CO2023011623A2 - Compuestos inhibidores de fgfr3 - Google Patents

Compuestos inhibidores de fgfr3

Info

Publication number
CO2023011623A2
CO2023011623A2 CONC2023/0011623A CO2023011623A CO2023011623A2 CO 2023011623 A2 CO2023011623 A2 CO 2023011623A2 CO 2023011623 A CO2023011623 A CO 2023011623A CO 2023011623 A2 CO2023011623 A2 CO 2023011623A2
Authority
CO
Colombia
Prior art keywords
inhibitory compounds
fgfr3 inhibitory
achondroplasia
fibrosis
fgfr3
Prior art date
Application number
CONC2023/0011623A
Other languages
English (en)
Inventor
Adedoyin David Abraham
Desta Doro Bume
Kevin Ronald Condroski
Andrew Karl Dilger
Robert Alan Hazlitt
Timothy Scott Kercher
Andrew Terrance Metcalf
Kaveri Balan Urkalan
Shane Michael Walls
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CO2023011623A2 publication Critical patent/CO2023011623A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

La presente invención proporciona los compuestos de la fórmula: , para usar en el tratamiento de la esclerosis sistémica, la fibrosis (p. ej., fibrosis pulmonar), la acondroplasia, la displasia tanatofórica (p. ej., tipo I), la acondroplasia grave con retraso del desarrollo y acantosis nigricans (SADDAN), el síndrome de Muenke o el cáncer.
CONC2023/0011623A 2021-03-04 2023-09-01 Compuestos inhibidores de fgfr3 CO2023011623A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163156527P 2021-03-04 2021-03-04
PCT/US2022/018644 WO2022187443A1 (en) 2021-03-04 2022-03-03 Fgfr3 inhibitor compounds

Publications (1)

Publication Number Publication Date
CO2023011623A2 true CO2023011623A2 (es) 2023-09-18

Family

ID=80937162

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2023/0011623A CO2023011623A2 (es) 2021-03-04 2023-09-01 Compuestos inhibidores de fgfr3

Country Status (17)

Country Link
US (1) US11878976B2 (es)
EP (1) EP4301468A1 (es)
JP (1) JP7480438B2 (es)
KR (1) KR20230130170A (es)
CN (1) CN117120439A (es)
AR (1) AR125588A1 (es)
AU (1) AU2022229380A1 (es)
BR (1) BR112023015519A2 (es)
CA (1) CA3210594A1 (es)
CO (1) CO2023011623A2 (es)
CR (1) CR20230427A (es)
DO (1) DOP2023000176A (es)
EC (1) ECSP23066654A (es)
IL (1) IL304886A (es)
PE (1) PE20231563A1 (es)
TW (2) TW202402754A (es)
WO (1) WO2022187443A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024054814A1 (en) 2022-09-07 2024-03-14 Eli Lilly And Company Co-crystals of 4-[4-[3-chloro-4-[1-(2-pyridyl)-2-hydroxy-ethoxy]pyrazolo[1,5-a]pyridin-6-yl]-5-methyl- triazol-1-yl]piperidine-1 -carbonitrile derivatives with gallic acid and nicotine amide

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010017047A1 (en) * 2008-08-05 2010-02-11 Merck & Co., Inc. Therapeutic compounds
MX347851B (es) 2010-03-10 2017-05-16 Incyte Corp Derivados de piperidin-4-il azetidina como inhibidores de janus cinasa 1 (jak1).
CN101833512A (zh) 2010-04-22 2010-09-15 中兴通讯股份有限公司 一种内存回收方法及其装置
WO2013055645A1 (en) 2011-10-12 2013-04-18 Array Biopharma Inc. 5,7-substituted-imidazo[1,2-c]pyrimidines
DK2872491T3 (da) 2012-07-11 2021-08-09 Blueprint Medicines Corp Inhibitorer af fibroblastvækstfaktorreceptoren
AU2014296184B2 (en) 2013-07-31 2017-04-27 Gilead Sciences, Inc. Syk inhibitors
GB201416754D0 (en) * 2014-09-23 2014-11-05 Mission Therapeutics Ltd Novel compounds
EA038045B1 (ru) 2015-02-20 2021-06-28 Инсайт Корпорейшн Бициклические гетероциклы в качестве ингибиторов fgfr
EA036058B1 (ru) 2015-04-29 2020-09-21 Уси Форчун Фармасьютикал Ко., Лтд Ингибитор jak
EP3298011B1 (en) * 2015-05-22 2021-11-17 Principia Biopharma Inc. Quinolone derivatives as fibroblast growth factor receptor inhibitors
AU2017317864B2 (en) 2016-09-01 2020-01-16 Transthera Sciences (Nanjing), Inc. Inhibitors of fibroblast growth factor receptor and use thereof
CN107315291B (zh) 2017-07-19 2020-06-16 深圳市华星光电半导体显示技术有限公司 一种goa显示面板及goa显示装置
WO2019034973A1 (en) 2017-08-14 2019-02-21 Pfizer Inc. PYRAZOLO [1,5-A] PYRAZIN-4-YL AND RELATED DERIVATIVES
CN113490666A (zh) * 2018-12-19 2021-10-08 奥瑞生物药品公司 作为fgfr酪氨酸激酶的抑制剂的取代的吡唑并[1,5-a]吡啶化合物

Also Published As

Publication number Publication date
CR20230427A (es) 2023-09-26
US11878976B2 (en) 2024-01-23
PE20231563A1 (es) 2023-10-03
WO2022187443A1 (en) 2022-09-09
US20230095122A1 (en) 2023-03-30
KR20230130170A (ko) 2023-09-11
AR125588A1 (es) 2023-08-02
EP4301468A1 (en) 2024-01-10
ECSP23066654A (es) 2024-02-29
AU2022229380A1 (en) 2023-08-24
DOP2023000176A (es) 2023-09-29
BR112023015519A2 (pt) 2023-10-03
CN117120439A (zh) 2023-11-24
JP2023554598A (ja) 2023-12-28
CA3210594A1 (en) 2022-09-09
JP7480438B2 (ja) 2024-05-09
TW202402754A (zh) 2024-01-16
IL304886A (en) 2023-10-01
TW202300491A (zh) 2023-01-01
TWI820622B (zh) 2023-11-01

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