CN221148479U

CN221148479U - Reagent strip and reagent strip consumable

Info

Publication number: CN221148479U
Application number: CN202322881269.2U
Authority: CN
Inventors: 李军
Original assignee: Xiamen Baotai Biotechnology Co ltd
Current assignee: Xiamen Baotai Biotechnology Co ltd
Priority date: 2023-10-26
Filing date: 2023-10-26
Publication date: 2024-06-14
Anticipated expiration: 2033-10-26

Abstract

The utility model discloses a reagent strip and reagent strip consumable, relating to the technical field of in vitro detection, wherein the reagent strip mainly comprises a substrate, a detection reagent unit, a fixing film and a sealing film; the substrate is used as a carrier, the fixing film and the sealing film are combined, a plurality of detection reagent units are arranged at intervals and sealed and fixedly arranged on the upper end face of the substrate, so that a reagent strip capable of being continuously detected for many times is formed, and the reagent strip has the advantages of being capable of being independently stored, good in sealing effect, convenient to use and the like. In the reagent strip consumable, the front end of the reagent strip is wound on a receiving cylinder, the rear end of the reagent strip is wound on a discharging cylinder, so that a consumable in a roll form is formed, and the consumable is sealed by adopting a packaging bag and the like and separated from a reagent card box, so that independent retail can be realized. The reagent card box matched with the reagent card box can realize recycling in a manner of purchasing and installing the consumable materials, so that the use cost is reduced.

Description

Reagent strip and reagent strip consumable

Technical Field

The utility model relates to the technical field of in-vitro detection, in particular to a reagent strip and a reagent strip consumable.

Background

In-vitro instant detection is a detection mode for rapidly obtaining a detection result by using a portable analysis instrument and a matched reagent on a sampling site, and is a product which is developed more mature in the fields of household and personal use, such as a blood glucose meter, blood glucose test paper, pregnancy test paper and the like.

The detection reagent units formed by stacking and arranging the multiple layers of reagent pads are often used on POCT devices by a dry chemical method, after the sample is filtered by a screening layer to remove interfering substances, the detection index in the sample is subjected to chemical reaction with a reagent layer specific reactant, and the generated product is subjected to color reaction with an indicator layer, so that detection is realized by naked eye observation or an area array CCD image acquisition method.

As disclosed in patent document No. 201921555165.X, a chromatographic cassette and a chromatographic detection card generally use a plastic film to fix a detection reagent unit on a substrate, and then use a housing of a portable detection device such as a kit to store a reagent strip in the content of the detection device, so as to prevent the detection reagent unit from being wetted and polluted. This approach has the following problems: the reagent strips are provided with a reagent detection unit, and cannot be detected continuously for a plurality of times. Moreover, the reagent strip does not have a sealing structure, and the reagent strip is required to be stored in a sealing way by means of a reagent box, so that the reagent strip is difficult to store independently. The sealing performance of the shell of the kit is limited, the sealing effect is poor, and the shelf life of the reagent strip is short; therefore, it is necessary to design and develop a reagent strip which has good sealing property and can be continuously detected for a plurality of times.

Disclosure of Invention

The present utility model is directed to a reagent strip and a reagent strip consumable, which are aimed at overcoming the above-mentioned problems in the prior art.

In order to achieve the above purpose, the present utility model provides the following technical solutions:

a reagent strip comprising a substrate and a detection reagent unit; further comprises:

The fixed film is provided with a plurality of hollowed-out parts at intervals; the fixing film is sealed and attached to the upper end face of the substrate, the detection reagent units are fixedly arranged between the substrate and the fixing film at intervals, the hollowed-out parts are in one-to-one correspondence with the detection reagent units, so that the middle area of the upper end face of the detection reagent unit is exposed out of the hollowed-out parts, and the edge area of the upper end face of the detection reagent unit is sealed and attached to the fixing film;

And the sealing film is sealed and adhered to each hollow part of the fixing film, and one side of the sealing film is provided with an easy-to-tear strip in an extending manner.

Further, the substrate is provided with a plurality of positioning holes in a spaced arrangement.

Furthermore, the substrate is provided with a plurality of detection reagent units in a central axis arrangement manner, and a plurality of positioning holes are respectively arranged at the edges of two sides.

