CO5650163A2 - Proceso para preparar difluorobencilepoxido - Google Patents
Proceso para preparar difluorobencilepoxidoInfo
- Publication number
- CO5650163A2 CO5650163A2 CO03102567A CO03102567A CO5650163A2 CO 5650163 A2 CO5650163 A2 CO 5650163A2 CO 03102567 A CO03102567 A CO 03102567A CO 03102567 A CO03102567 A CO 03102567A CO 5650163 A2 CO5650163 A2 CO 5650163A2
- Authority
- CO
- Colombia
- Prior art keywords
- yloxycarbonyl
- group
- ester according
- chlorobenzyloxycarbonyl
- benzyloxycarbonyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D301/00—Preparation of oxiranes
- C07D301/02—Synthesis of the oxirane ring
- C07D301/24—Synthesis of the oxirane ring by splitting off HAL—Y from compounds containing the radical HAL—C—C—OY
- C07D301/26—Y being hydrogen
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epoxy Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
1.- Un éster de fórmula (II)en e cual R1 se elige del grupo integrado por: (I) alquilo de C1-C4 sustituido opcionalmente con un -CI; (II) -CH2-CH=CH2, (III) fenilo opcionalmente sustituido con un: (A) -NO2 (B) -F, -CI, Br, -I, (C) -C=N (D) -CH2-f donde el anillo f está opcionalmente sustituido con (1) -NO2, (2) -F,- CI, -Br, -I(3) -C=N, en el cual el GRUPO PROTECTOR se selecciona del grupo integrado por t-butoxicarbonilo, benciloxicarbonilo, formilo, tritilo, ftalimido, tricloroacetilo, cloroacetilo, bromoacetilo, iodoacetilo, 4-fenilbenciloxicarbonilo, 2-metilbenciloxicarbonilo, 4-etoxibenciloxicarbonilo, 4-fluorobenciloxicarbonilo, 4-clorobenciloxicarbonilo, 3-clorobenciloxicarbonilo, 2-clorobenciloxicarbonilo, 2,4-diclorobenciloxicarbonilo, 4-bromobenciloxicarbonilo, 3-bromobenciloxicarbonilo, 4-nitrobenciloxicarbonilo, 4-cianobenciloxicarbonilo, 2-(4-fenil)isopropoxicarbonilo, 1,1-difenilet-1-iloxicarbonilo, 1,1-difenilprop-1-iloxycarbonilo, 2-fenilprop-2-iloxicarbonilo, 2-(p-toluil)-prop-2-iloxicarbonilo, ciclopentaniloxicarbonilo, 1-metiIciclopentaniloxicarbonilo, ciclohexaniloxicarbonilo, 1-metil-ciclohexaniloxicarbonilo, 2-metilciclohexaniloxicarbonilo, 2-(4-toluilsulfonil)etoxicarbonilo, 2-(metilsulfonil)etoxicarbonilo, 2-(trifenilfosfino)etoxicarbonilo, (trimetilsililmetil)-prop-1-eniloxicarbonilo, 5-benzoisoxalilmetoxicarbonilo, 4-acetoxibenciloxicarbonilo, 2,2,2-tricloroetoxicarbonilo, 2-etinil-2-propoxicarbonilo, ciclopropilmetoxicarbonilo, 4- (deciloxil)benciloxicarbonilo, isoborniloxicarbonilo, 1-piperidiloxicarbonilo, carbonato de 9-fluoroenilmetilo, -CH-CH=CH2 y - f -C(=N)-H.2.- Un éster de acuerdo a la reivindicación 1 en el cual el GRUPO PROTECTOR es terbutoxicarbonilo.3.- Un éster de acuerdo a la reivindicación 1 en el cual el GRUPO PROTECTOR es benciloxicarbonilo. 4.- Un éster de acuerdo la reivindicación 1 en el cual R1 es un alquilo de C1-C2.5.- Un éster de acuerdo a la reivindicación 1 en el cual R1 es un alquilo C1.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28577201P | 2001-04-23 | 2001-04-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO5650163A2 true CO5650163A2 (es) | 2006-06-30 |
Family
ID=23095626
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO03102567A CO5650163A2 (es) | 2001-04-23 | 2003-11-20 | Proceso para preparar difluorobencilepoxido |
Country Status (23)
Country | Link |
---|---|
US (3) | US6849750B2 (es) |
