CN220817457U - Buffer solution conveying and cleaning pipeline system - Google Patents
Buffer solution conveying and cleaning pipeline system Download PDFInfo
- Publication number
- CN220817457U CN220817457U CN202322323024.8U CN202322323024U CN220817457U CN 220817457 U CN220817457 U CN 220817457U CN 202322323024 U CN202322323024 U CN 202322323024U CN 220817457 U CN220817457 U CN 220817457U
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- pipeline
- cleaning
- communicated
- buffer
- liquid inlet
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- 238000004140 cleaning Methods 0.000 title claims abstract description 81
- 239000007853 buffer solution Substances 0.000 title claims abstract description 34
- 239000007788 liquid Substances 0.000 claims abstract description 84
- 239000000872 buffer Substances 0.000 claims abstract description 31
- 238000004891 communication Methods 0.000 claims description 20
- 238000003860 storage Methods 0.000 claims description 12
- 238000011084 recovery Methods 0.000 claims description 10
- 238000005406 washing Methods 0.000 claims 7
- 238000011010 flushing procedure Methods 0.000 claims 5
- 239000000463 material Substances 0.000 abstract description 10
- 238000004519 manufacturing process Methods 0.000 abstract description 7
- 239000000243 solution Substances 0.000 description 9
- 238000000034 method Methods 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 238000010926 purge Methods 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000011550 stock solution Substances 0.000 description 2
- 150000001450 anions Chemical class 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000005352 clarification Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
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- Pipeline Systems (AREA)
Abstract
The utility model provides a buffer solution conveying and cleaning pipeline system, which belongs to the technical field of biological pharmacy and comprises a transfer pipeline, a cleaning pipeline and a plurality of target devices. The liquid inlet end of the transfer pipeline is communicated with buffer liquid supply equipment; the liquid inlet end of the cleaning pipeline is communicated with a cleaning liquid supply device; the target equipment is communicated with a liquid inlet pipeline, the liquid inlet pipeline is communicated with a transfer pipeline through a first pipeline, a first switching valve is arranged on the first pipeline, the liquid inlet pipeline is communicated with a cleaning pipeline through a second pipeline, and a second switching valve is arranged on the second pipeline; the first switching valve and the second switching valve are switched on and off so that the target equipment is switched to be communicated with the transfer pipeline or the cleaning pipeline through the corresponding liquid inlet pipeline. According to the buffer solution conveying and cleaning pipeline system, each target device can selectively convey and clean materials, so that the simultaneous conveyance and cleaning of materials of different pipelines of the same buffer solution of a plurality of target devices are realized, and the production efficiency is improved.
Description
Technical Field
The utility model belongs to the technical field of biological pharmacy, and particularly relates to a buffer solution conveying and cleaning pipeline system.
Background
During the production of biopharmaceutical stock solutions, large amounts of buffer are required in both the separation and purification stages, e.g., upstream clarification filtration systems, downstream multi-step chromatography (affinity, anion, cation etc.).
The process equipment mentioned above may require the same buffer for its use. This may result in a single buffer reservoir being supplied to multiple process targets. One buffer reservoir supplies a plurality of target devices, each of which can be supplied with buffer via a transfer line. The material transfer pipelines need to be cleaned regularly at the same time, and the cleaning pipelines are usually communicated with the transfer pipelines, so that the material transfer pipelines can be cleaned sequentially through the cleaning pipelines only after all materials are transferred. Therefore, the problem of production scheduling is related, the scheduling time of the whole process is prolonged, the working time of workers is prolonged, and the production efficiency is greatly affected.
Disclosure of utility model
The utility model aims to provide a buffer solution conveying and cleaning pipeline system, which can solve the problem that the material conveying and cleaning of different pipelines of the same buffer solution are simultaneously carried out, and improves the production efficiency.
In order to achieve the above purpose, the utility model adopts the following technical scheme: there is provided a buffer delivery and wash line system comprising:
the liquid inlet end of the transfer pipeline is communicated with buffer liquid supply equipment;
the liquid inlet end of the cleaning pipeline is communicated with a cleaning liquid supply device;
The liquid inlet pipeline is communicated with the transfer pipeline through a first pipeline, a first switching valve is arranged on the first pipeline, the liquid inlet pipeline is communicated with the cleaning pipeline through a second pipeline, and a second switching valve is arranged on the second pipeline;
The first switching valve and the second switching valve are switched on and off, so that the target equipment is switched and communicated with the transfer pipeline or the cleaning pipeline through the corresponding liquid inlet pipeline.
