CN221156214U - Stirring device for heparin sodium alcohol precipitation - Google Patents

Stirring device for heparin sodium alcohol precipitation Download PDF

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Publication number
CN221156214U
CN221156214U CN202322912648.3U CN202322912648U CN221156214U CN 221156214 U CN221156214 U CN 221156214U CN 202322912648 U CN202322912648 U CN 202322912648U CN 221156214 U CN221156214 U CN 221156214U
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CN
China
Prior art keywords
stirring
shaft
gear
heparin sodium
transmission
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CN202322912648.3U
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Chinese (zh)
Inventor
庹修国
庹利
周岭
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Yibin Lihao Animal Products Co ltd
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Yibin Lihao Animal Products Co ltd
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Abstract

The utility model relates to the technical field of heparin sodium preparation and discloses a stirring device for heparin sodium alcohol precipitation, which comprises a stirring box body, wherein an upper stirring shaft and a lower stirring shaft are coaxially arranged in the stirring box body, the upper stirring shaft is rotationally connected to the top of the stirring box body, the lower stirring shaft is rotationally connected to the bottom of the stirring box body, the rotation direction of the upper stirring shaft is opposite to that of the lower stirring shaft, a plurality of upper stirring blades are fixedly sleeved on the upper stirring shaft, the plurality of upper stirring blades are uniformly distributed along the axial direction of the upper stirring shaft, a plurality of lower stirring blades are fixedly sleeved on the lower stirring shaft, and the plurality of lower stirring blades are uniformly distributed along the axial direction of the lower stirring shaft. The stirring directions of the upper stirring shaft and the lower stirring shaft are different, so that stirring turbulence is generated in the stirring box body, the movement strength of heparin sodium is improved, the stirring strength is higher, impurities in the heparin sodium can be removed by full stirring, and the alcohol precipitation purity is improved.

Description

Stirring device for heparin sodium alcohol precipitation
Technical Field
The utility model relates to the technical field of heparin sodium preparation, in particular to a stirring device for heparin sodium alcohol precipitation.
Background
Heparin sodium can interfere with many links of the blood coagulation process, and has anticoagulation effect in vivo and in vitro. The mechanism of action is complex, and the inhibition of the latter on activated II, IX, X, XI and XII coagulation factors is enhanced mainly by binding to antithrombin III, and the consequences thereof relate to inhibition of platelet aggregation and destruction, inhibition of the formation of thromboplastin, inhibition of prothrombin to thrombin, inhibition of thrombin and thus inhibition of fibrinogen to fibrin, thus exerting an anticoagulant effect. The purpose of alcohol precipitation in the heparin sodium extraction process is to remove impurities and retain active ingredients in the medicine. The stirring mode in the traditional classifying alcohol precipitation device for heparin sodium extraction is single, and the stirring intensity is mainly insufficient, so that the alcohol precipitation purity is not high, and the heparin sodium extraction quality is affected.
Disclosure of utility model
The utility model aims to overcome the defects of the prior art, and provides a stirring device for heparin sodium alcohol precipitation, which has higher stirring strength, can sufficiently stir and remove impurities in heparin sodium, and improves the alcohol precipitation purity.
The aim of the utility model is realized by the following technical scheme: the utility model provides a heparin sodium is agitating unit for alcohol precipitation, includes the stirring box, coaxial last (mixing) shaft and lower (mixing) shaft of being provided with in the stirring box, it connects to go up (mixing) shaft rotation the top of stirring box, lower (mixing) shaft rotates and connects the bottom of stirring box, go up (mixing) shaft the direction of rotation with the direction of rotation of lower (mixing) shaft is opposite, go up (mixing) shaft is last to be fixedly overlapped and be equipped with a plurality of stirring vane, a plurality of go up stirring vane along go up the axial equipartition of (mixing) shaft, lower (mixing) shaft is last to be fixedly overlapped and is equipped with a plurality of stirring vane down, a plurality of stirring vane is followed down the axial equipartition of (mixing) shaft down.
In some embodiments, a transmission case is arranged between the upper stirring shaft and the lower stirring shaft, a supporting rod is connected to the side wall of the transmission case, the supporting rod is fixedly connected to the side wall of the stirring case body, a transmission mechanism is arranged in the transmission case, and the upper stirring shaft is connected with the lower stirring shaft through the transmission mechanism.
In some embodiments, the transmission mechanism comprises a first transmission shaft and a second transmission shaft, the first transmission shaft and the second transmission shaft are both rotationally connected with the transmission case, the upper stirring shaft penetrates into the transmission case and is sleeved with a first gear, the first transmission shaft is sleeved with a second gear and a third gear, the first gear is meshed with the second gear, the second transmission shaft is sleeved with a fourth gear, the third gear is meshed with the fourth gear, the lower stirring shaft penetrates into the transmission case and is sleeved with a fifth gear, and the fourth gear is meshed with the fifth gear.
In some embodiments, a first seal ring is disposed between the upper stirring shaft and the transmission case, the first seal ring being in a compressed state.
In some embodiments, a second seal ring is disposed between the lower stirring shaft and the transmission case, the second seal ring being in a compressed state.
In some embodiments, a motor is arranged at the top of the stirring box body, and an output shaft of the motor is in transmission connection with the upper stirring shaft.
In some embodiments, the top of the stirring tank is provided with a feed hopper and a water inlet pipe.
In some embodiments, the top of the stirring box body is fixed with a support leg, and one side of the bottom of the stirring box body is provided with a water outlet.
The beneficial effects of the utility model are as follows:
the stirring directions of the upper stirring shaft and the lower stirring shaft are different, so that stirring turbulence is generated in the stirring box body, the movement strength of heparin sodium is improved, the stirring strength is higher, impurities in the heparin sodium can be removed by full stirring, and the alcohol precipitation purity is improved.
Drawings
Fig. 1 is a schematic diagram of the internal structure of a stirring device for heparin sodium alcohol precipitation;
FIG. 2 is an enlarged view of FIG. 1 at A;
In the figure, the stirring box body comprises a stirring box body 1-upper stirring shaft, a stirring box body 3-lower stirring shaft, stirring blades 4-upper stirring blades, stirring blades 5-lower stirring blades, a driving box 6-transmission box, a driving shaft 7-first, a driving shaft 8-second, a driving shaft 9-first gear, a driving gear 10-second, a driving gear 11-third, a driving gear 12-supporting rod 13-fourth, a driving gear 14-fifth, a driving gear 15-first sealing ring 16-second sealing ring 17-motor 18-feeding hopper 19-water inlet pipe 20-supporting leg 21-water outlet.
Detailed Description
The technical solution of the present utility model will be described in further detail with reference to the accompanying drawings, but the scope of the present utility model is not limited to the following description.
As shown in fig. 2, a stirring device for heparin sodium alcohol precipitation comprises a stirring box body 1, an upper stirring shaft 2 and a lower stirring shaft 3 are coaxially arranged in the stirring box body 1, the upper stirring shaft 2 is rotationally connected to the top of the stirring box body 1, the lower stirring shaft 3 is rotationally connected to the bottom of the stirring box body 1, the rotation direction of the upper stirring shaft 2 is opposite to that of the lower stirring shaft 3, a plurality of upper stirring blades 4 are fixedly sleeved on the upper stirring shaft 2, a plurality of lower stirring blades 5 are uniformly distributed along the axial direction of the upper stirring shaft 2 in a sleeved mode on the lower stirring shaft 3, a plurality of lower stirring blades 5 are uniformly distributed along the axial direction of the lower stirring shaft 3 in a fixed mode, the upper stirring shaft 2 drives the upper stirring blades 4 to rotate so as to drive heparin sodium in the stirring box body 1 to rotate, and simultaneously the lower stirring shaft 3 drives the lower stirring blades 4 to rotate.
Further, as shown in fig. 1, a feed hopper 18 and a water inlet pipe 19 are arranged at the top of the stirring box body 1, the heparin sodium raw material is put into the stirring box body 1 through the feed hopper 18, heparin sodium extracting solution is added into the stirring box body 1 through the water inlet pipe 19, and then the heparin sodium extracting solution is fully mixed through stirring, so that heparin sodium with higher purity is extracted, cooling water is injected into the water inlet pipe 19, and the liquid in the stirring box body 1 is subjected to cooling treatment, so that the temperature in the box body is reduced, the temperature of ethanol is reduced, and impurities with lower solubility are separated out due to the reduction of the temperature of the ethanol, so that the quality of ethanol precipitation is further improved; the top of the stirring box body 1 is fixed with a supporting leg 20, and one side of the bottom of the stirring box body 1 is provided with a water outlet 21.
In some embodiments, as shown in fig. 1 and 2, a transmission case 6 is arranged between an upper stirring shaft 2 and a lower stirring shaft 3, a supporting rod 12 is connected to the side wall of the transmission case 6, the supporting rod 12 is fixedly connected to the side wall of the stirring case 1, a transmission mechanism is arranged in the transmission case 6, the upper stirring shaft 2 is connected with the lower stirring shaft 3 through the transmission mechanism, the transmission mechanism comprises a first transmission shaft 7 and a second transmission shaft 8, the first transmission shaft 7 and the second transmission shaft 8 are both rotatably connected with the transmission case 6, the upper stirring shaft 2 penetrates into the transmission case 6 and is sleeved with a first gear 9, the first transmission shaft 7 is sleeved with a second gear 10 and a third gear 11, the first gear 9 is meshed with the second gear 10, the second transmission shaft 8 is sleeved with a fourth gear 13, the third gear 11 is meshed with the fourth gear 13, the lower stirring shaft 3 penetrates into the transmission case 6 and is sleeved with a fifth gear 14, the fourth gear 13 is meshed with the fifth gear 14, the top of the stirring box body 1 is provided with a motor 17, an output shaft of the motor 17 is in transmission connection with the upper stirring shaft 2, the motor 2 drives the upper stirring shaft 2 to rotate, the upper stirring shaft 2 drives an upper stirring blade 4 on the upper stirring shaft 2 to rotate, meanwhile, the upper stirring shaft 2 drives a first transmission shaft 7 to rotate through the engagement of a first gear 9 and a second gear 10, the first transmission shaft 7 drives a second transmission shaft 8 to rotate through the engagement of a third gear 11 and a fourth gear 13, the second transmission shaft 8 drives a lower stirring shaft 3 to rotate through the engagement of a fifth gear 14 and the fourth gear 13, so that the upper stirring shaft 2 and the lower stirring shaft 3 can be simultaneously driven to rotate through only one power source, the rotation directions of the upper stirring shaft 2 and the lower stirring shaft 3 are opposite, no power equipment is required to be arranged at the bottom of the stirring box body 1, the integrity of the bottom of the stirring box body 1 is ensured, therefore, the bottom of the stirring box body 1 cannot be leaked due to the arrangement of the lower stirring shaft 3, and the tightness of the stirring box body is effectively ensured.
In some embodiments, as shown in fig. 2, a first sealing ring 15 is arranged between the upper stirring shaft 2 and the transmission case 6, the first sealing ring 15 is in a compressed state, so that the sealing strength between the upper stirring shaft 2 and the transmission case 6 is improved, a second sealing ring 16 is arranged between the lower stirring shaft 3 and the transmission case 6, the second sealing ring 16 is in a compressed state, so that the sealing strength between the lower stirring shaft 3 and the transmission case 6 is improved, and heparin sodium is prevented from entering the transmission case 6.
In the description of the present utility model, it should be understood that the terms "coaxial," "bottom," "one end," "top," "middle," "other end," "upper," "one side," "top," "inner," "front," "center," "two ends," etc. indicate orientations or positional relationships based on the orientation or positional relationships shown in the drawings, are merely for convenience in describing the present utility model and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present utility model; and those of ordinary skill in the art will appreciate that the benefits achieved by the present utility model are merely better than those achieved by the current embodiments of the prior art in certain circumstances and are not intended to be the most excellent uses directly in the industry.
The foregoing is merely a preferred embodiment of the utility model, and it is to be understood that the utility model is not limited to the form disclosed herein but is not to be construed as excluding other embodiments, but is capable of numerous other combinations, modifications and environments and is capable of modifications within the scope of the inventive concept, either as taught or as a matter of routine skill or knowledge in the relevant art. And that modifications and variations which do not depart from the spirit and scope of the utility model are intended to be within the scope of the appended claims.

