CO4600681A1 - Composicion farmaceutica para la modulacion inmunitaria - Google Patents
Composicion farmaceutica para la modulacion inmunitariaInfo
- Publication number
- CO4600681A1 CO4600681A1 CO97009092A CO97009092A CO4600681A1 CO 4600681 A1 CO4600681 A1 CO 4600681A1 CO 97009092 A CO97009092 A CO 97009092A CO 97009092 A CO97009092 A CO 97009092A CO 4600681 A1 CO4600681 A1 CO 4600681A1
- Authority
- CO
- Colombia
- Prior art keywords
- pharmaceutical composition
- peptide
- immunity modulation
- adjuvant
- treated
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 230000036039 immunity Effects 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 5
- 239000002671 adjuvant Substances 0.000 abstract 2
- 230000002519 immonomodulatory effect Effects 0.000 abstract 2
- 239000003446 ligand Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5156—Animal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55522—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Abstract
Composición farmacéutica que contiene al menos un péptido deacción inmunomoduladora junto con un coadyuvante, caracterizada porque el coadyuvante presenta la capacidad de aumentar la fijación del péptido a células del individuo a tratar o la entrada del péptido en la célula y determinar una intensificación de la acción inmunomoduladora del péptido.Composición farmacéutica según la reivindicación 1 caracterizada porque el péptido es un ligando para al menos una molécula de MHC que es expresado por el individuo a tratar.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19607044A DE19607044A1 (de) | 1996-02-24 | 1996-02-24 | Tumorvakzine und Verfahren zu ihrer Herstellung |
DE19638313A DE19638313C2 (de) | 1996-09-19 | 1996-09-19 | Pharmazeutische Zusammensetzung für die Immunmodulation |
DE19648687A DE19648687A1 (de) | 1996-11-25 | 1996-11-25 | Pharmazeutische Zusammensetzung für die Immunmodulation |
Publications (1)
Publication Number | Publication Date |
---|---|
CO4600681A1 true CO4600681A1 (es) | 1998-05-08 |
Family
ID=27215945
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO97009092A CO4600681A1 (es) | 1996-02-24 | 1997-02-20 | Composicion farmaceutica para la modulacion inmunitaria |
Country Status (35)
Country | Link |
---|---|
US (1) | US7105162B1 (es) |
EP (1) | EP0881906B2 (es) |
JP (1) | JP4184433B2 (es) |
KR (1) | KR100457647B1 (es) |
CN (1) | CN1177610C (es) |
AR (1) | AR005945A1 (es) |
AT (1) | ATE274350T1 (es) |
AU (1) | AU722264B2 (es) |
BG (1) | BG63682B1 (es) |
BR (1) | BR9707694A (es) |
CA (1) | CA2243559C (es) |
CO (1) | CO4600681A1 (es) |
CZ (1) | CZ295396B6 (es) |
DE (1) | DE59711873D1 (es) |
DK (1) | DK0881906T4 (es) |
EE (1) | EE04481B1 (es) |
ES (1) | ES2225951T5 (es) |
HK (1) | HK1017257A1 (es) |
HR (1) | HRP970100B1 (es) |
HU (1) | HU224410B1 (es) |
ID (1) | ID16038A (es) |
IL (1) | IL125361A (es) |
MY (1) | MY119276A (es) |
NO (1) | NO983850L (es) |
NZ (1) | NZ332020A (es) |
PE (1) | PE55398A1 (es) |
PL (1) | PL189413B1 (es) |
PT (1) | PT881906E (es) |
RO (1) | RO119344B1 (es) |
RS (1) | RS50101B (es) |
SI (1) | SI0881906T2 (es) |
SK (1) | SK284582B6 (es) |
TR (1) | TR199801649T2 (es) |
TW (1) | TW585774B (es) |
