CN2304399Y - Slow degradated collagen membrane net for medical uses - Google Patents
Slow degradated collagen membrane net for medical uses Download PDFInfo
- Publication number
- CN2304399Y CN2304399Y CN 97207492 CN97207492U CN2304399Y CN 2304399 Y CN2304399 Y CN 2304399Y CN 97207492 CN97207492 CN 97207492 CN 97207492 U CN97207492 U CN 97207492U CN 2304399 Y CN2304399 Y CN 2304399Y
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- collagen membrane
- wound surface
- collagen
- utility
- model
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Abstract
The utility model relates to a biological material, which is used for the repair for soft tissue defects and especially provides a novel medical used material for solving wound surface coverage after burn. The utility model is a collagen membrane composed of sponge-shaped main body reticular collagen fiber. The structure of the collagen membrane is similar to the structure of dermal dermis, capillary vessels and meat issues can be guided to grow into and fill reticular frame space, dermis tissues with a certain of thickness are formed, and the wound surface is prompted to heal early. Because chemical treatment is conducted for the collagen membrane by using cross-linking agent, the collagen membrane has a function of slow degradation, antigenicity is weak, ductility is low, tension is high, break is uneasy, the collagen membrane does not need tearing off after the wound surface is covered, the collagen membrane can directly take part in the healing of the wound surface, histiocyte is guided to grow, the healing is accelerated, and a body self is assimilated into integration at last.
Description
This utility model is a kind of biomaterial for medical purpose, covers a kind of new medical material is provided for the reparation of soft tissue defects particularly solves burns rear wound.
Skin is the organ of human body maximum, and the serious burn patient often faces the skin donor site relative deficiency, and exploring and study the artificial covering of burn wound is when previous big problem.
The wound-surface cover kind is more at present, and synthetic material and natural biologic material two big classes are arranged:
1. synthetic material is as polyurethane film, silicon rubber film, and the former water penetration is very poor, easily causes forming under the covering hydrops, though the latter has elasticity preferably, ventilative and poisture-penetrability, but silicone rubber can not combine with fibrin, must assist other material to attach with wound surface.
2. natural biologic material is to utilize animal tendon or skin, extracts collagen and prepares film forming, and the collagem membrane of this atresia is as wound-surface cover, though adhesiveness, antigenicity, tissue intersolubility still can, but mechanical strength is low, easily broken, be unfavorable for operation technique, and itself can not be accepted, also can not participate in tissue repair and wound healing process directly by tissue, only play the flap coverage effect, with after promptly tear off.
The purpose of this utility model is to provide a kind of, has the solid netted foraminous collagem membrane that slow Degradation can be absorbed by body again, do not need behind the flap coverage to tear off, participate in wound repair directly, transmitting tissue's cell is grown into, healing acceleration prevents that wound surface from shrinking, and finally is body self assimilate into one.
The purpose of this utility model is to realize like this, selecting healthy Corii Sus domestica for use is primary raw material, through pickling, the salt wash rice, extract collagen fiber, utilize poly-glycosaminoglycan (6-chondroitin sulfate) to make and have space network with the collagen co-precipitation, and foraminous collagem membrane is used cross-linking agent (aldehyde compound) then, collagem membrane is carried out chemical crosslinking handle, so just, obtain the solid netted collagem membrane (Fig. 1 of macromole, Fig. 2), be white semitransparent thin film, quality softness (Fig. 3), average pore size are 44.2 μ m, thick 0.3mm solid netted has pore structure, be spongiform collagem membrane, not easily broken, form-dependent character can cut randomly according to wound surface well, need not sew up, simple to operate.
Analyze its function and effect from structure in conjunction with the accompanying drawings:
1. framework effect, collagen fiber itself are exactly the substrate composition of dermal tissue, the network structure of protocollagen film is similar to the corium structure of skin, can guide blood capillary, the granulation tissue fill frame space of growing into forms certain thickness dermal tissue, and in time the newborn epidermis cell for the wound surface edge provides nutrition, be its place of increment expansion rapidly, thereby impel wound surface to heal early.
2. increase skin elasticity and rub resistance power: newborn epidermis usually can cause skin thin excessively owing to lacking dermal tissue behind the burn wound healing, flexibility decrease, rub resistance power difference and occur ulceration very easily once again.This netted collagem membrane can be participated in the formation of dermal tissue structure directly, has strengthened the thickness and the pliability of skin, and skin elasticity and rub resistance power are improved.
3. delay the speed that is degraded: though collagen possesses good poor antigen and histocompatibility, but be subjected to the effect of collagenase in the body easily and degrade, do not wait dermal tissue to form and just lost the framework effect, adopt cross-linking agent (aldehyde compound) that the protocollagen film is carried out cross-linking chemistry handles for this reason, the solid netted foraminous collagem membrane of resulting like this macromole (Fig. 1), strengthened the anti-breaking capacity of collagem membrane, and delayed: can the long period be present in wound surface, keep frame structure guiding granulation cell and grow into by the speed of degraded by collagenase in the body.
Description of drawings:
Fig. 1. the netted collagem membrane of the slow degraded diagrammatic sketch of bowing.
Fig. 2. the netted collagem membrane A of slow degraded portion enlarged diagram.
Fig. 3. the netted collagem membrane section plasticity sketch map of slow degraded.
Claims (2)
1. this utility model relates to the netted collagem membrane of a kind of medical slow degradation-type and it is characterized in that: this collagen film is spongy, and it is the porose space network that is made of collagen fiber.
2. the netted collagem membrane of a kind of medical slow degradation-type according to claim 1 is characterized in that: the protocollagen film is to carry out the 3 D cross-linked cancellated macromole collagen fiber thin film that chemical treatment obtains with aldehyde compound as cross-linking agent.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 97207492 CN2304399Y (en) | 1997-01-16 | 1997-01-16 | Slow degradated collagen membrane net for medical uses |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 97207492 CN2304399Y (en) | 1997-01-16 | 1997-01-16 | Slow degradated collagen membrane net for medical uses |
Publications (1)
Publication Number | Publication Date |
---|---|
CN2304399Y true CN2304399Y (en) | 1999-01-20 |
Family
ID=33927240
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN 97207492 Expired - Fee Related CN2304399Y (en) | 1997-01-16 | 1997-01-16 | Slow degradated collagen membrane net for medical uses |
Country Status (1)
Country | Link |
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CN (1) | CN2304399Y (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100402097C (en) * | 2006-07-24 | 2008-07-16 | 暨南大学 | Skin wound repairing agar/collagen dressing and its prepn and application |
CN1779002B (en) * | 2004-11-20 | 2010-04-07 | 张立文 | Reducing leather base cloth with collagenous fiber and processing method thereof |
CN105734718A (en) * | 2016-03-07 | 2016-07-06 | 北京科技大学 | Preparation method of multi-stage pore-size distribution material |
-
1997
- 1997-01-16 CN CN 97207492 patent/CN2304399Y/en not_active Expired - Fee Related
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1779002B (en) * | 2004-11-20 | 2010-04-07 | 张立文 | Reducing leather base cloth with collagenous fiber and processing method thereof |
CN100402097C (en) * | 2006-07-24 | 2008-07-16 | 暨南大学 | Skin wound repairing agar/collagen dressing and its prepn and application |
CN105734718A (en) * | 2016-03-07 | 2016-07-06 | 北京科技大学 | Preparation method of multi-stage pore-size distribution material |
CN105734718B (en) * | 2016-03-07 | 2018-11-27 | 北京科技大学 | A kind of preparation method of multistage aperture distributed material |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C19 | Lapse of patent right due to non-payment of the annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |