CO5290295A1 - Gen de streptomyces avermitilis que dirige la relacion de avermectinas b2:b1 - Google Patents

Gen de streptomyces avermitilis que dirige la relacion de avermectinas b2:b1

Info

Publication number
CO5290295A1
CO5290295A1 CO00058605A CO00058605A CO5290295A1 CO 5290295 A1 CO5290295 A1 CO 5290295A1 CO 00058605 A CO00058605 A CO 00058605A CO 00058605 A CO00058605 A CO 00058605A CO 5290295 A1 CO5290295 A1 CO 5290295A1
Authority
CO
Colombia
Prior art keywords
avermitilis
avermectines
directs
relationship
streptomyces gene
Prior art date
Application number
CO00058605A
Other languages
English (en)
Inventor
Chen Yan
Gustafsson Claes
Krebber Anke
Jeremy Stephen Minshull
Ai Raillard Sun
Jonelle Stutzman-Eng Kim
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of CO5290295A1 publication Critical patent/CO5290295A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C12P19/623—Avermectin; Milbemycin; Ivermectin; C-076

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención se refiere a moléculas polinucleotídicas que comprenden secuencias de nucleótidos que codifican un producto génico AveC, moléculas polinucleotídicas que pueden usarse para alterar la relación o cantidad de avermectinas de clases 2:1 producidas en cultivos de fermentación de S. avermitilis. La presente invención se refiere además a vectores, células huésped y cepas mutantes de S. Avermitilis en las que el gem aveC se ha inactivado o mutado para cambiar la relación o cantidad de avermectinas de clases 2:1 producidas.
CO00058605A 1999-08-12 2000-08-04 Gen de streptomyces avermitilis que dirige la relacion de avermectinas b2:b1 CO5290295A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14864599P 1999-08-12 1999-08-12

Publications (1)

Publication Number Publication Date
CO5290295A1 true CO5290295A1 (es) 2003-06-27

Family

ID=22526696

Family Applications (1)

Application Number Title Priority Date Filing Date
CO00058605A CO5290295A1 (es) 1999-08-12 2000-08-04 Gen de streptomyces avermitilis que dirige la relacion de avermectinas b2:b1

Country Status (39)

Country Link
US (3) US6632673B1 (es)
EP (1) EP1200606B1 (es)
JP (1) JP3884651B2 (es)
KR (1) KR100489856B1 (es)
CN (1) CN1186446C (es)
AP (1) AP2002002418A0 (es)
AR (1) AR022646A1 (es)
AT (1) ATE341632T1 (es)
AU (1) AU778837B2 (es)
BG (1) BG65902B1 (es)
BR (1) BRPI0013119B8 (es)
CA (1) CA2380872C (es)
CO (1) CO5290295A1 (es)
CY (1) CY1105778T1 (es)
CZ (1) CZ304402B6 (es)
DE (1) DE60031126T2 (es)
DK (1) DK1200606T3 (es)
EA (1) EA200200056A1 (es)
ES (1) ES2272299T3 (es)
GT (1) GT200000136A (es)
HK (1) HK1046710B (es)
HR (1) HRP20020130A2 (es)
HU (1) HU230600B1 (es)
IL (2) IL147563A0 (es)
IS (1) IS6250A (es)
MA (1) MA26813A1 (es)
MX (1) MXPA02001513A (es)
NO (1) NO20020664L (es)
NZ (1) NZ516517A (es)
OA (1) OA11998A (es)
PA (1) PA8499501A1 (es)
PE (1) PE20010690A1 (es)
PL (1) PL203818B1 (es)
PT (1) PT1200606E (es)
SK (1) SK288086B6 (es)
TN (1) TNSN00171A1 (es)
UY (1) UY26286A1 (es)
WO (1) WO2001012821A1 (es)
ZA (1) ZA200201072B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60031126T2 (de) * 1999-08-12 2007-02-08 Pfizer Products Inc., Groton Streptomyces avermitilis gen zum regulieren des verhältnisses der b2:b1 avermectinen
EP1476539B1 (en) 2002-02-12 2009-03-25 Pfizer Products Inc. Streptomyces avermitilis gene directing the ratio of b2:b1 avermectins
US7943160B2 (en) * 2002-05-09 2011-05-17 Scimetrics Limited Corp. Pest control methods
US9493744B2 (en) * 2012-06-20 2016-11-15 Genentech, Inc. Methods for viral inactivation and other adventitious agents
KR102657859B1 (ko) 2021-04-07 2024-04-16 윤재식 일체형 내화 소켓

