CN221206908U - Resin washing equipment - Google Patents
Resin washing equipment Download PDFInfo
- Publication number
- CN221206908U CN221206908U CN202323183894.6U CN202323183894U CN221206908U CN 221206908 U CN221206908 U CN 221206908U CN 202323183894 U CN202323183894 U CN 202323183894U CN 221206908 U CN221206908 U CN 221206908U
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- China
- Prior art keywords
- liquid storage
- tank body
- storage tank
- tank
- charging
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- 238000005406 washing Methods 0.000 title claims abstract description 43
- 239000011347 resin Substances 0.000 title claims abstract description 38
- 229920005989 resin Polymers 0.000 title claims abstract description 38
- 239000007788 liquid Substances 0.000 claims abstract description 81
- 238000003756 stirring Methods 0.000 claims abstract description 11
- 238000011049 filling Methods 0.000 claims abstract description 5
- 238000007599 discharging Methods 0.000 claims abstract description 3
- 238000010511 deprotection reaction Methods 0.000 abstract description 5
- 239000002699 waste material Substances 0.000 abstract description 5
- 238000009833 condensation Methods 0.000 abstract description 3
- 230000005494 condensation Effects 0.000 abstract description 3
- 238000009792 diffusion process Methods 0.000 abstract description 3
- 229920001184 polypeptide Polymers 0.000 description 5
- 102000004196 processed proteins & peptides Human genes 0.000 description 5
- 108090000765 processed proteins & peptides Proteins 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 238000005086 pumping Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000000967 suction filtration Methods 0.000 description 1
- 230000002522 swelling effect Effects 0.000 description 1
Landscapes
- Cleaning By Liquid Or Steam (AREA)
Abstract
The utility model discloses resin washing equipment, which comprises a tank body without a stirring device, a first liquid storage tank and a second liquid storage tank, wherein the tank body is used for filling resin to be washed, the top of the tank body is provided with a plurality of charging ports, and the bottom of the tank body is provided with a liquid outlet; the number of the charging ports is more than or equal to 3, the charging ports are uniformly distributed, the first liquid storage tank is connected with the charging ports of the tank body, one end of the second liquid storage tank is connected with the liquid discharging ports of the tank body, and the other end of the second liquid storage tank is connected with the charging ports of the tank body. After the stirring step is removed, each condensation and deprotection cycle can save 50-80 minutes, and the diffusion of the object to be cleaned in the system is reduced. The utility model reduces the consumption of the washing solution and the output of the waste liquid at the same time, and saves the cost. The utility model has simple structure and can be realized without too much improvement.
Description
Technical Field
The utility model belongs to the technical field of resin equipment, and relates to resin washing equipment.
Background
The resin used in polypeptide synthesis is a high molecular polymer, has better swelling property in DMF, and can absorb more liquid in the resin and gaps. In the prior art, the resin is washed by adding DMF and stirring for 3-5 minutes, the substances to be washed are uniformly distributed in the system, and the substances to be washed remain in the resin and gaps along with DMF after suction filtration. Therefore, the number of times of washing is increased to ensure thorough washing. The washing process is time consuming and the use of DMF is more.
The prior art comprises the following steps: after the polypeptide coupling is completed, DMF which is 1 time of the resin volume is added, and the mixture is stirred for 3 to 5 minutes and then pumped down, and the process is repeated for 6 times; after deprotection was completed, DMF was added in an amount 1 time the resin volume and stirred for 3-5 minutes and then drained and repeated 10 times. Referring to fig. 4, the washing of the prior art is long, and has more consumption of DMF, waste and great influence on the synthesis efficiency.
Disclosure of utility model
In order to solve the problems, the utility model provides resin washing equipment, which adopts a certain volume of solution to wash continuously or repeatedly, removes the step of stirring and mixing uniformly, and reduces the diffusion of the to-be-washed objects in a system.
In order to achieve the above purpose, the present utility model adopts the following technical scheme:
The resin washing equipment comprises a tank body which does not contain a stirring device, a first liquid storage tank and a second liquid storage tank, wherein the tank body is used for filling resin to be washed, a plurality of charging ports are arranged at the top of the tank body, and a liquid outlet is arranged at the bottom of the tank body; the number of the charging ports is more than or equal to 3, the charging ports are uniformly distributed, the first liquid storage tank is connected with the charging ports of the tank body, one end of the second liquid storage tank is connected with the liquid discharging ports of the tank body, and the other end of the second liquid storage tank is connected with the charging ports of the tank body.
As a preferable mode of the utility model, the number of the charging holes is 5.
As a preferable mode of the utility model, the number of the charging holes is 9.
As a preferable mode of the utility model, the liquid discharge port is provided with a liquid discharge valve.
As a preferable scheme of the utility model, the height-to-diameter ratio of the tank body is 3:1.
As a preferable scheme of the utility model, one charging port is positioned at the center of the upper surface of the tank body, two charging ports are positioned at two sides of the center, and the straight line of the remaining two charging ports is perpendicular to the straight line of the two charging ports.
