CO6141481A2 - Flavirus seudoinfecciosos y usos de los mismos - Google Patents

Flavirus seudoinfecciosos y usos de los mismos

Info

Publication number
CO6141481A2
CO6141481A2 CO08102799A CO08102799A CO6141481A2 CO 6141481 A2 CO6141481 A2 CO 6141481A2 CO 08102799 A CO08102799 A CO 08102799A CO 08102799 A CO08102799 A CO 08102799A CO 6141481 A2 CO6141481 A2 CO 6141481A2
Authority
CO
Colombia
Prior art keywords
virus
protein
prm
pseudo
flaviviridae family
Prior art date
Application number
CO08102799A
Other languages
English (en)
Inventor
Peter Mason
Iiya Frolov
Elena Frolova
Original Assignee
Regenst Of The University Of Texas System Board Of
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regenst Of The University Of Texas System Board Of filed Critical Regenst Of The University Of Texas System Board Of
Publication of CO6141481A2 publication Critical patent/CO6141481A2/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C07K14/18—Togaviridae; Flaviviridae
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24161—Methods of inactivation or attenuation
    • C12N2770/24162—Methods of inactivation or attenuation by genetic engineering
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1.- Un virus seudoinfeccioso de replicación deficiente de la familia Flaviviridae, que comprende: una eliminación en la secuencia de nucleótido que codifica proteína de cápsido (C) de tal manera que la eliminación no interrumpe la secuencia de ARN requerida para la ciclización del genoma, la secuencia de serial para la proteína prM que se requiere para la maduración apropiada de prM/M o una combinación de estos, en donde dicho virus seudoinfeccioso e replicación deficiente solo replica en células que expresan proteína C o C, prM, proteína de la envoltura, proteína C mutada, prM mutada, proteína de la envoltura mutada o combinaciones de estas de un virus de la familia Flaviviridae. 2.- El virus seudoinfeccioso de replicación deficiente de la familia Flaviviridae de la reivindicación 1, en donde dicho virus es un Flavivirus, virus Hepaci o virus Pesti u otras quimeras de dichos virus creados al intercambiar casetes prM-E de otros virus con los casetes prM-E del virus seudoinfeccioso. 3.- El virus seudoinfeccioso de replicación deficiente de la familia Flaviviridae de la reivindicación 2, en donde dicho Flavivirus es un virus de fiebre amarilla, un virus del Nilo del Oeste, un virus de dengue, un virus de la encefalitis vector- garrapata, un virus de la encefalitis Saint Louis, un virus de encefalitis Japonés o un virus de encefalitis del Valle Murray. 4.- El virus seudoinfeccioso de replicación deficiente de la familia Flaviviridae de la reivindicación 3, en donde la secuencia de nucleótido que codifica C de dicho Flavivirus que se elimina codifica los aminoácidos 26 a 100 o una combinación de aminoácidos dentro de los aminoácidos 26 a 100 de la proteína C. 5.- El virus seudoinfeccioso de replicación deficiente de la familia Flaviviridae de la reivindicación 2, en donde dicho Hepacivirus es un virus de Hepatitis C.
CO08102799A 2006-02-27 2008-09-26 Flavirus seudoinfecciosos y usos de los mismos CO6141481A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77718906P 2006-02-27 2006-02-27

Publications (1)

Publication Number Publication Date
CO6141481A2 true CO6141481A2 (es) 2010-03-19

Family

ID=38438014

Family Applications (1)

Application Number Title Priority Date Filing Date
CO08102799A CO6141481A2 (es) 2006-02-27 2008-09-26 Flavirus seudoinfecciosos y usos de los mismos

Country Status (20)

Country Link
US (2) US8252574B2 (es)
EP (1) EP1991709B1 (es)
JP (2) JP5538729B2 (es)
KR (1) KR101499750B1 (es)
CN (1) CN101454022B (es)
AP (1) AP2008004629A0 (es)
AU (1) AU2007217352B2 (es)
BR (1) BRPI0708332A2 (es)
CA (1) CA2643819C (es)
CO (1) CO6141481A2 (es)
CR (1) CR10323A (es)
EA (1) EA016490B1 (es)
HN (1) HN2008001324A (es)
IL (1) IL193522A (es)
MY (1) MY151062A (es)
NZ (1) NZ570881A (es)
SG (1) SG172642A1 (es)
UA (1) UA101597C2 (es)
WO (1) WO2007098267A2 (es)
ZA (1) ZA200807544B (es)

