CN221085636U - Constant-temperature preparation box for production of cytarabine and daunorubicin compound liposome - Google Patents
Constant-temperature preparation box for production of cytarabine and daunorubicin compound liposome Download PDFInfo
- Publication number
- CN221085636U CN221085636U CN202322991406.8U CN202322991406U CN221085636U CN 221085636 U CN221085636 U CN 221085636U CN 202322991406 U CN202322991406 U CN 202322991406U CN 221085636 U CN221085636 U CN 221085636U
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- CN
- China
- Prior art keywords
- rotating shaft
- feeding
- cytarabine
- stirring
- daunorubicin
- Prior art date
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- 238000002360 preparation method Methods 0.000 title claims abstract description 46
- 239000002502 liposome Substances 0.000 title claims abstract description 19
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 title claims abstract description 18
- 229960000684 cytarabine Drugs 0.000 title claims abstract description 18
- 229960000975 daunorubicin Drugs 0.000 title claims abstract description 18
- UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 title claims abstract description 17
- -1 daunorubicin compound Chemical class 0.000 title claims abstract description 15
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 9
- 238000003756 stirring Methods 0.000 claims description 49
- 239000002994 raw material Substances 0.000 claims description 23
- 238000007599 discharging Methods 0.000 claims description 9
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 4
- 239000000463 material Substances 0.000 description 7
- 230000000694 effects Effects 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 238000011282 treatment Methods 0.000 description 3
- 208000032839 leukemia Diseases 0.000 description 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 description 1
- 201000003793 Myelodysplastic syndrome Diseases 0.000 description 1
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000001174 ascending effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000003560 cancer drug Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
The utility model relates to the technical field of medicament preparation and production, and discloses a constant-temperature preparation box for producing cytarabine and daunorubicin compound liposome.
Description
Technical Field
The utility model relates to the technical field of medicament preparation production, in particular to a constant-temperature preparation box for producing cytarabine and daunorubicin compound liposome.
Background
Daunorubicin and cytarabine compound liposomes are a cancer drug for the treatment of adults with newly diagnosed acute myelogenous leukemia, when the leukemia is caused by previous treatments or associated with certain changes in the bone marrow called myelodysplasia, the active substances in the liposomes, daunorubicin and cytarabine have been used for many years for the treatment of leukemia and other types of cancer, they interfere in different ways with the production of new DNA in the cell, which means that the cell cannot grow and reproduce, and eventually dies.
This medicine liposome is in the production process, need stir mixed raw materials and dispersion, consequently, need use agitating unit to accomplish this production technology, but most stirring structure is unipolar single row blade, and stirring efficiency is low, is equipped with a center pin generally, sets up the strip blade in the outside of center pin, and its stirring vane simple structure only can carry out the ascending mixture of horizontal direction to the material and can not overturn the material from the staving to carrying out intensive mixing above, can lead to stirring inhomogeneous like this, and there is stirring dead angle, leads to stirring effect inequality.
Disclosure of utility model
The utility model aims to provide a constant-temperature preparation box for producing cytarabine and daunorubicin compound liposome, which adopts the structure to work, so that the problems that the stirring effect is not ideal because the stirring device in the conventional constant-temperature preparation box for producing cytarabine and daunorubicin compound liposome is simple in structure and can only mix materials horizontally and can not turn the materials from a barrel to the upper surface to fully stir and mix the materials are solved.
In order to achieve the above purpose, the present utility model provides the following technical solutions: the utility model provides a compound liposome production of cytarabine and daunorubicin is with constant temperature preparation case, includes the thermostated container, and the inside of thermostated container is provided with prepares the room, and the top of preparing the room is provided with feeding component, and the inside of preparing the room is provided with stirring subassembly, carries the raw materials through feeding component, makes the raw materials evenly, dispersedly get into and prepares the room, stirs the raw materials through stirring subassembly for the raw materials intensive mixing.
Preferably, the feeding assembly comprises a feeding barrel arranged above the preparation chamber, the inside of the feeding barrel is communicated with the inside of the preparation chamber, a feeding pipe is arranged above the feeding barrel, the feeding pipe extends to the outside of the incubator, a pipe cover is arranged at one end of the feeding pipe, which is positioned outside the incubator, and the feeding pipe is used for feeding materials into the preparation chamber.
Preferably, the inside of a feeding cylinder is provided with a rotating shaft, the upper end of the rotating shaft extends to the outside of the feeding cylinder, a spiral blade is arranged outside the rotating shaft and is attached to the inner wall of the feeding cylinder, raw materials are conveyed through the spiral blade, and the raw materials uniformly and dispersedly enter the preparation chamber to prevent insufficient reaction caused by accumulation.
Preferably, the inside of incubator is provided with drive assembly, and drive assembly is including setting up the motor on the incubator, and the one end of motor is connected with the pivot two, and the one end that the motor was kept away from to the pivot two extends to the inside of preparing the room, and the one end that the pivot is close to the motor is provided with the master gear, drives the rotation of pivot two through the motor, makes stirring assembly in the pivot two stir the mixture to the medicament.
