CS335390A3 - Nonionic contrast means and process for preparing thereof - Google Patents
Nonionic contrast means and process for preparing thereofInfo
- Publication number
- CS335390A3 CS335390A3 CS903353A CS335390A CS335390A3 CS 335390 A3 CS335390 A3 CS 335390A3 CS 903353 A CS903353 A CS 903353A CS 335390 A CS335390 A CS 335390A CS 335390 A3 CS335390 A3 CS 335390A3
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- preparing
- contrast means
- nonionic contrast
- compounds
- indicated
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0452—Solutions, e.g. for injection
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Triiodo-5-aminoisophthalamides in which the amino and one of the amide nitrogen groups are substituted are indicated. The compounds have at least two hydroxyl groups and low viscosity and osmolality. Processes for the preparation of the compounds are indicated.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37571489A | 1989-07-05 | 1989-07-05 | |
US43152789A | 1989-11-03 | 1989-11-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
CS335390A3 true CS335390A3 (en) | 1992-01-15 |
CS277109B6 CS277109B6 (en) | 1992-11-18 |
Family
ID=27007168
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CS903353A CS277109B6 (en) | 1989-07-05 | 1990-07-04 | Nonionic contrast means and process for preparing thereof |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0406992B1 (en) |
JP (1) | JP3249112B2 (en) |
AT (1) | ATE119783T1 (en) |
AU (1) | AU643447B2 (en) |
CA (1) | CA2020489C (en) |
CS (1) | CS277109B6 (en) |
DE (1) | DE59008695D1 (en) |
DK (1) | DK0406992T3 (en) |
ES (1) | ES2069677T3 (en) |
GR (1) | GR3015580T3 (en) |
HU (1) | HU219585B (en) |
IE (1) | IE65719B1 (en) |
IL (1) | IL94718A (en) |
NO (1) | NO179247C (en) |
PT (1) | PT94595B (en) |
RU (1) | RU2060246C1 (en) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4109169A1 (en) * | 1991-03-20 | 1992-09-24 | Koehler Chemie Dr Franz | WATER-SOLUBLE NON-IONIC X-RAY CONTRASTING AGENTS AND AGENTS AND METHOD FOR THE PRODUCTION THEREOF |
DE4341472A1 (en) * | 1993-12-02 | 1995-06-08 | Schering Ag | A method for increasing the stability of liposome suspensions containing hydrophilic drugs |
GB9618056D0 (en) * | 1996-08-29 | 1996-10-09 | Nycomed Imaging As | Process |
DE19731591C2 (en) * | 1997-07-17 | 1999-09-16 | Schering Ag | Pharmaceutical compositions containing triiodoaromatics containing perfluoroalkyl groups and their use in tumor therapy and interventional radiology |
ITMI20010773A1 (en) * | 2001-04-11 | 2002-10-11 | Chemi Spa | PROCESS FOR THE PRODUCTION OF HIGH PURITY IOEXOLO |
AU2008273037B2 (en) * | 2007-07-12 | 2012-11-15 | Ge Healthcare As | Contrast agents |
EP2240432B1 (en) * | 2008-01-14 | 2012-07-04 | Mallinckrodt LLC | Process for the preparation of iosimenol |
EP2093206A1 (en) | 2008-02-20 | 2009-08-26 | BRACCO IMAGING S.p.A. | Process for the iodination of aromatic compounds |
EP2230227A1 (en) | 2009-03-20 | 2010-09-22 | Bracco Imaging S.p.A | Process for the preparation of triiodinated carboxylic aromatic derivatives |
KR101699065B1 (en) | 2009-07-07 | 2017-01-23 | 브라코 이미징 에스.피.에이. | Process for the preparation of a iodinating agent |
JP6325547B2 (en) | 2012-09-27 | 2018-05-16 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | Preparation of X-ray contrast agent ioforminol |
CN110573493A (en) * | 2017-05-01 | 2019-12-13 | 大塚制药株式会社 | Method for preparing iomesol |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4021481A (en) * | 1969-06-27 | 1977-05-03 | Nyegaard & Co. A/S | Amido derivatives of 2,4,6-triiodobenzoic acids containing at least one N-hydroxyalkyl and at least two hydroxyl groups |
GB1538076A (en) * | 1974-11-15 | 1979-01-10 | Addressograph Multigraph | Apparatus for electrostatic reprography |
