CU23578A1 - Proteína de la cápsida del virus dengue inductora de respuesta protectora y composición vacunal - Google Patents
Proteína de la cápsida del virus dengue inductora de respuesta protectora y composición vacunalInfo
- Publication number
- CU23578A1 CU23578A1 CU20050168A CU20050168A CU23578A1 CU 23578 A1 CU23578 A1 CU 23578A1 CU 20050168 A CU20050168 A CU 20050168A CU 20050168 A CU20050168 A CU 20050168A CU 23578 A1 CU23578 A1 CU 23578A1
- Authority
- CU
- Cuba
- Prior art keywords
- capsid protein
- denges
- vaccine composition
- virus capsid
- protection response
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/295—Polyvalent viral antigens; Mixtures of viral and bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/18—Togaviridae; Flaviviridae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
- C12N2770/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
En esta invención se describe la obtención de la proteína de la cápsida de los serotipos del virus Dengue por vía recombinante y particulada capaz de inducir en el receptor una respuesta inmune protectora frente al reto viral, sin inducir el fenómeno de inmunoamplificación dependiente de Acs. También se describen compuestos vacunales que contienen las mezclas de las proteínas recombinantes de la cápsida con el dominio III de los cuatro serotipos del virus dengue. Estas proteínas y sus mezclas son aplicables a la industria farmacéutica en la obtención de preparados vacunales contra el dengue.
Priority Applications (19)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU20050168A CU23578A1 (es) | 2005-09-16 | 2005-09-16 | Proteína de la cápsida del virus dengue inductora de respuesta protectora y composición vacunal |
ARP060104044A AR058049A1 (es) | 2005-09-16 | 2006-09-15 | Proteina de la capsida del virus dengue inductora de respuesta protectora y composicion farmaceutica |
CN2006800422806A CN101304760B (zh) | 2005-09-16 | 2006-09-18 | 诱导保护性应答的登革病毒衣壳蛋白以及药物组合物 |
PCT/CU2006/000008 WO2007031034A1 (es) | 2005-09-16 | 2006-09-18 | Proteína de la cápsida del virus dengue inductora de respuesta protectora y composición farmacéutica |
AU2006291863A AU2006291863B2 (en) | 2005-09-16 | 2006-09-18 | Dengue virus capsid protein which induces a protective response and pharmaceutical composition |
JP2008530308A JP5657204B2 (ja) | 2005-09-16 | 2006-09-18 | デングウイルスのカプシドタンパク質を有する、デングウイルスに対する防御反応を誘導することができる医薬品組成物 |
ES06791279.0T ES2444691T3 (es) | 2005-09-16 | 2006-09-18 | Proteína de la cápside del virus del Dengue que induce una respuesta protectora y su composición farmacéutica |
EP06791279.0A EP1944038B1 (en) | 2005-09-16 | 2006-09-18 | Dengue virus capsid protein which induces a protective response and pharmaceutical composition |
RU2008114841/15A RU2008114841A (ru) | 2005-09-16 | 2006-09-18 | Фармацевтическая композиция, способная индуцировать защитный иммунный ответ против вируса денге, содержащая капсидный белок этого вируса |
US12/067,129 US7790173B2 (en) | 2005-09-16 | 2006-09-18 | Pharmaceutical compound capable of induce immune protective response against Dengue virus having the capsid protein of the Dengue virus |
KR1020087008971A KR101350318B1 (ko) | 2005-09-16 | 2006-09-18 | 보호 반응을 유도하는 댕기열 바이러스 캡시드 단백질 및약학적 조성물 |
CA2622827A CA2622827C (en) | 2005-09-16 | 2006-09-18 | Pharmaceutical compound capable of inducing immune protective response against dengue virus having the capsid protein of the dengue virus |
PT67912790T PT1944038E (pt) | 2005-09-16 | 2006-09-18 | Proteína da cápside do vírus da dengue que induz uma resposta protectora, e composição farmacêutica |
KR1020137022261A KR20130100026A (ko) | 2005-09-16 | 2006-09-18 | 보호 반응을 유도하는 댕기열 바이러스 캡시드 단백질 및 약학적 조성물 |
BRPI0616224A BRPI0616224B8 (pt) | 2005-09-16 | 2006-09-18 | composição farmacêutica |
DK06791279.0T DK1944038T3 (en) | 2005-09-16 | 2006-09-18 | Dengue virus capsid protein that induces a protective response AND PHARMACEUTICAL COMPOSITION |
MYPI20080715A MY149395A (en) | 2005-09-16 | 2006-09-19 | Pharmaceutical compound capable of induce immune protective response against dengue virus having the capsid protein of the dengue virus |
MYPI2011003797A MY161452A (en) | 2005-09-16 | 2006-09-19 | Dengue virus capsid protein which induces a protective response and pharmaceutical composition |