Further, the positioning hole is located between two adjacent detection reagent units.

Further, at least one white balance calibration unit is disposed at the front end of the substrate.

Further, the substrate is made of a light-transmitting flexible material.

Still further, the substrate is a PET plate, a PMMA film, or a PC film.

The invention also discloses a reagent strip consumable, which comprises a receiving cylinder, a discharging cylinder and the reagent strip with any structure as described above, wherein the front end of the reagent strip is wound on the receiving cylinder, and the rear end of the reagent strip is wound on the discharging cylinder.

Further, the discharging cylinder is a regular polygon prism, and a positioning protrusion is fixedly arranged at the edge of the regular polygon prism; the positioning holes of the reagent strips are matched with the positioning protrusions, and the detection reagent units are positioned on the edges of the regular polygon prism.

Further, a rear extension section is arranged at the rear end of the reagent strip, a clamping groove is arranged on the discharging barrel, and the rear extension section is clamped in the clamping groove;

further, a front extension section is provided at the front end of the reagent strip, and the front extension section is wound around the receiving cylinder.

Compared with the prior art, the utility model has the beneficial effects that:

The utility model uses the substrate as the carrier, clamps the plurality of detection reagent units on the substrate at intervals by using the fixing film, then uses the sealing film to carry out detachable sealing treatment on the plurality of detection reagent units to form a reagent strip capable of continuously detecting for many times, and has the advantages of independent storage, good sealing effect, convenient use and the like.

In the second embodiment of the utility model, the substrate is also provided with a plurality of positioning holes at intervals, so that the substrate is conveniently positioned and wound outside the winding drum to form consumable materials in a winding drum form, is convenient to store, and better protects the reagent strips.

Thirdly, in the utility model, the substrate is made of a light-transmitting flexible material, so that the reagent strip can be wound conveniently. Because of the light transmittance, the detection device can conveniently detect the detection reagent unit by a CCD image acquisition method from bottom to top through the substrate.

Fourth, in the utility model, the front end of the reagent strip is wound on the receiving cylinder, and the rear end is wound on the discharging cylinder, so that a consumable in a roll form is formed, and the consumable is sealed by adopting a packaging bag and the like, thereby facilitating retail sales. The reagent card box can be recycled by purchasing and installing the consumable materials, and the consumable materials of the reagent strip can be separated from the reagent card box for independent selling.

Fifthly, in the utility model, the discharging barrel is a regular polygon prism, and when the reagent strip is wound on the discharging barrel, the positioning protrusions at the edges and corners of the regular polygon prism are mutually matched with the positioning holes, so that firm winding is ensured; the detection reagent unit is positioned on the prism surface of the regular polygon prism, so that the deformation of the detection reagent unit is avoided. The blowing section of thick bamboo is regular polygon prism, can segment the expansion action of reagent strip, and the expansion of a detection reagent unit is accomplished to every fixed angle of rotation, provides the controllability of reagent card box. Taking a regular hexagon as an example of the discharging cylinder, the discharging cylinder completes the unfolding segmentation of one detection reagent unit every 60 degrees of rotation.

Sixth, the rear end of the reagent strip is provided with a rear extension section, the discharging barrel is provided with a clamping groove for clamping the rear extension section, the clamping groove is matched with the rear extension section to position a winding starting point, and the positioning hole is right positioned on the positioning protrusion after the reagent strip is wound, so that the assembly difficulty is reduced. The front end of the reagent strip is provided with the front extension section for winding the receiving cylinder, so that winding is completed by the simplest structure, the processing and manufacturing difficulty of the reagent strip and the receiving cylinder is reduced, and the cost is reduced.

Drawings

FIG. 1 is a schematic top view of a reagent strip according to the present utility model. The sealing film at the white balance calibration unit is not drawn for distinguishing the detection reagent unit from the white balance calibration unit, and the exposed part of the sealing film is subjected to pattern filling treatment.

FIG. 2 is a partial cross-sectional view of the reagent strip of the present utility model taken along the direction A-A in FIG. 1.

FIG. 3 is a schematic perspective view of a reagent strip consumable in accordance with the present utility model. Wherein the reagent strips do not show a fixing membrane and a sealing membrane.

