CO7160011A2 - Compuestos de azetidina y piperidina útiles como inhibidores de pde10 - Google Patents
Compuestos de azetidina y piperidina útiles como inhibidores de pde10Info
- Publication number
- CO7160011A2 CO7160011A2 CO15003862A CO15003862A CO7160011A2 CO 7160011 A2 CO7160011 A2 CO 7160011A2 CO 15003862 A CO15003862 A CO 15003862A CO 15003862 A CO15003862 A CO 15003862A CO 7160011 A2 CO7160011 A2 CO 7160011A2
- Authority
- CO
- Colombia
- Prior art keywords
- azetidine
- piperidine compounds
- compounds useful
- pde10 inhibitors
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Abstract
Se describen compuestos de azetidina y piperidina defórmula (I): (I), como se define en la memoriadescriptiva, las composiciones que los contienen y procesospara preparar dichos compuestos e intermediarios de losmismos. También se dan a conocer en el presente métodos paratratar trastornos cognitivos o enfermedades que puedentratarse mediante la inhibición de PDE10, tal como enfermedadde Huntington, esquizofrenia, trastorno bipolar, trastornoobsesivo-compulsivo y similares.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261659911P | 2012-06-14 | 2012-06-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO7160011A2 true CO7160011A2 (es) | 2015-01-15 |
Family
ID=48692687
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO15003862A CO7160011A2 (es) | 2012-06-14 | 2015-01-08 | Compuestos de azetidina y piperidina útiles como inhibidores de pde10 |
Country Status (25)
Country | Link |
---|---|
US (3) | US8691986B2 (es) |
EP (1) | EP2864317A1 (es) |
JP (1) | JP2015519402A (es) |
KR (1) | KR20150023417A (es) |
CN (1) | CN104619694A (es) |
AP (1) | AP2014008136A0 (es) |
AR (1) | AR091436A1 (es) |
AU (1) | AU2013274153B2 (es) |
BR (1) | BR112014031368A2 (es) |
CA (1) | CA2875802A1 (es) |
CL (1) | CL2014003391A1 (es) |
CO (1) | CO7160011A2 (es) |
CR (1) | CR20150012A (es) |
EA (1) | EA201590014A1 (es) |
HK (1) | HK1203935A1 (es) |
IL (1) | IL235901A0 (es) |
MA (1) | MA37748B1 (es) |
MX (1) | MX2014014924A (es) |
PE (1) | PE20150348A1 (es) |
PH (1) | PH12014502780A1 (es) |
SG (1) | SG11201408168UA (es) |
TN (1) | TN2014000510A1 (es) |
TW (1) | TWI508959B (es) |
UY (1) | UY34858A (es) |
WO (1) | WO2013188724A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103221404B (zh) | 2010-05-13 | 2015-12-16 | 安姆根有限公司 | 可用作pde10抑制剂的不饱和氮杂环化合物 |
AR091436A1 (es) * | 2012-06-14 | 2015-02-04 | Amgen Inc | Compuestos de azetidina y piperidina utiles como inhibidores de pde10 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4107288A (en) | 1974-09-18 | 1978-08-15 | Pharmaceutical Society Of Victoria | Injectable compositions, nanoparticles useful therein, and process of manufacturing same |
PT72878B (en) | 1980-04-24 | 1983-03-29 | Merck & Co Inc | Process for preparing mannich-base hydroxamic acid pro-drugs for the improved delivery of non-steroidal anti-inflammatory agents |
US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
AU2011253058A1 (en) * | 2010-05-13 | 2012-12-06 | Amgen Inc. | Heteroaryloxycarbocyclyl compounds as PDE10 inhibitors |
CN103221404B (zh) * | 2010-05-13 | 2015-12-16 | 安姆根有限公司 | 可用作pde10抑制剂的不饱和氮杂环化合物 |
US8946230B2 (en) * | 2010-05-13 | 2015-02-03 | Amgen Inc. | Aryl- and heteroaryl- nitrogen-heterocyclic compounds as PDE10 inhibitors |
EP2569302A1 (en) * | 2010-05-13 | 2013-03-20 | Amgen, Inc | Heteroaryloxyheterocyclyl compounds as pde10 inhibitors |
AR091436A1 (es) * | 2012-06-14 | 2015-02-04 | Amgen Inc | Compuestos de azetidina y piperidina utiles como inhibidores de pde10 |
-
2013
- 2013-06-13 AR ARP130102085 patent/AR091436A1/es unknown
- 2013-06-13 UY UY0001034858A patent/UY34858A/es not_active Application Discontinuation
- 2013-06-14 AP AP2014008136A patent/AP2014008136A0/xx unknown
- 2013-06-14 SG SG11201408168UA patent/SG11201408168UA/en unknown
- 2013-06-14 AU AU2013274153A patent/AU2013274153B2/en not_active Expired - Fee Related
- 2013-06-14 CA CA2875802A patent/CA2875802A1/en not_active Abandoned
- 2013-06-14 MX MX2014014924A patent/MX2014014924A/es unknown
- 2013-06-14 JP JP2015517445A patent/JP2015519402A/ja active Pending
- 2013-06-14 KR KR1020147035700A patent/KR20150023417A/ko not_active Application Discontinuation
- 2013-06-14 TW TW102121229A patent/TWI508959B/zh not_active IP Right Cessation
