CO6190616A2 - Carboxamidas n-fenil-bipirrolidina sustituidas y su uso terapeutico - Google Patents
Carboxamidas n-fenil-bipirrolidina sustituidas y su uso terapeuticoInfo
- Publication number
- CO6190616A2 CO6190616A2 CO10044768A CO10044768A CO6190616A2 CO 6190616 A2 CO6190616 A2 CO 6190616A2 CO 10044768 A CO10044768 A CO 10044768A CO 10044768 A CO10044768 A CO 10044768A CO 6190616 A2 CO6190616 A2 CO 6190616A2
- Authority
- CO
- Colombia
- Prior art keywords
- phenyl
- substituted
- bipirrolidine
- carboxamids
- therapeutic use
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invención describe y reivindica una serie de carboxarnidas N-fenil-bipirrolidina sustituida de fórmula (I).En la que R, R1, R2, R3 y R4 son como se describieron en la presente. Más específicamente, los compuestos de esta invención son moduladores de los receptores H3 y, por lo tanto, son útiles como agentes farmacéuticos, especialmente en el tratamiento y/o la prevención de una variedad de enfermedades moduladas por los receptores H3, incluyendo enfermedades asociadas con el sistema nervioso central. Además, la presente invención también describe métodos para la preparación de carboxamidas N-fenil-bipirrolidina sustituidas e intermedios para ello. 1.- Un compuesto de fórmula (I):en la que R, R1, R2 y R3 son iguales o diferentes e independientemente uno del otro se seleccionan entre hidrógeno, alquilo (C1-C4) o CF3;R4 se selecciona del grupo que consiste en dimetilaminometilo, metanosulfonilmetilo, fenoximetilo, vinilbenceno, etinilbenceno, vinilpiridina, fenilo, benzofuranilo, dihidro-benzofuranilo, oxo-tetrahidro-benzofuranilo, benzodioxolilo, oxo-cromenilo, dihidrobenzo-dioxinilo, dioxo tetrahidro-1H-benzo[e]diazepinilo, imidazopiridinilo, benzotriazolilo, benzoimidazolilo, oxo-dihidro-benzoimidazolilo, indolilo, indazolilo, naftiridinilo, quinolinilo, benzoimidazotiazolilo, piridinilo, pirimidinilo, pirrolilo, triazolilo, tienilo, tiazolilo, tetrahidrofuranilo o pirrolidinilo; donde dicho R4 está opcionalmente sustituido una o más veces con un sustituyente seleccionado entre halógeno, hidroxi, metilo, etilo, isopropilo, propoxietilo, fenilo, benzoilo, metoxi, difluorometoxi, CF3, CN, acetilo, metanosulfonilo, sulfamoilo, dimetilamino, N-formil-metilamino, 2-hidroxietilamino, 2-metoxietilamido, benciloximetilo, carboxifenoxi, pirazolilo, 3,5-dimetil-pirazolilo, imidazolilo, triazolilo, oxazolilo, piridinilo, oxo-dihidro-piridinilo, pirimidinil-metilamino, N-acetil-piperidinilo, morfolinilo, morfolinilmetilo o 2-oxo-pirrolidinilo; o su sal o su enantiómero o diastereómero.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98060107P | 2007-10-17 | 2007-10-17 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6190616A2 true CO6190616A2 (es) | 2010-08-19 |
Family
ID=40243633
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO10044768A CO6190616A2 (es) | 2007-10-17 | 2010-04-16 | Carboxamidas n-fenil-bipirrolidina sustituidas y su uso terapeutico |
Country Status (26)
Country | Link |
---|---|
US (1) | US8618159B2 (es) |
EP (1) | EP2212282B1 (es) |
JP (1) | JP5255644B2 (es) |
KR (1) | KR20100092441A (es) |
CN (1) | CN101903339B (es) |
AT (1) | ATE525350T1 (es) |
AU (1) | AU2008312638B2 (es) |
BR (1) | BRPI0818626A2 (es) |
CA (1) | CA2702482C (es) |
CO (1) | CO6190616A2 (es) |
CY (1) | CY1112683T1 (es) |
DK (1) | DK2212282T3 (es) |
ES (1) | ES2374116T3 (es) |
HK (1) | HK1146054A1 (es) |
HR (1) | HRP20110953T1 (es) |
IL (1) | IL205003A0 (es) |
MA (1) | MA31855B1 (es) |
MX (1) | MX2010004094A (es) |
MY (1) | MY149650A (es) |
NZ (1) | NZ584688A (es) |
