CR20140528A - Difluoro-hexahidro-ciclopentaoxacinilos y difluoro-hexahidro-benzooxacinilos como inhibidores de Bace1 - Google Patents
Difluoro-hexahidro-ciclopentaoxacinilos y difluoro-hexahidro-benzooxacinilos como inhibidores de Bace1Info
- Publication number
- CR20140528A CR20140528A CR20140528A CR20140528A CR20140528A CR 20140528 A CR20140528 A CR 20140528A CR 20140528 A CR20140528 A CR 20140528A CR 20140528 A CR20140528 A CR 20140528A CR 20140528 A CR20140528 A CR 20140528A
- Authority
- CR
- Costa Rica
- Prior art keywords
- hexahydro
- difluoro
- cyclopentaoxacinyls
- benzooxacinyls
- bace1 inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Abstract
La presente invención proporciona diflouroro-ciclopentaoxacinilos y difluoroenzooxacinilos de fórmula I
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12173690 | 2012-06-26 | ||
PCT/EP2013/063086 WO2014001228A1 (en) | 2012-06-26 | 2013-06-24 | Difluoro-hexahydro-cyclopentaoxazinyls and difluoro-hexahydro-benzooxazinyls as bace1 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
CR20140528A true CR20140528A (es) | 2015-01-12 |
Family
ID=48672630
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20140528A CR20140528A (es) | 2012-06-26 | 2014-11-18 | Difluoro-hexahidro-ciclopentaoxacinilos y difluoro-hexahidro-benzooxacinilos como inhibidores de Bace1 |
Country Status (22)
Country | Link |
---|---|
US (1) | US9181232B2 (es) |
EP (1) | EP2864324B1 (es) |
JP (1) | JP6251257B2 (es) |
KR (1) | KR20150023450A (es) |
CN (1) | CN104470915B (es) |
AU (1) | AU2013283524B2 (es) |
BR (1) | BR112014029742A2 (es) |
CA (1) | CA2872181A1 (es) |
CL (1) | CL2014003325A1 (es) |
CO (1) | CO7151509A2 (es) |
CR (1) | CR20140528A (es) |
EA (1) | EA025273B1 (es) |
HK (1) | HK1206344A1 (es) |
IL (1) | IL236138A (es) |
MA (1) | MA37763B1 (es) |
MX (1) | MX2014014937A (es) |
NZ (1) | NZ702253A (es) |
PE (1) | PE20142450A1 (es) |
PH (1) | PH12014502623B1 (es) |
SG (1) | SG11201407576YA (es) |
UA (1) | UA113309C2 (es) |
WO (1) | WO2014001228A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20130018370A (ko) | 2008-06-13 | 2013-02-20 | 시오노기세야쿠 가부시키가이샤 | β 세크레타제 저해 작용을 갖는 황 함유 복소환 유도체 |
WO2011071135A1 (ja) † | 2009-12-11 | 2011-06-16 | 塩野義製薬株式会社 | オキサジン誘導体 |
WO2014065434A1 (en) | 2012-10-24 | 2014-05-01 | Shionogi & Co., Ltd. | Dihydrooxazine or oxazepine derivatives having bace1 inhibitory activity |
WO2014134341A1 (en) | 2013-03-01 | 2014-09-04 | Amgen Inc. | Perfluorinated 5,6-dihydro-4h-1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use |
EP2964644B1 (en) | 2013-03-08 | 2018-12-26 | Amgen, Inc. | Perfluorinated cyclopropyl fused 1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use |
TW201623295A (zh) | 2014-04-11 | 2016-07-01 | 塩野義製藥股份有限公司 | 具有bace1抑制活性之二氫噻及二氫衍生物 |
MX2017001794A (es) | 2014-08-08 | 2017-06-29 | Amgen Inc | Compuestos de tiazin-2-amina fusionados con ciclopropilo como inhibidores de beta-secretasa y metodos de uso. |
RU2712272C2 (ru) | 2015-03-20 | 2020-01-28 | Ф. Хоффманн-Ля Рош Аг | Ингибиторы бета-секретазы |
US11629154B2 (en) | 2018-04-27 | 2023-04-18 | Shionogi & Co., Ltd. | Tetrahydropyranooxazine derivatives having selective BACE1 inhibitory activity |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPWO2010047372A1 (ja) | 2008-10-22 | 2012-03-22 | 塩野義製薬株式会社 | Bace1阻害活性を有する2−アミノピリミジン−4−オンおよび2−アミノピリジン誘導体 |