As a preferable scheme of the utility model, one charging port is positioned at the center of the upper surface of the tank body, and the rest charging ports are uniformly arranged along the center of the circle.
As a preferable mode of the utility model, the tank body is a cylinder.
As a preferable scheme of the utility model, a first pump is arranged on a pipeline connected with the liquid outlet and the second liquid storage tank, a second pump and a second valve are arranged on a pipeline connected with the second liquid storage tank and the charging port, and a third pump and a first valve are arranged on a pipeline connected with the first liquid storage tank and the charging port.
As a preferable scheme of the utility model, the resin washing equipment further comprises a third liquid storage tank, one end of the third liquid storage tank is connected with a liquid outlet of the tank body, the other end of the third liquid storage tank is connected with a charging port, and a fourth pump and a third valve are arranged on a pipeline connected with the charging port.
Compared with the prior art, the utility model has the following beneficial effects:
1) After the stirring step is removed, each condensation and deprotection cycle can save 50-80 minutes, and the diffusion of the object to be cleaned in the system is reduced.
2) The utility model reduces the consumption of the washing solution and the output of the waste liquid at the same time, and saves the cost.
3) The utility model has simple structure and can be realized without too much improvement.
Drawings
Fig. 1 is a schematic structural view of the present utility model.
Fig. 2 is a top view of example 1.
Fig. 3 is a top view of example 2.
FIG. 4 is a graph comparing the prior art washing system before and after washing.
FIG. 5 is a comparison of the present utility model before and after washing.
In the figure, 1. A tank body; 2. a feed inlet; 3. a liquid outlet; 4. a second liquid storage tank; 5. a second pump; 6. a first pump; 7. a third pump; 8. a first liquid storage tank; 9. a second valve; 10. a first valve; 11. a third liquid storage tank; 12. a fourth pump; 13. a third valve; 14. and a three-way valve.
Detailed Description
For a further understanding of the present utility model, the present utility model will be described in detail with reference to the drawings and examples.
The utility model is described in further detail below with reference to the drawings and examples. It is to be understood that the specific embodiments described herein are merely illustrative of the utility model and are not limiting of the utility model. It should be noted that, for convenience of description, only the portions related to the utility model are shown in the drawings. The first, second, etc. words are provided for convenience in describing the technical scheme of the present utility model, and have no specific limitation, and are all generic terms, and do not constitute limitation to the technical scheme of the present utility model. It should be noted that, without conflict, the embodiments of the present utility model and features of the embodiments may be combined with each other. In the description of the present utility model, it should be noted that the directions or positional relationships indicated by the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. are based on the directions or positional relationships shown in the drawings, are merely for convenience of describing the present utility model and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present utility model. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance. Unless specifically stated or limited otherwise, the terms "mounted," "connected," and "coupled" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present utility model will be understood in specific cases by those of ordinary skill in the art. The technical schemes in the same embodiment and the technical schemes in different embodiments can be arranged and combined to form a new technical scheme without contradiction or conflict, which is within the scope of the utility model.
The utility model is based on the existing polypeptide synthesis technology, and improves the equipment used in the washing procedure after polypeptide coupling and the washing procedure after polypeptide deprotection.
The prior washing equipment is characterized in that DMF is added through a single feeding port arranged at the top, and is fully washed through stirring equipment and discharged through a liquid outlet. However, the washing is time-consuming, and the DMF is used more, so that waste is caused.
Referring to fig. 1, the utility model provides a resin washing device, which comprises a tank body 1 without a stirring device, a first liquid storage tank 4 and a second liquid storage tank 8, wherein the tank body 1 is used for filling resin to be washed, a plurality of charging ports 2 are arranged at the top of the tank body 1, and a liquid outlet 3 is arranged at the bottom of the tank body 1; the feeding ports 2 are uniformly distributed, the first liquid storage tank 8 is connected with the feeding ports 2 of the tank body 1, one end of the second liquid storage tank 4 is connected with the liquid discharge port 3 of the tank body 1, and the other end of the second liquid storage tank is connected with the feeding ports 2 of the tank body 1.
Example 1
Referring to fig. 1 and 2, the resin washing apparatus provided in this embodiment includes a tank 1 not including a stirring device, a first liquid storage tank 8, a second liquid storage tank 4, and a third liquid storage tank 11, where the tank 1 is used for filling resin to be washed, a plurality of charging ports 2 are provided at the top of the tank 1, and a liquid outlet 3 is provided at the bottom of the tank 1; wherein, charge door 2 evenly distributed sets up, 8 in the first liquid storage jar with charge door 2 of jar body 1 is connected, the one end of second liquid storage jar 4 with the leakage fluid dram 3 of jar body 1 is connected, the other end with charge door 2 of jar body 1 is connected, and the quantity of charge door 2 is 5, and one of them charge door is located the centre of a circle department of jar body 1 upper surface, and wherein two charge doors are located the both sides at centre of a circle, are first straight line with the centre of a circle. The other two charging ports are also positioned at two sides of the circle center, and the formed second straight line is perpendicular to the first straight line.
