CO4440600A1 - CONVERSION OF SUBSTITUTED 8-CHLOROQUINOLINS TO 8-HYDROXYQUIN- SUBSTITUTED NOLINES - Google Patents

Abstract

REIVINDICACION NUMERO UN PROCEDIMIENTO PARA PREPARAR 8-HIDROXIQUINOLINAS SUSTITUIDAS QUE COMPRENDE LA REACCION DE LA 8-CLO- ROQUINOLINA SUSTITUIDA DE LA FORMULA FIGURA 1 EN DONDE R ES ALQUILO C1-C4, HIDROXIALQUILO C1-C4, ALCOXI C1-C4-ALQUILO C1-C4, HALOALQUILO C1-C4, O DIALQUILAMINO C1-C4-ALQUILO C1-C4 EN UN REACTOR A PRESION AGITADO CON UNA SOLUCION ALCALINA DE DILU- CION EN PRESENCIA DE UN CATALIZADOR CUPRICO A UNA TEMPERATURA DENTRO DE LA GAMA DE 150-200 GRADOS CENTIGRADOS. FIGURA 2CLAIMED NUMBER A PROCEDURE FOR PREPARING 8-HYDROXYQUINOLINES SUBSTITUTED FOR THE REACTION OF THE 8-CLO-ROQUINOLINE SUBSTITUTED FROM THE FORMULA FIGURE 1 WHERE R IS ALKYL C1-C4-C4-ACI-C4-C4, , HALOALKYL C1-C4, OR DIALKYLAMINE C1-C4-ALKYL C1-C4 IN A SHAKEN PRESSURE REACTOR WITH A DILUTION ALKALINE SOLUTION IN THE PRESENCE OF A CUPRIC CATALYST AT A TEMPERATURE WITHIN THE 150-200 DEGREE RANGE. FIGURE 2