ZA200802740A ZA200802740B (en) | 2005-09-16 | 2008-03-27 | Dengue virus capsid protein which induces a protective response and pharmaceutical composition |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU20050168A CU23578A1 (es) | 2005-09-16 | 2005-09-16 | Proteína de la cápsida del virus dengue inductora de respuesta protectora y composición vacunal |
Publications (1)
Publication Number | Publication Date |
---|---|
CU23578A1 true CU23578A1 (es) | 2010-09-30 |
Family
ID=40132555
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CU20050168A CU23578A1 (es) | 2005-09-16 | 2005-09-16 | Proteína de la cápsida del virus dengue inductora de respuesta protectora y composición vacunal |
Country Status (17)
Country | Link |
---|---|
US (1) | US7790173B2 (es) |
EP (1) | EP1944038B1 (es) |
JP (1) | JP5657204B2 (es) |
KR (2) | KR20130100026A (es) |
CN (1) | CN101304760B (es) |
AR (1) | AR058049A1 (es) |
AU (1) | AU2006291863B2 (es) |
BR (1) | BRPI0616224B8 (es) |
CA (1) | CA2622827C (es) |
CU (1) | CU23578A1 (es) |
DK (1) | DK1944038T3 (es) |
ES (1) | ES2444691T3 (es) |
MY (2) | MY161452A (es) |
PT (1) | PT1944038E (es) |
RU (1) | RU2008114841A (es) |
WO (1) | WO2007031034A1 (es) |
ZA (1) | ZA200802740B (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2594612A1 (en) | 2005-01-19 | 2006-07-27 | Vaxinnate Corporation | Compositions comprising pathogen-associated molecular patterns and antigens and their use to stimulate an immune response |
JP2011519828A (ja) * | 2008-04-18 | 2011-07-14 | バクシネート コーポレーション | フラジェリンの欠失変異体と使用方法 |
WO2009152147A2 (en) * | 2008-06-09 | 2009-12-17 | La Jolla Institute For Allergy And Immunology | Compositions and methods for dengue virus (dv) treatment and vaccination |
CA2770888C (en) * | 2009-08-31 | 2020-04-14 | Gen-Probe Incorporated | Dengue virus assay |
WO2012178196A2 (en) * | 2011-06-24 | 2012-12-27 | La Jolla Institute For Allergy And Immunology | Protection against dengue virus and prevention of severe dengue disease |
US10308689B2 (en) | 2010-06-24 | 2019-06-04 | La Jolla Institute For Allergy And Immunology | Dengue virus (DV) polypeptide sequences, T cell epitopes and methods and uses thereof |
SG11201502618PA (en) * | 2012-10-04 | 2015-05-28 | Univ Leland Stanford Junior | Methods and reagents for detection, quantitation, and serotyping of dengue viruses |
CU24188B1 (es) | 2012-12-27 | 2016-07-29 | Ct De Ingeniería Genética Y Biotecnología | Composición vacunal contra el virus dengue |
SG11201706342PA (en) * | 2015-02-09 | 2017-09-28 | Academia Sinica | An epitope-substituted vaccine for use in improving safety and immunogenicity against dengue viruses |
SG10201607778XA (en) * | 2016-09-16 | 2018-04-27 | Chugai Pharmaceutical Co Ltd | Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use |
WO2018169550A1 (en) * | 2017-03-17 | 2018-09-20 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Real-time rt-pcr assay for detection of dengue, chikungunya, and zika viruses |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CU22302A1 (es) | 1990-09-07 | 1995-01-31 | Cigb | Secuencia nucleotidica codificante para una proteina de la membrana externa de neisseria meningitidis y uso de dicha proteina en preparados vacunales |
ES2153223T3 (es) * | 1991-09-19 | 2001-02-16 | Us Health | Flavivirus quimericos y/o flavivirus de crecimiento restringido. |
PT836482E (pt) * | 1995-05-24 | 2003-02-28 | Hawaii Biotech Group | Vacina subunitaria contra infeccao por flavirus |
CU22559A1 (es) | 1996-01-17 | 1999-05-03 | Ct Ingenieria Genetica Biotech | Sistema de expresión de antígenos heterologos en e. coli como proteínas de fusión |
WO1997043310A1 (en) | 1996-05-10 | 1997-11-20 | Schering Corporation | Synthetic inhibitors of hepatitis c virus ns3 protease |
CU22666A1 (es) | 1996-11-25 | 2001-04-27 | Inst De Medicina Tropical Pedro Kouri | Procedimiento para la expresión de genes de los virus del dengue en la levadura pichia pastoris, adns recombinantes y microorganismos transformados |
CU22683A1 (es) * | 1997-01-15 | 2001-07-20 | Inst De Medicina Tropical Pedro Kouri | Epítopes de la proteína pre-m/m del virus del dengue, péptidos sintéticos, proteínas quiméricas y sus usos |