Preferably, a pinion is arranged on one side of the main gear, the pinion is arranged outside the first rotating shaft, one side of the main gear is meshed with one side of the pinion, and the helical blade on the first rotating shaft is used for pushing raw materials into the preparation chamber through the transmission of the pinion by the main gear.
Preferably, the stirring assembly comprises a screw conveying propeller arranged outside a second rotating shaft, a connecting rod is arranged at one end of the second rotating shaft, a mounting plate is arranged at the other end of the connecting rod, a stirring rod is connected to the lower portion of the mounting plate, a stirring arm is arranged outside the stirring rod, raw materials are overturned from a barrel body to the upper side through the screw conveying propeller, and stirring turbulence is increased by matching with the stirring arm, so that the raw materials are fully stirred and mixed.
Preferably, a discharging pipe is arranged below the preparation chamber, the lower end of the discharging pipe extends to the outside of the constant temperature box, and the reacted materials are collected through the discharging pipe.
Compared with the prior art, the utility model has the following beneficial effects:
According to the thermostatic preparation box for producing cytarabine and daunorubicin compound liposome, the motor in the driving assembly controls the rotation of the rotating shaft II connected with the motor, so that the main gear of the rotating shaft II drives the auxiliary gear to drive the spiral blade on the rotating shaft I to push raw materials into the preparation chamber uniformly, at the moment, the spiral conveying paddles arranged outside the rotating shaft II turn the raw materials deposited at the bottom of the preparation chamber from the barrel body to the upper side, and the stirring rod and the stirring arm are matched to increase turbulence in the preparation chamber, increase the stirring speed, reduce stirring dead angles, enable the raw materials to be mixed more fully and improve the reaction effect.
Drawings
FIG. 1 is a schematic view of the structure of the plane of the present utility model;
FIG. 2 is a schematic view of the structure of the interior of the incubator of the present utility model;
FIG. 3 is a schematic diagram of a driving assembly according to the present utility model;
FIG. 4 is a schematic view of the configuration of the preparation chamber of the present utility model;
FIG. 5 is a schematic structural view of the stirring assembly of the present utility model.
In the figure: 1. a constant temperature box; 2. a feeding assembly; 21. a feeding cylinder; 22. a feed pipe; 23. a tube cover; 24. a first rotating shaft; 25. a helical blade; 3. a preparation chamber; 4. a drive assembly; 41. a motor; 42. a second rotating shaft; 43. a main gear; 44. a pinion gear; 5. a stirring assembly; 51. a screw conveyor propeller; 52. a connecting rod; 53. a mounting plate; 54. a stirring rod; 55. a stirring arm; 6. and a discharging pipe.
Detailed Description
The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
For a further understanding of the present utility model, the present utility model will be described in detail with reference to the drawings.
Referring to fig. 1-5, a thermostatic preparation box for producing cytarabine and daunorubicin compound liposome comprises a thermostatic box 1, wherein a preparation chamber 3 is arranged in the thermostatic box 1, a feeding component 2 is arranged above the preparation chamber 3, and a stirring component 5 is arranged in the preparation chamber 3.
The feeding component 2 comprises a feeding cylinder 21 arranged above the preparation chamber 3, the inside of the feeding cylinder 21 is communicated with the inside of the preparation chamber 3, a feeding pipe 22 is arranged above the feeding cylinder 21, the feeding pipe 22 extends to the outside of the constant temperature box 1, a pipe cover 23 is arranged at one end of the feeding pipe 22, which is positioned at the outside of the constant temperature box 1, a rotating shaft 24 is arranged inside the feeding cylinder 21, the upper end of the rotating shaft 24 extends to the outside of the feeding cylinder 21, a helical blade 25 is arranged at the outside of the rotating shaft 24, the helical blade 25 is attached to the inner wall of the feeding cylinder 21, a driving component 4 is arranged inside the constant temperature box 1, the driving component 4 comprises a motor 41 arranged on the constant temperature box 1, one end of the motor 41 is connected with a rotating shaft II 42, one end of the rotating shaft II 42, which is far away from the motor 41, extends to the inside of the preparation chamber 3, one end of the rotating shaft 42, which is close to the motor 41, is provided with a main gear 43, one side of the main gear 43 is provided with a pinion 44, the auxiliary gear 44 is arranged outside the first rotating shaft 24, one side of the main gear 43 is meshed with one side of the auxiliary gear 44, the stirring assembly 5 comprises a screw conveying propeller 51 arranged outside the second rotating shaft 42, one end of the second rotating shaft 42 is provided with a connecting rod 52, the other end of the connecting rod 52 is provided with a mounting plate 53, a stirring rod 54 is connected below the mounting plate 53, a stirring arm 55 is arranged outside the stirring rod 54, a discharging pipe 6 is arranged below the preparation chamber 3, the lower end of the discharging pipe 6 extends outside the incubator 1, the second rotating shaft 42 connected with the discharging pipe is controlled to rotate by a motor 41 in the driving assembly 4, so that the main gear 43 of the second rotating shaft 42 drives the auxiliary gear 44 to drive a screw blade 25 on the first rotating shaft 24 to push raw materials into the preparation chamber 3 uniformly, at the moment, the screw conveying propeller 51 arranged outside the second rotating shaft 42 turns the raw materials deposited at the bottom of the preparation chamber 3 from the upper surface of the barrel, the stirring rod 54 and the stirring arm 55 are matched to increase turbulence in the preparation chamber, increase the stirring speed, reduce stirring dead angles, enable raw materials to be more fully mixed and improve the reaction effect.
