CS335390A3 - Nonionic contrast means and process for preparing thereof - Google Patents

Nonionic contrast means and process for preparing thereof

Info

Publication number
CS335390A3
CS335390A3 CS903353A CS335390A CS335390A3 CS 335390 A3 CS335390 A3 CS 335390A3 CS 903353 A CS903353 A CS 903353A CS 335390 A CS335390 A CS 335390A CS 335390 A3 CS335390 A3 CS 335390A3
Authority
CS
Czechoslovakia
Prior art keywords
preparing
contrast means
nonionic contrast
compounds
indicated
Prior art date
Application number
CS903353A
Other languages
Czech (cs)
Other versions
CS277109B6 (en
Inventor
Milos Dr Sovak
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of CS335390A3 publication Critical patent/CS335390A3/en
Publication of CS277109B6 publication Critical patent/CS277109B6/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0452—Solutions, e.g. for injection

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Triiodo-5-aminoisophthalamides in which the amino and one of the amide nitrogen groups are substituted are indicated. The compounds have at least two hydroxyl groups and low viscosity and osmolality. Processes for the preparation of the compounds are indicated.
CS903353A 1989-07-05 1990-07-04 Nonionic contrast means and process for preparing thereof CS277109B6 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37571489A 1989-07-05 1989-07-05
US43152789A 1989-11-03 1989-11-03

Publications (2)

Publication Number Publication Date
CS335390A3 true CS335390A3 (en) 1992-01-15
CS277109B6 CS277109B6 (en) 1992-11-18

Family

ID=27007168

Family Applications (1)

Application Number Title Priority Date Filing Date
CS903353A CS277109B6 (en) 1989-07-05 1990-07-04 Nonionic contrast means and process for preparing thereof

Country Status (16)

Country Link
EP (1) EP0406992B1 (en)
JP (1) JP3249112B2 (en)
AT (1) ATE119783T1 (en)
AU (1) AU643447B2 (en)
CA (1) CA2020489C (en)
CS (1) CS277109B6 (en)
DE (1) DE59008695D1 (en)
DK (1) DK0406992T3 (en)
ES (1) ES2069677T3 (en)
GR (1) GR3015580T3 (en)
HU (1) HU219585B (en)
IE (1) IE65719B1 (en)
IL (1) IL94718A (en)
NO (1) NO179247C (en)
PT (1) PT94595B (en)
RU (1) RU2060246C1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4109169A1 (en) * 1991-03-20 1992-09-24 Koehler Chemie Dr Franz WATER-SOLUBLE NON-IONIC X-RAY CONTRASTING AGENTS AND AGENTS AND METHOD FOR THE PRODUCTION THEREOF
DE4341472A1 (en) * 1993-12-02 1995-06-08 Schering Ag A method for increasing the stability of liposome suspensions containing hydrophilic drugs
GB9618056D0 (en) * 1996-08-29 1996-10-09 Nycomed Imaging As Process
DE19731591C2 (en) * 1997-07-17 1999-09-16 Schering Ag Pharmaceutical compositions containing triiodoaromatics containing perfluoroalkyl groups and their use in tumor therapy and interventional radiology
ITMI20010773A1 (en) * 2001-04-11 2002-10-11 Chemi Spa PROCESS FOR THE PRODUCTION OF HIGH PURITY IOEXOLO
AU2008273037B2 (en) * 2007-07-12 2012-11-15 Ge Healthcare As Contrast agents
EP2240432B1 (en) * 2008-01-14 2012-07-04 Mallinckrodt LLC Process for the preparation of iosimenol
EP2093206A1 (en) 2008-02-20 2009-08-26 BRACCO IMAGING S.p.A. Process for the iodination of aromatic compounds
EP2230227A1 (en) 2009-03-20 2010-09-22 Bracco Imaging S.p.A Process for the preparation of triiodinated carboxylic aromatic derivatives
KR101699065B1 (en) 2009-07-07 2017-01-23 브라코 이미징 에스.피.에이. Process for the preparation of a iodinating agent
JP6325547B2 (en) 2012-09-27 2018-05-16 ジーイー・ヘルスケア・アクスイェ・セルスカプ Preparation of X-ray contrast agent ioforminol
CN110573493A (en) * 2017-05-01 2019-12-13 大塚制药株式会社 Method for preparing iomesol

