CS117692A3 - Heterocyclic amides, process of their preparation and pharmaceuticalcompositions containing such amides - Google Patents
Heterocyclic amides, process of their preparation and pharmaceuticalcompositions containing such amides Download PDFInfo
- Publication number
- CS117692A3 CS117692A3 CS921176A CS117692A CS117692A3 CS 117692 A3 CS117692 A3 CS 117692A3 CS 921176 A CS921176 A CS 921176A CS 117692 A CS117692 A CS 117692A CS 117692 A3 CS117692 A3 CS 117692A3
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- group
- formula
- dichloromethane
- pyridyl
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB919108358A GB9108358D0 (en) | 1991-04-18 | 1991-04-18 | Heterocyclic compounds |
GB919108357A GB9108357D0 (en) | 1991-04-18 | 1991-04-18 | Heterocyclic amides |
GB929205392A GB9205392D0 (en) | 1992-03-12 | 1992-03-12 | Heterocyclic amides |
Publications (1)
Publication Number | Publication Date |
---|---|
CS117692A3 true CS117692A3 (en) | 1992-11-18 |
Family
ID=27265602
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CS921176A CS117692A3 (en) | 1991-04-18 | 1992-04-16 | Heterocyclic amides, process of their preparation and pharmaceuticalcompositions containing such amides |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0509769B1 (no) |
JP (1) | JPH0656785A (no) |
KR (1) | KR920019750A (no) |
AU (1) | AU660664B2 (no) |
CA (1) | CA2065794A1 (no) |
CS (1) | CS117692A3 (no) |
DE (1) | DE69213537T2 (no) |
FI (1) | FI921598A (no) |
GB (1) | GB9207145D0 (no) |
HU (1) | HUT66541A (no) |
IE (1) | IE921159A1 (no) |
IL (1) | IL101555A0 (no) |
NO (1) | NO921451L (no) |
NZ (1) | NZ242322A (no) |
TW (1) | TW262475B (no) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5521179A (en) * | 1991-04-18 | 1996-05-28 | Zeneca Limited | Heterocyclic amides |
CA2133657A1 (en) * | 1992-04-16 | 1993-10-28 | Peter R. Bernstein | Substituted derivatives |
US5441960A (en) * | 1992-04-16 | 1995-08-15 | Zeneca Limited | 1-pyrimidinylacetamide human leukocyte elastate inhibitors |
GB9307555D0 (en) * | 1992-04-16 | 1993-06-02 | Zeneca Ltd | Heterocyclic compounds |
US5486529A (en) * | 1992-04-16 | 1996-01-23 | Zeneca Limited | Certain pyridyl ketones for treating diseases involving leukocyte elastase |
EP0636144A1 (en) * | 1992-04-16 | 1995-02-01 | Zeneca Limited | Alpha-aminoboronic acid peptides and their use as elastase inhibitors |
GB9211783D0 (en) * | 1992-06-04 | 1992-07-15 | Ici Plc | Amide derivatives |
GB9214053D0 (en) * | 1992-07-02 | 1992-08-12 | Ici Plc | Heterocyclic amides |
US6608204B1 (en) * | 1994-12-13 | 2003-08-19 | Corvas International, Inc. | Aromatic heterocyclic derivatives as enzyme inhibitors |
US5658930A (en) * | 1994-12-13 | 1997-08-19 | Corvas International, Inc. | Aromatic heterocyclic derivatives as enzyme inhibitors |
US5656645A (en) * | 1994-12-13 | 1997-08-12 | Corvas International, Inc. | Aromatic heterocyclic derivatives as enzyme inhibitors |
CN1188401C (zh) * | 1995-04-27 | 2005-02-09 | 三菱制药株式会社 | 杂环类酰胺化合物及其医药用途 |
WO1997001338A1 (en) * | 1995-06-27 | 1997-01-16 | Merck & Co., Inc. | Pyridinone-thrombin inhibitors |
US5668289A (en) * | 1996-06-24 | 1997-09-16 | Merck & Co., Inc. | Pyridinone thrombin inhibitors |
US5872138A (en) * | 1996-09-13 | 1999-02-16 | Merck & Co., Inc. | Thrombin inhibitors |
US5869487A (en) * | 1996-10-24 | 1999-02-09 | Merck & Co., Inc. | Pyrido 3,4-B!pyrazines for use as thrombin inhibitors |
EP0940400A4 (en) * | 1996-10-25 | 2002-10-02 | Mitsubishi Pharma Corp | NOVEL HETEROCYCLIC AMIDE COMPOUNDS AND THEIR USE FOR MEDICINAL PURPOSES |
US6017934A (en) * | 1997-01-22 | 2000-01-25 | Merck & Co., Inc. | Thrombin inhibitors |
US5792779A (en) * | 1997-02-19 | 1998-08-11 | Merck & Co., Inc. | Pyridinone thrombin inhibitors |
US6011038A (en) * | 1997-09-05 | 2000-01-04 | Merck & Co., Inc. | Pyrazinone thrombin inhibitors |
US6087373A (en) * | 1997-09-23 | 2000-07-11 | Merck & Co., Inc. | Thrombin inhibitors |
US6133297A (en) * | 1997-09-30 | 2000-10-17 | Merck & Co., Inc. | Thrombin inhibitors |