In one possible implementation, the liquid inlet pipeline is provided with a liquid inlet valve.
In one possible implementation, the transfer line is provided with a first on-off valve.
In one possible implementation, the cleaning pipeline is provided with a second on-off valve.
In one possible implementation, the first switching valve and the second switching valve are both solenoid diaphragm valves.
In one possible implementation, the buffer solution supply device is a buffer solution storage tank, and the liquid inlet end of the transfer pipeline is communicated with the bottom of the buffer solution storage tank; the cleaning liquid supply equipment is a cleaning liquid storage tank, and the liquid inlet end of the cleaning pipeline is communicated with the bottom of the cleaning liquid storage tank.
In one possible implementation, the transfer line and the purge line are each provided with a flow meter and a power pump.
In one possible implementation, the liquid discharge end of the transfer pipeline is communicated with a buffer liquid recovery tank, and the liquid discharge end of the cleaning pipeline is communicated with a cleaning liquid recovery tank.
In one possible implementation manner, a communication pipeline is arranged between the adjacent target devices, a liquid inlet end of the communication pipeline is communicated with the top of the target device at the front side, a liquid outlet end of the communication pipeline is communicated with the bottom of the target device at the rear side, and a third opening and closing valve is arranged on the communication pipeline.
The buffer solution conveying and cleaning pipeline system provided by the utility model has the beneficial effects that: compared with the prior art, the buffer solution is conveyed in the transfer pipeline, and the cleaning solution is conveyed in the cleaning pipeline. The liquid inlet pipeline of the target equipment is communicated with the transfer pipeline through a first pipeline, the liquid inlet pipeline of the target equipment is communicated with the cleaning pipeline through a second pipeline, a first switching valve is arranged on the first pipeline, and a second switching valve is arranged on the second pipeline. The first switching valve and the second switching valve are switched on and off so that the target equipment is switched to be communicated with the transfer pipeline or the cleaning pipeline through the corresponding liquid inlet pipeline. Each target device can selectively carry out material conveying and cleaning, so that the simultaneous carrying out of material conveying and cleaning of different pipelines of the same buffer solution of a plurality of target devices is realized, and the production efficiency is improved.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present utility model, the drawings that are needed in the embodiments or the description of the prior art will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present utility model, and that other drawings can be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a block diagram of a buffer delivery and purge piping system according to an embodiment of the present utility model;
Fig. 2 is a block diagram of a communication pipeline provided between adjacent target devices according to an embodiment of the present utility model.
Reference numerals illustrate:
1. A transfer line; 2. cleaning a pipeline; 3. a target device; 4. a liquid inlet pipeline; 5. a first pipeline; 6. a second pipeline; 7. a liquid inlet valve; 8. a first switching valve; 9. a second switching valve; 10. a first on-off valve; 11. a second opening and closing valve; 12. a buffer storage tank; 13. a cleaning liquid storage tank; 14. a flow meter; 15. a power pump; 16. a buffer recovery tank; 17. a cleaning liquid recovery tank; 18. a communication pipeline; 19. and thirdly, opening and closing the valve.
Detailed Description
In order to make the technical problems, technical schemes and beneficial effects to be solved more clear, the utility model is further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the utility model.
Referring to fig. 1, a buffer delivery and cleaning pipeline system according to the present utility model will now be described. A buffer solution conveying and cleaning pipeline system comprises a transfer pipeline 1, a cleaning pipeline 2 and a plurality of target devices 3.
The liquid inlet end of the transfer pipeline 1 is communicated with buffer liquid supply equipment; the liquid inlet end of the cleaning pipeline 2 is communicated with a cleaning liquid supply device; each target device 3 is communicated with a liquid inlet pipeline 4, the liquid inlet pipelines 4 are communicated with a transfer pipeline 1 through a first pipeline 5, a first switching valve 8 is arranged on the first pipeline 5, the liquid inlet pipelines 4 are communicated with a cleaning pipeline 2 through a second pipeline 6, and a second switching valve 9 is arranged on the second pipeline 6; the first switching valve 8 and the second switching valve 9 are switched on and off so that the target device 3 is switched to be communicated with the transfer pipeline 1 or the cleaning pipeline 2 through the corresponding liquid inlet pipeline 4.
