CN2892229Y - Dule opening type multifunctional rotating evaporation apparatus - Google Patents
Dule opening type multifunctional rotating evaporation apparatus Download PDFInfo
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- CN2892229Y CN2892229Y CN 200620000748 CN200620000748U CN2892229Y CN 2892229 Y CN2892229 Y CN 2892229Y CN 200620000748 CN200620000748 CN 200620000748 CN 200620000748 U CN200620000748 U CN 200620000748U CN 2892229 Y CN2892229 Y CN 2892229Y
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Abstract
The double-port multi-function rotary evaporator comprises a temperature control heating tank, a rotary evaporation bottle, a rotary driver and a support, and is characterized in that necks on both ends of the double-port rotary evaporation bottle (3) are provided with an identical axle center; an angle ranging from 20 degrees to 70 degrees forms between an axial lead of the evaporation bottle (2) and the level. Inside the evaporation bottle (2), a stirring paddle (7) is provided and cross section of its propeller blade (7a) is falcate; distance between outside fringe of the propeller blade (7a) and the evaporation bottle body (2a) ranges from 0.1mm to 5mm; a handle of the propeller blade is fixed to a sealing shaft (7b); the evaporation bottle (2) and the stirring paddle (7) are driven by a motor (3a) and a motor (3b), respectively. When the utility model is in service, the overall system is ensured to be aseptic without assembling or disassembling the container; a reaction container can be large, accordingly productivity is improved; technical process is simplified and operation time is reduced.
Description
Technical field
The utility model relates to the evaporation drying device, relates to the rotary evaporator in fields such as being applicable to medicine, biochemistry, chemical particularly, particularly relates to the multi-functional rotation evaporimeter of dual-opening type.
Background technology
Commercially available rotary evaporator all is the single port formula at present, for example both at home and abroad commercially available product and in CN2608092Y disclosed tandem collect rotary evaporator continuously and just all have only an opening, the disadvantage of the rotary evaporator of this class single port formula is just the rotary evaporation bottle must be pulled down in the time will collecting solid product so that product is taken out, like this, operating difficulties when using large-scale bottle, can not continued operation, can't be used for industrial-scale production, more difficultly reach clean earning and produce and the requirement of preparation sterile preparation.Particularly in Chinese patent ZL02116766.4 and Chinese patent application 02128845.3 and International Patent Application PCT/CN03/00337, PCT/CN03/000663, require the preparation can be for the sterile preparation of direct packaging, at present still do not have on the market can be supporting with it rotary evaporation equipment.
Summary of the invention
The purpose of this utility model is to overcome the shortcoming that existing rotary evaporator exists, provide a kind of under the situation of not dismounting revolving bottle washing and sterilizing thereafter, can fully guarantee aseptic condition and the easy to operate multi-functional rotation evaporimeter of dual-opening type that can adapt to large-scale production.
Further purpose of the present utility model provides a kind of corollary equipment that is suitable as Chinese patent ZL02116766.4 etc., adapts to the multi-functional rotation evaporimeter of dual-opening type that large-scale production and sterile preparation require.
The technical solution of the utility model is as follows:
1. multi-functional rotation evaporimeter of dual-opening type, have temperature control heating tank, rotary evaporation bottle, rotating driver and support, wherein, the rotary evaporation bottle is that the neck of its upper/lower terminal of dual-opening type evaporative flask has same axle center, the opening of upper end neck is connected with the end of wireway, the opening of lower, neck end is connected with discharge device, the upper end neck is rotated driving by motor, form the angle of 20 °～70 ° (preferably 20～40 °) between the axial line of dual-opening type evaporative flask and the horizontal plane, lower, neck end is passed from the opening part on the temperature control heating tank wall.
2. the multi-functional rotation evaporimeter of aforesaid dual-opening type, wherein, the inside of evaporative flask has 2～4 (preferably 3) stirrer paddles, the cross section of the blade of paddle is a falcate, vertical range between the inwall of the outer ledge of this blade and the bottle of evaporative flask is between 0.1～5mm, and the shank of blade is fixed on by on the motor-driven seal shaft.
