CO5650163A2 - Proceso para preparar difluorobencilepoxido - Google Patents

Proceso para preparar difluorobencilepoxido

Info

Publication number
CO5650163A2
CO5650163A2 CO03102567A CO03102567A CO5650163A2 CO 5650163 A2 CO5650163 A2 CO 5650163A2 CO 03102567 A CO03102567 A CO 03102567A CO 03102567 A CO03102567 A CO 03102567A CO 5650163 A2 CO5650163 A2 CO 5650163A2
Authority
CO
Colombia
Prior art keywords
yloxycarbonyl
group
ester according
chlorobenzyloxycarbonyl
benzyloxycarbonyl
Prior art date
Application number
CO03102567A
Other languages
English (en)
Inventor
Michael R Reeder
Original Assignee
Elan Pharm Inc
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc, Upjohn Co filed Critical Elan Pharm Inc
Publication of CO5650163A2 publication Critical patent/CO5650163A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/36—Compounds containing oxirane rings with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D301/00—Preparation of oxiranes
    • C07D301/02—Synthesis of the oxirane ring
    • C07D301/24—Synthesis of the oxirane ring by splitting off HAL—Y from compounds containing the radical HAL—C—C—OY
    • C07D301/26—Y being hydrogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

1.- Un éster de fórmula (II)en e cual R1 se elige del grupo integrado por: (I) alquilo de C1-C4 sustituido opcionalmente con un -CI; (II) -CH2-CH=CH2, (III) fenilo opcionalmente sustituido con un: (A) -NO2 (B) -F, -CI, Br, -I, (C) -C=N (D) -CH2-f donde el anillo f está opcionalmente sustituido con (1) -NO2, (2) -F,- CI, -Br, -I(3) -C=N, en el cual el GRUPO PROTECTOR se selecciona del grupo integrado por t-butoxicarbonilo, benciloxicarbonilo, formilo, tritilo, ftalimido, tricloroacetilo, cloroacetilo, bromoacetilo, iodoacetilo, 4-fenilbenciloxicarbonilo, 2-metilbenciloxicarbonilo, 4-etoxibenciloxicarbonilo, 4-fluorobenciloxicarbonilo, 4-clorobenciloxicarbonilo, 3-clorobenciloxicarbonilo, 2-clorobenciloxicarbonilo, 2,4-diclorobenciloxicarbonilo, 4-bromobenciloxicarbonilo, 3-bromobenciloxicarbonilo, 4-nitrobenciloxicarbonilo, 4-cianobenciloxicarbonilo, 2-(4-fenil)isopropoxicarbonilo, 1,1-difenilet-1-iloxicarbonilo, 1,1-difenilprop-1-iloxycarbonilo, 2-fenilprop-2-iloxicarbonilo, 2-(p-toluil)-prop-2-iloxicarbonilo, ciclopentaniloxicarbonilo, 1-metiIciclopentaniloxicarbonilo, ciclohexaniloxicarbonilo, 1-metil-ciclohexaniloxicarbonilo, 2-metilciclohexaniloxicarbonilo, 2-(4-toluilsulfonil)etoxicarbonilo, 2-(metilsulfonil)etoxicarbonilo, 2-(trifenilfosfino)etoxicarbonilo, (trimetilsililmetil)-prop-1-eniloxicarbonilo, 5-benzoisoxalilmetoxicarbonilo, 4-acetoxibenciloxicarbonilo, 2,2,2-tricloroetoxicarbonilo, 2-etinil-2-propoxicarbonilo, ciclopropilmetoxicarbonilo, 4- (deciloxil)benciloxicarbonilo, isoborniloxicarbonilo, 1-piperidiloxicarbonilo, carbonato de 9-fluoroenilmetilo, -CH-CH=CH2 y - f -C(=N)-H.2.- Un éster de acuerdo a la reivindicación 1 en el cual el GRUPO PROTECTOR es terbutoxicarbonilo.3.- Un éster de acuerdo a la reivindicación 1 en el cual el GRUPO PROTECTOR es benciloxicarbonilo. 4.- Un éster de acuerdo la reivindicación 1 en el cual R1 es un alquilo de C1-C2.5.- Un éster de acuerdo a la reivindicación 1 en el cual R1 es un alquilo C1.
CO03102567A 2001-04-23 2003-11-20 Proceso para preparar difluorobencilepoxido CO5650163A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28577201P 2001-04-23 2001-04-23

Publications (1)

Publication Number Publication Date
CO5650163A2 true CO5650163A2 (es) 2006-06-30

Family

ID=23095626

Family Applications (1)

Application Number Title Priority Date Filing Date
CO03102567A CO5650163A2 (es) 2001-04-23 2003-11-20 Proceso para preparar difluorobencilepoxido

Country Status (23)