FIG. 4 is a schematic diagram of an exploded structure of a reagent strip consumable in accordance with the present utility model. Wherein the reagent strips do not show a fixing membrane and a sealing membrane.

Fig. 5 is a schematic perspective view of a discharge vessel according to the present utility model.

Fig. 6 is a schematic perspective view of a receiving cylinder according to the present utility model.

Detailed Description

Specific embodiments of the present utility model will be described below with reference to the accompanying drawings. Numerous details are set forth in the following description in order to provide a thorough understanding of the present utility model, but it will be apparent to one skilled in the art that the present utility model may be practiced without these details.

In the direction expression, the utility model takes the advancing direction of the reagent strip during continuous test as the front end and takes the dropping direction of the sample as the upper end.

As shown in fig. 1 and 2, a reagent strip mainly includes a substrate 11, a detection reagent unit 12, a fixing film 13, and a sealing film 14. In the utility model, a substrate 11 is taken as a carrier, a fixing film 13 and a sealing film 14 are combined, and a plurality of detection reagent units 12 are arranged at intervals and sealed and fixed on the upper end surface of the substrate 11 to form a reagent strip capable of continuously detecting for a plurality of times.

As shown in fig. 1 and 2, specifically, a plurality of detection reagent units 12 are arranged at intervals on the upper end surface of the substrate 11; the fixing film 13 is sealed and attached to the upper end surface of the substrate 11, and a plurality of detection reagent units 12 are fixed between the substrate 11 and the fixing film 13 in a spaced arrangement. In addition, the fixed film 13 is provided with a plurality of hollowed-out parts 131 at intervals, and the hollowed-out parts 131 are in one-to-one correspondence with the detection reagent units 12, so that the middle area of the upper end surface of the detection reagent unit 12 is exposed in the hollowed-out parts 131, and a sample is conveniently dripped into the detection reagent unit 12.

As shown in fig. 1 and 2, in one embodiment, the fixing film 13 is sealed and attached to the substrate 11 and the plurality of detection reagent units 12 by an adhesive layer such as glue. The fixing film 13 is sealed and attached to the edge region of the upper end face of the detection reagent unit 12 at the edge region of the hollowed-out portion 131 by means of glue adhesion, thermocompression bonding, ultrasonic welding or the like, and the regions where the fixing film 13 contacts the upper end face of the substrate 11 are sealed and attached to the upper end face of the substrate 11, so that the plurality of detection reagent units 12 are sandwiched and arranged between the substrate 11 and the fixing film 13 at intervals. Taking glue adhesion as an example, the glue includes, but is not limited to, pressure sensitive adhesive, PP glue or AB glue.

As shown in fig. 1 and 2, the fixing film 13 may be an entire film with the same outer surface as the substrate 11, or may be a film segment including at least one hollowed-out portion 131, and the film segments are spliced to form the fixing film 13. In other words, the fixing film 13 may be integral or segmented.

As shown in fig. 1 and 2, a sealing film 14 is sealed and adhered on the fixing film 13 above each hollowed-out portion 131, for completely sealing the detection reagent unit 12. Specifically, the edge of the sealing film 14 is sealed and attached to the edge area of the hollow portion 131 of the fixing film 13 by an adhesive layer such as glue.

In one embodiment, as shown in fig. 1 and 2, a tear-off strip 141 extends from one side of the sealing film 14. The easy-to-tear strip 141 and the fixed film 13 are mutually separated, so that people can tear the sealing film 14 from the fixed film 13 through the easy-to-tear strip 141 conveniently. Preferably, the easy-to-tear tape 141 is integrally formed at the front end of the sealing film 14, so as to facilitate tearing of the sealing film 14.

As shown in fig. 1 and 2, the front end of the substrate 11 is provided with a white balance calibration unit 103. Of course, the number of the white balance calibration units 103 may be plural, and is not limited thereto. In addition, the white balance calibration unit 103 and the detection reagent unit 12 are both in the prior art, and specific structures can refer to the existing dry chemical detection type reagent products, and are not described herein.

As shown in fig. 1 and 2, in one embodiment, the front end of the reagent strip 1 is provided with a front extension 104 without the detection reagent unit 12 in addition to the white balance calibration unit 103, so that the front end of the substrate 11 is fixedly wound on a cylindrical member for convenient storage. Similarly, the rear end of the reagent strip 1 is provided with a rear extension 101.