3. the multi-functional rotation evaporimeter of aforesaid dual-opening type, wherein, the bottle of evaporative flask be shaped as in sphere, eggplant shape, the cylindrical shape any.
4. the multi-functional rotation evaporimeter of aforesaid dual-opening type, wherein, the end of discharge device has drainage conduit and the drainpipe that turns to controlled switching.
5. the multi-functional rotation evaporimeter of aforesaid dual-opening type, wherein said wireway has feed pipe, water inlet pipe, exhaust outlet and leakage fluid dram; Wherein, feed pipe extends to the opening part of the bottle of evaporative flask; Water inlet pipe extends to the middle part of wireway, and its end has spray head; Exhaust outlet upwards is connected with condenser; Leakage fluid dram is connected with liquid-collecting bottle downwards.
6. the multi-functional rotation evaporimeter of aforesaid dual-opening type, wherein, the material of dual-opening type evaporative flask is any in the composite of glass, corrosion-resistant metal materials, metal and glass; The material of paddle is any in the composite of stainless steel, stainless steel and fluoroplastics.
Compare with the state of the art, the utlity model has following beneficial effect:
1. can needn't open container directly by terminal drainage conduit discharging during discharging, therefore can guarantee the aseptic condition of whole system.
2. can exempt the mounting or dismounting operation, therefore container can be made 100 liters, 200 liters or bigger volume, thus boost productivity significantly.
3. can self-emptying and cleaning, thus can reach the operation serialization, simplify technical process significantly and shorten the production operation time.
Description of drawings
Fig. 1 is a general assembly drawing of the present utility model.
Fig. 2 is that bottle is the stereogram of the dual-opening type evaporative flask of sphere.
Fig. 3 is the schematic diagram with the paddle of the dual-opening type evaporative flask of Fig. 2 coupling.
Fig. 4 is that bottle is the stereogram of the dual-opening type evaporative flask of eggplant shape.
Fig. 5 is the schematic diagram with the paddle of the dual-opening type evaporative flask of Fig. 4 coupling
Fig. 6 is that bottle is the stereogram of columnar dual-opening type evaporative flask.
Fig. 7 is the schematic diagram with the paddle of the dual-opening type evaporative flask of Fig. 6 coupling
Fig. 8 is the profile that the A-A place along Fig. 5 cuts open.
Fig. 9 is the cutaway view of wireway.
Figure 10 is the schematic diagram of discharge device.
In Fig. 1 to Figure 10, each code name is defined as follows:
1-temperature control heating tank, opening on the 1a-heating tank wall, 2-dual-opening type evaporative flask, the bottle of 2a-dual-opening type evaporative flask, 2b-upper end neck, the 2c-lower, neck end, the 3a-motor, the 3b-motor, the 4-support, the 5-wireway, the 5a-feed pipe, the 5b-water inlet pipe, 5b '-spray head, the 5c-exhaust outlet, the 5d-leakage fluid dram, the sealable discharge device of 6-, the sealable drainage conduit of 6a-, the sealable drainpipe of 6b-, the 7-paddle, the 7a-blade, the 7b-seal shaft, the 8-condenser, the 9-liquid-collecting bottle, the 10-liquid reservoir, the 11-temperature regulating heater, the 12-speed regulator.
Should illustrate, in Fig. 1, wireway (5) all is the way of contact of salable rotation with tie point, the lower, neck end (2c) of upper end neck (2b) with the tie point of sealable discharge device (6) and the contact point that lower, neck end (2c) is passed heating tank wall opening (1a). this way of contact is a known technology, so do not illustrate in the accompanying drawings.In addition, also comprise the position (junctions of parts 2 and parts 4) of salable rotation in Fig. 1 of the CN2608092Y that the above-mentioned background technology is partly passed the imperial examinations at the provincial level out, but do not add any explanation, visible patent document is formerly also treated it as known technology.
The specific embodiment
Below in conjunction with accompanying drawing embodiment of the present utility model is described.