WO1999007733A2 (en) | 1997-08-11 | 1999-02-18 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis c inhibitor peptides |
DE69833002T2 (de) | 1997-10-08 | 2006-08-24 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Chimärer impfstoff gegen das zeckenenzephalitis virus |
BR0010361A (pt) | 1999-04-30 | 2003-06-10 | Chiron Corp | Seq ências genÈmicas de neisseria e uso destas |
CA3114957C (en) * | 2001-05-22 | 2022-02-08 | Stephen S. Whitehead | Development of mutations useful for attenuating dengue viruses and chimeric dengue viruses |
CU23245A1 (es) * | 2001-07-16 | 2007-10-17 | Inst De Medicina Tropical Pedr | CADENAS QUIMéRICAS CODIFICANTES PARA PROTEINAS INDUCTORAS DE EFECTOS CONTRA VIRUS. PREPARADOS UTILIZANDO PROTEINAS QUIMéRICAS |
WO2003101397A2 (en) * | 2002-05-31 | 2003-12-11 | Acambis, Inc. | Tetravalent dengue vaccines |
WO2004052293A2 (en) | 2002-12-11 | 2004-06-24 | Hawaii Biotech, Inc. | Recombinant vaccine against flavivirus infection |
EP1454988A1 (en) * | 2003-03-03 | 2004-09-08 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Infectious flavivirus pseudo-particles containing functional prM-E envelope proteins |
WO2005002501A2 (en) | 2003-04-22 | 2005-01-13 | Children's Medical Center Corporation | Novel druggable regions in the dengue virus envelope glycoprotein and methods of using the same |
CA2594612A1 (en) | 2005-01-19 | 2006-07-27 | Vaxinnate Corporation | Compositions comprising pathogen-associated molecular patterns and antigens and their use to stimulate an immune response |
CA2508266A1 (fr) | 2005-06-20 | 2006-12-20 | Institut Pasteur | Polypeptides chimeriques et leurs applications therapeutiques contre une infection a flaviviridae |
CU23632A1 (es) | 2006-04-28 | 2011-02-24 | Ct Ingenieria Genetica Biotech | Métodos para la identificación de candidatos terapéuticos contra enfermedades causadas por flavivirus y moléculas antivirales. |
-
2005
- 2005-09-16 CU CU20050168A patent/CU23578A1/es unknown
-
2006
- 2006-09-15 AR ARP060104044A patent/AR058049A1/es not_active Application Discontinuation
- 2006-09-18 CA CA2622827A patent/CA2622827C/en not_active Expired - Fee Related
- 2006-09-18 ES ES06791279.0T patent/ES2444691T3/es active Active
- 2006-09-18 CN CN2006800422806A patent/CN101304760B/zh active Active
- 2006-09-18 KR KR1020137022261A patent/KR20130100026A/ko not_active Application Discontinuation
- 2006-09-18 PT PT67912790T patent/PT1944038E/pt unknown
- 2006-09-18 BR BRPI0616224A patent/BRPI0616224B8/pt not_active IP Right Cessation
- 2006-09-18 AU AU2006291863A patent/AU2006291863B2/en not_active Ceased
- 2006-09-18 WO PCT/CU2006/000008 patent/WO2007031034A1/es active Application Filing
- 2006-09-18 RU RU2008114841/15A patent/RU2008114841A/ru not_active Application Discontinuation
- 2006-09-18 DK DK06791279.0T patent/DK1944038T3/en active
- 2006-09-18 US US12/067,129 patent/US7790173B2/en not_active Expired - Fee Related
- 2006-09-18 KR KR1020087008971A patent/KR101350318B1/ko active IP Right Grant
- 2006-09-18 JP JP2008530308A patent/JP5657204B2/ja not_active Expired - Fee Related
- 2006-09-18 EP EP06791279.0A patent/EP1944038B1/en active Active
- 2006-09-19 MY MYPI2011003797A patent/MY161452A/en unknown
- 2006-09-19 MY MYPI20080715A patent/MY149395A/en unknown
-
2008
- 2008-03-27 ZA ZA200802740A patent/ZA200802740B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
KR101350318B1 (ko) | 2014-01-14 |
WO2007031034A1 (es) | 2007-03-22 |
US20080311157A1 (en) | 2008-12-18 |
BRPI0616224B1 (pt) | 2019-01-15 |
EP1944038B1 (en) | 2013-11-27 |
AR058049A1 (es) | 2008-01-23 |
RU2008114841A (ru) | 2009-10-27 |
AU2006291863A1 (en) | 2007-03-22 |
KR20130100026A (ko) | 2013-09-06 |
ZA200802740B (en) | 2008-12-31 |
BRPI0616224A2 (pt) | 2013-02-19 |
CN101304760B (zh) | 2013-03-13 |
JP2009507864A (ja) | 2009-02-26 |
BRPI0616224B8 (pt) | 2021-05-25 |
CA2622827C (en) | 2015-12-15 |
JP5657204B2 (ja) | 2015-01-21 |
CN101304760A (zh) | 2008-11-12 |
MY149395A (en) | 2013-08-30 |
CA2622827A1 (en) | 2007-03-22 |
AU2006291863B2 (en) | 2012-09-20 |
MY161452A (en) | 2017-04-14 |
ES2444691T3 (es) | 2014-02-26 |
KR20080048068A (ko) | 2008-05-30 |
DK1944038T3 (en) | 2014-03-03 |
EP1944038A1 (en) | 2008-07-16 |
US7790173B2 (en) | 2010-09-07 |
PT1944038E (pt) | 2014-02-21 |
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