As shown in fig. 1 and 2, in a specific embodiment, the base plate 11 is provided with a plurality of positioning holes 102 at intervals, so that the reagent strips can be conveniently stored and fixedly stored on the tubular member in a positioning and winding manner, and the winding relationship between the reagent strips and the tubular member is consolidated, so that the winding position and the winding tightness are suitable. Preferably, the substrate 11 is provided with a plurality of the detection reagent units 12 in a central axis, and a plurality of positioning holes 102 are provided in an arrangement manner at both side edges, and the positioning holes 102 are located between two adjacent detection reagent units 12. Positioning holes 10 are formed in two sides of the positioning device, so that the positioning effect can be enhanced.

As shown in fig. 1 and 2, in one specific embodiment, the substrate 11 is a flexible material having light transmittance, including but not limited to a PET plate, a PMMA film, or a PC film. For example, since the PET plate is made of a light-transmitting material, a detection device such as an area array CCD image acquisition method may be placed on the substrate 11 during detection, and the detection reagent unit 12 after the sample is added may be detected by passing through the substrate 11 from top to bottom. In order to prevent the influence of the surrounding environment on the detection, the PET plate as the substrate 11 is subjected to light shielding treatment by applying a back paint or the like so that the PET plate is a light-permeable region only in the range of the orthographic projection region of the detection reagent unit 12, the remaining regions are light shielding regions, and the lower the light transmittance of the light shielding regions is (preferably, the light transmittance is between 0% and 10%). The detection reagent unit 12 may have a circular shape or may have a square shape. When the detection reagent unit 12 is circular, the light permeable region of the substrate 11 is preferably, but not limited to, circular, and the circular diameter of the light permeable region should be less than or equal to the diameter of the detection reagent unit 12.

Preferably, the fixing film 13 and the sealing film 14 include, but are not limited to, plastic films.

As shown in fig. 1-6, the utility model also discloses a reagent strip consumable, which comprises a receiving cylinder 3, a discharging cylinder 2 and a reagent strip 1 with the structure described above. The front end of the reagent strip 1 is wound on the receiving cylinder 3, and the rear end is wound on the discharging cylinder 2, so that a consumable in a roll form is formed, and the consumable is sealed by adopting a packaging bag and the like, so that the retail sale is facilitated.

As shown in fig. 3-5, in one embodiment, the discharge vessel 2 is in the shape of a regular polygon, including but not limited to a regular hexagon. And the corner of the regular polygon prism is fixedly provided with a positioning protrusion 21 matched with the positioning hole 102. Preferably, the rear end of the reagent strip 1 is provided with a rear extension 102, and the discharging barrel 2 is provided with a clamping groove 22 matched with the rear extension 102. The rear extension section 102 is clamped in the clamping groove 22, and then the rear end of the reagent strip 1 is wound on the discharging barrel 2 clockwise, so that each detection reagent unit 12 is positioned on the edge surface of the regular polygon prism, and the positioning hole 102 and the positioning protrusion 21 are inserted into each other, so that the unused reagent strip 1 is wound on the discharging barrel 2. The clamping groove 22 is matched with the rear extension section 102 to position the winding starting point, so that the positioning hole 102 is exactly positioned on the positioning protrusion 21 after the reagent strip 1 is wound, and the assembly difficulty is reduced.

Taking into consideration the influence of the thickness of the reagent strip 1 itself on winding, the intervals between the detection reagent units 12 are not uniform, taking the reagent strip 1 containing nine detection reagent units 12 as an example, six detection reagent units 12 near the rear end form a first winding layer directly attached to the surface of the discharge cylinder 2, and the intervals between the six detection reagent units 12 are substantially uniform; the remaining three detection reagent units 12 are second winding layers, and are attached to the first winding layers. The spacing between the remaining three detector reagent units 12 should be generally uniform, but slightly greater than the spacing between the six detector reagent units 12 to accommodate the effects of the first wrap thickness. Similarly, the spacing of the positioning holes 102 in the second winding layer should be slightly greater than the spacing of the positioning holes 102 in the first winding layer. Further, in order that the positioning hole 102 can be disengaged from the positioning projection 21, the reagent unit 12 is smoothly spread from the discharge tube 2, and the size of the positioning hole 102 should be slightly larger than the size of the positioning projection 21, particularly, the size in the front-rear direction.