PL (1) | PL2212282T3 (es) |
PT (1) | PT2212282E (es) |
RU (1) | RU2477719C2 (es) |
SI (1) | SI2212282T1 (es) |
WO (1) | WO2009052065A1 (es) |
ZA (1) | ZA201001946B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2010003949A (es) | 2007-10-17 | 2010-04-30 | Sanofi Aventis | N-fenil-bipirrolidina carboxamidas sustituidas y uso terapeutico de las mismas. |
PT2205558E (pt) | 2007-10-17 | 2012-11-02 | Sanofi Sa | Amidas de n-fenil-pirrolidinilmetilpirrolidina substituídas e sua utilização terapêutica como moduladores do receptor h3 da histamina |
EP2215058B1 (en) | 2007-10-17 | 2011-11-23 | Sanofi | Substituted n-phenyl-bipyrrolidine ureas and therapeutic use thereof |
AR074466A1 (es) | 2008-12-05 | 2011-01-19 | Sanofi Aventis | Piperidina espiro pirrolidinona y piperidinona sustituidas y su uso terapeutico en enfermedades mediadas por la modulacion de los receptores h3. |
AR074467A1 (es) | 2008-12-05 | 2011-01-19 | Sanofi Aventis | Tetrahidropiran espiro pirrolidinonas y piperidinonas sustituidas, composiciones farmaceuticas que las contienen y uso de las mismas en el tratamiento y/o prevencion de enfermedades del snc ,tales como alzheimer y parkinson, entre otras. |
WO2011143148A1 (en) | 2010-05-11 | 2011-11-17 | Sanofi | Substituted n-heteroaryl spirolactam bipyrrolidines, preparation and therapeutic use thereof |
TW201206444A (en) | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted N-heteroaryl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof |
EP2569296A1 (en) * | 2010-05-11 | 2013-03-20 | Sanofi | Substituted n-phenyl spirolactam bipyrrolidines, preparation and therapeutic use thereof |
TW201206889A (en) * | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted N-alkyl and N-acyl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof |
JP5968307B2 (ja) * | 2010-05-11 | 2016-08-10 | サノフイ | 置換フェニルシクロアルキルピロリジン(ピペリジン)スピロラクタム類及びアミド類、それらの製造及び治療的使用 |
AR081383A1 (es) | 2010-05-11 | 2012-08-29 | Sanofi Aventis | N-heteroaril bipirrolidin carboxamidas sustituidas, composiciones farmaceuticas que las contienen y uso de las mismas para el tratamiento de enfermedades del sistema nervioso central. |
JP2013529198A (ja) * | 2010-05-11 | 2013-07-18 | サノフイ | 置換されたn−ヘテロシクロアルキルビピロリジニルフェニルアミド誘導体、その製造及び治療上の使用 |
CN103717757A (zh) * | 2011-05-24 | 2014-04-09 | 威斯特研究所 | 用于调节爱泼斯坦-巴尔核抗原1的活性的组合物和方法 |
US9828345B2 (en) | 2013-02-28 | 2017-11-28 | Bristol-Myers Squibb Company | Phenylpyrazole derivatives as potent ROCK1 and ROCK2 inhibitors |
TW201444798A (zh) | 2013-02-28 | 2014-12-01 | 必治妥美雅史谷比公司 | 作爲強效rock1及rock2抑制劑之苯基吡唑衍生物 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20020507A1 (es) * | 2000-10-17 | 2002-06-25 | Schering Corp | Compuestos no-imidazoles como antagonistas del receptor histamina h3 |
AU2003287206A1 (en) * | 2002-10-23 | 2004-05-13 | Janssen Pharmaceutica, N.V. | Phenylpiperidines and phenylpyrrolidines as histamine h3 receptor modulators |
DE10306250A1 (de) * | 2003-02-14 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
US7223788B2 (en) * | 2003-02-14 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Substituted N-aryl heterocycles, process for their preparation and their use as medicaments |
US7951826B2 (en) | 2005-03-17 | 2011-05-31 | Eli Lilly And Company | Pyrrolidine derivatives as histamine H3 receptor antagonists |
EP1868991B1 (en) * | 2005-04-01 | 2014-07-30 | Eli Lilly And Company | Histamine h3 receptor agents, preparation and therapeutic uses |
CN101263112B (zh) * | 2005-07-01 | 2012-10-10 | 伊莱利利公司 | 组胺h3受体药物、其制备和治疗用途 |
