CO6251361A2 - Nuevos derivados de n- - Google Patents
Nuevos derivados de n-Info
- Publication number
- CO6251361A2 CO6251361A2 CO09122476A CO09122476A CO6251361A2 CO 6251361 A2 CO6251361 A2 CO 6251361A2 CO 09122476 A CO09122476 A CO 09122476A CO 09122476 A CO09122476 A CO 09122476A CO 6251361 A2 CO6251361 A2 CO 6251361A2
- Authority
- CO
- Colombia
- Prior art keywords
- alkoxyc1
- 6alkyl
- 6alkoxy
- compounds
- 6haloalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrane Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invención se refiere a nuevoscompuestos de fórmula (I) y a composicionesfarmacéuticas que contienen dichos compuestos y al usode dichos compuestos en terapia. La presente invenciónse refiere además a los procesos para la preparación dedichos compuestos y a nuevos intermedios útiles en lapreparación de los mismos.1.- Un compuesto de fórmula I,en la que:X es O o CH2;R1 es piridinilo, pirazolilo, isoxazolilo, pirimidinilo, piridazinilo, imidazopiridinilo o pirazinilo, que puede estar mono-, di-o trisustituido independientemente con R11, R12 y/o R13; donde R11, R12 y R13 se seleccionan independientemente entre halógeno, C1-6alquilo, C1-6alcoxi, C3-6cicloalquilo, C1-6hidroxiaIquilo, C3-6cicloalquiloxi, C3-6cicloalquilC1-6alcoxi, ciano, hidroxi, C1-6haloalquilo, C1-6haloalcoxi, C1-6haloalcoxiC1-6alcoxi, C1-6haloalcoxiC1-6alquilo, ácido C1-6alquilsulfónico, ácido C1-6haloalquilsulfónico, ácido C3-6cicloalquilsulfónico, ácido C3-6halocicloalquilsulfónico, ácido C3-6cicloalquilC1-6alquilsulfónico, ácido C3-6halocicloalquilC1-6alquilsulfónico, C1-6alquilsulfonil-, C1-6haloalquilsulfonil-, C3-6cicloalquilsulfonil-, C3-6halocicloalquilsulfonil-, C3-6cicloalquilC1-6alquilsulfonilo, C3-6halocicloalquilC1-6alquilsulfonilo, fenilo, fenilC1-6alquil-, fenoxi, C1-6alquilfenil-, C1-6alcoxifenil-, C1-6alquilamina, C1-6haloalquilamina, -C(O)NHC1-6alquilo, -C(O)N(C1-6alquil)2 y -C(O)NH2; R2 es pirazinilo, fenilo, piridinilo, quinoxalinilo, triazolilo, piridonilo, naftiridinilo, pirimidinilo o quinolinilo, que puede estar mono-, di- o trisustituido independientemente con R14, R15 y/o R16; donde R14, R15 y R16 se seleccionan independientemente entre halógeno, C1-6alquilo, C2-6alquenilo, C3-6alquinilo, C1-6alcoxi, C2-6alqueniloxi, C3-6alquiniloxi, C3-6cicloalquilo, C3-6heterocicloalquilo, C3-6cicloalquiloxi, C3-6 heterocicloalquiloxi, C3-6cicloalquilC1-6alcoxi, C1-6alquil-C3-6cicloalquilC1-6alcoxi, C3-6heterocicloalquilC1-6alcoxi, C1-6alquil-C3-6heterocicloalquilC1-6alcoxi, C1-6alcoxiC1-6alcoxi, C1-6alcoxiC1-6alquilo, C1-6hidroxialquilo, C1-6haloalquilo, ...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91331207P | 2007-04-23 | 2007-04-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6251361A2 true CO6251361A2 (es) | 2011-02-21 |
Family