With reference now to Fig. 1,, hydrogen bond at preparation medicine, compound, during the nonbonding complex, with feed pipe (5a) the decompression suction of feed liquid from wireway (5), in temperature control heating tank (1), add liquid medium before this (as water, glycerine or silicone oil) so that the major part of the bottle (2a) of medium submergence evaporative flask, start temperature regulating heater (11) and make the homogeneous media ground in the heating tank (1) reach set point of temperature.Start motor (3a) so that evaporative flask (2) rotates.The rotation of dependence evaporative flask (2) is evenly heated material and is depressurized evaporation and concentration, in course of reaction, vaporized gas enters condenser (8) from the exhaust outlet (5c) of wireway (5), becomes liquid and enters liquid-collecting bottle (9), enters then in the liquid reservoir (10).When the preparation solid material, as the hydrogen bond of medicine, during the nonbonding complex, through evaporation, concentrate, material is expanded, after drying is finished, starts motor (3b) so that seal shaft (7b) rotation, the stirrer paddle (7a) that is fixed on the seal shaft (7b) begins to stir, when stirrer paddle is done to rotate at a slow speed counterclockwise as shown in Figure 8, solid material is scraped by bottle, when making counterclockwise fast rotational solid material is pulverized.Start motor (3b), make stirrer paddle (7a) do clockwise rotation at a slow speed, can scrape like this and get pressed powder and make pressed powder flow to evaporative flask lower, neck end (2c) along the meniscus of stirrer paddle (7a), can waltz through discharge nozzle (6a) and discharge powdery product, and directly enter hermetically in the finished product packing container, thereby guarantee that product is aseptic.
After discharging finishes, spray ordinary water successively from the spray head of the water inlet pipe (5b) of wireway (5) (5b '), pure water and ethanol to clean whole system, are done the standby of operation next time.
Enumerate embodiment below and further specify the utility model.
The preparation of embodiment diazepam-HP-β-CD ternary complex
With diazepam 100g, HP-β-CI 1700g,, citric acid 34g is in mixer, add ethanol 5L, warm so that its dissolve fully, with activated carbon decolorizing depyrogenation and filtration, with obtain clear and bright solution suction as shown in Figure 1 volume is in the dual-opening type evaporative flask (2) of 50L with vacuum decompression method then with obtaining solution.The inclination angle of this evaporative flask is 30 °, wherein has 3 stirrer paddles (7a), and the distance of the outer ledge of stirrer paddle (7a) and bottle (2a) is 2mm.Starting the temperature-controlling system of heating makes the water-bath of temperature control heating tank (1) keep 80 ℃.It is 120 rev/mins that starter motor (3a) makes rotating speed.Decompression is reclaimed ethanol down, continues decompression, is incubated 80 ℃, and material took place expanded, 80 ℃ of following vacuum drying 2.5 hours.Remove vacuum, after purifying after filtration, return-air enters in the bottle, and starter motor (3b), make stirrer paddle (7a) do to rotate at a slow speed clockwise to carry out scraper, then make counterclockwise fast rotational so that solids is pulverized, make stirrer paddle (7a) do clockwise rotation at a slow speed again, make powdery product flow and drainage conduit (6a) discharging by discharge device the aseptic pocket that is subjected to of discharging opening place ligation along the meniscus of stirrer paddle (7a).Technology whole process 4～5 hours, yield reaches 90%, and product reaches aseptic requirement, but direct packaging is a powder-injection.
Wash with water by water inlet pipe (5b) after the discharging, evaporative flask (2) is rotated at a slow speed, use pure water again, with ethanol drip washing (recovery ethanol), stand-by at last.
Claims (10)
1. multi-functional rotation evaporimeter of dual-opening type, has the temperature control heating tank, the rotary evaporation bottle, rotating driver and support, it is characterized in that, rotary evaporation bottle wherein is dual-opening type evaporative flask (2), on it, the neck at following two ends (2b), (2c) has same axle center, the opening of upper end neck (2b) is connected with the end of wireway (5), the opening of lower, neck end (2c) is connected with discharge device (6), upper end neck (2b) is rotated driving by motor (3a), form 20 °～70 ° angle between the axial line of dual-opening type evaporative flask (2) and the horizontal plane, lower, neck end (2c) is passed from the opening (1a) on temperature control heating tank (1) wall.