Compared with the prior art, the buffer liquid conveying and cleaning pipeline system provided by the utility model has the advantages that the buffer liquid is conveyed in the transfer pipeline 1, and the cleaning liquid is conveyed in the cleaning pipeline 2. The liquid inlet pipeline 4 of the target equipment 3 is communicated with the transfer pipeline 1 through a first pipeline 5, the liquid inlet pipeline 4 of the target equipment 3 is communicated with the cleaning pipeline 2 through a second pipeline 6, a first switching valve 8 is arranged on the first pipeline 5, and a second switching valve 9 is arranged on the second pipeline 6. The first switching valve 8 and the second switching valve 9 are switched on and off so that the target device 3 is switched to be communicated with the transfer pipeline 1 or the cleaning pipeline 2 through the corresponding liquid inlet pipeline 4. Each target device 3 can selectively carry out material conveying and cleaning, so that the simultaneous carrying out of material conveying and cleaning of different pipelines of the same buffer solution of a plurality of target devices 3 is realized, and the production efficiency is improved.
Wherein the target device 3 is a tank body device such as a separation tank or a purification tank of pharmaceutical stock solution.
The liquid inlet pipeline 4 is provided with a liquid inlet valve 7, and the liquid inlet valve 7 is in an open state when the target device 3 needs to receive buffer liquid or cleaning liquid, and is in a closed state when working independently.
The transfer pipeline 1 is provided with a first opening and closing valve 10, and when the transfer pipeline 1 needs to convey the buffer solution to the target equipment 3, the first opening and closing valve 10 is in a closed state, so that the buffer solution can be guaranteed to be conveyed to the target equipment 3 with the required buffer solution. When the first switching valve 8 of the corresponding first pipeline 5 needs to be switched, in order to ensure the continuity of the buffer solution entering other target devices 3, the first opening and closing valve 10 can be opened, and the buffer solution which does not enter the target devices 3 flows into the buffer solution recovery tank 16 at the liquid discharge end of the transfer pipeline 1 for recovery.
The cleaning pipeline 2 is provided with a second opening and closing valve 11, the functions of which are similar to those of the first opening and closing valve 10, and the opening and closing of the cleaning pipeline are realized, so that the cleaning of the target equipment 3 is realized, and when the second switching valve 9 of the second pipeline 6 is switched, the cleaning liquid which does not enter the target equipment 3 is stored in the cleaning liquid recovery tank 17 at the liquid discharge end of the cleaning pipeline 2 for recovery.
The first switching valve 8 and the second switching valve 9 are electromagnetic diaphragm valves, so that accurate and rapid switching of the first pipeline 5 and the second pipeline 6 which are communicated with the same liquid inlet pipeline 4 can be realized, and the automation level is improved.
Specifically, the buffer solution supply device is a buffer solution storage tank 12, and the liquid inlet end of the transfer pipeline 1 is communicated with the bottom of the buffer solution storage tank 12; the cleaning supply equipment is a cleaning liquid storage tank 13, and the liquid inlet end of the cleaning pipeline 2 is communicated with the bottom of the cleaning liquid storage tank 13.
The transfer pipeline 1 and the cleaning pipeline 2 are respectively provided with a flowmeter 14 and a power pump 15, and the flowmeter 14 can monitor the liquid flow in the transfer pipeline 1 and the cleaning pipeline 2 at all times so as to judge the running state of the system. The power pump 15 can provide power for the delivery of the buffer and the cleaning liquid.
In some embodiments, a communication pipeline 18 is arranged between the adjacent target devices 3, the liquid inlet end of the communication pipeline 18 is communicated with the top of the front target device 3, the liquid outlet end of the communication pipeline 18 is communicated with the bottom of the rear target device 3, and a third opening and closing valve 19 is arranged on the communication pipeline 18.