ID=39876087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO09122476A CO6251361A2 (es) | 2007-04-23 | 2009-10-29 | Nuevos derivados de n- |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US8143408B2 (es) |
| EP (1) | EP2158198B1 (es) |
| JP (1) | JP2010525056A (es) |
| KR (1) | KR20100015827A (es) |
| CN (1) | CN101687860B (es) |
| AR (1) | AR066266A1 (es) |
| AU (1) | AU2008241610B2 (es) |
| BR (1) | BRPI0810354A2 (es) |
| CA (1) | CA2685141A1 (es) |
| CL (1) | CL2008001170A1 (es) |
| CO (1) | CO6251361A2 (es) |
| EC (1) | ECSP099706A (es) |
| IL (1) | IL201309A0 (es) |
| MX (1) | MX2009011364A (es) |
| MY (1) | MY146662A (es) |
| NZ (1) | NZ581353A (es) |
| PE (1) | PE20090727A1 (es) |
| RU (1) | RU2460730C2 (es) |
| SA (1) | SA08290245B1 (es) |
| TW (1) | TW200848037A (es) |
| UY (1) | UY31046A1 (es) |
| WO (1) | WO2008130320A2 (es) |
| ZA (1) | ZA200907137B (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SA08290245B1 (ar) * | 2007-04-23 | 2012-02-12 | استرازينيكا ايه بي | مشتقات كربو كساميد جديدة من -n (8-اريل رباعي هيدرو نفثالين غير متجانس- 2- يل) أو -n (5-اريل كرومان غير متجانس -3-يل) لعلاج الألم |
| AR074760A1 (es) * | 2008-12-18 | 2011-02-09 | Metabolex Inc | Agonistas del receptor gpr120 y usos de los mismos en medicamentos para el tratamiento de diabetes y el sindrome metabolico. |
| EP3725775A1 (en) | 2009-02-17 | 2020-10-21 | Syntrix Biosystems, Inc. | Pyridine- and pyrimidinecarboxamides as cxcr2 modulators |
| ES2613664T3 (es) * | 2009-10-26 | 2017-05-25 | Signal Pharmaceuticals, Llc | Procedimientos de síntesis y purificación de compuestos de heteroarilo |
| UA103272C2 (uk) | 2009-12-11 | 2013-09-25 | Ф. Хоффманн-Ля Рош Аг | 2-аміно-5,5-дифтор-5,6-дигідро-4h-оксазини як інгібітори bace1 і/або bace2 |
| CN102971304A (zh) | 2010-02-01 | 2013-03-13 | 日本化学医药株式会社 | Gpr119激动剂 |
| AU2011293612B2 (en) | 2010-08-23 | 2015-11-26 | Syntrix Biosystems Inc. | Aminopyridine- and aminopyrimidinecarboxamides as CXCR2 modulators |
| WO2012039657A1 (en) * | 2010-09-22 | 2012-03-29 | Astrazeneca Ab | Novel chromane compound for the treatment of pain disorders |
| CN102408385B (zh) * | 2011-06-20 | 2014-06-18 | 雅本化学股份有限公司 | 一种2-取代-2h-1,2,3-三氮唑衍生物的制备方法 |
| CN102408386B (zh) * | 2011-07-27 | 2014-05-07 | 雅本化学股份有限公司 | 2,4-二取代-2h-1,2,3-三氮唑衍生物的制备方法 |
| CN102603659B (zh) * | 2012-03-01 | 2014-03-26 | 雅本化学股份有限公司 | 1-取代-4-溴-1h-1,2,3-三氮唑-5-羧酸及其制备方法 |
| US9139529B2 (en) * | 2013-01-31 | 2015-09-22 | Vertex Pharmaceuticals Incorporated | Substituted quinoxalines as sodium channel modulators |
| US8969365B2 (en) | 2013-08-02 | 2015-03-03 | Syntrix Biosystems, Inc. | Thiopyrimidinecarboxamides as CXCR1/2 modulators |
| US10561676B2 (en) | 2013-08-02 | 2020-02-18 | Syntrix Biosystems Inc. | Method for treating cancer using dual antagonists of CXCR1 and CXCR2 |
| US10046002B2 (en) | 2013-08-02 | 2018-08-14 | Syntrix Biosystems Inc. | Method for treating cancer using chemokine antagonists |
