CR20160282A - Quinazolin-thf-aminas como inhibidores de pde1 - Google Patents
Quinazolin-thf-aminas como inhibidores de pde1Info
- Publication number
- CR20160282A CR20160282A CR20160282A CR20160282A CR20160282A CR 20160282 A CR20160282 A CR 20160282A CR 20160282 A CR20160282 A CR 20160282A CR 20160282 A CR20160282 A CR 20160282A CR 20160282 A CR20160282 A CR 20160282A
- Authority
- CR
- Costa Rica
- Prior art keywords
- quinazolin
- thf
- aminas
- pde1 inhibitors
- pde1
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención proporciona quinazolin-THF-aminas como inhibidores de PDE1 y su uso como un medicamento, en particular para el tratamiento de trastornos neurodegenerativos y trastornos psiquiátricos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA201300707 | 2013-12-19 | ||
DKPA201400249 | 2014-05-06 | ||
PCT/EP2014/078475 WO2015091805A1 (en) | 2013-12-19 | 2014-12-18 | Quinazolin-thf-amines as pde1 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
CR20160282A true CR20160282A (es) | 2016-09-06 |
Family
ID=52350066
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20160282A CR20160282A (es) | 2013-12-19 | 2014-12-18 | Quinazolin-thf-aminas como inhibidores de pde1 |
Country Status (26)
Country | Link |
---|---|
US (3) | US9701665B2 (es) |
EP (1) | EP3083607B1 (es) |
JP (1) | JP6419832B2 (es) |
KR (1) | KR20160098269A (es) |
CN (1) | CN105829300B (es) |
AP (1) | AP2016009293A0 (es) |
AU (1) | AU2014368601B2 (es) |
BR (1) | BR112016013946A8 (es) |
CA (1) | CA2933299A1 (es) |
CL (1) | CL2016001488A1 (es) |
CR (1) | CR20160282A (es) |
DO (1) | DOP2016000152A (es) |
EA (1) | EA201691108A1 (es) |
EC (1) | ECSP16061208A (es) |
ES (1) | ES2728079T3 (es) |
GE (1) | GEP201706764B (es) |
IL (1) | IL246230A0 (es) |
MX (1) | MX2016007945A (es) |
PE (1) | PE20160855A1 (es) |
PH (1) | PH12016501173A1 (es) |
RU (1) | RU2016125315A (es) |
SG (1) | SG11201604936TA (es) |
SV (1) | SV2016005220A (es) |
TN (1) | TN2016000239A1 (es) |
TW (1) | TW201609713A (es) |
WO (1) | WO2015091805A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW201609713A (zh) * | 2013-12-19 | 2016-03-16 | H 朗德貝克公司 | 作爲pde1抑制劑之喹唑啉-thf-胺 |
US10005764B2 (en) | 2014-04-04 | 2018-06-26 | H. Lundbeck A/S | Halogenated quinazolin-THF-amines as PDE1 inhibitors |
TWI729109B (zh) * | 2016-04-12 | 2021-06-01 | 丹麥商H 朗德貝克公司 | 作爲PDE1抑制劑的1,5-二氫-4H-吡唑并[3,4-d]嘧啶-4-酮和1,5-二氫-4H-吡唑并[4,3-c]吡啶-4-酮 |
AU2017388054B2 (en) | 2016-12-28 | 2022-03-24 | Dart Neuroscience, Llc | Substituted pyrazolopyrimidinone compounds as PDE2 inhibitors |
WO2019104285A1 (en) | 2017-11-27 | 2019-05-31 | Dart Neuroscience, Llc | Substituted furanopyrimidine compounds as pde1 inhibitors |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2429132T3 (es) * | 2001-08-31 | 2013-11-13 | The Rockefeller University | Atividad de fosfodiesterasa y regulación de la señalización mediada por fosfodiesterasa 1-B en el cerebro |