2. the multi-functional rotation evaporimeter of dual-opening type as claimed in claim 1, it is characterized in that, the inside of evaporative flask (2) has 2～4 stirrer paddles (7a), the cross section of the blade (7a) of paddle (7) is a falcate, vertical range between the inwall of the bottle (2a) of outer ledge of this blade (7a) and evaporative flask (2) is between 0.1～5mm, and the shank of blade (7a) is fixed on the seal shaft (7b) that is driven by motor (3b).
3. the multi-functional rotation evaporimeter of dual-opening type as claimed in claim 2 is characterized in that the inside of evaporative flask (2) has 3 stirrer paddles (7a).
4. the multi-functional rotation evaporimeter of dual-opening type as claimed in claim 1 or 2 is characterized in that, evaporative flask (2) bottle (2a) be shaped as sphere.
5. the multi-functional rotation evaporimeter of dual-opening type as claimed in claim 1 or 2 is characterized in that, evaporative flask (2) bottle (2a) be shaped as eggplant shape.
6. the multi-functional rotation evaporimeter of dual-opening type as claimed in claim 1 or 2 is characterized in that, evaporative flask (2) bottle (2a) be shaped as cylindrical shape.
7. the multi-functional rotation evaporimeter of dual-opening type as claimed in claim 1 or 2 is characterized in that, the end of wherein said discharge device (6) has drainage conduit (6a) and the drainpipe (6b) that turns to controlled open and close.
8. the multi-functional rotation evaporimeter of dual-opening type as claimed in claim 1 or 2 is characterized in that, wherein said wireway (5) has feed pipe (5a), water inlet pipe (5b), exhaust outlet (5c) and leakage fluid dram (5d); Wherein, feed pipe (5a) extends to the opening part of the bottle (2a) of evaporative flask (2); Water inlet pipe (5b) extends to the middle part of wireway (5), and its end has spray head (5b '); Exhaust outlet (5c) upwards is connected with condenser (8); Leakage fluid dram (5d) is connected with liquid-collecting bottle (9) downwards.
9. the multi-functional rotation evaporimeter of dual-opening type as claimed in claim 1 or 2 is characterized in that, the material of dual-opening type evaporative flask (2) wherein is any in the composite of glass, corrosion-resistant metal materials, metal and glass.
10. the multi-functional rotation evaporimeter of dual-opening type as claimed in claim 2 is characterized in that, the material of paddle wherein (7) is any in the composite of stainless steel, stainless steel and fluoroplastics.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200620000748 CN2892229Y (en) | 2006-01-13 | 2006-01-13 | Dule opening type multifunctional rotating evaporation apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200620000748 CN2892229Y (en) | 2006-01-13 | 2006-01-13 | Dule opening type multifunctional rotating evaporation apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN2892229Y true CN2892229Y (en) | 2007-04-25 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200620000748 Expired - Fee Related CN2892229Y (en) | 2006-01-13 | 2006-01-13 | Dule opening type multifunctional rotating evaporation apparatus |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN2892229Y (en) |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102186547A (en) * | 2008-10-15 | 2011-09-14 | 艾卡工厂有限及两合公司 | Rotary evaporator |
| CN103111081A (en) * | 2011-11-17 | 2013-05-22 | 成都欣捷高新技术开发有限公司 | Rotary evaporator |
| CN103203110A (en) * | 2013-03-20 | 2013-07-17 | 健雄职业技术学院 | Rotary drum evaporator |