As shown in fig. 3 and 6, in one embodiment, the front end of the reagent strip 1 is provided with a front extension section 104, and the front extension section 104 is not provided with the detection reagent unit 12, and when assembled, the front extension section is wound on the receiving cylinder 3, so that the front end of the reagent strip 1 is connected to the receiving cylinder 3, and the used reagent strip 1 is conveniently wound on the receiving cylinder 3. Preferably, the length of the front extension 104 is greater than the circumference of the receiving cylinder 3, so that a closed loop layer is formed by the front extension 104.

As shown in fig. 1 to 6, in addition, the inner wall of the discharging barrel 2 is provided with a first engaging portion 23, and the inner wall of the receiving barrel 3 is provided with a second engaging portion 31, so that a driving component (not shown in the drawings) assembled inside the reagent cartridge is connected in a transmission manner, and the discharging barrel 2 and the receiving barrel 3 are driven to rotate by the driving component. Specifically, when the driving assembly is used for enabling the discharging barrel 2 to rotate and spread the reagent strips 1, the receiving barrel 3 also rotates and winds the reagent strips 1, so that the reagent strip part spread between the discharging barrel 2 and the receiving barrel 3 is always in a proper tight state.

The foregoing is merely illustrative of specific embodiments of the present utility model, but the design concept of the present utility model is not limited thereto, and any insubstantial modification of the present utility model by using the design concept shall fall within the scope of the present utility model.

Claims

1. A reagent strip comprising a substrate (11) and a detection reagent unit (12); characterized by further comprising:

The fixing film (13), a plurality of hollowed-out parts (131) are arranged on the fixing film (13) at intervals; the fixing film (13) is sealed and attached to the upper end face of the substrate (11), the detection reagent units (12) are fixedly arranged between the substrate (11) and the fixing film (13) at intervals, the hollowed-out parts (131) are in one-to-one correspondence with the detection reagent units (12), the middle area of the upper end face of the detection reagent unit (12) is exposed out of the hollowed-out parts (131), and the edge area of the upper end face of the detection reagent unit (12) is sealed and attached to the fixing film (13);

Sealing film (14), fixed membrane (13) are sealed at every fretwork portion (131) all to be pasted sealing film (14), just one side extension of sealing film (14) is provided with easy tear strip (141).

2. A reagent strip according to claim 1, wherein: the base plate (11) is provided with a plurality of positioning holes (102) in a spaced arrangement.

3. A reagent strip according to claim 2, wherein: the substrate (11) is provided with a plurality of detection reagent units (12) in a central axis arrangement mode, and a plurality of positioning holes (102) are formed in two side edges in a distribution mode.

4. A reagent strip according to claim 1, wherein: at least one white balance calibration unit (103) is arranged at the front end of the substrate (11).

5. A reagent strip according to any one of claims 1-4, wherein: the substrate (11) is a light-transmitting flexible material.

6. A reagent strip according to claim 5, wherein: the substrate (11) is a PET plate, PMMA film or PC film.

7. A reagent strip consumable, characterized in that: the reagent strip (1) is characterized by comprising a receiving cylinder (3), a discharging cylinder (2) and the reagent strip (1) according to any one of claims 1-6, wherein the front end of the reagent strip (1) is wound on the receiving cylinder (3), and the rear end of the reagent strip is wound on the discharging cylinder (2).

8. A reagent strip consumable according to claim 7, wherein: the outer surface of the discharging cylinder (2) is a regular polygon prism, and a positioning bulge (21) is fixedly arranged at the edge angle of the regular polygon prism; the positioning holes (102) of the reagent strips (1) are matched with the positioning protrusions (21), and the detection reagent units (12) are positioned on the prism faces of the regular polygon.

9. A reagent strip consumable according to claim 7 or 8, wherein: the rear end of the reagent strip (1) is provided with a rear extension section (101), the discharging barrel (2) is provided with a clamping groove (22), and the rear extension section (101) is clamped in the clamping groove (22).

10. A reagent strip consumable according to claim 9, wherein: the front end of the reagent strip (1) is provided with a front extension section (104), and the front extension section (104) is wound on the receiving cylinder (3).