CS648290A3 - Iodinated benzene derivatives, process for their preparation and contrast means containing them - Google Patents

Iodinated benzene derivatives, process for their preparation and contrast means containing them

Info

Publication number
CS648290A3
CS648290A3 CS906482A CS648290A CS648290A3 CS 648290 A3 CS648290 A3 CS 648290A3 CS 906482 A CS906482 A CS 906482A CS 648290 A CS648290 A CS 648290A CS 648290 A3 CS648290 A3 CS 648290A3
Authority
CS
Czechoslovakia
Prior art keywords
preparation
means containing
benzene derivatives
contrast means
iodinated benzene
Prior art date
Application number
CS906482A
Other languages
Czech (cs)
Inventor
Michael Schaefer
Zrihrn Dugast
Michel Guillemot
Didier Doucet
Dominique Meyer
Original Assignee
Guerbet Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guerbet Sa filed Critical Guerbet Sa
Publication of CS648290A3 publication Critical patent/CS648290A3/en
Publication of CZ283986B6 publication Critical patent/CZ283986B6/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compounds having general formula (I), wherein R is selected among 2,3-dihydroxypropyl and 1,3-dihydroxy-2-propyl groups. These compounds can be used as contrasting products for X-ray image formation.
CS906482A 1990-01-05 1990-12-20 Iodinated benzene derivatives, process for their preparation and contrast means containing them CZ283986B6 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9000106A FR2656865B1 (en) 1990-01-05 1990-01-05 NON-IONIC IODINE COMPOUND, PROCESS FOR PREPARING THE SAME, AND CONTRAST PRODUCT CONTAINING THE SAME.

Publications (2)

Publication Number Publication Date
CS648290A3 true CS648290A3 (en) 1992-02-19
CZ283986B6 CZ283986B6 (en) 1998-07-15

Family

ID=9392557

Country Status (25)

Country Link
EP (1) EP0437144B1 (en)
JP (1) JP2529032B2 (en)
KR (1) KR100194506B1 (en)
AT (1) ATE114639T1 (en)
CA (1) CA2050334C (en)
CZ (1) CZ283986B6 (en)
DE (1) DE69014581T2 (en)
DK (1) DK0437144T3 (en)
ES (1) ES2067710T3 (en)
FI (1) FI102746B (en)
FR (1) FR2656865B1 (en)
GR (1) GR3015183T3 (en)
HK (1) HK1006019A1 (en)
HU (1) HUT59079A (en)
IE (1) IE65329B1 (en)
IL (1) IL96812A (en)
NO (1) NO180297C (en)
NZ (1) NZ236675A (en)
PL (1) PL165683B1 (en)
PT (1) PT96410B (en)
RO (1) RO108559B1 (en)
SK (1) SK279646B6 (en)
TR (1) TR24944A (en)
WO (1) WO1991009836A1 (en)
ZA (1) ZA9173B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2687669B1 (en) * 1992-02-24 1997-12-19 Guerbet Sa COMPOUNDS FOR USE IN CONTRAST PRODUCTS FOR RADIOGRAPHY.
IT1256163B (en) * 1992-10-27 1995-11-29 Zambon Spa PROCESS FOR THE PREPARATION OF AN INTERMEDIATE OF THE ORGANIC SYNTHESIS
IT1283319B1 (en) * 1996-03-29 1998-04-16 Zambon Spa PROCESS FOR THE PREPARATION OF A USEFUL INTERMEDIATE IN THE SYNTHESIS OF HYDURATED CONTRAST MEDIA
PT108524B (en) 2015-06-02 2017-12-15 Hovione Farmaciência S A PROCESS FOR THE PREPARATION OF USEFUL INTERMEDIARIES IN THE PREPARATION OF NON-IONIC CONTRACTING AGENTS
CN108947959B (en) * 2017-05-27 2022-09-20 正大天晴药业集团股份有限公司 Preparation method of non-ionic iodine contrast agent intermediate
CN110903275A (en) * 2018-09-14 2020-03-24 苏州科伦药物研究有限公司 Process for producing iobitridol, intermediate therefor, and process for producing the same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2909439A1 (en) * 1979-03-08 1980-09-18 Schering Ag NEW NON-ionic x-ray contrast agents
DE3429949A1 (en) * 1984-08-10 1986-02-20 Schering AG, 1000 Berlin und 4709 Bergkamen Novel non-ionic 2,4,6-triiodoisophthalic acid bisamides, process for the preparation thereof and the use thereof as X-ray contrast media
IL90326A (en) * 1988-06-02 1993-05-13 Guerbet Sa Non-ionic triiodobenzene compounds and contrast media containing them

Also Published As

Publication number Publication date
DE69014581T2 (en) 1995-06-08
EP0437144A1 (en) 1991-07-17
HK1006019A1 (en) 1999-02-05
HUT59079A (en) 1992-04-28
HU912860D0 (en) 1992-02-28
NO180297B (en) 1996-12-16
IE910035A1 (en) 1991-07-17
FR2656865A1 (en) 1991-07-12
AU7057491A (en) 1991-07-24
NO913403D0 (en) 1991-08-30
IL96812A (en) 1995-05-26
NZ236675A (en) 1992-08-26
KR920701132A (en) 1992-08-11
AU641212B2 (en) 1993-09-16
CA2050334A1 (en) 1991-07-06
WO1991009836A1 (en) 1991-07-11
JPH05132455A (en) 1993-05-28
ES2067710T3 (en) 1995-04-01
DE69014581D1 (en) 1995-01-12
TR24944A (en) 1992-07-01
PL165683B1 (en) 1995-01-31
NO180297C (en) 1997-03-26
DK0437144T3 (en) 1995-01-23
KR100194506B1 (en) 1999-06-15
IL96812A0 (en) 1991-09-16
PT96410B (en) 1998-06-30
IE65329B1 (en) 1995-10-18
ATE114639T1 (en) 1994-12-15
SK279646B6 (en) 1999-01-11
ZA9173B (en) 1992-08-26
JP2529032B2 (en) 1996-08-28
PL288603A1 (en) 1992-04-06
NO913403L (en) 1991-08-30
FI102746B1 (en) 1999-02-15
GR3015183T3 (en) 1995-05-31
CA2050334C (en) 1999-09-07
EP0437144B1 (en) 1994-11-30
FI914114A0 (en) 1991-09-02
CZ283986B6 (en) 1998-07-15
FI102746B (en) 1999-02-15
PT96410A (en) 1991-10-15
RO108559B1 (en) 1994-06-30
FR2656865B1 (en) 1993-03-26
FI914114A (en) 1992-06-29

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Legal Events

Date Code Title Description
IF00 In force as of 2000-06-30 in czech republic
MM4A Patent lapsed due to non-payment of fee

Effective date: 20081220