CO4920247A1 - Procedimiento para la sintesis de benzotiofenos - Google Patents

Procedimiento para la sintesis de benzotiofenos

Info

Publication number
CO4920247A1
CO4920247A1 CO97067013A CO97067013A CO4920247A1 CO 4920247 A1 CO4920247 A1 CO 4920247A1 CO 97067013 A CO97067013 A CO 97067013A CO 97067013 A CO97067013 A CO 97067013A CO 4920247 A1 CO4920247 A1 CO 4920247A1
Authority
CO
Colombia
Prior art keywords
benzothiophenes
synthesis
procedure
formula
compound
Prior art date
Application number
CO97067013A
Other languages
English (en)
Inventor
Jeffrey Thomas Vicenzi
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CO4920247A1 publication Critical patent/CO4920247A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms

Abstract

Un procedimiento para la preparación de un compuesto defórmula Iben la que los grupos R son iguales o diferentes y representan alquilo C1 -C6 , el cual comprende:la ciclización de un compuesto dialcoxi de fórmula IIen presencia de ácido metonosulfónico.
CO97067013A 1996-11-19 1997-11-14 Procedimiento para la sintesis de benzotiofenos CO4920247A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3118196P 1996-11-19 1996-11-19

Publications (1)

Publication Number Publication Date
CO4920247A1 true CO4920247A1 (es) 2000-05-29

Family

ID=21858059

Family Applications (1)

Application Number Title Priority Date Filing Date
CO97067013A CO4920247A1 (es) 1996-11-19 1997-11-14 Procedimiento para la sintesis de benzotiofenos

Country Status (23)

Country Link
US (1) US5969157A (es)
EP (1) EP0842930B1 (es)
JP (1) JP2001504497A (es)
KR (1) KR20000053333A (es)
CN (1) CN1130357C (es)
AR (1) AR010615A1 (es)
AT (1) ATE217620T1 (es)
AU (1) AU726401B2 (es)
BR (1) BR9712773A (es)
CA (1) CA2271922A1 (es)
CO (1) CO4920247A1 (es)
DE (1) DE69712590T2 (es)
DK (1) DK0842930T3 (es)
ES (1) ES2173399T3 (es)
HU (1) HUP9904510A3 (es)
ID (1) ID18917A (es)
IL (1) IL129868A (es)
PE (1) PE16799A1 (es)
PT (1) PT842930E (es)
SI (1) SI0842930T1 (es)
TW (1) TW461888B (es)
WO (1) WO1998022456A1 (es)
ZA (1) ZA9710262B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6335600A (en) * 1999-07-29 2001-02-19 Eli Lilly And Company A novel crystalline form of 6-hydroxy-3-(4-[2-(piperidin-1-yl)ethoxy]phenoxy)-2-(4-metho yphenyl)benzo[b]thiophene hydrochloride
US6921827B2 (en) * 2000-11-27 2005-07-26 Eli Lilly And Company Process for preparing 3-aryl-benzo{b} thiophenes
US20050069962A1 (en) * 2001-10-12 2005-03-31 Archer Robert M Antibody complexes and methods for immunolabeling
US8323903B2 (en) 2001-10-12 2012-12-04 Life Technologies Corporation Antibody complexes and methods for immunolabeling
NZ537328A (en) * 2002-05-31 2008-04-30 Genetic Technologies Ltd Maternal antibodies as fetal cell markers to identify and enrich fetal cells from maternal blood
US7964734B2 (en) 2002-09-30 2011-06-21 A/S Gea Farmaceutisk Fabrik Raloxifene acid addition salts and/or solvates thereof, improved method for purification of said raloxifene acid addition salts and/or solvates thereof and pharmaceutical compositions comprising these
AU2004217872B2 (en) * 2003-03-05 2010-03-25 Genetic Technologies Limited Identification of fetal DNA and fetal cell markers in maternal plasma or serum
KR20090082399A (ko) 2006-10-17 2009-07-30 씨아이피엘에이 엘티디. 벤조티오펜 화합물의 결정형 및 그의 제조방법
WO2010121294A1 (en) 2009-04-21 2010-10-28 Genetic Technologies Limited Methods for obtaining fetal genetic material