Working principle: firstly, the motor 41 in the driving assembly 4 controls the rotation of the second rotating shaft 42 connected with the motor, so that the main gear 43 of the second rotating shaft 42 drives the auxiliary gear 44 to drive the spiral blade 25 on the first rotating shaft 24 to push raw materials into the preparation chamber 3 uniformly, at the moment, the spiral conveying propeller 51 arranged outside the second rotating shaft 42 turns the raw materials deposited at the bottom of the preparation chamber 3 from the barrel body to the upper side, and the stirring rod 54 and the stirring arm 55 are matched to increase turbulence in the preparation chamber, increase the stirring speed, reduce the stirring dead angle, enable the raw materials to be mixed more fully and improve the reaction effect.
It is noted that relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present utility model have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the utility model, the scope of which is defined in the appended claims and their equivalents.
Claims (7)
1. The utility model provides a compound liposome production of cytarabine and daunorubicin is with constant temperature preparation case, includes thermostated container (1), and the inside of thermostated container (1) is provided with prepares room (3), its characterized in that: the upper side of preparing room (3) is provided with feeding subassembly (2), and the inside of preparing room (3) is provided with stirring subassembly (5), carries the raw materials through feeding subassembly (2), makes the raw materials evenly, dispersedly get into preparing room (3), stirs the raw materials through stirring subassembly (5) for the raw materials intensive mixing.
2. The thermostatic preparation box for producing cytarabine and daunorubicin compound liposome according to claim 1, wherein the feeding component (2) comprises a feeding cylinder (21) arranged above the preparation chamber (3), the inside of the feeding cylinder (21) is communicated with the inside of the preparation chamber (3), a feeding pipe (22) is arranged above the feeding cylinder (21), the feeding pipe (22) extends to the outside of the incubator (1), and a pipe cover (23) is arranged at one end of the feeding pipe (22) positioned at the outside of the incubator (1).
3. The thermostatic preparation box for producing cytarabine and daunorubicin compound liposome according to claim 2, wherein a first rotating shaft (24) is arranged in the feeding barrel (21), the upper end of the first rotating shaft (24) extends to the outer part of the feeding barrel (21), a helical blade (25) is arranged on the outer part of the first rotating shaft (24), and the helical blade (25) is attached to the inner wall of the feeding barrel (21).
4. The thermostatic preparation box for producing cytarabine and daunorubicin compound liposome according to claim 1, wherein a driving component (4) is arranged in the incubator (1), the driving component (4) comprises a motor (41) arranged on the incubator (1), one end of the motor (41) is connected with a second rotating shaft (42), one end, far away from the motor (41), of the second rotating shaft (42) extends to the inside of the preparation chamber (3), and one end, close to the motor (41), of the second rotating shaft (42) is provided with a main gear (43).
5. The thermostatic preparation box for producing cytarabine and daunorubicin compound liposome according to claim 4, wherein a pinion (44) is arranged on one side of the main gear (43), the pinion (44) is arranged outside the first rotating shaft (24), and one side of the main gear (43) is meshed with one side of the pinion (44).
6. The thermostatic preparation box for producing cytarabine and daunorubicin compound liposome according to claim 1, wherein the stirring assembly (5) comprises a screw conveying propeller (51) arranged outside a second rotating shaft (42), a connecting rod (52) is arranged at one end of the second rotating shaft (42), a mounting plate (53) is arranged at the other end of the connecting rod (52), a stirring rod (54) is connected below the mounting plate (53), and a stirring arm (55) is arranged outside the stirring rod (54).
7. The thermostatic preparation box for producing cytarabine and daunorubicin compound liposome according to claim 1, wherein a discharging pipe (6) is arranged below the preparation chamber (3), and the lower end of the discharging pipe (6) extends to the outside of the incubator (1).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322991406.8U CN221085636U (en) | 2023-11-07 | 2023-11-07 | Constant-temperature preparation box for production of cytarabine and daunorubicin compound liposome |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322991406.8U CN221085636U (en) | 2023-11-07 | 2023-11-07 | Constant-temperature preparation box for production of cytarabine and daunorubicin compound liposome |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN221085636U true CN221085636U (en) | 2024-06-07 |
Family
ID=91317359
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202322991406.8U Active CN221085636U (en) | 2023-11-07 | 2023-11-07 | Constant-temperature preparation box for production of cytarabine and daunorubicin compound liposome |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN221085636U (en) |
-
2023
- 2023-11-07 CN CN202322991406.8U patent/CN221085636U/en active Active
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