CO5080736A1 - Metodo de produccion de un compuesto de isoxazolidinediona - Google Patents
Metodo de produccion de un compuesto de isoxazolidinedionaInfo
- Publication number
- CO5080736A1 CO5080736A1 CO99019141A CO99019141A CO5080736A1 CO 5080736 A1 CO5080736 A1 CO 5080736A1 CO 99019141 A CO99019141 A CO 99019141A CO 99019141 A CO99019141 A CO 99019141A CO 5080736 A1 CO5080736 A1 CO 5080736A1
- Authority
- CO
- Colombia
- Prior art keywords
- compound
- jpeg
- formula
- emi file
- imf
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Un método para producir un compuesto de isoxazolidinediona de fórmula [11]<EMI FILE="99019141_1" ID="1" IMF=JPEG >Donde R es un grupo hidrocarburo aromático opcionalmente sustituido, un grupo hidrocarburo alicíclico oxi, un grupo heterocíclico opcionalmente sustituido o un grupo heterocíclico condensado opcionalmente sustituido, o una sal de los mismos comprendiendo las etapas dehacer reaccionar el compuesto [1]<EMI FILE="99019141_2" ID="2" IMF=JPEG >O una sal del mismo con un compuesto de la fórmula [2]<EMI FILE="99019141_3" ID="3" IMF=JPEG >En donde R es como está arriba definido, en la presencia de una base inorgánica en un solvente acuoso para dar un derivado aspartato de la fórmula [3]<EMI FILE="99019141_4" ID="4" IMF=JPEG >En donde R es como está arriba definidohacer reaccionar este compuesto con anhídrido acético usando dimetilaminopiridina como catalizador en presencia de una base seguido por calentamiento para descarboxilación para dar un compuesto de la fórmula [4]<EMI FILE="99019141_5" ID="5" IMF=JPEG >...
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10409898 | 1998-03-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO5080736A1 true CO5080736A1 (es) | 2001-09-25 |
Family
ID=14371652
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO99019141A CO5080736A1 (es) | 1998-03-30 | 1999-03-30 | Metodo de produccion de un compuesto de isoxazolidinediona |
Country Status (25)
Country | Link |
---|---|
US (4) | US6248897B1 (es) |
EP (3) | EP1384722A1 (es) |
JP (1) | JP2000143596A (es) |
KR (1) | KR100321608B1 (es) |
CN (4) | CN1130361C (es) |
AR (1) | AR015745A1 (es) |
AT (1) | ATE258931T1 (es) |
AU (1) | AU738200B2 (es) |
BR (1) | BR9906312A (es) |
CA (1) | CA2291620C (es) |
CO (1) | CO5080736A1 (es) |
CZ (1) | CZ296507B6 (es) |
DE (1) | DE69914557T2 (es) |
ES (1) | ES2211053T3 (es) |
HU (1) | HUP0003273A3 (es) |
IL (1) | IL133146A (es) |
NO (4) | NO314403B1 (es) |
NZ (1) | NZ501896A (es) |
PE (1) | PE20000359A1 (es) |
RU (1) | RU2180663C2 (es) |
SG (1) | SG73627A1 (es) |
SK (1) | SK161499A3 (es) |
TW (1) | TWI224594B (es) |
WO (1) | WO1999050267A1 (es) |
ZA (1) | ZA997705B (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2180663C2 (ru) | 1998-03-30 | 2002-03-20 | Джапан Тобакко Инк. | Способ получения изоксазолидиндионового соединения, способ получения оксазолилэтанольного соединения (варианты), способ получения аспартатного соединения, способ получения оксазолилацетатного соединения, способ получения метансульфонатного соединения, способ получения бензилиденового соединения |
US6784199B2 (en) | 2000-09-21 | 2004-08-31 | Aryx Therapeutics | Isoxazolidine compounds useful in the treatment of diabetes, hyperlipidemia, and atherosclerosis in mammals |
US6958355B2 (en) | 2000-04-24 | 2005-10-25 | Aryx Therapeutics, Inc. | Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis |
US6680387B2 (en) | 2000-04-24 | 2004-01-20 | Aryx Therapeutics | Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis |
US6768008B2 (en) | 2000-04-24 | 2004-07-27 | Aryx Therapeutics | Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis |
JP4073786B2 (ja) * | 2001-04-16 | 2008-04-09 | 田辺三菱製薬株式会社 | 高コンダクタンス型カルシウム感受性kチャネル開口薬 |
US6696474B2 (en) * | 2002-04-03 | 2004-02-24 | Warner Lambert Co. Llc. | Antidiabetic agents |
US6716842B2 (en) * | 2002-04-05 | 2004-04-06 | Warner-Lambert Company, Llc | Antidiabetic agents |
TWI343915B (en) * | 2002-10-07 | 2011-06-21 | Hoffmann La Roche | Chirale ppar agonists |
DE10328174A1 (de) * | 2003-06-24 | 2005-01-13 | Bayer Healthcare Ag | Verfahren zur Herstellung von Aryloxazolylethylalkohol |
BRPI0609580A2 (pt) * | 2005-03-22 | 2010-04-20 | Hoffmann La Roche | composto, polimorfo cristalino, processo para a sua manufatura, composições farmacêuticas que o contêm, método para o tratamento e/ou profilaxia de enfermidades que estão associadas com dpp-iv e utilização do composto |
EP1892231A1 (en) * | 2006-08-21 | 2008-02-27 | Bayer Schering Pharma Aktiengesellschaft | A large scale method for the deoxofluorination of ketones |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1859667A (en) * | 1930-05-14 | 1932-05-24 | J K Gruner Lumber Company | Jointed lumber |
JPS58219169A (ja) | 1982-06-15 | 1983-12-20 | Takeda Chem Ind Ltd | オキサゾ−ル酢酸誘導体 |
CN1003445B (zh) | 1984-10-03 | 1989-03-01 | 武田药品工业株式会社 | 噻唑烷二酮衍生物,其制备方法和用途 |
US5059720A (en) * | 1990-01-31 | 1991-10-22 | E. I. Du Pont De Nemours And Company | Hydroxy containing fluorovinyl compounds and polymers thereof |
KR930701420A (ko) | 1990-08-23 | 1993-06-11 | 알렌 제이. 스피겔 | 혈당저하제로서의 하이드록시우레아 유도체 |
CA2075553A1 (en) * | 1992-08-07 | 1994-02-08 | George Zafir | Insulated panel |
DE69322639T2 (de) * | 1992-12-28 | 1999-07-22 | I.G. Technical Research Inc., Higashine, Yamagata | Feuerbeständiges wärmeisolierendes paneel |
JPH07188227A (ja) | 1993-12-24 | 1995-07-25 | Japan Tobacco Inc | チアゾリジン誘導体及びオキサゾール誘導体 |
EP0684242B1 (en) | 1993-12-27 | 1999-05-06 | Japan Tobacco Inc. | Isoxazolidinedione derivative and use thereof |
TW403748B (en) * | 1994-11-02 | 2000-09-01 | Takeda Chemical Industries Ltd | An oxazolidinedione derivative, its production and a pharmaceutical composition for lowering blood sugar and lipid in blood comprising the same |
NZ314406A (en) * | 1996-03-18 | 2000-12-22 | Sankyo Co | Treatment or prophylaxis of pancreatitis with a medicament containing an insulin sensitiser including oxazoles and thiazoles |
US5768850A (en) * | 1997-02-04 | 1998-06-23 | Chen; Alen | Method for erecting floor boards and a board assembly using the method |
RU2180663C2 (ru) * | 1998-03-30 | 2002-03-20 | Джапан Тобакко Инк. | Способ получения изоксазолидиндионового соединения, способ получения оксазолилэтанольного соединения (варианты), способ получения аспартатного соединения, способ получения оксазолилацетатного соединения, способ получения метансульфонатного соединения, способ получения бензилиденового соединения |
