CU23562A3 - ESTEREOSELECTIVE BIOCONVERSION OF ALIFATIC DINITRILS IN CYANOCARBOXYLIC ACIDS - Google Patents

ESTEREOSELECTIVE BIOCONVERSION OF ALIFATIC DINITRILS IN CYANOCARBOXYLIC ACIDS

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Publication number
CU23562A3
CU23562A3 CU20060191A CU20060191A CU23562A3 CU 23562 A3 CU23562 A3 CU 23562A3 CU 20060191 A CU20060191 A CU 20060191A CU 20060191 A CU20060191 A CU 20060191A CU 23562 A3 CU23562 A3 CU 23562A3
Authority
CU
Cuba
Prior art keywords
bioconversion
estereoselective
dinitrils
alifatic
cyanocarboxylic acids
Prior art date
Application number
CU20060191A
Other languages
Spanish (es)
Inventor
John Wing Wong
Justin Kaine Weaver
Michael Paul Burns
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Priority to CU20060191A priority Critical patent/CU23562A3/en
Publication of CU23562A3 publication Critical patent/CU23562A3/en

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invenciónestá dirigida a una bioconversión regio- y estereoselectiva de dinitrilos alifáticos seleccionados en los correspondientes ácidos cianocarboxílicos. Más particularmente, la presente invención proporciona métodos para la conversión de 2-isobutil-succinonitrilo en ácido (S)-3-ciano-5-metilhexanoico, el cual es un producto intermedio útil en la síntesis de ácido (S)-3-(aminometil)-5-metilhaxanoico (pregabalina). La pregabalina puede usarse para tratar ciertas enfermedades cerebrales, por ejemplo, en el tratamiento y prevención de trastornos repentinos, dolor, y trastornos psicóticos.The present invention is directed to a regional and stereoselective bioconversion of aliphatic dinitriles selected in the corresponding cyanocarboxylic acids. More particularly, the present invention provides methods for the conversion of 2-isobutyl-succinonitrile into (S) -3-cyano-5-methylhexanoic acid, which is an intermediate product useful in the synthesis of (S) -3- ( aminomethyl) -5-methylhaxanoic (pregabalin). Pregabalin can be used to treat certain brain diseases, for example, in the treatment and prevention of sudden disorders, pain, and psychotic disorders.

CU20060191A 2006-09-29 2006-09-29 ESTEREOSELECTIVE BIOCONVERSION OF ALIFATIC DINITRILS IN CYANOCARBOXYLIC ACIDS CU23562A3 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CU20060191A CU23562A3 (en) 2006-09-29 2006-09-29 ESTEREOSELECTIVE BIOCONVERSION OF ALIFATIC DINITRILS IN CYANOCARBOXYLIC ACIDS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU20060191A CU23562A3 (en) 2006-09-29 2006-09-29 ESTEREOSELECTIVE BIOCONVERSION OF ALIFATIC DINITRILS IN CYANOCARBOXYLIC ACIDS

Publications (1)

Publication Number Publication Date
CU23562A3 true CU23562A3 (en) 2010-08-30

Family

ID=43302547

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20060191A CU23562A3 (en) 2006-09-29 2006-09-29 ESTEREOSELECTIVE BIOCONVERSION OF ALIFATIC DINITRILS IN CYANOCARBOXYLIC ACIDS

Country Status (1)

Country Link
CU (1) CU23562A3 (en)

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