EP (1) | EP1381597B1 (es) |
JP (1) | JP2004529152A (es) |
KR (1) | KR20040047750A (es) |
CN (1) | CN1612871A (es) |
AP (1) | AP2003002897A0 (es) |
AR (1) | AR035960A1 (es) |
AT (1) | ATE401299T1 (es) |
BR (1) | BR0209163A (es) |
CA (1) | CA2445163A1 (es) |
CO (1) | CO5650163A2 (es) |
DE (1) | DE60227652D1 (es) |
EA (1) | EA007535B1 (es) |
ES (1) | ES2309170T3 (es) |
IL (2) | IL158585A0 (es) |
MX (1) | MXPA03009723A (es) |
NO (1) | NO20034738L (es) |
NZ (1) | NZ529169A (es) |
OA (1) | OA12597A (es) |
PE (1) | PE20021068A1 (es) |
PL (1) | PL365058A1 (es) |
WO (1) | WO2002085877A2 (es) |
ZA (1) | ZA200308261B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0228410D0 (en) * | 2002-12-05 | 2003-01-08 | Glaxo Group Ltd | Novel Compounds |
WO2005087751A2 (en) | 2004-03-09 | 2005-09-22 | Elan Pharmaceuticals, Inc. | Substituted hydroxyethylamine aspartyl protease inhibitors |
CA2573138A1 (en) | 2004-07-09 | 2006-01-26 | Elan Pharmaceuticals Inc. | Oxime derivative substituted hydroxyethylamine aspartyl protease inhibitors |
WO2007047305A1 (en) | 2005-10-12 | 2007-04-26 | Elan Pharmaceuticals, Inc. | Methods of treating amyloidosis using cyclopropyl derivative aspartyl protease inhibitors |
WO2019168874A1 (en) | 2018-02-27 | 2019-09-06 | The Research Foundation For The State University Of New York | Difluoromethoxylation and trifluoromethoxylation compositions and methods for synthesizing same |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2788044B2 (ja) | 1989-02-06 | 1998-08-20 | サントリー株式会社 | マレイミド誘導体およびそれを有効成分として含有する農園芸用殺菌剤 |
US5482947A (en) | 1990-11-19 | 1996-01-09 | Talley; John J. | Retroviral protease inhibitors |
US5583238A (en) | 1990-11-19 | 1996-12-10 | G. D. Searle & Co. | Method for making intermediates useful in synthesis of retroviral protease inhibitors |
US5559256A (en) * | 1992-07-20 | 1996-09-24 | E. R. Squibb & Sons, Inc. | Aminediol protease inhibitors |
RU2146668C1 (ru) | 1992-08-25 | 2000-03-20 | Джи Ди Сирл энд Компани | Сульфонилалканоиламино-гидроксиэтиламино-сульфонамидное соединение, фармацевтические композиции и способы лечения и ингибирования ретровирусных протеаз |
US5481011A (en) * | 1994-12-13 | 1996-01-02 | Bristol-Myers Squibb Company | Process for preparing N-protected amino acid α-halomethyl ketones and alcohols from N-protected amino acid esters |
US5985911A (en) * | 1997-01-07 | 1999-11-16 | Abbott Laboratories | C-terminal ketone inhibitors of matrix metalloproteinases and TNFα secretion |
DE69828682T2 (de) * | 1997-02-04 | 2006-04-06 | The Regents Of The University Of California, Oakland | Nanomolare, non-peptidische inhibitoren von cathepsin d |
CA2273643A1 (en) | 1998-06-09 | 1999-12-09 | F. Hoffmann-La Roche Ag | Stereoselective reduction of carbonyl compounds |
AU2001252958A1 (en) | 2000-03-23 | 2001-10-03 | Elan Pharmaceuticals, Inc. | Compounds and methods to treat alzheimer's disease |
US20030096864A1 (en) | 2000-06-30 | 2003-05-22 | Fang Lawrence Y. | Compounds to treat alzheimer's disease |
US6846813B2 (en) | 2000-06-30 | 2005-01-25 | Pharmacia & Upjohn Company | Compounds to treat alzheimer's disease |
ATE302751T1 (de) | 2000-06-30 | 2005-09-15 | Elan Pharm Inc | Verbindungen zur behandlung der alzheimerischen krankheit |