| BR112016017996A2 (pt) * | 2014-02-06 | 2017-08-08 | Abbvie Inc | 6-heteroariloxi- or 6-ariloxi-quinolina-2-carboxamidas e método de uso |
| KR102412146B1 (ko) | 2015-02-11 | 2022-06-22 | 주식회사 아이엔테라퓨틱스 | 소디움 채널 차단제 |
| PE20181301A1 (es) | 2015-11-13 | 2018-08-09 | Dae Woong Pharma | Bloqueador del canal de sodio |
| CN105541774B (zh) * | 2016-01-13 | 2018-06-15 | 华中师范大学 | 3,4-二氢香豆素类化合物及其制备方法和用途 |
| KR20200020911A (ko) * | 2017-06-30 | 2020-02-26 | 바이엘 애니멀 헬스 게엠베하 | 새로운 아자퀴놀린 유도체 |
| CA3087283A1 (en) | 2018-01-19 | 2019-07-25 | Cytokinetics, Inc. | Dihydrobenzofuran and inden analogs as cardiac sarcomere inhibitors |
| AU2019232437A1 (en) | 2018-03-07 | 2020-10-08 | Bayer Aktiengesellschaft | Identification and use of ERK5 inhibitors |
| WO2020005887A1 (en) | 2018-06-26 | 2020-01-02 | Cytokinetics, Inc. | Cardiac sarcomere inhibitors |
| MX2021001636A (es) | 2018-09-10 | 2021-05-12 | Kaken Pharma Co Ltd | Derivado de amida heteroaromatico y medicamento que contiene el mismo. |
| WO2020234103A1 (en) | 2019-05-21 | 2020-11-26 | Bayer Aktiengesellschaft | Identification and use of kras inhibitors |
| KR20240015622A (ko) | 2021-03-04 | 2024-02-05 | 싸이토키네틱스, 인코포레이티드 | 심장 근절 억제제 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8904361D0 (sv) * | 1989-12-22 | 1989-12-22 | Astra Ab | New chroman and thiochroman derivatives |
| WO1994012493A1 (en) * | 1992-11-25 | 1994-06-09 | Sandoz, Ltd. | 2,2-dialkyl- and 2,2-dialkyl-3,4-dihydro-3-hydroxy-2h-1-benzopyr ans, their use as pharmaceuticals |
| JPH0827153A (ja) * | 1994-07-12 | 1996-01-30 | Nippon Kayaku Co Ltd | アザクロマン誘導体及びその用途 |
| SE9601110D0 (sv) | 1996-03-22 | 1996-03-22 | Astra Ab | Substituted 1,2,3,4-tetrahydronaphthalene derivatives |
| GB9713804D0 (en) * | 1997-06-30 | 1997-09-03 | Novo Nordisk As | Particulate polymeric materials and their use |
| JPH1135569A (ja) | 1997-07-22 | 1999-02-09 | Meiji Milk Prod Co Ltd | ポリフェノール化合物及びこれを含有する医薬 |
| SE9702799D0 (sv) * | 1997-07-25 | 1997-07-25 | Astra Ab | New compounds |
| SE9703377D0 (sv) | 1997-09-18 | 1997-09-18 | Astra Ab | New compounds |
| SE9703378D0 (sv) * | 1997-09-18 | 1997-09-18 | Astra Ab | New compounds |
| US7615563B2 (en) | 2003-08-08 | 2009-11-10 | Gonzalez Iii Jesus E | Compositions useful as inhibitors of voltage-gated sodium channels |
| TW200524888A (en) * | 2003-08-08 | 2005-08-01 | Vertex Pharma | Compositions useful as inhibitors of voltage-gated ion channels |
| WO2006119451A1 (en) * | 2005-05-04 | 2006-11-09 | Vertex Pharmaceuticals Incorporated | Pyrimidines and pyrazines useful as modulators of ion channels |
| EP2044019A1 (en) * | 2006-07-12 | 2009-04-08 | Astra Zeneca AB | 3-oxoisoindoline-1-carboxamide derivatives as analgesic agents |
| SA08290245B1 (ar) * | 2007-04-23 | 2012-02-12 | استرازينيكا ايه بي | مشتقات كربو كساميد جديدة من -n (8-اريل رباعي هيدرو نفثالين غير متجانس- 2- يل) أو -n (5-اريل كرومان غير متجانس -3-يل) لعلاج الألم |
-
2008
- 2008-04-21 SA SA8290245A patent/SA08290245B1/ar unknown
