CS226006B2 - Method of preparing 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline - Google Patents

Method of preparing 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline Download PDF

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Publication number
CS226006B2
CS226006B2 CS795460A CS546079A CS226006B2 CS 226006 B2 CS226006 B2 CS 226006B2 CS 795460 A CS795460 A CS 795460A CS 546079 A CS546079 A CS 546079A CS 226006 B2 CS226006 B2 CS 226006B2
Authority
CS
Czechoslovakia
Prior art keywords
chloride
reaction
aluminum chloride
mmol
mixture
Prior art date
Application number
CS795460A
Other languages
Czech (cs)
English (en)
Inventor
Bing L Lam
Wilford L Mendelson
Charles B Spainhour
Original Assignee
Smithkline Beckman Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beckman Corp filed Critical Smithkline Beckman Corp
Publication of CS226006B2 publication Critical patent/CS226006B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CS795460A 1978-08-10 1979-08-09 Method of preparing 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline CS226006B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/932,586 US4251660A (en) 1978-08-10 1978-08-10 Method for preparing tetrahydroisoquinolines

Publications (1)

Publication Number Publication Date
CS226006B2 true CS226006B2 (en) 1984-03-19

Family

ID=25462546

Family Applications (1)

Application Number Title Priority Date Filing Date
CS795460A CS226006B2 (en) 1978-08-10 1979-08-09 Method of preparing 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline

Country Status (29)

Country Link
US (1) US4251660A (de)
EP (1) EP0008405B1 (de)
JP (1) JPS5524196A (de)
AR (1) AR220218A1 (de)
AT (1) ATE258T1 (de)
AU (1) AU522843B2 (de)
BG (1) BG32714A3 (de)
CA (1) CA1130290A (de)
CS (1) CS226006B2 (de)
DD (1) DD145532A5 (de)
DE (1) DE2961141D1 (de)
DK (1) DK330579A (de)
ES (1) ES483151A1 (de)
FI (1) FI65062C (de)
GR (1) GR69853B (de)
HU (1) HU178110B (de)
IE (1) IE48618B1 (de)
IL (1) IL57980A (de)
IN (1) IN152421B (de)
IT (1) IT1227791B (de)
MX (1) MX5581E (de)
NO (1) NO153807C (de)
NZ (1) NZ191227A (de)
PH (1) PH24441A (de)
PL (1) PL217684A1 (de)
PT (1) PT70029A (de)
RO (1) RO78160A (de)
SU (1) SU860698A3 (de)
ZA (1) ZA793308B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3272044D1 (de) * 1981-11-27 1986-08-21 Smithkline Beckman Corp 3-benzazepines as alpha-2 antagonists
US4541954A (en) * 1984-09-05 1985-09-17 Smithkline Beckman Corporation Method for preparing 6-chloro-N-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2771468A (en) * 1954-02-19 1956-11-20 Sterling Drug Inc 4-aralkyl-3-morpholones, 4-aralkyl-3-homomorpholones and their preparation
US3947456A (en) * 1970-01-06 1976-03-30 Hoffman-La Roche Inc. Substituted 4-phenyl isoquinolines
US3752892A (en) * 1970-03-11 1973-08-14 Ciba Geigy Corp Anorexigenic tetrahydrobenzazepine derivative method and composition thereof

Also Published As

Publication number Publication date
FI65062B (fi) 1983-11-30
ES483151A1 (es) 1980-04-16
DK330579A (da) 1980-02-11
FI792436A (fi) 1980-02-11
MX5581E (es) 1983-10-26
NO153807C (no) 1986-05-28
NO792601L (no) 1980-02-12
RO78160A (ro) 1982-02-01
IT7924894A0 (it) 1979-08-02
IE791534L (en) 1980-02-10
EP0008405A2 (de) 1980-03-05
FI65062C (fi) 1984-03-12
SU860698A3 (ru) 1981-08-30
AU4954779A (en) 1980-02-14
US4251660A (en) 1981-02-17
JPS5524196A (en) 1980-02-21
PT70029A (en) 1979-09-01
AU522843B2 (en) 1982-07-01
ATE258T1 (de) 1981-10-15
ZA793308B (en) 1980-09-24
IN152421B (de) 1984-01-07
IL57980A0 (en) 1979-12-30
IT1227791B (it) 1991-05-07
PL217684A1 (de) 1980-06-16
DE2961141D1 (en) 1981-12-10
HU178110B (en) 1982-03-28
AR220218A1 (es) 1980-10-15
NO153807B (no) 1986-02-17
IL57980A (en) 1984-08-31
GR69853B (de) 1982-07-19
NZ191227A (en) 1981-10-19
PH24441A (en) 1990-06-25
EP0008405A3 (en) 1980-04-30
IE48618B1 (en) 1985-03-20
EP0008405B1 (de) 1981-09-30
CA1130290A (en) 1982-08-24
DD145532A5 (de) 1980-12-17
BG32714A3 (en) 1982-09-15

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