CO5570663A2 - Derivados del acido mandelico - Google Patents

Derivados del acido mandelico

Info

Publication number
CO5570663A2
CO5570663A2 CO05049707A CO05049707A CO5570663A2 CO 5570663 A2 CO5570663 A2 CO 5570663A2 CO 05049707 A CO05049707 A CO 05049707A CO 05049707 A CO05049707 A CO 05049707A CO 5570663 A2 CO5570663 A2 CO 5570663A2
Authority
CO
Colombia
Prior art keywords
alkoxy
alkyl
aryl
carbamoyl
carbonyl
Prior art date
Application number
CO05049707A
Other languages
English (en)
Inventor
David Banner
Luca Claudio Gobbi
Zbinden Katrin Groebke
Ulrike Obst
Christoph Martin Stahl
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CO5570663A2 publication Critical patent/CO5570663A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
    • C07C259/18—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56—Amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

1.- Compuestos de formula (I) en dondeR1 es hidrógeno, OH, NH2, alcoxiC1-7-carbonilo, aril-alcoxiC1-7-carbonilo, ariloxi-carbonilo, alquiloC1-7-carbonilo, aril-carbonilo, o alcoxiC1-7-carbonilo, que está sustituido con halógeno; R2, R3 y R4 cada uno independientemente es seleccionado del grupo consistente de hidrógeno, halógeno, hidroxi, carboxi-alquiloC1-7-NH, carbamoil-alquiloC1-7-NH, alcoxiC1-7- carbonil-alquiloC1-7-NH, hidroxi-cicloalquiloC3-10-oxi, dihidroxi-cicloalquiloC3-10-oxi, arilo, ariloxi, aril-NH, aril-alquiloC1-7-NH, aril-alquiloC1-7-SO2NH, aril-alcoxiC1-7-carbonil-NH, aril-alquiloC1-7-NH-carbonil-NH, heteroariloxi, heteroaril-alquiloC1-7-NH, y alcoxiC1-7, cuyo alcoxiC1-7 puede estar opcionalmente sustituido con hidroxi, carboxi, carbamoilo, carbamimidoilo, CF3, arilo, heteroarilo, alquiloC1-7-carbamoilo, alcoxiC1-7-carbonilo, arilo-carbamoilo, alcoxiC1-7-alquiloC1-7- carbamoilo, heterociclil-alquiloC1-7-carbamoilo, o N (alquiloC1-7)2-alquiloC1-7-carbamoilo;R5 es alquiloC1-7 o cicloalquiloC3-10, o, Si X es O o NR12, R5 también puede ser hidrógeno;R6 es hidrógeno, alquiloC1-7, o fluoro-alquiloC1-7;Y es N o C-R11;R7, R8, R9, R10 y R11 cada uno independientemente es seleccionado del grupo consistente de hidrógeno, hidroxi, halógeno, amino, alquiloC1-7-amino, di-alquiloC1-7-amino, alquiloC1-7-carbonil-amino, NO2, fluoro-alquiloC1-7, alcoxiC1-7, hidroxi-alcoxiC1-7, fluoro-alcoxiC1-7, alquinilC2-7, hidroxi-alquinilC2-7, arilo, aril-alcoxiC1-7, ariloxi, ariloxi-alcoxiC1-7, heterociclilo, heterocicliloxi, alcoxiC1-7-carbonil-alcoxiC1-7, carbamoil-alcoxiC1-7, carboxi-alcoxiC1-7, cicloalquilC3-10oxi, heteroarilo, amino-alcoxiC1-7, alquiloC1-7-amino-alcoxiC1-7, y di-alquilC1-7-amino-alcoxiC1-7, alquiloC1-7-carbonil-amino-alcoxiC1-7, HO-N=CH, HCO, fluoroalquiloC1-7-SO2-O, (alcoxiC1-7)2-4, CH(alcoxiC1-7), hidroxi-cloro-alcoxiC1-7, aril-alcoxiC1-7-alcoxiC1-7, aril-NH, aril-NH-alquiloC1-7, aril-alquiloC1-7-carbonilo-NH, heterociclil-alquiloC1-7, heterociclil-carbonilo, heterociclil-alcoxiC1-7, alquiloC1-7-carbamoilo, fluoro-alquiloC1-7-carbamoilo, cicloalquiloC3-10-carbamoilo, cicloalquiloC3-10-alquiloC1-7-carbamoilo, di-alquiloC1-7-carbamoilo, ...
CO05049707A 2002-11-25 2005-05-23 Derivados del acido mandelico CO5570663A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02026365 2002-11-25