WO (1) | WO1997030721A1 (es) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CO4600681A1 (es) | 1996-02-24 | 1998-05-08 | Boehringer Ingelheim Pharma | Composicion farmaceutica para la modulacion inmunitaria |
DE19803453A1 (de) * | 1998-01-30 | 1999-08-12 | Boehringer Ingelheim Int | Vakzine |
ATE365050T1 (de) * | 1998-02-25 | 2007-07-15 | Us Gov Sec Army | Verwendung von hautpenetrationsförderern und für die zerstörung der oberen hautschichten geeigneten mitteln zur erhöhung der transkutanen immunantwort |
AU765260B2 (en) * | 1998-04-20 | 2003-09-11 | Torrey Pines Institute For Molecular Studies | Topical immunostimulation to induce langerhans cell migration |
ES2572834T3 (es) * | 1999-02-17 | 2016-06-02 | Csl Limited | Complejos inmunogénicos y métodos relacionados con los mismos |
DE19909503A1 (de) * | 1999-03-04 | 2000-09-07 | Boehringer Ingelheim Int | Tumorassoziiertes Antigen |
US6809179B1 (en) | 1999-08-04 | 2004-10-26 | Boehringer Ingelheim International Gmbh | Tumor-associated antigen (R11) |
AT408721B (de) | 1999-10-01 | 2002-02-25 | Cistem Biotechnologies Gmbh | Pharmazeutische zusammensetzung enthaltend ein antigen |
AT409085B (de) * | 2000-01-28 | 2002-05-27 | Cistem Biotechnologies Gmbh | Pharmazeutische zusammensetzung zur immunmodulation und herstellung von vakzinen |
US20020009491A1 (en) * | 2000-02-14 | 2002-01-24 | Rothbard Jonathan B. | Compositions and methods for enhancing drug delivery across biological membranes and tissues |
AT409762B (de) * | 2000-04-13 | 2002-11-25 | Cistem Biotechnologies Gmbh | Verfahren zur identifizierung von zytokin sekretierenden zellen |
AT410173B (de) | 2000-06-08 | 2003-02-25 | Cistem Biotechnologies Gmbh | Antigene zusammensetzung |
KR20020014459A (ko) * | 2000-08-18 | 2002-02-25 | 서진호 | 양이온성 아미노산이 부가된 융합단백질 및 이를 이용한생물공정의 개선방법 |
JP2004519452A (ja) * | 2001-01-05 | 2004-07-02 | インターツェル・アクチェンゲゼルシャフト | ポリカチオン性化合物の用途 |
EP1347776A2 (en) * | 2001-01-05 | 2003-10-01 | Intercell Biomedizinische Forschungs- und Entwicklungs AG | Anti-inflammatory use of polycationic compounds |
US7244438B2 (en) | 2001-01-05 | 2007-07-17 | Intercell Ag | Uses for polycationic compounds |
AT410798B (de) | 2001-01-26 | 2003-07-25 | Cistem Biotechnologies Gmbh | Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen |
FR2824326B1 (fr) * | 2001-05-04 | 2004-03-19 | Commissariat Energie Atomique | Melange de peptides issus des proteines e6 et/ou e7 de papillomavirus et leurs applications |
CA2452909A1 (en) * | 2001-12-07 | 2003-06-13 | Intercell Ag | Immunostimulatory oligodeoxynucleotides |
US20050221350A1 (en) * | 2002-05-29 | 2005-10-06 | Toni Weinschenk | Method for identifying immunoreactive peptides |
JP2005533855A (ja) | 2002-07-24 | 2005-11-10 | インターツェル・アクチェンゲゼルシャフト | 病原性ウイルスからの別のリーディングフレームによりコードされる抗原 |
EP2402026A3 (en) | 2002-09-13 | 2012-04-18 | Intercell AG | Method for isolating hepatitis C virus peptides |
AU2003274011B2 (en) | 2002-10-15 | 2010-03-04 | Intercell Ag | Nucleic acids coding for adhesion factor of group B streptococcus, adhesion factors of group B streptococcus and further uses thereof |
JP2006520202A (ja) | 2003-03-04 | 2006-09-07 | インターツェル・アクチェンゲゼルシャフト | ストレプトコッカス・ピオゲネス抗原 |
ATE485056T1 (de) | 2003-03-24 | 2010-11-15 | Intercell Ag | Verbesserte impfstoffe |
