active Application Filing
- 2014-07-22 ZA ZA2014/05418A patent/ZA201405418B/en unknown
- 2014-07-22 SA SA114350669A patent/SA114350669B1/ar unknown
- 2014-07-22 HU HUE14178030A patent/HUE029616T2/en unknown
- 2014-07-22 PL PL14178030.4T patent/PL2829545T3/pl unknown
- 2014-07-22 EP EP14178030.4A patent/EP2829545B1/fr active Active
- 2014-07-22 TW TW103125160A patent/TWI527824B/zh not_active IP Right Cessation
- 2014-07-22 EA EA201400754A patent/EA027444B1/ru unknown
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- 2014-07-22 AR ARP140102712A patent/AR097008A1/es unknown
- 2014-07-22 SI SI201430059A patent/SI2829545T1/sl unknown
- 2014-07-22 RS RS20160693A patent/RS55098B1/sr unknown
- 2014-07-22 JP JP2014148946A patent/JP5894638B2/ja active Active
- 2014-07-22 ME MEP-2016-208A patent/ME02641B/me unknown
- 2014-07-22 PT PT141780304T patent/PT2829545T/pt unknown
- 2014-07-22 DK DK14178030.4T patent/DK2829545T3/en active
- 2014-07-22 US US14/337,577 patent/US9115159B2/en active Active
- 2014-07-22 ES ES14178030.4T patent/ES2593417T3/es active Active
- 2014-07-22 NI NI201400080A patent/NI201400080A/es unknown
- 2014-07-22 BR BR102014017997A patent/BR102014017997B1/pt active IP Right Grant
- 2014-07-22 RU RU2014130129A patent/RU2617682C2/ru active
- 2014-07-23 KR KR1020140093393A patent/KR101713103B1/ko active IP Right Grant
- 2014-07-23 CN CN201410354089.1A patent/CN104341451B/zh active Active
- 2014-07-23 CU CUP2014000095A patent/CU24316B1/xx unknown
2015
- 2015-03-02 HK HK15102098.0A patent/HK1201536A1/zh not_active IP Right Cessation
- 2015-06-01 HK HK15105213.3A patent/HK1204623A1/xx unknown
- 2015-07-16 US US14/800,871 patent/US9597341B2/en active Active
2016
- 2016-07-18 CY CY20161100696T patent/CY1117834T1/el unknown
- 2016-09-20 HR HRP20161202TT patent/HRP20161202T8/hr unknown
- 2016-12-23 KR KR1020160177980A patent/KR20170001694A/ko not_active Application Discontinuation
2017
- 2017-02-06 US US15/425,119 patent/US20170143746A1/en not_active Abandoned

Also Published As

Publication number	Publication date
HK1204623A1 (en)	2015-11-27
BR102014017997A2 (pt)	2015-11-17
ECSP14008757A (es)	2016-01-29
NZ627178A (en)	2016-01-29
IL233580B (en)	2020-03-31
HRP20161202T8 (hr)	2016-12-30
GEP201706704B (en)	2017-07-25
ES2593417T3 (es)	2016-12-09
PL2829545T3 (pl)	2016-12-30
SG10201403939WA (en)	2015-02-27
MA37213A1 (fr)	2016-06-30
MX351467B (es)	2017-10-17
SV2014004771A (es)	2015-01-28
CL2014001865A1 (es)	2015-06-26
TW201504254A (zh)	2015-02-01
AU2014203808A1 (en)	2015-02-12
JP2015028017A (ja)	2015-02-12
PH12014000194B1 (en)	2015-06-29
SA114350669B1 (ar)	2016-04-11
MY173258A (en)	2020-01-09
ME02641B (me)	2017-06-20
DOP2014000163A (es)	2015-01-15
US9115159B2 (en)	2015-08-25
NI201400080A (es)	2014-10-24
US20150031648A1 (en)	2015-01-29
RS55098B1 (sr)	2016-12-30
EA201400754A2 (ru)	2014-12-30
MD4551B1 (ro)	2018-02-28
TWI527824B (zh)	2016-04-01
CR20140336A (es)	2015-10-07
BR102014017997B1 (pt)	2020-05-19
AU2014203808B2 (en)	2018-09-20
FR3008979B1 (fr)	2015-07-24
US20170143746A1 (en)	2017-05-25
CA2856886C (fr)	2016-08-02
CN104341451B (zh)	2018-04-03
KR20170001694A (ko)	2017-01-04
HUE029616T2 (en)	2017-03-28
HRP20161202T1 (hr)	2016-11-04
SI2829545T1 (sl)	2016-10-28
ZA201405418B (en)	2020-02-26
EP2829545A1 (fr)	2015-01-28
IL233580A0 (en)	2014-11-02
TN2014000301A1 (fr)	2015-12-21
PH12014000194A1 (en)	2015-06-29
RU2014130129A (ru)	2016-02-10
UA119738C2 (uk)	2019-08-12
AP2014007773A0 (en)	2014-07-31
AR097008A1 (es)	2016-02-10
MX2014008866A (es)	2015-07-21
MD20140073A2 (en)	2015-01-31
CU20140095A7 (es)	2016-02-29
US9597341B2 (en)	2017-03-21
KR20150011785A (ko)	2015-02-02
EA027444B1 (ru)	2017-07-31
HK1201536A1 (zh)	2015-09-04
PE20150218A1 (es)	2015-02-14
DK2829545T3 (en)	2016-09-19
CY1117834T1 (el)	2017-05-17
RU2617682C2 (ru)	2017-04-26
EP2829545B1 (fr)	2016-06-22
KR101713103B1 (ko)	2017-03-07
MD4551C1 (ro)	2018-09-30
WO2015011399A1 (fr)	2015-01-29
PT2829545T (pt)	2016-07-13
EA201400754A3 (ru)	2015-03-31
MA37213B1 (fr)	2017-03-31
JO3160B1 (ar)	2017-09-20
FR3008979A1 (fr)	2015-01-30
CN104341451A (zh)	2015-02-11
US20150313923A1 (en)	2015-11-05
UY35661A (es)	2015-02-27
JP5894638B2 (ja)	2016-03-30
CA2856886A1 (fr)	2015-01-23

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