AU2746999A (en) * | 1998-03-11 | 1999-09-27 | Welfide Corporation | Ige antibody production inhibitors and autoimmune diseases inhibitors |
US6147078A (en) * | 1998-05-19 | 2000-11-14 | Merck & Co., Inc. | Pyrazinone thrombin inhibitors |
AU758237B2 (en) * | 1998-09-28 | 2003-03-20 | Merck & Co., Inc. | Thrombin inhibitors |
US6610692B1 (en) | 1998-10-30 | 2003-08-26 | Merck & Co., Inc. | Thrombin inhibitors |
AU752186B2 (en) | 1998-10-30 | 2002-09-12 | Merck & Co., Inc. | Thrombin inhibitors |
US6239132B1 (en) | 1999-04-23 | 2001-05-29 | Merck & Co., Inc. | Thrombin inhibitors |
UA58636C2 (uk) | 1999-06-04 | 2003-08-15 | Мерк Енд Ко., Інк. | Піразинонові інгібітори тромбіну, фармацевтична композиція, спосіб інгібування утворення тромбів у крові, спосіб лікування станів, пов'язаних із тромбоутворенням |
JP2003501389A (ja) | 1999-06-04 | 2003-01-14 | メルク エンド カムパニー インコーポレーテッド | トロンビン阻害物質 |
EP1259506A1 (en) | 1999-11-23 | 2002-11-27 | Merck & Co., Inc. | Pyrazinone thrombin inhibitors |
AU2001245856A1 (en) | 2000-03-23 | 2001-10-03 | Merck & Co., Inc. | Thrombin inhibitors |
TW200500341A (en) * | 2002-11-12 | 2005-01-01 | Astrazeneca Ab | Novel compounds |
PE20050159A1 (es) * | 2003-05-27 | 2005-04-19 | Vertex Pharma | Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa |
SE0302487D0 (sv) * | 2003-09-18 | 2003-09-18 | Astrazeneca Ab | Novel compounds |
CN101098855B (zh) | 2004-11-24 | 2012-06-06 | 沃泰克斯药物股份有限公司 | 3-[2-(3-酰氨基-2-氧代-2h-吡啶-1-基)-乙酰氨基]-4-氧代-戊酸衍生物及其作为天冬氨酸特异性半胱氨酸蛋白酶抑制剂的用途 |
MX2007015427A (es) * | 2005-06-07 | 2008-04-16 | Pharmacopeia Inc | Inhibidores de azinona y diazinona v3 para depresion y trastornos de estres. |
EP1902065A2 (en) * | 2005-06-08 | 2008-03-26 | Novartis AG | Cyclic amide derivatives inhibitors of the inhibitor of apoptosis proteins, their preparation, and their use |
CN110950807B (zh) * | 2018-09-26 | 2023-03-03 | 中国科学院上海药物研究所 | 联芳基类化合物、其制备方法、药物组合物及其应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4474778A (en) * | 1983-11-09 | 1984-10-02 | E. R. Squibb & Sons, Inc. | Lactam containing compounds, their pharmaceutical compositions and method of use |
GB8600263D0 (en) * | 1985-01-22 | 1986-02-12 | Ici America Inc | Peptide derivatives |
-
1992
- 1992-04-01 GB GB929207145A patent/GB9207145D0/en active Pending
- 1992-04-10 NZ NZ242322A patent/NZ242322A/en unknown
- 1992-04-10 KR KR1019920006072A patent/KR920019750A/ko not_active Application Discontinuation
- 1992-04-10 IE IE115992A patent/IE921159A1/en unknown
- 1992-04-10 HU HU9201225A patent/HUT66541A/hu unknown
- 1992-04-10 IL IL101555A patent/IL101555A0/xx unknown
- 1992-04-10 CA CA002065794A patent/CA2065794A1/en not_active Abandoned
- 1992-04-10 FI FI921598A patent/FI921598A/fi not_active Application Discontinuation
- 1992-04-10 AU AU14827/92A patent/AU660664B2/en not_active Ceased
- 1992-04-10 NO NO92921451A patent/NO921451L/no unknown
- 1992-04-15 DE DE69213537T patent/DE69213537T2/de not_active Expired - Fee Related
- 1992-04-15 EP EP92303358A patent/EP0509769B1/en not_active Expired - Lifetime
- 1992-04-16 CS CS921176A patent/CS117692A3/cs unknown
- 1992-04-18 JP JP4143140A patent/JPH0656785A/ja active Pending
- 1992-04-29 TW TW081103383A patent/TW262475B/zh active
Also Published As
Publication number | Publication date |
---|---|
NO921451L (no) | 1992-10-19 |
HUT66541A (en) | 1994-12-28 |
IL101555A0 (en) | 1992-12-30 |
CA2065794A1 (en) | 1992-10-19 |
GB9207145D0 (en) | 1992-05-13 |
DE69213537D1 (de) | 1996-10-17 |
FI921598A0 (fi) | 1992-04-10 |
TW262475B (en) | 1995-11-11 |
IE921159A1 (en) | 1992-10-21 |
HU9201225D0 (en) | 1992-07-28 |
NZ242322A (en) | 1994-12-22 |
EP0509769A3 (en) | 1993-09-01 |
EP0509769A2 (en) | 1992-10-21 |
JPH0656785A (ja) | 1994-03-01 |
NO921451D0 (no) | 1992-04-10 |
DE69213537T2 (de) | 1997-02-20 |
KR920019750A (ko) | 1992-11-19 |
FI921598A (fi) | 1992-10-19 |
AU1482792A (en) | 1992-10-22 |
EP0509769B1 (en) | 1996-09-11 |
AU660664B2 (en) | 1995-07-06 |
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