DE19851200C1 (de) * | 1998-11-06 | 2000-03-30 | Kronotex Gmbh Holz Und Kunstha | Fußbodenpaneele |
US8234204B2 (en) * | 2000-11-13 | 2012-07-31 | Goldman, Sachs & Co. | Method and system for matching short trading positions with long trading positions |
-
1999
- 1999-03-19 RU RU99128102/04A patent/RU2180663C2/ru not_active IP Right Cessation
- 1999-03-19 EP EP03020538A patent/EP1384722A1/en not_active Withdrawn
- 1999-03-19 CA CA002291620A patent/CA2291620C/en not_active Expired - Fee Related
- 1999-03-19 CN CN99800858A patent/CN1130361C/zh not_active Expired - Fee Related
- 1999-03-19 WO PCT/JP1999/001434 patent/WO1999050267A1/ja active IP Right Grant
- 1999-03-19 DE DE69914557T patent/DE69914557T2/de not_active Expired - Fee Related
- 1999-03-19 SK SK1614-99A patent/SK161499A3/sk unknown
- 1999-03-19 ES ES99909293T patent/ES2211053T3/es not_active Expired - Lifetime
- 1999-03-19 US US09/424,711 patent/US6248897B1/en not_active Expired - Fee Related
- 1999-03-19 CN CNB2003101013392A patent/CN1235887C/zh not_active Expired - Fee Related
- 1999-03-19 EP EP99909293A patent/EP0992503B1/en not_active Expired - Lifetime
- 1999-03-19 KR KR1019997011020A patent/KR100321608B1/ko not_active IP Right Cessation
- 1999-03-19 NZ NZ501896A patent/NZ501896A/xx unknown
- 1999-03-19 CN CNA2005101200256A patent/CN1781915A/zh active Pending
- 1999-03-19 AU AU28548/99A patent/AU738200B2/en not_active Ceased
- 1999-03-19 AT AT99909293T patent/ATE258931T1/de not_active IP Right Cessation
- 1999-03-19 CZ CZ0422499A patent/CZ296507B6/cs not_active IP Right Cessation
- 1999-03-19 IL IL13314699A patent/IL133146A/en not_active IP Right Cessation
- 1999-03-19 CN CNB2003101013405A patent/CN1232511C/zh not_active Expired - Fee Related
- 1999-03-19 HU HU0003273A patent/HUP0003273A3/hu unknown
- 1999-03-19 BR BR9906312-3A patent/BR9906312A/pt not_active IP Right Cessation
- 1999-03-19 EP EP03020537A patent/EP1375499A1/en not_active Withdrawn
- 1999-03-26 TW TW088104758A patent/TWI224594B/zh not_active IP Right Cessation
- 1999-03-30 SG SG1999001563A patent/SG73627A1/en unknown
- 1999-03-30 AR ARP990101416A patent/AR015745A1/es not_active Application Discontinuation
- 1999-03-30 CO CO99019141A patent/CO5080736A1/es unknown
- 1999-03-30 PE PE1999000258A patent/PE20000359A1/es not_active Application Discontinuation
- 1999-11-29 NO NO19995851A patent/NO314403B1/no not_active IP Right Cessation
- 1999-12-15 ZA ZA9907705A patent/ZA997705B/xx unknown
- 1999-12-20 JP JP11360189A patent/JP2000143596A/ja active Pending
-
2001
- 2001-04-23 US US09/839,215 patent/US6444827B2/en not_active Expired - Fee Related
-
2002
- 2002-07-19 US US10/198,171 patent/US6699996B2/en not_active Expired - Fee Related
- 2002-08-26 NO NO20024058A patent/NO315198B1/no not_active IP Right Cessation
- 2002-08-26 NO NO20024059A patent/NO315197B1/no not_active IP Right Cessation
- 2002-08-26 NO NO20024060A patent/NO315199B1/no not_active IP Right Cessation
-
2003
- 2003-09-30 US US10/673,512 patent/US6995271B2/en not_active Expired - Fee Related
Also Published As
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