PE20020276A1 (es) | 2000-06-30 | 2002-04-06 | Elan Pharm Inc | COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER |
AU2002360508A1 (en) | 2001-12-06 | 2003-06-23 | Elan Pharmaceuticals, Inc. | Substituted hydroxyethylamines |
-
2002
- 2002-04-19 AR ARP020101444A patent/AR035960A1/es unknown
- 2002-04-23 DE DE60227652T patent/DE60227652D1/de not_active Expired - Fee Related
- 2002-04-23 PL PL02365058A patent/PL365058A1/xx not_active Application Discontinuation
- 2002-04-23 OA OA1200300276A patent/OA12597A/en unknown
- 2002-04-23 US US10/128,122 patent/US6849750B2/en not_active Expired - Fee Related
- 2002-04-23 EP EP02728882A patent/EP1381597B1/en not_active Expired - Lifetime
- 2002-04-23 CA CA002445163A patent/CA2445163A1/en not_active Abandoned
- 2002-04-23 KR KR10-2003-7013902A patent/KR20040047750A/ko not_active Application Discontinuation
- 2002-04-23 BR BR0209163-1A patent/BR0209163A/pt not_active IP Right Cessation
- 2002-04-23 IL IL15858502A patent/IL158585A0/xx unknown
- 2002-04-23 MX MXPA03009723A patent/MXPA03009723A/es active IP Right Grant
- 2002-04-23 AT AT02728882T patent/ATE401299T1/de not_active IP Right Cessation
- 2002-04-23 CN CNA02812636XA patent/CN1612871A/zh active Pending
- 2002-04-23 ES ES02728882T patent/ES2309170T3/es not_active Expired - Lifetime
- 2002-04-23 NZ NZ529169A patent/NZ529169A/en unknown
- 2002-04-23 WO PCT/US2002/012591 patent/WO2002085877A2/en active IP Right Grant
- 2002-04-23 PE PE2002000343A patent/PE20021068A1/es not_active Application Discontinuation
- 2002-04-23 JP JP2002583404A patent/JP2004529152A/ja active Pending
- 2002-04-23 EA EA200301133A patent/EA007535B1/ru not_active IP Right Cessation
- 2002-04-23 AP APAP/P/2003/002897A patent/AP2003002897A0/en unknown
-
2003
- 2003-10-23 NO NO20034738A patent/NO20034738L/no not_active Application Discontinuation
- 2003-10-23 ZA ZA200308261A patent/ZA200308261B/en unknown
- 2003-10-23 IL IL158585A patent/IL158585A/en not_active IP Right Cessation
- 2003-11-20 CO CO03102567A patent/CO5650163A2/es not_active Application Discontinuation
-
2005
- 2005-02-01 US US11/048,389 patent/US7638646B2/en not_active Expired - Fee Related
-
2009
- 2009-12-23 US US12/646,526 patent/US20100099898A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
MXPA03009723A (es) | 2004-03-16 |
ZA200308261B (en) | 2004-05-24 |
BR0209163A (pt) | 2004-08-24 |
WO2002085877A2 (en) | 2002-10-31 |
CN1612871A (zh) | 2005-05-04 |
PL365058A1 (en) | 2004-12-27 |
ES2309170T3 (es) | 2008-12-16 |
US7638646B2 (en) | 2009-12-29 |
US20050130936A1 (en) | 2005-06-16 |
KR20040047750A (ko) | 2004-06-05 |
US20100099898A1 (en) | 2010-04-22 |
US6849750B2 (en) | 2005-02-01 |
IL158585A (en) | 2009-06-15 |
EA200301133A1 (ru) | 2004-04-29 |
ATE401299T1 (de) | 2008-08-15 |
EP1381597B1 (en) | 2008-07-16 |
US20030004360A1 (en) | 2003-01-02 |
OA12597A (en) | 2006-06-08 |
WO2002085877A3 (en) | 2003-03-06 |
CA2445163A1 (en) | 2002-10-31 |
PE20021068A1 (es) | 2002-12-11 |
NZ529169A (en) | 2005-06-24 |
AP2003002897A0 (en) | 2003-12-31 |
EP1381597A2 (en) | 2004-01-21 |
EA007535B1 (ru) | 2006-10-27 |
NO20034738L (no) | 2003-12-04 |
AR035960A1 (es) | 2004-07-28 |
DE60227652D1 (de) | 2008-08-28 |
NO20034738D0 (no) | 2003-10-23 |
IL158585A0 (en) | 2004-05-12 |
JP2004529152A (ja) | 2004-09-24 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Application refused |