Claims (8)

1. The utility model provides a heparin sodium is agitating unit for alcohol precipitation, includes stirring box (1), its characterized in that, coaxial stirring shaft (2) and lower (3) that are provided with in stirring box (1), go up (2) rotation and connect stirring box (1) top, lower (3) rotation is connected stirring box (1) bottom, go up (2) rotation direction with lower (3) rotation opposite direction, go up (2) on fixed cover be equipped with a plurality of last stirring vane (4), a plurality of go up (4) along the axial equipartition of last (2) stirring vane, fixed cover is equipped with a plurality of (5) down on (3) stirring vane, a plurality of (5) are followed down the axial equipartition of (3) stirring vane.
2. The stirring device for heparin sodium alcohol precipitation according to claim 1, wherein a transmission case (6) is arranged between the upper stirring shaft (2) and the lower stirring shaft (3), a supporting rod (12) is connected to the side wall of the transmission case (6), the supporting rod (12) is fixedly connected to the side wall of the stirring case body (1), a transmission mechanism is arranged in the transmission case (6), and the upper stirring shaft (2) is connected with the lower stirring shaft (3) through the transmission mechanism.
3. The stirring device for heparin sodium alcohol precipitation according to claim 2, wherein the transmission mechanism comprises a first transmission shaft (7) and a second transmission shaft (8), the first transmission shaft (7) and the second transmission shaft (8) are both rotationally connected with the transmission case (6), the upper stirring shaft (2) penetrates into the transmission case (6) and is sleeved with a first gear (9), the first transmission shaft (7) is sleeved with a second gear (10) and a third gear (11), the first gear (9) is meshed with the second gear (10), the second transmission shaft (8) is sleeved with a fourth gear (13), the third gear (11) is meshed with the fourth gear (13), the lower stirring shaft (3) penetrates into the transmission case (6) and is sleeved with a fifth gear (14), and the fourth gear (13) is meshed with the fifth gear (14).
4. A stirring device for heparin sodium alcohol precipitation according to claim 3, characterized in that a first sealing ring (15) is arranged between the upper stirring shaft (2) and the transmission case (6), and the first sealing ring (15) is in a compressed state.
5. The stirring device for heparin sodium alcohol precipitation as claimed in claim 4, wherein a second sealing ring (16) is arranged between the lower stirring shaft (3) and the transmission case (6), and the second sealing ring (16) is in a compressed state.
6. The stirring device for heparin sodium alcohol precipitation according to claim 1, wherein a motor (17) is arranged at the top of the stirring box body (1), and an output shaft of the motor (17) is in transmission connection with the upper stirring shaft (2).
7. The stirring device for heparin sodium alcohol precipitation according to claim 1, wherein a feed hopper (18) and a water inlet pipe (19) are arranged at the top of the stirring box body (1).
8. The stirring device for heparin sodium alcohol precipitation as claimed in claim 7, wherein the top of the stirring box body (1) is fixedly provided with a supporting leg (20), and one side of the bottom of the stirring box body (1) is provided with a water outlet (21).
CN202322912648.3U 2023-10-30 2023-10-30 Stirring device for heparin sodium alcohol precipitation Active CN221156214U (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202322912648.3U CN221156214U (en) 2023-10-30 2023-10-30 Stirring device for heparin sodium alcohol precipitation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202322912648.3U CN221156214U (en) 2023-10-30 2023-10-30 Stirring device for heparin sodium alcohol precipitation

Publications (1)

Publication Number Publication Date
CN221156214U true CN221156214U (en) 2024-06-18

Family

ID=91538098

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202322912648.3U Active CN221156214U (en) 2023-10-30 2023-10-30 Stirring device for heparin sodium alcohol precipitation

Country Status (1)

Country Link
CN (1) CN221156214U (en)

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