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4021481A (en) * 1969-06-27 1977-05-03 Nyegaard & Co. A/S Amido derivatives of 2,4,6-triiodobenzoic acids containing at least one N-hydroxyalkyl and at least two hydroxyl groups
GB1538076A (en) * 1974-11-15 1979-01-10 Addressograph Multigraph Apparatus for electrostatic reprography
CH608189A5 (en) * 1974-12-13 1978-12-29 Savac Ag
FI760068A (en) * 1975-02-03 1976-08-04 Schering Ag
KR830001643B1 (en) * 1978-07-04 1983-08-22 울프 블릭스 Method for preparing physiologically acceptable sterile injectable solutions of X-ray contrast agents
DE2909439A1 (en) * 1979-03-08 1980-09-18 Schering Ag NEW NON-ionic x-ray contrast agents
NL7905021A (en) * 1979-06-27 1980-12-30 Pielkenrood Vinitex Bv DEVICE FOR SEPARATING SUSPENDED COMPONENTS FROM A LIQUID.
DE3001292A1 (en) * 1980-01-11 1981-07-16 Schering Ag Berlin Und Bergkamen, 1000 Berlin NON-ionic 5-C SUBSTITUTED 2,4,6-TRIJOD ISOPHTHALIC ACID DERIVATIVES
DE3150916A1 (en) * 1981-12-18 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen N-HYDROXYAETHYLATED 2,4,6-TRIJODAMINOISIOPHTHALIC ACID-BISTRIHYDROXYBUTYLAMIDES, THEIR PRODUCTION AND THEIR CONTAINING X-RAY CONTRASTING AGENTS "
DE3731542A1 (en) * 1987-09-17 1989-03-30 Schering Ag NEW DICARBONIC ACID-BIS (3,5-DICARBAMOYL-2,4,6-TRIIOD-ANILIDE), METHOD FOR THE PRODUCTION THEREOF AND THESE CONTAINING X-RAY AGENTS
DE3739098A1 (en) * 1987-11-16 1989-05-24 Schering Ag NEW SUBSTITUTED DICARBONIC ACID-BIS (3,5-DICARBAMOYL-2,4,6-TRIYOD ANILIDE), METHOD FOR THE PRODUCTION THEREOF AND THEIR CONTAINING X-RAY CONTRASTING AGENTS
US5149777A (en) * 1988-07-20 1992-09-22 Novo Nordisk A/S Human insulin analogs and preparations containing them

Also Published As

Publication number Publication date
DK0406992T3 (en) 1995-07-24
IE902340A1 (en) 1991-01-16
AU5869490A (en) 1991-01-10
HU904104D0 (en) 1990-12-28
ATE119783T1 (en) 1995-04-15
PT94595A (en) 1991-03-20
EP0406992A3 (en) 1991-09-18
CA2020489C (en) 2005-01-11
IL94718A0 (en) 1991-04-15
PT94595B (en) 1997-02-28
JP3249112B2 (en) 2002-01-21
HU219585B (en) 2001-05-28
CA2020489A1 (en) 1991-01-06
AU643447B2 (en) 1993-11-18
EP0406992A2 (en) 1991-01-09
CS277109B6 (en) 1992-11-18
ES2069677T3 (en) 1995-05-16
IL94718A (en) 1994-10-21
NO902986L (en) 1991-01-07
EP0406992B1 (en) 1995-03-15
HUT57708A (en) 1991-12-30
DE59008695D1 (en) 1995-04-20
IE65719B1 (en) 1995-11-15
RU2060246C1 (en) 1996-05-20
JPH03115232A (en) 1991-05-16
GR3015580T3 (en) 1995-06-30
NO902986D0 (en) 1990-07-04
NO179247B (en) 1996-05-28
NO179247C (en) 1996-09-04

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Legal Events

Date Code Title Description
IF00 In force as of 2000-06-30 in czech republic
MK4A Patent expired

Effective date: 20100704