Publications (1)

Publication Number Publication Date
CO5570663A2 true CO5570663A2 (es) 2005-10-31

Family

ID=32337999

Family Applications (1)

Application Number Title Priority Date Filing Date
CO05049707A CO5570663A2 (es) 2002-11-25 2005-05-23 Derivados del acido mandelico

Country Status (24)

Country Link
US (1) US7129238B2 (es)
EP (1) EP1567498B1 (es)
JP (1) JP4271657B2 (es)
KR (1) KR100705156B1 (es)
CN (1) CN1714079A (es)
AR (1) AR042109A1 (es)
AT (1) ATE384696T1 (es)
AU (1) AU2003292072B2 (es)
BR (1) BR0316508A (es)
CA (1) CA2505542A1 (es)
CO (1) CO5570663A2 (es)
DE (1) DE60318890T2 (es)
ES (1) ES2298583T3 (es)
GT (1) GT200300252A (es)
MX (1) MXPA05005446A (es)
NO (1) NO20052311L (es)
PA (1) PA8589201A1 (es)
PE (1) PE20040696A1 (es)
PL (1) PL377511A1 (es)
RU (1) RU2005120146A (es)
TW (1) TW200410921A (es)
UY (1) UY28090A1 (es)
WO (1) WO2004048335A2 (es)
ZA (1) ZA200503989B (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200410921A (en) 2002-11-25 2004-07-01 Hoffmann La Roche Mandelic acid derivatives
US7247654B2 (en) * 2003-06-04 2007-07-24 Bristol-Myers Squibb Company 3,4-disubstituted benzamidines and benzylamines, and analogues thereof, useful as serine protease inhibitors
US7056932B2 (en) * 2003-12-19 2006-06-06 Hoffman-La Roche Inc. Heterocyclyl substituted 1-alkoxy acetic acid amides
UA87854C2 (en) * 2004-06-07 2009-08-25 Мерк Энд Ко., Инк. N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
EP1791810A1 (en) * 2004-09-06 2007-06-06 F. Hoffmann-Roche AG 4-aminomethyl benzamidine derivatives and their use as factor viia inhibitors
CA2616184A1 (en) * 2005-08-02 2007-02-08 Merck & Co., Inc. N-(pyridin-4-yl)-2-phenylbutanamides as androgen receptor modulators
CN103641776A (zh) * 2007-04-24 2014-03-19 日本曹达株式会社 N-亚甲基取代甲胺多聚物的制造方法和三嗪衍生物
EP2650282B1 (en) 2007-04-24 2017-06-07 Nippon Soda Co., Ltd. Process for producing substituted methylamine compound and triazine derivative
CN104370804A (zh) * 2007-04-24 2015-02-25 日本曹达株式会社 取代甲胺化合物的制造方法
EP2234954B1 (en) * 2007-12-20 2015-02-18 Envivo Pharmaceuticals, Inc. Tetrasubstituted benzenes
WO2010022148A1 (en) * 2008-08-19 2010-02-25 The Trustees Of The University Of Pennsylvania Methods for the preparation of irciniastatin and analogs thereof
EP2272661A1 (en) * 2009-07-10 2011-01-12 Amcor Flexibles Transpac N.V. Packaging material with integrated pressure relief valve
RU2545456C2 (ru) 2010-03-12 2015-03-27 Омерос Корпорейшн Pde10 ингибиторы и содержащие их композиции и способы
GB201006042D0 (en) 2010-04-12 2010-05-26 Givaudan Sa Improvements in or relating to organic compounds
CA2800521A1 (en) 2010-05-24 2011-12-01 Toa Eiyo Ltd. Fused imidazole derivative
CN103044176A (zh) * 2012-12-12 2013-04-17 云南民族大学 一种氢气参与环醚开环制备卤代醇的高效方法
WO2014107277A1 (en) * 2012-12-13 2014-07-10 Glaxosmithkline Llc Enhancer of zeste homolog 2 inhibitors
NZ630810A (en) 2014-04-28 2016-03-31 Omeros Corp Processes and intermediates for the preparation of a pde10 inhibitor
NZ630803A (en) 2014-04-28 2016-03-31 Omeros Corp Optically active pde10 inhibitor
US10100024B2 (en) 2014-07-29 2018-10-16 Evonik Degussa Gmbh Process for the epoxidation of an olefin
JP2018513153A (ja) 2015-04-24 2018-05-24 オメロス コーポレーション Ｐｄｅ１０インヒビターならびに関連する組成物および方法
