CU23562A3 - ESTEREOSELECTIVE BIOCONVERSION OF ALIFATIC DINITRILS IN CYANOCARBOXYLIC ACIDS - Google Patents
ESTEREOSELECTIVE BIOCONVERSION OF ALIFATIC DINITRILS IN CYANOCARBOXYLIC ACIDSInfo
- Publication number
- CU23562A3 CU23562A3 CU20060191A CU20060191A CU23562A3 CU 23562 A3 CU23562 A3 CU 23562A3 CU 20060191 A CU20060191 A CU 20060191A CU 20060191 A CU20060191 A CU 20060191A CU 23562 A3 CU23562 A3 CU 23562A3
- Authority
- CU
- Cuba
- Prior art keywords
- bioconversion
- estereoselective
- dinitrils
- alifatic
- cyanocarboxylic acids
- Prior art date
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente invenciónestá dirigida a una bioconversión regio- y estereoselectiva de dinitrilos alifáticos seleccionados en los correspondientes ácidos cianocarboxílicos. Más particularmente, la presente invención proporciona métodos para la conversión de 2-isobutil-succinonitrilo en ácido (S)-3-ciano-5-metilhexanoico, el cual es un producto intermedio útil en la síntesis de ácido (S)-3-(aminometil)-5-metilhaxanoico (pregabalina). La pregabalina puede usarse para tratar ciertas enfermedades cerebrales, por ejemplo, en el tratamiento y prevención de trastornos repentinos, dolor, y trastornos psicóticos.The present invention is directed to a regional and stereoselective bioconversion of aliphatic dinitriles selected in the corresponding cyanocarboxylic acids. More particularly, the present invention provides methods for the conversion of 2-isobutyl-succinonitrile into (S) -3-cyano-5-methylhexanoic acid, which is an intermediate product useful in the synthesis of (S) -3- ( aminomethyl) -5-methylhaxanoic (pregabalin). Pregabalin can be used to treat certain brain diseases, for example, in the treatment and prevention of sudden disorders, pain, and psychotic disorders.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU20060191A CU23562A3 (en) | 2006-09-29 | 2006-09-29 | ESTEREOSELECTIVE BIOCONVERSION OF ALIFATIC DINITRILS IN CYANOCARBOXYLIC ACIDS |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU20060191A CU23562A3 (en) | 2006-09-29 | 2006-09-29 | ESTEREOSELECTIVE BIOCONVERSION OF ALIFATIC DINITRILS IN CYANOCARBOXYLIC ACIDS |
Publications (1)
Publication Number | Publication Date |
---|---|
CU23562A3 true CU23562A3 (en) | 2010-08-30 |
Family
ID=43302547
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CU20060191A CU23562A3 (en) | 2006-09-29 | 2006-09-29 | ESTEREOSELECTIVE BIOCONVERSION OF ALIFATIC DINITRILS IN CYANOCARBOXYLIC ACIDS |
Country Status (1)
Country | Link |
---|---|
CU (1) | CU23562A3 (en) |
-
2006
- 2006-09-29 CU CU20060191A patent/CU23562A3/en active IP Right Grant
Similar Documents
Publication | Publication Date | Title |
---|---|---|
UY28851A1 (en) | ESTEREOSELECTIVE BIOCONVERSION OF ALIFATIC DINITRILS IN CYANOCARBOXYLIC ACIDS | |
ATE469674T1 (en) | 5-AMINOLEVULIC ACID DERIVATIVES FOR THE TREATMENT OF ACNE | |
WO2009050506A3 (en) | Combination 059 | |
MY145439A (en) | Use of flibanserin for the treatment of pre-menopausal sexual desire disorders | |
EA200801551A1 (en) | USE OF SULPHONAMIDE DERIVATIVES IN THE TREATMENT OF METABOLISM AND NERVOUS SYSTEM DISORDERS | |
EA200970287A1 (en) | METHODS, COMPOUNDS, COMPOSITIONS AND MEDIA SUITABLE FOR DELIVERY OF 3-AMINO-1-PROPANSULPHONE ACID | |
ZA200810113B (en) | Method for the treatment and prevention of ocular disorders | |
GB2459809A (en) | Fatty acid formulations and methods of use thereof | |
UY27872A1 (en) | CASPASA INHIBITORS AND USES OF THE SAME. | |
WO2007067495A3 (en) | Levodopa prodrug mesylate, compositions thereof, and uses thereof | |
GT200500127A (en) | COMPOSITIONS AND METHODS FOR THE TREATMENT OF PREMENSTRUAL DYSPHORIC DISORDER | |
EA200700909A1 (en) | AZAINDOLKARBOXAMIDES | |
WO2007127377A8 (en) | Combinations comprising omega-3 fatty acid compounds for the treatment of cardiovascular disease | |
ATE507827T1 (en) | TREATMENT OF PERVASIVE DEVELOPMENTAL DISORDERS | |
WO2007027476A3 (en) | Treating premature ejaculation using gabapentin and pregabalin prodrugs | |
BR0306855A (en) | Method for the treatment of cognitive disorders | |
CU23562A3 (en) | ESTEREOSELECTIVE BIOCONVERSION OF ALIFATIC DINITRILS IN CYANOCARBOXYLIC ACIDS | |
WO2010028130A3 (en) | Antidepressant compounds | |
AR066371A1 (en) | FORMULATIONS OF N-HALOGENATED AMINO ACIDS CONTAINING ALIFATIC ACIDS | |
TW200512003A (en) | Enhanced method of treatment of growth disorders | |
TW200505830A (en) | Cycloalkyl-substituted alkanoic acid derivatives, processes for their preparation and their use as pharmaceuticals | |
WO2010086429A3 (en) | Intermediates in the enantioselective synthesis of 3-(aminomethyl)-5-methyl-hexanoic acid | |
ATE442055T1 (en) | FISH FOOD WITH SOY PROTEIN | |
EA200802400A1 (en) | POLYMORPHIC FORMS AND METHOD | |
ATE464042T1 (en) | USE OF NEBOGLAMINE TO TREAT SCHIZOPHRENIA |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant of patent |