CH608189A5 (en) * | 1974-12-13 | 1978-12-29 | Savac Ag | |
FI760068A (en) * | 1975-02-03 | 1976-08-04 | Schering Ag | |
KR830001643B1 (en) * | 1978-07-04 | 1983-08-22 | 울프 블릭스 | Method for preparing physiologically acceptable sterile injectable solutions of X-ray contrast agents |
DE2909439A1 (en) * | 1979-03-08 | 1980-09-18 | Schering Ag | NEW NON-ionic x-ray contrast agents |
NL7905021A (en) * | 1979-06-27 | 1980-12-30 | Pielkenrood Vinitex Bv | DEVICE FOR SEPARATING SUSPENDED COMPONENTS FROM A LIQUID. |
DE3001292A1 (en) * | 1980-01-11 | 1981-07-16 | Schering Ag Berlin Und Bergkamen, 1000 Berlin | NON-ionic 5-C SUBSTITUTED 2,4,6-TRIJOD ISOPHTHALIC ACID DERIVATIVES |
DE3150916A1 (en) * | 1981-12-18 | 1983-06-30 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | N-HYDROXYAETHYLATED 2,4,6-TRIJODAMINOISIOPHTHALIC ACID-BISTRIHYDROXYBUTYLAMIDES, THEIR PRODUCTION AND THEIR CONTAINING X-RAY CONTRASTING AGENTS " |
DE3731542A1 (en) * | 1987-09-17 | 1989-03-30 | Schering Ag | NEW DICARBONIC ACID-BIS (3,5-DICARBAMOYL-2,4,6-TRIIOD-ANILIDE), METHOD FOR THE PRODUCTION THEREOF AND THESE CONTAINING X-RAY AGENTS |
DE3739098A1 (en) * | 1987-11-16 | 1989-05-24 | Schering Ag | NEW SUBSTITUTED DICARBONIC ACID-BIS (3,5-DICARBAMOYL-2,4,6-TRIYOD ANILIDE), METHOD FOR THE PRODUCTION THEREOF AND THEIR CONTAINING X-RAY CONTRASTING AGENTS |
US5149777A (en) * | 1988-07-20 | 1992-09-22 | Novo Nordisk A/S | Human insulin analogs and preparations containing them |
-
1990
- 1990-06-13 IL IL9471890A patent/IL94718A/en unknown
- 1990-06-28 IE IE234090A patent/IE65719B1/en not_active IP Right Cessation
- 1990-06-29 EP EP90250167A patent/EP0406992B1/en not_active Expired - Lifetime
- 1990-06-29 AT AT90250167T patent/ATE119783T1/en not_active IP Right Cessation
- 1990-06-29 DE DE59008695T patent/DE59008695D1/en not_active Expired - Lifetime
- 1990-06-29 ES ES90250167T patent/ES2069677T3/en not_active Expired - Lifetime
- 1990-06-29 DK DK90250167.5T patent/DK0406992T3/en active
- 1990-07-04 NO NO902986A patent/NO179247C/en not_active IP Right Cessation
- 1990-07-04 AU AU58694/90A patent/AU643447B2/en not_active Expired
- 1990-07-04 CS CS903353A patent/CS277109B6/en not_active IP Right Cessation
- 1990-07-04 RU SU904830459A patent/RU2060246C1/en active
- 1990-07-04 PT PT94595A patent/PT94595B/en not_active IP Right Cessation
- 1990-07-05 CA CA002020489A patent/CA2020489C/en not_active Expired - Lifetime
- 1990-07-05 HU HU104/90A patent/HU219585B/en unknown
- 1990-07-05 JP JP17650590A patent/JP3249112B2/en not_active Expired - Lifetime
-
1995
- 1995-03-30 GR GR950400758T patent/GR3015580T3/en unknown
Also Published As
Publication number | Publication date |
---|---|
DK0406992T3 (en) | 1995-07-24 |
IE902340A1 (en) | 1991-01-16 |
AU5869490A (en) | 1991-01-10 |
HU904104D0 (en) | 1990-12-28 |
ATE119783T1 (en) | 1995-04-15 |
PT94595A (en) | 1991-03-20 |
EP0406992A3 (en) | 1991-09-18 |
CA2020489C (en) | 2005-01-11 |
IL94718A0 (en) | 1991-04-15 |
PT94595B (en) | 1997-02-28 |
JP3249112B2 (en) | 2002-01-21 |
HU219585B (en) | 2001-05-28 |
CA2020489A1 (en) | 1991-01-06 |
AU643447B2 (en) | 1993-11-18 |
EP0406992A2 (en) | 1991-01-09 |
CS277109B6 (en) | 1992-11-18 |
ES2069677T3 (en) | 1995-05-16 |
IL94718A (en) | 1994-10-21 |
NO902986L (en) | 1991-01-07 |
EP0406992B1 (en) | 1995-03-15 |
HUT57708A (en) | 1991-12-30 |
DE59008695D1 (en) | 1995-04-20 |
IE65719B1 (en) | 1995-11-15 |
RU2060246C1 (en) | 1996-05-20 |
JPH03115232A (en) | 1991-05-16 |
GR3015580T3 (en) | 1995-06-30 |
NO902986D0 (en) | 1990-07-04 |
NO179247B (en) | 1996-05-28 |
NO179247C (en) | 1996-09-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
IF00 | In force as of 2000-06-30 in czech republic | ||
MK4A | Patent expired |
Effective date: 20100704 |