PL3288927T3 (pl) 2015-04-28 2020-03-31 Evonik Degussa Gmbh Sposób epoksydacji propenu
US9920045B2 (en) 2015-11-04 2018-03-20 Omeros Corporation Solid state forms of a PDE10 inhibitor
BR112018010746B1 (pt) 2015-11-25 2020-10-06 Evonik Operations Gmbh Método para produzir propileno glicol a partir de propeno e peróxido de hidrogênio
PL3380460T3 (pl) 2015-11-26 2021-11-08 Evonik Operations Gmbh Sposób i reaktor epoksydacji propenu
EP3380459B1 (en) 2015-11-26 2020-01-01 Evonik Operations GmbH Process for the epoxidation of an olefin
PL3380458T3 (pl) 2015-11-26 2020-03-31 Evonik Degussa Gmbh Sposób epoksydowania propenu
TWI707847B (zh) 2015-11-26 2020-10-21 德商贏創運營有限公司 丙烯之環氧化方法
KR102625924B1 (ko) 2016-01-19 2024-01-16 에보닉 오퍼레이션스 게엠베하 올레핀의 에폭시화 방법
HUE052019T2 (hu) 2016-03-21 2021-04-28 Evonik Operations Gmbh Eljárás propén epoxidálására
EP3246323A1 (en) 2016-05-17 2017-11-22 Evonik Degussa GmbH Integrated process for making propene oxide from propane
WO2018205244A1 (en) 2017-05-12 2018-11-15 Evonik Degussa Gmbh Process for the epoxidation of propene
EP3406603A1 (en) 2017-05-22 2018-11-28 Evonik Degussa GmbH Process for the epoxidation of propene
EP3438101A1 (en) 2017-08-01 2019-02-06 Evonik Degussa GmbH Process for the epoxidation of propene
CA3181637A1 (en) * 2020-06-10 2021-12-16 Ulf Bjorklund Method for preparing a crystalline form of rabeximod
CN117377662A (zh) 2021-05-10 2024-01-09 赢创运营有限公司 用于制造环氧丙烷的集成设备和集成方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4128681A1 (de) * 1991-08-29 1993-03-04 Bayer Ag Substituierte mandelsaeurederivate, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
US6060491A (en) * 1997-06-19 2000-05-09 Dupont Pharmaceuticals 6-membered aromatics as factor Xa inhibitors
DE59808751D1 (de) * 1997-12-04 2003-07-24 Hoffmann La Roche N-(4-carbamimido-phenyl)-glycinamidderivate
US6358960B1 (en) * 1998-02-17 2002-03-19 Ono Pharmaceutical Co., Ltd. Amidino derivatives and drugs containing the same as the active ingredient
EP1149069B1 (en) * 1998-12-14 2004-08-25 F. Hoffmann-La Roche Ag Phenylglycine derivatives
AU2001243598A1 (en) * 2000-03-13 2001-09-24 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted benzenes useful for selective inhibition of the coagulation cascade
US6548694B2 (en) * 2000-05-23 2003-04-15 Hoffman-La Roche Inc. N-(4-carbamimidoyl-phenyl)-glycine derivatives
DE10027024A1 (de) * 2000-05-31 2001-12-06 Merck Patent Gmbh Carbaminsäureester
DE10037146A1 (de) * 2000-07-29 2002-02-07 Merck Patent Gmbh Acetamidderivate
DE10040783A1 (de) * 2000-08-21 2002-03-07 Merck Patent Gmbh AZA-Aminosäurederivate (Faktor X¶a¶-Inhibitoren 15)
EP1193248A1 (en) * 2000-09-30 2002-04-03 Aventis Pharma Deutschland GmbH Malonamid and malonamic ester derivatives with antithrombotic activity, their preparation and their use
AU2002213393B2 (en) * 2000-10-20 2007-02-15 Biocryst Pharmaceuticals, Inc. Biaryl compounds as serine protease inhibitors
US6713467B2 (en) * 2000-11-07 2004-03-30 Bristol-Myers Squibb Company Acid derivatives useful as serine protease inhibitors
US7001887B2 (en) * 2001-02-02 2006-02-21 Chugai Seiyaku Kabushiki Kaisha Peptide derivatives
GB0121337D0 (en) * 2001-09-04 2001-10-24 Astrazeneca Ab Chemical compounds
TW200410921A (en) 2002-11-25 2004-07-01 Hoffmann La Roche Mandelic acid derivatives