GB0912778D0 (en) * | 2009-07-22 | 2009-08-26 | Eisai London Res Lab Ltd | Fused aminodihydro-oxazine derivatives |
UA103272C2 (uk) * | 2009-12-11 | 2013-09-25 | Ф. Хоффманн-Ля Рош Аг | 2-аміно-5,5-дифтор-5,6-дигідро-4h-оксазини як інгібітори bace1 і/або bace2 |
WO2011071135A1 (ja) * | 2009-12-11 | 2011-06-16 | 塩野義製薬株式会社 | オキサジン誘導体 |
-
2013
- 2013-06-24 CA CA2872181A patent/CA2872181A1/en not_active Abandoned
- 2013-06-24 UA UAA201500578A patent/UA113309C2/uk unknown
- 2013-06-24 NZ NZ702253A patent/NZ702253A/en not_active IP Right Cessation
- 2013-06-24 EA EA201590066A patent/EA025273B1/ru not_active IP Right Cessation
- 2013-06-24 MX MX2014014937A patent/MX2014014937A/es unknown
- 2013-06-24 SG SG11201407576YA patent/SG11201407576YA/en unknown
- 2013-06-24 BR BR112014029742A patent/BR112014029742A2/pt not_active IP Right Cessation
- 2013-06-24 AU AU2013283524A patent/AU2013283524B2/en not_active Expired - Fee Related
- 2013-06-24 WO PCT/EP2013/063086 patent/WO2014001228A1/en active Application Filing
- 2013-06-24 JP JP2015519008A patent/JP6251257B2/ja not_active Expired - Fee Related
- 2013-06-24 MA MA37763A patent/MA37763B1/fr unknown
- 2013-06-24 PE PE2014002406A patent/PE20142450A1/es not_active Application Discontinuation
- 2013-06-24 KR KR20147036016A patent/KR20150023450A/ko not_active Application Discontinuation
- 2013-06-24 US US14/406,289 patent/US9181232B2/en not_active Expired - Fee Related
- 2013-06-24 EP EP13730887.0A patent/EP2864324B1/en not_active Not-in-force
- 2013-06-24 CN CN201380033783.7A patent/CN104470915B/zh not_active Expired - Fee Related
-
2014
- 2014-11-18 CR CR20140528A patent/CR20140528A/es unknown
- 2014-11-24 PH PH12014502623A patent/PH12014502623B1/en unknown
- 2014-12-05 CL CL2014003325A patent/CL2014003325A1/es unknown
- 2014-12-08 IL IL236138A patent/IL236138A/en not_active IP Right Cessation
- 2014-12-10 CO CO14271199A patent/CO7151509A2/es unknown
-
2015
- 2015-07-21 HK HK15106931.2A patent/HK1206344A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR20150023450A (ko) | 2015-03-05 |
CA2872181A1 (en) | 2014-01-03 |
US20150133440A1 (en) | 2015-05-14 |
JP2015521640A (ja) | 2015-07-30 |
HK1206344A1 (en) | 2016-01-08 |
EA025273B1 (ru) | 2016-12-30 |
NZ702253A (en) | 2016-06-24 |
PH12014502623A1 (en) | 2015-01-21 |
AU2013283524A1 (en) | 2014-11-13 |
CL2014003325A1 (es) | 2015-04-24 |
PE20142450A1 (es) | 2015-01-28 |
MA37763B1 (fr) | 2017-05-31 |
US9181232B2 (en) | 2015-11-10 |
EA201590066A1 (ru) | 2015-04-30 |
SG11201407576YA (en) | 2015-03-30 |
UA113309C2 (xx) | 2017-01-10 |
PH12014502623B1 (en) | 2015-01-21 |
MX2014014937A (es) | 2015-03-09 |
WO2014001228A1 (en) | 2014-01-03 |
BR112014029742A2 (pt) | 2017-06-27 |
IL236138A0 (en) | 2015-02-01 |
JP6251257B2 (ja) | 2017-12-20 |
CN104470915A (zh) | 2015-03-25 |
IL236138A (en) | 2016-10-31 |
EP2864324A1 (en) | 2015-04-29 |
CO7151509A2 (es) | 2014-12-29 |
EP2864324B1 (en) | 2018-03-28 |
AU2013283524B2 (en) | 2017-03-30 |
CN104470915B (zh) | 2019-07-26 |
MA37763A1 (fr) | 2016-08-31 |
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