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU509682B2 (en) * 1975-10-28 1980-05-22 Eli Lilly And Company 2-Aroyl-3-Phenylbenzothiophene Derivatives
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
AT364852B (de) * 1977-11-05 1981-11-25 Thomae Gmbh Dr K Verfahren zur herstellung von kondensierten isothiazol-3(2h)-on-1,1-dioxiden und von deren salzen
US4436748A (en) * 1980-10-20 1984-03-13 Hoechst-Roussel Pharmaceuticals Inc. Benzo[b]thiophenes
IL65378A (en) * 1981-04-03 1986-02-28 Lilly Co Eli Process for preparing 3-(4-aminoethoxybenzoyl)benzo-(b)thiophenes
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
US4380635A (en) * 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
US4544746A (en) * 1982-05-17 1985-10-01 Ciba-Geigy Corporation Process for preparing 2-anilinoacridone
JP3157882B2 (ja) * 1991-11-15 2001-04-16 帝国臓器製薬株式会社 新規なベンゾチオフエン誘導体
DE4204969A1 (de) * 1992-02-19 1993-08-26 Basf Ag Verfahren zur herstellung von benzo(b)thiophenen
US5466810A (en) * 1994-06-10 1995-11-14 Eli Lilly And Company 2-amino-3-aroyl-benzo[β]thiophenes and methods for preparing and using same to produce 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-aminoethoxy)-benzoyl]benzo[β]thiophenes
DE4423893C2 (de) * 1994-07-07 1996-09-05 Freudenberg Carl Fa Flachdichtung mit flexibler Leiterplatte
US5523416A (en) * 1994-07-22 1996-06-04 Eli Lilly And Company Process for preparing 3-(4-aminoethoxy-benzoyl) benzo (B)-thiophenes
US5552401A (en) * 1995-02-28 1996-09-03 Eli Lilly And Company 2-benzyl-3-arylbenzothiophenes
US5614639A (en) * 1995-03-31 1997-03-25 Eli Lilly And Company Process for preparing 2-substituted benzo[b]thiophene compounds and intermediates thereof
US5606076A (en) * 1995-06-07 1997-02-25 Eli Lilly And Company Process for the synthesis of benzo[b]thiophenes
US5606075A (en) * 1995-06-07 1997-02-25 Eli Lilly And Company Process for the synthesis of benzo[b]thiophenes

Also Published As

Publication number Publication date
DE69712590T2 (de) 2002-10-31
CN1237968A (zh) 1999-12-08
WO1998022456A1 (en) 1998-05-28
KR20000053333A (ko) 2000-08-25
ATE217620T1 (de) 2002-06-15
CA2271922A1 (en) 1998-05-28
PE16799A1 (es) 1999-02-19
EP0842930B1 (en) 2002-05-15
JP2001504497A (ja) 2001-04-03
ZA9710262B (en) 1999-05-13
US5969157A (en) 1999-10-19
BR9712773A (pt) 1999-10-26
HUP9904510A2 (hu) 2000-05-28
AR010615A1 (es) 2000-06-28
EP0842930A1 (en) 1998-05-20
HUP9904510A3 (en) 2000-08-28
DE69712590D1 (de) 2002-06-20
AU726401B2 (en) 2000-11-09
ES2173399T3 (es) 2002-10-16
SI0842930T1 (en) 2002-10-31
IL129868A (en) 2002-09-12
CN1130357C (zh) 2003-12-10
IL129868A0 (en) 2000-02-29
DK0842930T3 (da) 2002-07-15
PT842930E (pt) 2002-08-30
TW461888B (en) 2001-11-01
ID18917A (id) 1998-05-20
AU5462298A (en) 1998-06-10

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