Also Published As

Publication number Publication date
EP1567498B1 (en) 2008-01-23
JP2006515284A (ja) 2006-05-25
PE20040696A1 (es) 2004-10-08
RU2005120146A (ru) 2006-05-10
PA8589201A1 (es) 2004-07-26
AU2003292072B2 (en) 2006-12-07
DE60318890T2 (de) 2009-01-15
AR042109A1 (es) 2005-06-08
WO2004048335A3 (en) 2004-08-19
DE60318890D1 (de) 2008-03-13
EP1567498A2 (en) 2005-08-31
GT200300252A (es) 2004-06-28
ES2298583T3 (es) 2008-05-16
AU2003292072A1 (en) 2004-06-18
TW200410921A (en) 2004-07-01
ATE384696T1 (de) 2008-02-15
ZA200503989B (en) 2006-12-27
KR20050086774A (ko) 2005-08-30
CN1714079A (zh) 2005-12-28
KR100705156B1 (ko) 2007-04-09
UY28090A1 (es) 2004-05-31
US20040122057A1 (en) 2004-06-24
PL377511A1 (pl) 2006-02-06
WO2004048335A2 (en) 2004-06-10
BR0316508A (pt) 2005-10-04
JP4271657B2 (ja) 2009-06-03
NO20052311L (no) 2005-06-16
MXPA05005446A (es) 2005-08-26
US7129238B2 (en) 2006-10-31
CA2505542A1 (en) 2004-06-10

Similar Documents

Publication Publication Date Title
CO5570663A2 (es) Derivados del acido mandelico
ATE477254T1 (de) Pyrrolidine als inhibitoren von iap
ATE453639T1 (de) Phenylsubstituierte pyrimidinverbindungen zur verwendung als kinasehemmer
CO5640118A2 (es) 5,7-diaminopirazol[4,3-d]piridinas utiles en el tratamiento de la hipertension
PE20070808A1 (es) COMPUESTOS DERIVADOS DE ISOQUINOLINA COMO INHIBIDORES DE Rho-QUINASA
CO5550462A2 (es) Derivados de dolastatina 10
PE20110059A1 (es) Isoquinolinas e isoquinolinonas sustituidas en calidad de inhibidores de la rho-quinasa
TW200745116A (en) Macrocylic inhibitors of hepatitis C virus
DE602006012801D1 (de) Verwendung von 1- benzyl-1- hydroxy-2, 3-diamino-propylaminen, 3-benzyl-3 hydroxy-2-amino-propionsäureamiden und verwandten verbindungen als analgetika
IN2012DN04853A (es)
AR040349A1 (es) Quinolinas sustituidas como antagonistas del receptor ccr5
GEP20125456B (en) Azetidines as mek inhibitors for the treatment of proliferative diseases
ATE553106T1 (de) Heteroarylpyrrolopyridinone als kinaseinhibitoren
PE20070217A1 (es) Derivados de isoquinolona sustituidos con piperidinilo
MXPA05009059A (es) Derivados de heteroarilcarbamoilbenceno.
PE20071321A1 (es) Bencensulfonil-cromano, tiocromano, tetrahidronaftaleno e inhibidores de gamma secretasa relacionados
MY135309A (en) Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors
TW201129553A (en) Dipeptidyl peptidase inhibitors
AR034985A1 (es) Compuesto biciclico; produccion y uso del mismo
DE60234028D1 (de) Hydantion-derivate als hemmer von matrix-metalloproteinasen
CY1107846T1 (el) Παραγωγα κιναζολινονης χρησιμα ως βανιλλοειδεις ανταγωνιστες
AR054482A1 (es) Derivados de azetidinona para el tratamiento de hiperlipidemias
PE20070352A1 (es) Compuestos de imidazol sustituidos como inhibidores de ksp
MX2014001023A (es) Derivados de quinazolina.
MXPA04004501A (es) Derivados de 4-4-difluoro-1,2,3,4-tetrahidro-5h-1-benzazepina o sales de los mismos.

Legal Events

Date Code Title Description
FA Application withdrawn