AU2006308167A1 (en) * | 2005-10-27 | 2007-05-03 | Ucb Pharma, S.A. | Compounds comprising a lactam or a lactam derivative moiety, processes for making them, and their uses |
PT2205558E (pt) * | 2007-10-17 | 2012-11-02 | Sanofi Sa | Amidas de n-fenil-pirrolidinilmetilpirrolidina substituídas e sua utilização terapêutica como moduladores do receptor h3 da histamina |
EP2215058B1 (en) * | 2007-10-17 | 2011-11-23 | Sanofi | Substituted n-phenyl-bipyrrolidine ureas and therapeutic use thereof |
MX2010003949A (es) | 2007-10-17 | 2010-04-30 | Sanofi Aventis | N-fenil-bipirrolidina carboxamidas sustituidas y uso terapeutico de las mismas. |
-
2008
- 2008-10-14 RU RU2010119560/04A patent/RU2477719C2/ru not_active IP Right Cessation
- 2008-10-14 MX MX2010004094A patent/MX2010004094A/es active IP Right Grant
- 2008-10-14 ES ES08839473T patent/ES2374116T3/es active Active
- 2008-10-14 BR BRPI0818626A patent/BRPI0818626A2/pt not_active IP Right Cessation
- 2008-10-14 CN CN2008801211996A patent/CN101903339B/zh not_active Expired - Fee Related
- 2008-10-14 WO PCT/US2008/079760 patent/WO2009052065A1/en active Application Filing
- 2008-10-14 EP EP08839473A patent/EP2212282B1/en active Active
- 2008-10-14 PL PL08839473T patent/PL2212282T3/pl unknown
- 2008-10-14 AU AU2008312638A patent/AU2008312638B2/en not_active Ceased
- 2008-10-14 DK DK08839473.9T patent/DK2212282T3/da active
- 2008-10-14 AT AT08839473T patent/ATE525350T1/de active
- 2008-10-14 JP JP2010530052A patent/JP5255644B2/ja not_active Expired - Fee Related
- 2008-10-14 CA CA2702482A patent/CA2702482C/en not_active Expired - Fee Related
- 2008-10-14 SI SI200830482T patent/SI2212282T1/sl unknown
- 2008-10-14 NZ NZ584688A patent/NZ584688A/en not_active IP Right Cessation
- 2008-10-14 MY MYPI2010001276A patent/MY149650A/en unknown
- 2008-10-14 KR KR1020107010545A patent/KR20100092441A/ko not_active Application Discontinuation
- 2008-10-14 PT PT08839473T patent/PT2212282E/pt unknown
-
2010
- 2010-03-15 US US12/724,035 patent/US8618159B2/en active Active
- 2010-03-18 ZA ZA201001946A patent/ZA201001946B/xx unknown
- 2010-04-11 IL IL205003A patent/IL205003A0/en unknown
- 2010-04-16 CO CO10044768A patent/CO6190616A2/es not_active Application Discontinuation
- 2010-05-17 MA MA32846A patent/MA31855B1/fr unknown
-
2011
- 2011-01-12 HK HK11100255.7A patent/HK1146054A1/xx not_active IP Right Cessation
- 2011-12-19 HR HR20110953T patent/HRP20110953T1/hr unknown
- 2011-12-21 CY CY20111101272T patent/CY1112683T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
PL2212282T3 (pl) | 2012-02-29 |
CA2702482C (en) | 2012-11-27 |
ZA201001946B (en) | 2010-10-27 |
MA31855B1 (fr) | 2010-11-01 |
HRP20110953T1 (hr) | 2012-01-31 |
US20100173897A1 (en) | 2010-07-08 |
KR20100092441A (ko) | 2010-08-20 |
EP2212282A1 (en) | 2010-08-04 |
AU2008312638B2 (en) | 2013-05-16 |
AU2008312638A1 (en) | 2009-04-23 |
PT2212282E (pt) | 2012-01-09 |
DK2212282T3 (da) | 2012-01-23 |
MX2010004094A (es) | 2010-04-30 |
RU2010119560A (ru) | 2011-11-27 |
NZ584688A (en) | 2011-12-22 |
CA2702482A1 (en) | 2009-04-23 |
CY1112683T1 (el) | 2016-02-10 |
CN101903339A (zh) | 2010-12-01 |
EP2212282B1 (en) | 2011-09-21 |
WO2009052065A1 (en) | 2009-04-23 |
ATE525350T1 (de) | 2011-10-15 |
US8618159B2 (en) | 2013-12-31 |
JP5255644B2 (ja) | 2013-08-07 |
CN101903339B (zh) | 2012-06-27 |
ES2374116T3 (es) | 2012-02-13 |
HK1146054A1 (en) | 2011-05-13 |
RU2477719C2 (ru) | 2013-03-20 |
IL205003A0 (en) | 2010-11-30 |
BRPI0818626A2 (pt) | 2015-09-29 |
MY149650A (en) | 2013-09-30 |
SI2212282T1 (sl) | 2012-01-31 |
JP2011500696A (ja) | 2011-01-06 |
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