CR20120150A - Derivados de 3,5-diciano-4-(1h-indazol-5-il)-2,6-dimetil-1,4-dihidropiridina fluoro-sustituidos y procedimientos de uso de los mismos - Google Patents

Derivados de 3,5-diciano-4-(1h-indazol-5-il)-2,6-dimetil-1,4-dihidropiridina fluoro-sustituidos y procedimientos de uso de los mismos

Info

Publication number
CR20120150A
CR20120150A CR20120150A CR20120150A CR20120150A CR 20120150 A CR20120150 A CR 20120150A CR 20120150 A CR20120150 A CR 20120150A CR 20120150 A CR20120150 A CR 20120150A CR 20120150 A CR20120150 A CR 20120150A
Authority
CR
Costa Rica
Prior art keywords
indazol
fluoro
dimethyl
derivatives
diuidropiridine
Prior art date
Application number
CR20120150A
Other languages
English (en)
Inventor
Martin Michels
Markus Follmann
Alexandros Vakalopoulos
Katja Zimmermann
Nicole Teusch
Mario Lobell
Donald Bierer
Karen Engel
Original Assignee
Bayer Shering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Shering Pharma Ag filed Critical Bayer Shering Pharma Ag
Publication of CR20120150A publication Critical patent/CR20120150A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

La presente invención se refiere a nuevos derivados de 3,5-diciano-4-(1H-indazol-5-il)-2,6-dimetil-1,4-dihidropiridina fluoro-sustituidos que tienen actividad inhibidora de tirosina quinasa de proteínas, a un procedimiento para la aplicación de los mismos y al uso de los mismos para el tratamiento de enfermedades mediadas por c-Met o de afecciones mediadas por c Met, en particular cáncer y otros trastornos proliferativos.
CR20120150A 2009-10-06 2012-03-27 Derivados de 3,5-diciano-4-(1h-indazol-5-il)-2,6-dimetil-1,4-dihidropiridina fluoro-sustituidos y procedimientos de uso de los mismos CR20120150A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP09172304 2009-10-06

Publications (1)

Publication Number Publication Date
CR20120150A true CR20120150A (es) 2012-08-03

Family

ID=43357944

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20120150A CR20120150A (es) 2009-10-06 2012-03-27 Derivados de 3,5-diciano-4-(1h-indazol-5-il)-2,6-dimetil-1,4-dihidropiridina fluoro-sustituidos y procedimientos de uso de los mismos

Country Status (27)

Country Link
US (1) US9422263B2 (es)
EP (1) EP2485726B1 (es)
JP (1) JP5753175B2 (es)
KR (1) KR20120091005A (es)
CN (1) CN102573838B (es)
AR (1) AR078486A1 (es)
AU (1) AU2010305550A1 (es)
BR (1) BR112012006842A2 (es)
CA (1) CA2773676C (es)
CL (1) CL2012000753A1 (es)
CR (1) CR20120150A (es)
CU (1) CU20120051A7 (es)
DO (1) DOP2012000085A (es)
EC (1) ECSP12011748A (es)
ES (1) ES2458117T3 (es)
HK (1) HK1172835A1 (es)
IL (1) IL218415A0 (es)
IN (1) IN2012DN02675A (es)
MX (1) MX2012003603A (es)
NZ (1) NZ599006A (es)
PE (1) PE20121392A1 (es)
RU (1) RU2012111695A (es)
SG (1) SG178990A1 (es)
TW (1) TW201124396A (es)
UY (1) UY32922A (es)
WO (1) WO2011042368A1 (es)
ZA (1) ZA201201524B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009056886A1 (de) * 2009-12-03 2011-06-09 Bayer Schering Pharma Aktiengesellschaft cMet-Inhibitoren zur Behandlung der Endometriose

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3635977A (en) 1969-11-03 1972-01-18 American Cyanamid Co Certain 6-trifluoromethylcytosines and thiocytosines their synthesis and their use in the synthesis of uracisls and thiouracil
DK0379917T3 (da) 1989-01-26 1995-12-11 Bayer Ag Optisk aktive (meth)acrylsyre-drivater, deres fremstilling, deres polymerisation til optisk aktive polymere og disses anvendelse
DE19546136A1 (de) 1995-12-11 1997-06-12 Bayer Ag Chirale stationäre Phasen für die chromatographische Trennung von optischen Isomeren
KR20050004214A (ko) 2002-05-31 2005-01-12 에자이 가부시키가이샤 피라졸 화합물 및 이것을 포함하여 이루어지는 의약 조성물
WO2005085227A1 (en) 2004-03-02 2005-09-15 Smithkline Beecham Corporation Inhibitors of akt activity
EP1722792A1 (de) 2004-03-03 2006-11-22 Boehringer Ingelheim International GmbH Ausgewählte cgrp-antagonisten, verfahren zu deren herstellung sowie deren verwendung als arzneimittel
CA2589777A1 (en) 2004-12-13 2006-06-22 Irm Llc Compounds and compositions as modulators of steroidal receptors and calcium channel activities
WO2006074419A2 (en) 2005-01-07 2006-07-13 Roskamp Research Llc Compounds for inhibiting beta-amyloid production and methods of identifying the compounds
US7632839B2 (en) * 2005-01-19 2009-12-15 Merck & Co. Inc. Mitotic kinesin inhibitors
WO2008071451A1 (en) * 2006-12-14 2008-06-19 Bayer Schering Pharma Aktiengesellschaft Dihydropyridine derivatives useful as protein kinase inhibitors

Also Published As

Publication number Publication date
PE20121392A1 (es) 2012-10-14
JP5753175B2 (ja) 2015-07-22
KR20120091005A (ko) 2012-08-17
US20120264785A1 (en) 2012-10-18
JP2013506699A (ja) 2013-02-28
RU2012111695A (ru) 2013-10-10
EP2485726A1 (en) 2012-08-15
MX2012003603A (es) 2012-04-20
US9422263B2 (en) 2016-08-23
TW201124396A (en) 2011-07-16
ECSP12011748A (es) 2012-05-30
HK1172835A1 (en) 2013-05-03
NZ599006A (en) 2013-11-29
CA2773676C (en) 2017-07-04
IL218415A0 (en) 2012-04-30
UY32922A (es) 2011-04-29
CA2773676A1 (en) 2011-04-14
WO2011042368A1 (en) 2011-04-14
CU20120051A7 (es) 2012-06-29
CL2012000753A1 (es) 2012-09-14
CN102573838A (zh) 2012-07-11
CN102573838B (zh) 2014-09-24
SG178990A1 (en) 2012-04-27
IN2012DN02675A (es) 2015-09-04
ZA201201524B (en) 2013-05-29
EP2485726B1 (en) 2014-03-12
BR112012006842A2 (pt) 2016-06-07
DOP2012000085A (es) 2012-07-15
AU2010305550A1 (en) 2012-03-29
ES2458117T3 (es) 2014-04-30
AR078486A1 (es) 2011-11-09

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