CA2520868A1 (en) | 2003-03-31 | 2004-10-14 | Intercell Ag | Staphylococcus epidermidis antigens |
EP2314719A1 (en) | 2003-04-15 | 2011-04-27 | Intercell AG | S. pneumoniae antigens |
AU2004235952A1 (en) | 2003-05-07 | 2004-11-18 | Intercell Ag | Streptococcus agalactiae antigens I + II |
EP2327720A1 (en) | 2003-05-30 | 2011-06-01 | Intercell AG | Enterococcus antigens |
PL1648502T3 (pl) | 2003-07-11 | 2011-05-31 | Intercell Ag | Szczepionki przeciwko HCV |
EP1722819B1 (en) | 2004-03-12 | 2007-12-26 | Intercell AG | Method for solubilising peptide mixtures |
DE102004038134B4 (de) | 2004-08-05 | 2013-07-25 | Johann Wolfgang Goethe-Universität Frankfurt am Main | Multivalente Chelatoren zum Modifizieren und Organisieren von Zielmolekülen, Verfahren zu ihrer Herstellung sowie ihre Verwendung |
EP2149583B1 (en) | 2004-09-24 | 2015-10-28 | Novartis AG | Modified VP1-capsid protein of parvovirus B19 |
CA2583026A1 (en) * | 2004-10-29 | 2006-05-04 | Intercell Ag | Hcv vaccines for chronic hcv patients |
US7785612B2 (en) | 2005-04-20 | 2010-08-31 | Taiho Pharmaceutical Co., Ltd. | Polyamino acid for use as adjuvant |
EP1887084A1 (en) * | 2006-08-10 | 2008-02-13 | International Investment and Patents SA | Plasmids with immunological action |
WO2008031133A2 (en) | 2006-09-15 | 2008-03-20 | Intercell Ag | Borrelia antigens |
JP2008174490A (ja) * | 2007-01-18 | 2008-07-31 | Nitto Denko Corp | 抗原性ペプチドを主成分とする薬剤 |
EP2497779A1 (en) | 2007-05-02 | 2012-09-12 | Intercell AG | Klebsiella antigens |
KR100748265B1 (ko) * | 2007-06-15 | 2007-08-10 | (주)성문엔지니어링 | 공동주택에 배선된 전선의 합선방지구조 |
EP2511291A3 (en) | 2007-06-18 | 2012-11-07 | Intercell AG | Chlamydia antigens |
US8747861B2 (en) | 2007-08-02 | 2014-06-10 | Biondvax Pharmaceuticals Ltd. | Multimeric multiepitope influenza vaccines |
CN103083643B (zh) * | 2008-03-27 | 2015-01-07 | 雀巢产品技术援助有限公司 | 增加肽、肽模拟物和其他胃肠道转运蛋白底物吸收的方法 |
AU2009323682A1 (en) | 2008-12-03 | 2010-06-10 | Protea Vaccine Technologies Ltd. | Glutamyl tRNA synthetase (GtS) fragments |
WO2010092176A2 (en) | 2009-02-13 | 2010-08-19 | Intercell Ag | Nontypable haemophilus influenzae antigens |
CN102740882A (zh) * | 2009-08-27 | 2012-10-17 | 诺华有限公司 | 含有铝、寡核苷酸和聚阳离子的佐剂 |
CN102695500A (zh) | 2009-11-09 | 2012-09-26 | 聚光灯技术合伙有限责任公司 | 多糖基水凝胶 |
NZ599527A (en) | 2009-11-09 | 2014-04-30 | Spotlight Technology Partners Llc | Fragmented hydrogels |
WO2011067758A2 (en) | 2009-12-02 | 2011-06-09 | Protea Vaccine Technologies Ltd. | Immunogenic fragments and multimers from streptococcus pneumoniae proteins |
WO2011101465A1 (en) | 2010-02-19 | 2011-08-25 | Intercell Ag | Ic31 nanoparticles |
CN103517713A (zh) | 2011-02-22 | 2014-01-15 | 彼昂德瓦克斯医药有限公司 | 在改善的季节性和大流行性流感疫苗中的多聚体多表位多肽 |
RU2478399C2 (ru) * | 2011-06-16 | 2013-04-10 | Государственное научное учреждение Всероссийский научно-исследовательский институт бруцеллеза и туберкулеза животных Российской академии сельскохозяйственных наук (ГНУ ВНИИБТЖ Россельхозакадемии) | Способ получения специфического иммуномодулятора |
US20140271723A1 (en) * | 2013-03-15 | 2014-09-18 | Saint Louis University | Adjuvant compositions and methods of using thereof |
IL293135A (en) | 2015-05-13 | 2022-07-01 | Agenus Inc | A preparation containing at least two different complexes of purified stress protein linked to an antigenic peptide |
