CO7071121A2 - Métodos para sintetizar derivados del precusor z de molibdopterina - Google Patents

Métodos para sintetizar derivados del precusor z de molibdopterina

Info

Publication number
CO7071121A2
CO7071121A2 CO13199113A CO13199113A CO7071121A2 CO 7071121 A2 CO7071121 A2 CO 7071121A2 CO 13199113 A CO13199113 A CO 13199113A CO 13199113 A CO13199113 A CO 13199113A CO 7071121 A2 CO7071121 A2 CO 7071121A2
Authority
CO
Colombia
Prior art keywords
molybdopterin
precusor
synthesizing
derivatives
methods
Prior art date
Application number
CO13199113A
Other languages
English (en)
Inventor
Xiangtian Long
Danmei Dai
Andreas Brunner
Derek Kevin Watt
Keith Clinch
Sylvia Myrna Baars
Rachel Anne Dixon
Gillian Mary Little
Cyrille Abel Sebastien Landreau
Nicolas Georges Rene Proisy
Original Assignee
Alexion Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alexion Pharma Inc filed Critical Alexion Pharma Inc
Publication of CO7071121A2 publication Critical patent/CO7071121A2/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574Esters of oxyacids of phosphorus
    • C07F9/65744Esters of oxyacids of phosphorus condensed with carbocyclic or heterocyclic rings or ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14Ortho-condensed systems
    • C07D491/147Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
CO13199113A 2011-02-18 2013-08-22 Métodos para sintetizar derivados del precusor z de molibdopterina CO7071121A2 (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201161444389P 2011-02-18 2011-02-18
US201161444280P 2011-02-18 2011-02-18
US201161444399P 2011-02-18 2011-02-18
US201161498801P 2011-06-20 2011-06-20
US201161498808P 2011-06-20 2011-06-20
US201261599314P 2012-02-15 2012-02-15

Publications (1)

Publication Number Publication Date
CO7071121A2 true CO7071121A2 (es) 2014-09-30

Family

ID=46672966

Family Applications (1)

Application Number Title Priority Date Filing Date
CO13199113A CO7071121A2 (es) 2011-02-18 2013-08-22 Métodos para sintetizar derivados del precusor z de molibdopterina

Country Status (16)

Country Link
US (2) US9260462B2 (es)
EP (1) EP2675278B1 (es)
JP (1) JP5972911B2 (es)
KR (1) KR20140007431A (es)
AR (1) AR085291A1 (es)
AU (1) AU2012219292B2 (es)
BR (1) BR112013020864A2 (es)
CA (1) CA2827679C (es)
CO (1) CO7071121A2 (es)
EA (1) EA201391206A1 (es)
ES (1) ES2569252T3 (es)
IL (1) IL227917A0 (es)
MX (1) MX2013009501A (es)
SG (1) SG192826A1 (es)
TW (1) TW201241005A (es)
WO (1) WO2012112922A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG192826A1 (en) 2011-02-18 2013-09-30 Alexion Pharma Internat Sarl Methods for synthesizing molybdopterin precursor z derivatives
ES2959188T3 (es) * 2015-01-15 2024-02-21 Mayo Found Medical Education & Res Procedimientos de tratamiento de trastornos inflamatorios neurológicos
WO2017019532A1 (en) 2015-07-24 2017-02-02 Alexion Pharmaceuticals, Inc. Precursor z (cpmp) to treat molybdenum cofactor deficiency type a
BR112018012914B1 (pt) 2015-12-22 2023-04-18 SHY Therapeutics LLC Composto, uso de um composto e composição farmacêutica
KR20200041294A (ko) 2017-06-21 2020-04-21 샤이 테라퓨틱스 엘엘씨 암, 염증성 질환, 신경발달질환 및 섬유증 질환의 치료를 위하여 Ras 수퍼패밀리와 상호작용하는 화합물
WO2023227763A1 (en) 2022-05-27 2023-11-30 Arlanxeo Deutschland Gmbh Rubber compounds of functionalized conjugated diene rubbers and silica fillers

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
CA1262347A (en) 1985-01-28 1989-10-17 Suntory Limited Preparation process of (6r)-tetrahydro-l-biopterin
WO2000078968A2 (en) * 1999-06-18 2000-12-28 Elitra Pharmaceuticals, Inc. Nucleotide sequences of moraxella catarrhalis genome
PT1294358E (pt) 2000-06-28 2004-12-31 Smithkline Beecham Plc Processo de moagem por via humida
US20030207430A1 (en) * 2001-03-01 2003-11-06 Tang Y. Tom Human enzyme molecules
DE102004004642A1 (de) 2004-01-29 2006-04-27 Schwarz, Guenter, Dr. Produktion, Gewinnung und therapeutischer Einsatz des Molybdopterin-Derivats Precursor Z zur Therapie der Stoffwechselerkrankung humaner Molybdäncofaktor-Defizienz und anderer assoziierter Krankheiten
WO2007052308A2 (en) 2005-11-03 2007-05-10 Brain N' Beyond Biotech Pvt. Ltd. Glyco-phosphorylated biologically active agents
CA2675134A1 (en) 2007-01-12 2008-07-24 Biomarin Pharmaceutical Inc. Pterin analogs
US7888506B2 (en) * 2007-01-26 2011-02-15 Duquesne University Of The Holy Spirit Composition, synthesis, and use of a new class of fluorophores
CA2711444C (en) 2008-01-07 2017-12-12 Biomarin Pharmaceutical Inc. Method of synthesizing tetrahydrobiopterin
JP5587213B2 (ja) * 2008-02-26 2014-09-10 サンド・アクチエンゲゼルシヤフト モルホリン誘導体の調製
SG192826A1 (en) 2011-02-18 2013-09-30 Alexion Pharma Internat Sarl Methods for synthesizing molybdopterin precursor z derivatives

Also Published As

Publication number Publication date
US20140323726A1 (en) 2014-10-30
US9260462B2 (en) 2016-02-16
ES2569252T3 (es) 2016-05-09
AU2012219292A1 (en) 2013-03-14
MX2013009501A (es) 2014-02-03
EP2675278A1 (en) 2013-12-25
WO2012112922A1 (en) 2012-08-23
EP2675278B1 (en) 2016-02-17
CA2827679A1 (en) 2012-08-23
CA2827679C (en) 2020-06-02
AU2012219292B2 (en) 2015-03-05
EA201391206A1 (ru) 2014-02-28
JP2014510054A (ja) 2014-04-24
BR112013020864A2 (pt) 2019-09-24
AR085291A1 (es) 2013-09-18
IL227917A0 (en) 2013-09-30
TW201241005A (en) 2012-10-16
US20140303367A1 (en) 2014-10-09
KR20140007431A (ko) 2014-01-17
JP5972911B2 (ja) 2016-08-17
EP2675278A4 (en) 2014-08-20
SG192826A1 (en) 2013-09-30
NZ614009A (en) 2014-08-29

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