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN167980B (es) * 1987-01-23 1991-01-19 Pfizer
US5238848A (en) 1987-01-23 1993-08-24 Pfizer Inc Cultures for production of avermectins
US5525506A (en) 1987-01-23 1996-06-11 Pfizer Inc. Process for production of avermectins and cultures therefor
US5234831A (en) 1987-01-23 1993-08-10 Pfizer Inc Cultures for production of B avermectins
US5240850A (en) 1987-10-23 1993-08-31 Pfizer Inc. Cultures for production of avermectin aglycones
DE3881147T2 (de) 1987-10-23 1993-09-02 Pfizer Verfahren zur herstellung von aglykonen von avermectin und sie enthaltende kulturen.
US5252474A (en) 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
DE69023036T2 (de) 1989-03-31 1996-06-13 Merck & Co Inc Klonierung von Streptomyces avermitilis Genen zur Biosynthese von Avermectin und Verfahren zu ihrer Verwendung.
ES2204914T3 (es) 1993-07-30 2004-05-01 Pfizer Inc. Genes que codifican el complejo alfa cetoacido deshidrogenasa de cadena ramificada de streptomyces avermitilis.
FI942725A (fi) 1993-12-16 1995-06-17 Pfizer Haaraketjuista alfaketohappodenydrogenaasikompleksia koodaavia geenejä Streptomyces avermitiliksesta
US6335160B1 (en) 1995-02-17 2002-01-01 Maxygen, Inc. Methods and compositions for polypeptide engineering
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US6096548A (en) 1996-03-25 2000-08-01 Maxygen, Inc. Method for directing evolution of a virus
CA2266423A1 (en) 1996-09-27 1998-04-02 Maxygen, Inc. Methods for optimization of gene therapy by recursive sequence shuffling and selection
WO1998031837A1 (en) 1997-01-17 1998-07-23 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
AU1449499A (en) 1997-10-31 1999-05-24 Maxygen, Incorporated Modification of virus tropism and host range by viral genome shuffling
US6248579B1 (en) * 1998-02-13 2001-06-19 Pfizer Inc Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins
KR20040099389A (ko) * 1998-02-13 2004-11-26 화이자 프로덕츠 인코포레이티드 스트렙토마이세스 하이그로스코피쿠스 유전자
DE60031126T2 (de) * 1999-08-12 2007-02-08 Pfizer Products Inc., Groton Streptomyces avermitilis gen zum regulieren des verhältnisses der b2:b1 avermectinen

Also Published As

Publication number Publication date
SK288086B6 (sk) 2013-06-03
PA8499501A1 (es) 2001-12-14
IL147563A (en) 2009-06-15
CN1373809A (zh) 2002-10-09
AU5838600A (en) 2001-03-13
IS6250A (is) 2002-01-25
HU230600B1 (hu) 2017-02-28
NO20020664D0 (no) 2002-02-11
JP3884651B2 (ja) 2007-02-21
UY26286A1 (es) 2001-03-16
HRP20020130A2 (en) 2003-06-30
KR20020029379A (ko) 2002-04-18
EP1200606A1 (en) 2002-05-02
BG65902B1 (bg) 2010-04-30
EP1200606B1 (en) 2006-10-04
MXPA02001513A (es) 2002-07-02
US20030232415A1 (en) 2003-12-18
KR100489856B1 (ko) 2005-05-17
US7858340B2 (en) 2010-12-28
SK1392002A3 (en) 2002-12-03
GT200000136A (es) 2002-02-01
CA2380872A1 (en) 2001-02-22
NO20020664L (no) 2002-02-11
TNSN00171A1 (fr) 2005-11-10
BRPI0013119B8 (pt) 2021-05-25
PL203818B1 (pl) 2009-11-30
US6632673B1 (en) 2003-10-14
ATE341632T1 (de) 2006-10-15
IL147563A0 (en) 2002-08-14
DK1200606T3 (da) 2007-01-08
EA200200056A1 (ru) 2002-06-27
PE20010690A1 (es) 2001-07-06
AU778837B2 (en) 2004-12-23
BR0013119A (pt) 2002-04-23
PL353874A1 (en) 2003-12-01
PT1200606E (pt) 2006-12-29
CA2380872C (en) 2007-11-27
JP2003507017A (ja) 2003-02-25
HUP0202487A2 (en) 2002-10-28
BR0013119B1 (pt) 2014-02-25
WO2001012821A1 (en) 2001-02-22
AR022646A1 (es) 2002-09-04
CZ304402B6 (cs) 2014-04-16
HK1046710B (zh) 2005-05-13
AP2002002418A0 (en) 2002-03-31
HK1046710A1 (en) 2003-01-24
ZA200201072B (en) 2003-04-30
HUP0202487A3 (en) 2004-07-28
ES2272299T3 (es) 2007-05-01
DE60031126T2 (de) 2007-02-08
US20040009560A1 (en) 2004-01-15
CN1186446C (zh) 2005-01-26
OA11998A (en) 2006-04-18
DE60031126D1 (de) 2006-11-16
CY1105778T1 (el) 2011-02-02
CZ2002296A3 (cs) 2002-08-14
BG106479A (bg) 2002-10-31
NZ516517A (en) 2003-10-31
MA26813A1 (fr) 2004-12-20

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