WO2017159686A1 (ja) * | 2016-03-15 | 2017-09-21 | Repertoire Genesis株式会社 | 免疫療法のためのモニタリングまたは診断ならびに治療剤の設計 |
AU2017268822B2 (en) * | 2016-05-27 | 2020-03-26 | Etubics Corporation | Neoepitope vaccine compositions and methods of use thereof |
TW201813664A (zh) | 2016-10-11 | 2018-04-16 | 賽多利克公司 | 醫藥 |
CN107469067B (zh) * | 2017-09-05 | 2018-06-19 | 浙江大学 | 一种多肽及其改造体在制备免疫调节药物中的应用 |
AU2019261451A1 (en) | 2018-04-26 | 2020-12-03 | Agenus Inc. | Heat shock protein-binding peptide compositions and methods of use thereof |
CN110870913A (zh) * | 2018-08-31 | 2020-03-10 | 成都夸常奥普医疗科技有限公司 | 氨基酸类营养素作为疫苗佐剂的应用以及包含氨基酸营养素作为佐剂的疫苗 |
CN110870912A (zh) * | 2018-08-31 | 2020-03-10 | 成都夸常奥普医疗科技有限公司 | 亚甲蓝类染料作为疫苗佐剂的应用、包含该佐剂的疫苗及其应用 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1290141A (es) | 1968-05-31 | 1972-09-20 | ||
US4847240A (en) * | 1978-01-16 | 1989-07-11 | The Trustees Of Boston University | Method of effecting cellular uptake of molecules |
US4728639A (en) * | 1982-07-27 | 1988-03-01 | University Of Tennessee Research Corporation | Type-specific opsonic antibodies evoked with a synthetic peptide of streptococcal M protein conjugated to polylysine without adjuvant |
US6022544A (en) * | 1983-01-24 | 2000-02-08 | The John Hopkins University | Therapeutic suppression of specific immune responses by administration of oligomeric forms of antigen of controlled chemistry |
US4956273A (en) * | 1985-10-24 | 1990-09-11 | Southwest Foundation For Biomedical Research | Synthetic peptides and method of use for diagnosis and vaccination for AIDS and ARC |
BE1000587A4 (fr) | 1986-06-13 | 1989-02-14 | Oncogen | Coordinats et procedes en vue d'augmenter la proliferation des lymphocytes b. |
EP0346022B1 (en) * | 1988-06-10 | 1996-02-14 | United Biomedical, Inc. | Peptide fragments of HIV |
AU4525589A (en) * | 1988-10-27 | 1990-05-14 | Regents Of The University Of Minnesota | Liposome immunoadjuvants containing il-2 |
US5480967A (en) | 1990-01-05 | 1996-01-02 | United Biomedical, Inc. | HIV-1 core protein fragments |
US5342774A (en) | 1991-05-23 | 1994-08-30 | Ludwig Institute For Cancer Research | Nucleotide sequence encoding the tumor rejection antigen precursor, MAGE-1 |
US6235525B1 (en) | 1991-05-23 | 2001-05-22 | Ludwig Institute For Cancer Research | Isolated nucleic acid molecules coding for tumor rejection antigen precursor MAGE-3 and uses thereof |
WO1993019768A1 (en) | 1992-04-03 | 1993-10-14 | The Regents Of The University Of California | Self-assembling polynucleotide delivery system |
EP0658113B1 (en) | 1992-08-31 | 2004-10-20 | Ludwig Institute For Cancer Research | Isolated nonapeptide derived from mage-3 gene and presented by hla-a1, and uses thereof |
US5571711A (en) | 1993-06-17 | 1996-11-05 | Ludwig Institute For Cancer Research | Isolated nucleic acid molecules coding for BAGE tumor rejection antigen precursors |
US5409703A (en) * | 1993-06-24 | 1995-04-25 | Carrington Laboratories, Inc. | Dried hydrogel from hydrophilic-hygroscopic polymer |
CZ3000U1 (cs) | 1993-07-12 | 1995-02-22 | Kufudakis Alekos | Farmaceutický prostředek pro imunomodulační a adjuvantní léčbu |