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CN101018860B (zh) * 2004-07-12 2013-02-27 美国天甲生物医药有限公司 黄病毒疫苗
CA2643819C (en) 2006-02-27 2018-11-27 Ilya Frolov Pseudoinfectious flavivirus and uses thereof
JP5779352B2 (ja) 2008-03-14 2015-09-16 サノフィ パスツール バイオロジクス リミテッド ライアビリティ カンパニー 複製欠損フラビウイルスワクチンおよびワクチンベクター
EP2408477A4 (en) * 2009-03-16 2013-03-27 Sanofi Pasteur Biologics Llc REPLICATION DEFECTS FLAVIVIRUS VACCINE VACCINATORS AGAINST RESPIRATORY SYNZYTIAL VIRUS
EP2435572B1 (en) 2009-05-28 2017-08-16 The United States of America, as Represented by The Secretary, Department of Health and Human Services Antigenic chimeric tick-borne encephalitis virus (tbev)/dengue virus type 4 (den4) recombinant viruses
BRPI0914507A2 (pt) * 2009-12-23 2012-04-10 Fundacao Oswaldo Cruz vacina para lentivìrus baseada em vìrus recombinante vacinal da febre amarela
WO2012027473A2 (en) * 2010-08-24 2012-03-01 The University Of North Carolina At Chapel Hill Immunogenic compositions comprising alphavirus vectored dengue virus e protein antigens
US9402890B2 (en) * 2011-02-01 2016-08-02 Uab Research Foundation Methods and compositions for pseudoinfectious alphaviruses
CA2896931A1 (en) * 2012-01-09 2013-07-18 Sanofi Pasteur Biologics, Llc Purification of flaviviruses
WO2013138776A1 (en) 2012-03-16 2013-09-19 Merial Limited Novel methods for providing long-term protective immunity against rabies in animals, based upon administration of replication-deficient flavivirus expressing rabies g
US8961995B2 (en) 2012-09-20 2015-02-24 Uab Research Foundation Methods and compositions for alphavirus replicons
HUE043096T2 (hu) * 2014-06-20 2019-07-29 Univ Aix Marseille Eljárás egy fertõzõ RNS vírus gyors létrehozására
EP3031923A1 (en) * 2014-12-11 2016-06-15 Institut Pasteur Lentiviral vector-based japanese encephalitis immunogenic composition
WO2018048869A1 (en) * 2016-09-06 2018-03-15 Bioventures, Llc Compositions and methods for generating reversion free attenuated and/or replication incompetent vaccine vectors
US10590171B2 (en) 2016-10-28 2020-03-17 The Board Of Regents Of The University Of Texas System Exosomes and methods of making and using the same
BR112019016309A2 (pt) * 2017-02-14 2020-03-31 The Board Of Regents Of The University Of Texas System Vírus da zika atenuado vivo com deleção 3'utr, vacina contendo o mesmo e uso da mesma
PE20191842A1 (es) 2017-05-08 2019-12-31 Gritstone Oncology Inc Vectores de neoantigeno de alfavirus
EP3735271A4 (en) 2018-01-04 2022-06-15 Iconic Therapeutics, Inc. ANTI-TISSUE FACTOR ANTIBODIES, ANTIBODY DRUG CONJUGATES AND RELATED METHODS
TW202110870A (zh) 2019-05-30 2021-03-16 美商葛利史東腫瘤科技公司 經修飾之腺病毒
CA3162690A1 (en) 2019-12-31 2021-07-08 Minoru S. H. Ko Temperature-based transient delivery of nucleic acids and proteins to cells and tissues
JP2023519173A (ja) * 2020-03-09 2023-05-10 アークトゥラス・セラピューティクス・インコーポレイテッド 免疫応答を誘導するための組成物及び方法
CN116438308A (zh) 2020-08-06 2023-07-14 磨石生物公司 多表位疫苗盒
WO2022249757A1 (ja) * 2021-05-27 2022-12-01 マイキャン・テクノロジーズ株式会社 疑似ウイルスを使用した抗体依存性感染増強反応の評価法

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CA2643819C (en) 2006-02-27 2018-11-27 Ilya Frolov Pseudoinfectious flavivirus and uses thereof

Also Published As

Publication number Publication date
CR10323A (es) 2009-01-29
WO2007098267A3 (en) 2008-11-20
AU2007217352A1 (en) 2007-08-30
HN2008001324A (es) 2010-10-29
MY151062A (en) 2014-03-31
IL193522A (en) 2014-05-28
ZA200807544B (en) 2009-11-25
CN101454022A (zh) 2009-06-10
JP2009528032A (ja) 2009-08-06
CA2643819C (en) 2018-11-27
BRPI0708332A2 (pt) 2011-05-24
JP5538729B2 (ja) 2014-07-02
CA2643819A1 (en) 2007-08-30
JP2014121324A (ja) 2014-07-03
AP2008004629A0 (en) 2008-10-31
EP1991709A4 (en) 2009-10-21
US8252574B2 (en) 2012-08-28
US20090155301A1 (en) 2009-06-18
EP1991709B1 (en) 2017-01-25
EA016490B1 (ru) 2012-05-30
AU2007217352B2 (en) 2013-09-26
EP1991709A2 (en) 2008-11-19
KR20090008193A (ko) 2009-01-21
KR101499750B1 (ko) 2015-03-06
UA101597C2 (uk) 2013-04-25
WO2007098267A2 (en) 2007-08-30
CN101454022B (zh) 2013-09-04
NZ570881A (en) 2011-09-30
EA200870304A1 (ru) 2009-02-27
IL193522A0 (en) 2009-05-04
SG172642A1 (en) 2011-07-28
US9273288B2 (en) 2016-03-01
US20130023031A1 (en) 2013-01-24

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