CO4230100A1 - Procedimiento para convertir loracarbef dihidrato en loracarbef monohidrato - Google Patents

Procedimiento para convertir loracarbef dihidrato en loracarbef monohidrato

Info

Publication number
CO4230100A1
CO4230100A1 CO94023737A CO94023737A CO4230100A1 CO 4230100 A1 CO4230100 A1 CO 4230100A1 CO 94023737 A CO94023737 A CO 94023737A CO 94023737 A CO94023737 A CO 94023737A CO 4230100 A1 CO4230100 A1 CO 4230100A1
Authority
CO
Colombia
Prior art keywords
loracarbef
converting
procedure
dihydrate
monohydrate
Prior art date
Application number
CO94023737A
Other languages
English (en)
Inventor
Strouse Erin Eckert
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CO4230100A1 publication Critical patent/CO4230100A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

REIVINDICACION NUMERO UN PROCEDIMIENTO PARA LA PREPARACION DE LA FORMA DE MONOHIDRATO CRISTALINO DEL COMPUESTO DE FORMULA (I): GRAFICA 1 QUE COMPRENDE EXPONER LA FORMA DE DIHIDRATO CRIS- TALINO DEL COMPUESTO DE FORMULA (I) A UNA TEMPERA- TURA ENTRE APROXIMADAMENTE 50 GRADOS CENTIGRADOS Y APROXIMADAMENTE 65 GRADOS CENTIGRADOS Y UNA HU- MEDAD RELATIVA ENTRE APROXIMADAMENTE 60 Y APROXI- MADAMENTE 100%
CO94023737A 1993-06-04 1994-06-02 Procedimiento para convertir loracarbef dihidrato en loracarbef monohidrato CO4230100A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/071,550 US5374719A (en) 1993-06-04 1993-06-04 Process for converting loracarbef dihydrate to loracarbef monohydrate

Publications (1)

Publication Number Publication Date
CO4230100A1 true CO4230100A1 (es) 1995-10-19

Family

ID=22102051

Family Applications (1)

Application Number Title Priority Date Filing Date
CO94023737A CO4230100A1 (es) 1993-06-04 1994-06-02 Procedimiento para convertir loracarbef dihidrato en loracarbef monohidrato

Country Status (29)

Country Link
US (1) US5374719A (es)
EP (1) EP0627430B1 (es)
JP (1) JP3442479B2 (es)
KR (1) KR100311699B1 (es)
CN (1) CN1042424C (es)
AT (1) ATE146472T1 (es)
AU (1) AU678000B2 (es)
BR (1) BR9402149A (es)
CA (1) CA2125001C (es)
CO (1) CO4230100A1 (es)
CZ (1) CZ283468B6 (es)
DE (1) DE69401163T2 (es)
DK (1) DK0627430T3 (es)
ES (1) ES2097002T3 (es)
FI (1) FI108132B (es)
GR (1) GR3022111T3 (es)
HU (1) HU217066B (es)
IL (1) IL109871A (es)
MY (1) MY110724A (es)
NO (1) NO306302B1 (es)
NZ (1) NZ260653A (es)
PE (1) PE13195A1 (es)
PH (1) PH30304A (es)
PL (1) PL174539B1 (es)
RU (1) RU2124013C1 (es)
TW (1) TW252980B (es)
UA (1) UA27812C2 (es)
YU (1) YU33394A (es)
ZA (1) ZA943827B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5550231A (en) * 1993-06-15 1996-08-27 Eli Lilly And Company Loracarbef hydrochloride C1-C3 alcohol solvates and uses thereof
US5580977A (en) * 1995-03-01 1996-12-03 Eli Lilly And Company Process for preparing loracarbef monohydrate
US20070225285A1 (en) * 2005-11-04 2007-09-27 Amira Pharmaceuticals, Inc. 5-lipoxygenase-activating protein (flap) inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3531481A (en) * 1969-04-21 1970-09-29 Lilly Co Eli Method for manufacture of crystalline cephalosporin
US3502663A (en) * 1969-04-21 1970-03-24 Lilly Co Eli Crystalline cephalosporin,method for its manufacture
MY104063A (en) * 1987-10-06 1993-11-30 Lilly Co Eli Crystalline (beta)-lactam hydrate
US4977257A (en) * 1988-11-14 1990-12-11 Eli Lilly And Company DMF solvates of a β-lactam antibiotic
CA2002596A1 (en) * 1988-11-14 1990-05-14 Thomas M. Eckrich Hydrates of b-lactam antibiotic

Also Published As

Publication number Publication date
ZA943827B (en) 1995-12-01
CZ134294A3 (en) 1994-12-15
NO306302B1 (no) 1999-10-18
NO942048D0 (no) 1994-06-02
NZ260653A (en) 1995-12-21
EP0627430B1 (en) 1996-12-18
KR100311699B1 (ko) 2001-12-28
PE13195A1 (es) 1995-05-24
KR950000701A (ko) 1995-01-03
PL303676A1 (en) 1994-12-12
RU94019424A (ru) 1996-04-20
DE69401163D1 (de) 1997-01-30
HU9401675D0 (en) 1994-09-28
IL109871A0 (en) 1994-10-07
GR3022111T3 (en) 1997-03-31
YU33394A (sh) 1996-10-18
DK0627430T3 (da) 1997-06-02
JP3442479B2 (ja) 2003-09-02
BR9402149A (pt) 1994-12-27
CN1042424C (zh) 1999-03-10
TW252980B (es) 1995-08-01
NO942048L (no) 1994-12-05
CA2125001A1 (en) 1994-12-05
ES2097002T3 (es) 1997-03-16
JPH06345763A (ja) 1994-12-20
PH30304A (en) 1997-02-20
HUT67743A (en) 1995-04-28
RU2124013C1 (ru) 1998-12-27
IL109871A (en) 1998-08-16
FI942633A0 (fi) 1994-06-03
FI108132B (fi) 2001-11-30
FI942633A (fi) 1994-12-05
EP0627430A1 (en) 1994-12-07
AU6451694A (en) 1994-12-08
DE69401163T2 (de) 1997-04-30
PL174539B1 (pl) 1998-08-31
UA27812C2 (uk) 2000-10-16
AU678000B2 (en) 1997-05-15
HU217066B (hu) 1999-11-29
CN1097754A (zh) 1995-01-25
CA2125001C (en) 2004-08-03
ATE146472T1 (de) 1997-01-15
CZ283468B6 (cs) 1998-04-15
MY110724A (en) 1999-01-30
US5374719A (en) 1994-12-20

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