JP2828391B2 (ja) * | 1993-10-29 | 1998-11-25 | 東燃株式会社 | オリゴ糖を表面に有するリポソーム |
US6660276B1 (en) * | 1994-02-16 | 2003-12-09 | The University Of Virginia Patent Foundation | Peptides recognized by melanoma-specific cytotoxic lymphocytes, and uses therefor |
US6001809A (en) * | 1994-07-11 | 1999-12-14 | Elan Pharmaceuticals, Inc. | Inhibitors of leukocyte adhesion |
UY24367A1 (es) † | 1995-11-23 | 2000-10-31 | Boehringer Ingelheim Int | Vacunas contra tumores y procedimiento para su produccion |
CO4600681A1 (es) | 1996-02-24 | 1998-05-08 | Boehringer Ingelheim Pharma | Composicion farmaceutica para la modulacion inmunitaria |
-
1997
- 1997-02-20 CO CO97009092A patent/CO4600681A1/es unknown
- 1997-02-20 RS YUP-62/97A patent/RS50101B/sr unknown
- 1997-02-21 RO RO98-01305A patent/RO119344B1/ro unknown
- 1997-02-21 DK DK97905068T patent/DK0881906T4/da active
- 1997-02-21 JP JP52980697A patent/JP4184433B2/ja not_active Expired - Fee Related
- 1997-02-21 SI SI9730672T patent/SI0881906T2/sl unknown
- 1997-02-21 HU HU9901186A patent/HU224410B1/hu not_active IP Right Cessation
- 1997-02-21 WO PCT/EP1997/000828 patent/WO1997030721A1/de active IP Right Grant
- 1997-02-21 IL IL12536197A patent/IL125361A/en not_active IP Right Cessation
- 1997-02-21 NZ NZ332020A patent/NZ332020A/en not_active IP Right Cessation
- 1997-02-21 AT AT97905068T patent/ATE274350T1/de active
- 1997-02-21 HR HR970100A patent/HRP970100B1/xx not_active IP Right Cessation
- 1997-02-21 US US09/125,672 patent/US7105162B1/en not_active Expired - Fee Related
- 1997-02-21 EP EP97905068A patent/EP0881906B2/de not_active Expired - Lifetime
- 1997-02-21 AR ARP970100701A patent/AR005945A1/es active IP Right Grant
- 1997-02-21 PT PT97905068T patent/PT881906E/pt unknown
- 1997-02-21 CA CA2243559A patent/CA2243559C/en not_active Expired - Fee Related
- 1997-02-21 PL PL97328455A patent/PL189413B1/pl unknown
- 1997-02-21 BR BR9707694A patent/BR9707694A/pt not_active IP Right Cessation
- 1997-02-21 TR TR1998/01649T patent/TR199801649T2/xx unknown
- 1997-02-21 EE EE9800255A patent/EE04481B1/xx unknown
- 1997-02-21 CN CNB971925186A patent/CN1177610C/zh not_active Expired - Fee Related
- 1997-02-21 AU AU18759/97A patent/AU722264B2/en not_active Ceased
- 1997-02-21 KR KR10-1998-0706339A patent/KR100457647B1/ko not_active IP Right Cessation
- 1997-02-21 ES ES97905068T patent/ES2225951T5/es not_active Expired - Lifetime
- 1997-02-21 CZ CZ19982689A patent/CZ295396B6/cs not_active IP Right Cessation
- 1997-02-21 DE DE59711873T patent/DE59711873D1/de not_active Expired - Lifetime
- 1997-02-21 MY MYPI97000683A patent/MY119276A/en unknown
- 1997-02-21 SK SK1145-98A patent/SK284582B6/sk not_active IP Right Cessation
- 1997-02-24 TW TW086102221A patent/TW585774B/zh not_active IP Right Cessation
- 1997-02-24 ID IDP970541A patent/ID16038A/id unknown
- 1997-02-24 PE PE1997000130A patent/PE55398A1/es not_active IP Right Cessation
-
1998
- 1998-08-21 NO NO983850A patent/NO983850L/no not_active Application Discontinuation
- 1998-08-21 BG BG102714A patent/BG63682B1/bg active Active
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1999
- 1999-05-25 HK HK99102360A patent/HK1017257A1/xx not_active IP Right Cessation
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