- 2013-06-14 PE PE2014002438A patent/PE20150348A1/es not_active Application Discontinuation
- 2013-06-14 US US13/917,699 patent/US8691986B2/en active Active
- 2013-06-14 EA EA201590014A patent/EA201590014A1/ru unknown
- 2013-06-14 WO PCT/US2013/045768 patent/WO2013188724A1/en active Application Filing
- 2013-06-14 BR BR112014031368A patent/BR112014031368A2/pt not_active IP Right Cessation
- 2013-06-14 EP EP13731237.7A patent/EP2864317A1/en not_active Withdrawn
- 2013-06-14 CN CN201380031076.4A patent/CN104619694A/zh active Pending
- 2013-06-14 MA MA37748A patent/MA37748B1/fr unknown
-
2014
- 2014-01-31 US US14/170,146 patent/US9303028B2/en active Active
- 2014-11-25 IL IL235901A patent/IL235901A0/en not_active IP Right Cessation
- 2014-12-04 TN TN2014000510A patent/TN2014000510A1/fr unknown
- 2014-12-11 PH PH12014502780A patent/PH12014502780A1/en unknown
- 2014-12-12 CL CL2014003391A patent/CL2014003391A1/es unknown
-
2015
- 2015-01-08 CO CO15003862A patent/CO7160011A2/es unknown
- 2015-01-13 CR CR20150012A patent/CR20150012A/es unknown
- 2015-05-07 HK HK15104351.8A patent/HK1203935A1/xx unknown
-
2016
- 2016-03-01 US US15/058,023 patent/US9493459B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CR20150012A (es) | 2015-02-11 |
TWI508959B (zh) | 2015-11-21 |
HK1203935A1 (en) | 2015-11-06 |
AR091436A1 (es) | 2015-02-04 |
SG11201408168UA (en) | 2015-01-29 |
TN2014000510A1 (en) | 2016-03-30 |
TW201412729A (zh) | 2014-04-01 |
AP2014008136A0 (en) | 2014-12-31 |
IL235901A0 (en) | 2015-09-24 |
BR112014031368A2 (pt) | 2017-06-27 |
MX2014014924A (es) | 2015-03-09 |
CA2875802A1 (en) | 2013-12-19 |
US20160176874A1 (en) | 2016-06-23 |
US9493459B2 (en) | 2016-11-15 |
PE20150348A1 (es) | 2015-03-04 |
US9303028B2 (en) | 2016-04-05 |
JP2015519402A (ja) | 2015-07-09 |
EP2864317A1 (en) | 2015-04-29 |
AU2013274153A1 (en) | 2014-12-18 |
US20130338138A1 (en) | 2013-12-19 |
UY34858A (es) | 2013-11-29 |
KR20150023417A (ko) | 2015-03-05 |
CN104619694A (zh) | 2015-05-13 |
AU2013274153B2 (en) | 2016-05-19 |
US8691986B2 (en) | 2014-04-08 |
MA37748B1 (fr) | 2017-07-31 |
WO2013188724A1 (en) | 2013-12-19 |
US20140148435A1 (en) | 2014-05-29 |
EA201590014A1 (ru) | 2015-04-30 |
PH12014502780A1 (en) | 2015-02-02 |
MA37748A1 (fr) | 2016-11-30 |
CL2014003391A1 (es) | 2015-07-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO6630189A2 (es) | Compuestos heterocíclicos de nitrógeno útiles como inhibidores de pde10 | |
NI201700056A (es) | 2-amino-3,5-difluoro-6-metil-6-fenil-3,4,5,6-tetrahidropiridinas en calidad de inhibidores de bace1 para el tratamiento de la enfermedad de alzhéimer | |
ECSP16072941A (es) | 2-amino-3,5,5-trifluoro-3,4,5,6-tetrahidropiridinas como inhibidores de bace1 para el tratamiento de la enfermedad de alzheimer | |
PE20142335A1 (es) | Sintesis de compuestos heterociclicos | |
NZ700928A (en) | Dna-pk inhibitors | |
CO6382157A2 (es) | Compuestos pirazina como inhibidores de fosfodiesterasa 10 | |
ECSP11010885A (es) | Heteroarilos sustituidos | |
NZ629996A (en) | 2’- substituted carba-nucleoside analogs for antiviral treatment | |
BR112015001608A2 (pt) | inibidor lfa-1 e polimorfo do mesmo | |
BR112015001759A2 (pt) | agentes de modulação de atx | |
UY33950A (es) | Inhibidores de benzodioxano de la producciòn de leucotrieno | |
CR20140071A (es) | Nuevos compuestos de 4-piperidinilo para uso como inhibidores de la tankirasa | |
CU20140072A7 (es) | Derivados de dihidro-oxazina y dihidro-pirido-oxazina | |
EA201500298A1 (ru) | Алкоксипиразолы в качестве активаторов растворимой гуанилатциклазы | |
UY33910A (es) | 6-cicloalquil-pirazolopirimidinonas para el tratamiento de trastornos del SNC | |
ECSP17010238A (es) | Compuestos novedosos de pirimidina sustituidos | |
CO2017001506A2 (es) | Compuestos novedosos de pirimidina sustituidos | |
MX348024B (es) | Compuestos de adamantilo. | |
MX2016006744A (es) | Inhibidores de tirosina cinasa de bruton. | |
MX2016006763A (es) | Inhibidores de tirosina cinasa de bruton. | |
ECSP13013075A (es) | Método de tratamiento de la fiebre dengue | |
PE20150674A1 (es) | Azaheterociclos como inhibidores de bir2 y/o bir3 | |
CO7160011A2 (es) | Compuestos de azetidina y piperidina útiles como inhibidores de pde10 | |
MX2016006351A (es) | Inhibidores de tirosina cinasa de bruton. | |
UY32385A (es) | Amidas de pirazinona sustituida |