CO5021218A1 - Surfactante pulmonar natural porcino - Google Patents
Surfactante pulmonar natural porcinoInfo
- Publication number
- CO5021218A1 CO5021218A1 CO95062028A CO95062028A CO5021218A1 CO 5021218 A1 CO5021218 A1 CO 5021218A1 CO 95062028 A CO95062028 A CO 95062028A CO 95062028 A CO95062028 A CO 95062028A CO 5021218 A1 CO5021218 A1 CO 5021218A1
- Authority
- CO
- Colombia
- Prior art keywords
- phospholipids
- pulmonary surfactant
- pulmonary
- less
- phosphatidylinositol
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Un surfactante pulmonar de origen porcino que contiene de 90 a97% de fosfolípidos, de 0.5 a 1.3 de proteínas hidrófobas que incluyen las proteínas SPB y SPC y más de un 2% de acilglicéridos con predominio de triglicéridos provenientes de la fuente natural. Más del 40% de la composición fosfolipídica corresponde a fosfatidilcolina disaturada, el contenido de fosfatidilinositol es superior al 7% en relación a fosfolípidos y el contenido total de los fosfolípidos aniónicos (fosfatidilglicerol y fosfatidilinositol) es mayor de 12% respecto a fosfolípidos.Método para la obtención de surfactante pulmonar de origen porcino que comprende obtener soluciones electrolíticas de lavado pulmonar; centrifugar la fase menos densa o el lavado pulmonar a menos de 8.000 rpm y velocidad de flujo inferior a 0.5 L/min, posteriormente extraer el pellet con mezcla de solventes orgánicos y precipitar con acetona.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU1994153 | 1994-12-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO5021218A1 true CO5021218A1 (es) | 2001-03-27 |
Family
ID=5459462
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO95062028A CO5021218A1 (es) | 1994-12-29 | 1995-12-28 | Surfactante pulmonar natural porcino |
Country Status (3)
Country | Link |
---|---|
BR (1) | BR9506114A (es) |
CO (1) | CO5021218A1 (es) |
ES (1) | ES2092969B1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19705230C1 (de) * | 1997-02-12 | 1998-04-23 | Mse Pharmazeutika Gmbh | Zubereitung des Pulmonary Surfactant zur Instillation und zur oralen Anwendung |
GB0026239D0 (en) * | 2000-10-26 | 2000-12-13 | Britannia Pharmaceuticals Ltd | Surface active lipids in treatment of wet lung |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS55160721A (en) * | 1979-06-02 | 1980-12-13 | Tokyo Tanabe Co Ltd | Pulmonary surfactant ta-546, its preparation, and remedy for pulmonary hyaline membrane syndrome comprising it as active constituent |
JPS5845299A (ja) * | 1981-09-10 | 1983-03-16 | 東京田辺製薬株式会社 | 新規な表面活性物質、その製造法及びそれを含有する呼吸窮迫疾候群治療剤 |
JPS59164724A (ja) * | 1983-03-10 | 1984-09-17 | Tokyo Tanabe Co Ltd | サ−フアクタント及びそれを含有する呼吸窮迫症候群治療剤 |
IT1203873B (it) * | 1987-04-08 | 1989-02-23 | Chiesi Farma Spa | Composizioni farmaceutiche che lo surfattante polmonare naturale, contengono. metodo di preparazione e |
-
1995
- 1995-12-28 CO CO95062028A patent/CO5021218A1/es unknown
- 1995-12-28 BR BR9506114A patent/BR9506114A/pt not_active Application Discontinuation
- 1995-12-29 ES ES9502552A patent/ES2092969B1/es not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2092969A1 (es) | 1996-12-01 |
BR9506114A (pt) | 1997-12-23 |
ES2092969B1 (es) | 1997-07-01 |
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