The liquid outlet 3 is provided with a first pump 6 on a pipeline connected with the second liquid storage tank 4, the pipeline connected with the second liquid storage tank 4 and the charging port 2 is provided with a second pump 5 and a second valve 9, and the pipeline connected with the first liquid storage tank 8 and the charging port 2 is provided with a third pump 7 and a first valve 10.
The first liquid storage tank 8 is used for storing the initial washing liquid, and the second liquid storage tank 4 is used for temporarily storing and re-pumping the washing liquid discharged from the liquid outlet 3 into the tank body 1.
One end of the third liquid storage tank 11 is also connected with the liquid outlet 3, and a pipeline from the liquid outlet 3 passes through the first pump 6 and then is divided into two paths through the three-way valve 14, wherein one path pumps the resin washing liquid into the second liquid storage tank 4, and the other path pumps the resin washing liquid into the third liquid storage tank 11; the other end of the third liquid storage tank 11 is connected with the charging port 2 through a fourth pump 12 and a third valve 13.
In use, 6 resin volumes are washed altogether, the washing liquid of the first three resin volumes is directly discharged to the third liquid storage tank 11, and the thin liquid of the last three resin volumes is discharged to the second liquid storage tank 4 for the first three washes of the next cycle.
The pumping of wash liquid into the feed inlet 2 is controlled by the first valve 10 and the third pump 7.
The second valve 9 and the second pump 5 are used for controlling the temporarily stored washing liquid to be pumped into the charging port 2.
Example 2
Referring to fig. 1 and 3, in the resin washing apparatus provided in this embodiment, the number of the charging ports 2 is 9, one of the charging ports is located at the center of the upper surface of the tank 1, and the remaining charging ports are uniformly disposed around the center.
By the resin washing equipment, the washing liquid can be recycled, the consumption of the washing solution and the output of waste liquid are reduced, the cost is saved, and referring to fig. 5, after the stirring step is removed, each condensation and deprotection cycle can be saved by 50-80 minutes, and 90% of impurities can be removed by one washing.
The utility model and its embodiments have been described above by way of illustration and not limitation, and the utility model is illustrated in the accompanying drawings and described in the drawings in which the actual structure is not limited thereto. Therefore, if one of ordinary skill in the art is informed by this disclosure, the structural mode and the embodiments similar to the technical scheme are not creatively designed without departing from the gist of the present utility model.
Claims (10)
1. The resin washing equipment is characterized by comprising a tank body which does not comprise a stirring device, a first liquid storage tank and a second liquid storage tank, wherein the tank body is used for filling resin to be washed, a plurality of charging ports are arranged at the top of the tank body, and a liquid outlet is arranged at the bottom of the tank body; the number of the charging ports is more than or equal to 3, the charging ports are uniformly distributed, the first liquid storage tank is connected with the charging ports of the tank body, one end of the second liquid storage tank is connected with the liquid discharging ports of the tank body, and the other end of the second liquid storage tank is connected with the charging ports of the tank body.
2. A resin washing apparatus according to claim 1, wherein the number of said charging openings is 5.
3. A resin washing apparatus according to claim 1, wherein the number of said charging openings is 9.
4. A resin washing apparatus according to claim 1, wherein the drain port is provided with a drain valve.
5. A resin washing apparatus according to claim 1, wherein the height to diameter ratio of the tank is 3:1.
6. A resin washing apparatus according to claim 2, wherein one of said charging openings is located at the center of the upper surface of the tank body, two of the charging openings are located on both sides of the center, and the straight line of the remaining two charging openings is perpendicular to the straight line of the two charging openings.
7. A resin washing apparatus according to claim 3, wherein one of said feed openings is located at the center of the upper surface of the tank body, and the remaining feed openings are uniformly arranged along the center of the circle.
8. A resin washing apparatus according to claim 1, wherein the tank is cylindrical.
9. A resin washing apparatus according to any one of claims 1 to 8 wherein a first pump is provided on a conduit connecting the drain port to the second reservoir, a second pump and a second valve are provided on a conduit connecting the second reservoir to the feed port, and a third pump and a first valve are provided on a conduit connecting the first reservoir to the feed port.
10. The resin washing device according to claim 9, further comprising a third liquid storage tank, wherein one end of the third liquid storage tank is connected with the liquid outlet of the tank body, the other end of the third liquid storage tank is connected with the feed inlet, and a fourth pump and a third valve are arranged on a pipeline connected with the feed inlet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202323183894.6U CN221206908U (en) | 2023-11-24 | 2023-11-24 | Resin washing equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202323183894.6U CN221206908U (en) | 2023-11-24 | 2023-11-24 | Resin washing equipment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN221206908U true CN221206908U (en) | 2024-06-25 |
Family
ID=91545387
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202323183894.6U Active CN221206908U (en) | 2023-11-24 | 2023-11-24 | Resin washing equipment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN221206908U (en) |
-
2023
- 2023-11-24 CN CN202323183894.6U patent/CN221206908U/en active Active
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| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant |