CO5261594A1 - MYT1 CINASA INHIBITORS - Google Patents

MYT1 CINASA INHIBITORS

Info

Publication number
CO5261594A1
CO5261594A1 CO01015772A CO01015772A CO5261594A1 CO 5261594 A1 CO5261594 A1 CO 5261594A1 CO 01015772 A CO01015772 A CO 01015772A CO 01015772 A CO01015772 A CO 01015772A CO 5261594 A1 CO5261594 A1 CO 5261594A1
Authority
CO
Colombia
Prior art keywords
substituted
unsubstituted
aryl
group
heteroaryl
Prior art date
Application number
CO01015772A
Other languages
Spanish (es)
Inventor
Maria A Lago
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of CO5261594A1 publication Critical patent/CO5261594A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

Un compuesto de Fórmula (I), más abajo:<EMI FILE="01015772_1" ID="1" IMF=JPEG >en la que X e Y se seleccionan, independientemente, del grupo que consta de H, Br, CI, CH3, NO2, CN, NR1R2, C=ONR1R2MeO, HO, Me, OR; y un anillo arílico o heteroarílico sustituido independientemente con X e Y;R representa H o alquilo inferior;R1 y R2 se seleccionan independientemente del grupo que consta de H, alquilo inferior, sustituido o no sustituido con X, y un anillo aromático o heterocíclico, sustituido o no sustituido con Y y X;A se selecciona del grupo que consta de O, = O, =NR, =N-NHR3, =NH-NH-CS-NH2, y =NH-NH-CO-NH2; o A es alquilo inferior, sustituido o no sustituido con X, anillo arílico o heteroarílico;o A es un anillo heterocíclico; yR3 se selecciona del grupo que consta de R1, arilo, heteroarilo, C=OR1, C = O-arilo yC=O-heteroarilo, sustituido o no sustituido con X e Y.Un método para antagonizar un receptor de myt1 cinasa que comprende administrar al sujeto que lo necesite una cantidad eficaz de un compuesto según la reivindicación 1.A compound of Formula (I), below: <EMI FILE = "01015772_1" ID = "1" MFI = JPEG> in which X and Y are independently selected from the group consisting of H, Br, CI, CH3 , NO2, CN, NR1R2, C = ONR1R2MeO, HO, Me, OR; and an aryl or heteroaryl ring independently substituted with X and Y; R represents H or lower alkyl; R1 and R2 are independently selected from the group consisting of H, lower alkyl, substituted or unsubstituted with X, and an aromatic or heterocyclic ring, substituted or unsubstituted with Y and X; A is selected from the group consisting of O, = O, = NR, = N-NHR3, = NH-NH-CS-NH2, and = NH-NH-CO-NH2; or A is lower alkyl, substituted or unsubstituted with X, aryl or heteroaryl ring, or A is a heterocyclic ring; and R3 is selected from the group consisting of R1, aryl, heteroaryl, C = OR1, C = O-aryl and C = O-heteroaryl, substituted or unsubstituted with X and Y. A method for antagonizing a myt1 kinase receptor comprising administering to the subject in need an effective amount of a compound according to claim 1.

CO01015772A 2000-03-02 2001-02-28 MYT1 CINASA INHIBITORS CO5261594A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18653200P 2000-03-02 2000-03-02

Publications (1)

Publication Number Publication Date
CO5261594A1 true CO5261594A1 (en) 2003-03-31

Family

ID=22685317

Family Applications (1)

Application Number Title Priority Date Filing Date
CO01015772A CO5261594A1 (en) 2000-03-02 2001-02-28 MYT1 CINASA INHIBITORS

Country Status (3)

Country Link
AU (1) AU2001241917A1 (en)
CO (1) CO5261594A1 (en)
WO (1) WO2001064680A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7423031B2 (en) 2003-05-01 2008-09-09 Irm Llc Compounds and compositions as protein kinase inhibitors
US7385055B2 (en) * 2003-05-19 2008-06-10 Board Of Trustees Of Michigan State University Preparation of hymenialdisine derivatives and use thereof
JP5501251B2 (en) 2008-01-11 2014-05-21 アルバニー モレキュラー リサーチ， インコーポレイテッド (1-Azinone) substituted pyridoindoles as MCH antagonists
EP2448585B1 (en) 2009-07-01 2014-01-01 Albany Molecular Research, Inc. Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine mch-1 antagonists, methods of making, and use thereof
US8629158B2 (en) 2009-07-01 2014-01-14 Albany Molecular Research, Inc. Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
US8618299B2 (en) 2009-07-01 2013-12-31 Albany Molecular Research, Inc. Azinone-substituted azapolycycle MCH-1 antagonists, methods of making, and use thereof
US9073925B2 (en) 2009-07-01 2015-07-07 Albany Molecular Research, Inc. Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
WO2012088038A2 (en) 2010-12-21 2012-06-28 Albany Molecular Research, Inc. Piperazinone-substituted tetrahydro-carboline mch-1 antagonists, methods of making, and uses thereof
US8993765B2 (en) 2010-12-21 2015-03-31 Albany Molecular Research, Inc. Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof
CR20220558A (en) * 2020-04-01 2022-12-12 Repare Therapeutics Inc Compounds, pharmaceutical compositions, and methods of preparing compounds and of their use
WO2021195782A1 (en) * 2020-04-01 2021-10-07 Repare Therapeutics Inc. Methods of using myt1 inhibitors
CN115806555A (en) * 2021-09-16 2023-03-17 南开大学 Indolozezinone derivatives, preparation thereof and application thereof in preventing and treating plant viruses, killing insects and killing bacteria

Also Published As

Publication number Publication date
AU2001241917A1 (en) 2001-09-12
WO2001064680A1 (en) 2001-09-07

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