| CN104801056A (en) * | 2015-04-26 | 2015-07-29 | 朱金凤 | Intelligent temperature-control evaporation device |
| TWI501800B (en) * | 2011-08-04 | 2015-10-01 | Nat Inst Chung Shan Science & Technology | Rotary distillation equipment |
| CN105617694A (en) * | 2015-12-30 | 2016-06-01 | 重庆天凯药业有限公司 | Temperature-adjustable rotary evaporator |
| CN107670325A (en) * | 2017-11-18 | 2018-02-09 | 阜宁县安勤化学有限公司 | A kind of self-emptying crystallization apparatus |
| CN107737464A (en) * | 2017-11-18 | 2018-02-27 | 阜宁县安勤化学有限公司 | Rotary self-emptying crystallizer |
| CN107998676A (en) * | 2017-12-12 | 2018-05-08 | 郑州诚合信息技术有限公司 | A kind of efficient quick vaporizing devices |
| WO2019144730A1 (en) * | 2018-01-23 | 2019-08-01 | 北京师范大学 | Rotary evaporator capable of accurately quantifying concentrated liquid and/or distillate |
| CN110382069A (en) * | 2017-01-16 | 2019-10-25 | 汉斯海多尔夫有限公司 | Rotary evaporator with filter |
| WO2019229129A1 (en) * | 2018-05-30 | 2019-12-05 | Hans Heidolph GmbH | Cleaning device for a rotary evaporator |
| CN111714913A (en) * | 2020-07-31 | 2020-09-29 | 中国科学院上海应用物理研究所 | Rotary belt distillation device and method for separating ethanol in wine products |
-
2006
- 2006-01-13 CN CN 200620000748 patent/CN2892229Y/en not_active Expired - Fee Related
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102186547A (en) * | 2008-10-15 | 2011-09-14 | 艾卡工厂有限及两合公司 | Rotary evaporator |
| CN102186547B (en) * | 2008-10-15 | 2014-06-25 | 艾卡工厂有限及两合公司 | Rotary evaporator |
| TWI501800B (en) * | 2011-08-04 | 2015-10-01 | Nat Inst Chung Shan Science & Technology | Rotary distillation equipment |
| CN103111081A (en) * | 2011-11-17 | 2013-05-22 | 成都欣捷高新技术开发有限公司 | Rotary evaporator |
| CN103203110A (en) * | 2013-03-20 | 2013-07-17 | 健雄职业技术学院 | Rotary drum evaporator |
| CN104801056A (en) * | 2015-04-26 | 2015-07-29 | 朱金凤 | Intelligent temperature-control evaporation device |
| CN105617694A (en) * | 2015-12-30 | 2016-06-01 | 重庆天凯药业有限公司 | Temperature-adjustable rotary evaporator |
| CN110382069A (en) * | 2017-01-16 | 2019-10-25 | 汉斯海多尔夫有限公司 | Rotary evaporator with filter |
| CN107737464A (en) * | 2017-11-18 | 2018-02-27 | 阜宁县安勤化学有限公司 | Rotary self-emptying crystallizer |
| CN107670325A (en) * | 2017-11-18 | 2018-02-09 | 阜宁县安勤化学有限公司 | A kind of self-emptying crystallization apparatus |
| CN107998676A (en) * | 2017-12-12 | 2018-05-08 | 郑州诚合信息技术有限公司 | A kind of efficient quick vaporizing devices |
| WO2019144730A1 (en) * | 2018-01-23 | 2019-08-01 | 北京师范大学 | Rotary evaporator capable of accurately quantifying concentrated liquid and/or distillate |
| US11185791B2 (en) | 2018-01-23 | 2021-11-30 | Beijing Normal University | Rotary evaporator capable of accurately quantifying concentrated liquid and/or distillate |
| US11801452B2 (en) | 2018-01-23 | 2023-10-31 | Beijing Normal University | Rotary evaporator capable of accurately quantifying distillate |
| WO2019229129A1 (en) * | 2018-05-30 | 2019-12-05 | Hans Heidolph GmbH | Cleaning device for a rotary evaporator |
| CN112203736A (en) * | 2018-05-30 | 2021-01-08 | 汉斯海多尔夫有限公司 | Cleaning device for a rotary evaporator |
| US11395979B2 (en) | 2018-05-30 | 2022-07-26 | Hans Heidolph GmbH | Cleaning device for a rotary evaporator |
| CN111714913A (en) * | 2020-07-31 | 2020-09-29 | 中国科学院上海应用物理研究所 | Rotary belt distillation device and method for separating ethanol in wine products |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20070425 Termination date: 20140113 |