- 2008-04-22 WO PCT/SE2008/050459 patent/WO2008130320A2/en active Application Filing
- 2008-04-22 MY MYPI20094419A patent/MY146662A/en unknown
- 2008-04-22 NZ NZ581353A patent/NZ581353A/en not_active IP Right Cessation
- 2008-04-22 RU RU2009138137/04A patent/RU2460730C2/ru not_active IP Right Cessation
- 2008-04-22 US US12/596,878 patent/US8143408B2/en not_active Expired - Fee Related
- 2008-04-22 KR KR1020097022164A patent/KR20100015827A/ko not_active Application Discontinuation
- 2008-04-22 AU AU2008241610A patent/AU2008241610B2/en not_active Ceased
- 2008-04-22 MX MX2009011364A patent/MX2009011364A/es active IP Right Grant
- 2008-04-22 EP EP08779260A patent/EP2158198B1/en active Active
- 2008-04-22 CN CN2008800215491A patent/CN101687860B/zh not_active Expired - Fee Related
- 2008-04-22 CA CA002685141A patent/CA2685141A1/en not_active Abandoned
- 2008-04-22 BR BRPI0810354-2A2A patent/BRPI0810354A2/pt not_active IP Right Cessation
- 2008-04-22 JP JP2010506133A patent/JP2010525056A/ja active Pending
- 2008-04-23 TW TW097114910A patent/TW200848037A/zh unknown
- 2008-04-23 CL CL2008001170A patent/CL2008001170A1/es unknown
- 2008-04-23 PE PE2008000697A patent/PE20090727A1/es not_active Application Discontinuation
- 2008-04-23 UY UY31046A patent/UY31046A1/es not_active Application Discontinuation
- 2008-04-23 AR ARP080101710A patent/AR066266A1/es not_active Application Discontinuation
-
2009
- 2009-10-01 IL IL201309A patent/IL201309A0/en unknown
- 2009-10-13 ZA ZA200907137A patent/ZA200907137B/xx unknown
- 2009-10-29 EC EC2009009706A patent/ECSP099706A/es unknown
- 2009-10-29 CO CO09122476A patent/CO6251361A2/es not_active Application Discontinuation
-
2012
- 2012-03-23 US US13/427,981 patent/US20120238579A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MX2009011364A (es) | 2009-11-05 |
| TW200848037A (en) | 2008-12-16 |
| WO2008130320A3 (en) | 2008-12-18 |
| CN101687860B (zh) | 2012-07-04 |
| ECSP099706A (es) | 2009-11-30 |
| CL2008001170A1 (es) | 2009-05-22 |
| EP2158198A4 (en) | 2012-01-04 |
| KR20100015827A (ko) | 2010-02-12 |
| MY146662A (en) | 2012-09-14 |
| NZ581353A (en) | 2012-02-24 |
| RU2009138137A (ru) | 2011-05-27 |
| EP2158198A2 (en) | 2010-03-03 |
| IL201309A0 (en) | 2010-05-31 |
| ZA200907137B (en) | 2010-07-28 |
| BRPI0810354A2 (pt) | 2014-10-21 |
| AU2008241610B2 (en) | 2011-08-18 |
| SA08290245B1 (ar) | 2012-02-12 |
| RU2460730C2 (ru) | 2012-09-10 |
| EP2158198B1 (en) | 2013-03-20 |
| WO2008130320A2 (en) | 2008-10-30 |
| US8143408B2 (en) | 2012-03-27 |
| UY31046A1 (es) | 2008-11-28 |
| AR066266A1 (es) | 2009-08-05 |
| CN101687860A (zh) | 2010-03-31 |
| US20120238579A1 (en) | 2012-09-20 |
| PE20090727A1 (es) | 2009-07-23 |
| US20100137322A1 (en) | 2010-06-03 |
| AU2008241610A1 (en) | 2008-10-30 |
| JP2010525056A (ja) | 2010-07-22 |
| CA2685141A1 (en) | 2008-10-30 |
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