Country Link
US (3) US6849750B2 (es)
EP (1) EP1381597B1 (es)
JP (1) JP2004529152A (es)
KR (1) KR20040047750A (es)
CN (1) CN1612871A (es)
AP (1) AP2003002897A0 (es)
AR (1) AR035960A1 (es)
AT (1) ATE401299T1 (es)
BR (1) BR0209163A (es)
CA (1) CA2445163A1 (es)
CO (1) CO5650163A2 (es)
DE (1) DE60227652D1 (es)
EA (1) EA007535B1 (es)
ES (1) ES2309170T3 (es)
IL (2) IL158585A0 (es)
MX (1) MXPA03009723A (es)
NO (1) NO20034738L (es)
NZ (1) NZ529169A (es)
OA (1) OA12597A (es)
PE (1) PE20021068A1 (es)
PL (1) PL365058A1 (es)
WO (1) WO2002085877A2 (es)
ZA (1) ZA200308261B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0228410D0 (en) * 2002-12-05 2003-01-08 Glaxo Group Ltd Novel Compounds
WO2005087751A2 (en) 2004-03-09 2005-09-22 Elan Pharmaceuticals, Inc. Substituted hydroxyethylamine aspartyl protease inhibitors
CA2573138A1 (en) 2004-07-09 2006-01-26 Elan Pharmaceuticals Inc. Oxime derivative substituted hydroxyethylamine aspartyl protease inhibitors
WO2007047305A1 (en) 2005-10-12 2007-04-26 Elan Pharmaceuticals, Inc. Methods of treating amyloidosis using cyclopropyl derivative aspartyl protease inhibitors
WO2019168874A1 (en) 2018-02-27 2019-09-06 The Research Foundation For The State University Of New York Difluoromethoxylation and trifluoromethoxylation compositions and methods for synthesizing same

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2788044B2 (ja) 1989-02-06 1998-08-20 サントリー株式会社 マレイミド誘導体およびそれを有効成分として含有する農園芸用殺菌剤
US5482947A (en) 1990-11-19 1996-01-09 Talley; John J. Retroviral protease inhibitors
US5583238A (en) 1990-11-19 1996-12-10 G. D. Searle & Co. Method for making intermediates useful in synthesis of retroviral protease inhibitors
US5559256A (en) * 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
RU2146668C1 (ru) 1992-08-25 2000-03-20 Джи Ди Сирл энд Компани Сульфонилалканоиламино-гидроксиэтиламино-сульфонамидное соединение, фармацевтические композиции и способы лечения и ингибирования ретровирусных протеаз
US5481011A (en) * 1994-12-13 1996-01-02 Bristol-Myers Squibb Company Process for preparing N-protected amino acid α-halomethyl ketones and alcohols from N-protected amino acid esters
US5985911A (en) * 1997-01-07 1999-11-16 Abbott Laboratories C-terminal ketone inhibitors of matrix metalloproteinases and TNFα secretion
DE69828682T2 (de) * 1997-02-04 2006-04-06 The Regents Of The University Of California, Oakland Nanomolare, non-peptidische inhibitoren von cathepsin d
CA2273643A1 (en) 1998-06-09 1999-12-09 F. Hoffmann-La Roche Ag Stereoselective reduction of carbonyl compounds
AU2001252958A1 (en) 2000-03-23 2001-10-03 Elan Pharmaceuticals, Inc. Compounds and methods to treat alzheimer's disease
US20030096864A1 (en) 2000-06-30 2003-05-22 Fang Lawrence Y. Compounds to treat alzheimer's disease
US6846813B2 (en) 2000-06-30 2005-01-25 Pharmacia & Upjohn Company Compounds to treat alzheimer's disease
ATE302751T1 (de) 2000-06-30 2005-09-15 Elan Pharm Inc Verbindungen zur behandlung der alzheimerischen krankheit
PE20020276A1 (es) 2000-06-30 2002-04-06 Elan Pharm Inc COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER
AU2002360508A1 (en) 2001-12-06 2003-06-23 Elan Pharmaceuticals, Inc. Substituted hydroxyethylamines

Also Published As

Publication number Publication date
MXPA03009723A (es) 2004-03-16
ZA200308261B (en) 2004-05-24
BR0209163A (pt) 2004-08-24
WO2002085877A2 (en) 2002-10-31
CN1612871A (zh) 2005-05-04
PL365058A1 (en) 2004-12-27
ES2309170T3 (es) 2008-12-16
US7638646B2 (en) 2009-12-29
US20050130936A1 (en) 2005-06-16
KR20040047750A (ko) 2004-06-05
US20100099898A1 (en) 2010-04-22
US6849750B2 (en) 2005-02-01
IL158585A (en) 2009-06-15
EA200301133A1 (ru) 2004-04-29
ATE401299T1 (de) 2008-08-15
EP1381597B1 (en) 2008-07-16
US20030004360A1 (en) 2003-01-02
OA12597A (en) 2006-06-08
WO2002085877A3 (en) 2003-03-06
CA2445163A1 (en) 2002-10-31
PE20021068A1 (es) 2002-12-11
NZ529169A (en) 2005-06-24
AP2003002897A0 (en) 2003-12-31
EP1381597A2 (en) 2004-01-21
EA007535B1 (ru) 2006-10-27
NO20034738L (no) 2003-12-04
AR035960A1 (es) 2004-07-28
DE60227652D1 (de) 2008-08-28
NO20034738D0 (no) 2003-10-23
IL158585A0 (en) 2004-05-12
JP2004529152A (ja) 2004-09-24

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