ZA200507228B (en) * | 2003-04-01 | 2007-03-28 | Applied Research Systems | Inhibitors of phosphodiesterases in infertility |
EP1751159A2 (en) * | 2004-04-28 | 2007-02-14 | Cv Therapeutics, Inc. | Purine derivatives as a1 adenosine receptor antagonists |
WO2007022280A1 (en) * | 2005-08-16 | 2007-02-22 | Memory Pharmaceuticals Corporation | Phosphodiesterase 10 inhibitors |
CA2641670A1 (en) * | 2006-02-23 | 2007-08-30 | Pfizer Products Inc. | Substituted quinazolines as pde10 inhibitors |
WO2009137465A2 (en) * | 2008-05-05 | 2009-11-12 | University Of Rochester | Methods and compositions for the treatment or prevention of pathological cardiac remodeling and heart failure |
US9468637B2 (en) * | 2009-05-13 | 2016-10-18 | Intra-Cellular Therapies, Inc. | Organic compounds |
JP2013505909A (ja) * | 2009-09-24 | 2013-02-21 | ビーエーエスエフ ソシエタス・ヨーロピア | 無脊椎動物害虫を駆除するためのアミノキナゾリン化合物 |
TW201609713A (zh) | 2013-12-19 | 2016-03-16 | H 朗德貝克公司 | 作爲pde1抑制劑之喹唑啉-thf-胺 |
-
2014
- 2014-12-01 TW TW103141539A patent/TW201609713A/zh unknown
- 2014-12-18 AP AP2016009293A patent/AP2016009293A0/en unknown
- 2014-12-18 AU AU2014368601A patent/AU2014368601B2/en not_active Expired - Fee Related
- 2014-12-18 SG SG11201604936TA patent/SG11201604936TA/en unknown
- 2014-12-18 TN TN2016000239A patent/TN2016000239A1/en unknown
- 2014-12-18 CR CR20160282A patent/CR20160282A/es unknown
- 2014-12-18 CN CN201480068495.XA patent/CN105829300B/zh active Active
- 2014-12-18 CA CA2933299A patent/CA2933299A1/en not_active Abandoned
- 2014-12-18 MX MX2016007945A patent/MX2016007945A/es unknown
- 2014-12-18 PE PE2016000825A patent/PE20160855A1/es not_active Application Discontinuation
- 2014-12-18 GE GEAP201414180A patent/GEP201706764B/en unknown
- 2014-12-18 WO PCT/EP2014/078475 patent/WO2015091805A1/en active Application Filing
- 2014-12-18 EP EP14827431.9A patent/EP3083607B1/en active Active
- 2014-12-18 JP JP2016541407A patent/JP6419832B2/ja active Active
- 2014-12-18 US US15/105,647 patent/US9701665B2/en active Active
- 2014-12-18 BR BR112016013946A patent/BR112016013946A8/pt not_active IP Right Cessation
- 2014-12-18 KR KR1020167016258A patent/KR20160098269A/ko not_active Application Discontinuation
- 2014-12-18 US US14/574,425 patent/US20150175584A1/en not_active Abandoned
- 2014-12-18 RU RU2016125315A patent/RU2016125315A/ru unknown
- 2014-12-18 EA EA201691108A patent/EA201691108A1/ru unknown
- 2014-12-18 ES ES14827431T patent/ES2728079T3/es active Active
-
2016
- 2016-06-14 CL CL2016001488A patent/CL2016001488A1/es unknown
- 2016-06-15 IL IL246230A patent/IL246230A0/en not_active IP Right Cessation
- 2016-06-15 SV SV2016005220A patent/SV2016005220A/es unknown
- 2016-06-16 PH PH12016501173A patent/PH12016501173A1/en unknown
- 2016-06-17 DO DO2016000152A patent/DOP2016000152A/es unknown
- 2016-07-18 EC ECIEPI201661208A patent/ECSP16061208A/es unknown
-
2017
- 2017-06-05 US US15/614,104 patent/US10030007B2/en active Active
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