In this embodiment, a communication pipeline 18 is disposed between the adjacent target devices 3, the plurality of communication pipelines 18 form a serial pipeline among the plurality of target devices 3, if all the plurality of target devices 3 need to receive the buffer solution or the cleaning solution, the third on/off valves 19 on all the communication pipelines 18 are opened, the buffer solution or the cleaning solution simultaneously enters the plurality of target devices 3, and since the plurality of target devices 3 have a backward sequence of the liquid in the whole system, the front target device 3 will be filled with the buffer solution or the cleaning solution preferentially, and at this time, the redundant buffer solution or the cleaning solution in the front target device 3 can be conveyed to the rear target device 3 by the communication pipeline 18, so that the efficiency of the buffer solution or the cleaning solution entering the plurality of target devices 3 can be improved as a whole. In addition, under the actual working condition, different target devices 3 have certain difference in capacity, the communication pipeline 18 is arranged in the adjacent target devices 3, and under the opening state of the third opening and closing valve 19, the target device 3 with smaller capacity is filled with buffer solution or cleaning solution preferentially, so that redundant buffer solution or cleaning solution can be conveyed to the target device 3 with larger capacity through the communication pipeline 18, and the liquid conveying efficiency of the whole system can be greatly improved.
The foregoing description of the preferred embodiments of the utility model is not intended to be limiting, but rather is intended to cover all modifications, equivalents, and alternatives falling within the spirit and principles of the utility model.
Claims (9)
1. A buffer delivery and wash line system, comprising:
the buffer solution supplying device is characterized by comprising a transfer pipeline (1), wherein the liquid inlet end of the transfer pipeline (1) is communicated with buffer solution supplying equipment;
The cleaning device comprises a cleaning pipeline (2), wherein a liquid inlet end of the cleaning pipeline (2) is communicated with a cleaning liquid supply device;
Each target device (3) is communicated with a liquid inlet pipeline (4), the liquid inlet pipelines (4) are communicated with the transfer pipeline (1) through a first pipeline (5), a first switching valve (8) is arranged on the first pipeline (5), the liquid inlet pipelines (4) are communicated with the cleaning pipeline (2) through a second pipeline (6), and a second switching valve (9) is arranged on the second pipeline (6);
The first switching valve (8) and the second switching valve (9) are switched on and off, so that the target equipment (3) is switched to be communicated with the transfer pipeline (1) or the cleaning pipeline (2) through the corresponding liquid inlet pipeline (4).
2. Buffer delivery and washing line system according to claim 1, characterized in that the inlet line (4) is provided with an inlet valve (7).
3. Buffer delivery and washing line system according to claim 1, characterized in that the transfer line (1) is provided with a first on-off valve (10).
4. Buffer delivery and flushing line system according to claim 1, characterized in that the flushing line (2) is provided with a second on-off valve (11).
5. Buffer transfer and flushing piping system according to claim 1, characterized in that said first switching valve (8) and said second switching valve (9) are electromagnetic diaphragm valves.
6. Buffer delivery and washing line system according to claim 1, characterized in that the buffer supply device is a buffer tank (12), the liquid inlet end of the transfer line (1) being connected to the bottom of the buffer tank (12); the cleaning liquid supply equipment is a cleaning liquid storage tank (13), and the liquid inlet end of the cleaning pipeline (2) is communicated with the bottom of the cleaning liquid storage tank (13).
7. Buffer delivery and flushing line system according to claim 1, characterized in that the transfer line (1) and the flushing line (2) are provided with a flow meter (14) and a power pump (15).
8. Buffer delivery and washing line system according to claim 1, characterized in that the discharge end of the transfer line (1) is connected to a buffer recovery tank (16) and the discharge end of the washing line (2) is connected to a washing liquid recovery tank (17).
9. A buffer delivery and washing line system according to any of claims 1-8, characterized in that a communication line (18) is arranged between adjacent target devices (3), the liquid inlet end of the communication line (18) is connected to the top of the target device (3) on the front side, the liquid outlet end of the communication line (18) is connected to the bottom of the target device (3) on the rear side, and a third opening/closing valve (19) is arranged on the communication line (18).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322323024.8U CN220817457U (en) | 2023-08-28 | 2023-08-28 | Buffer solution conveying and cleaning pipeline system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202322323024.8U CN220817457U (en) | 2023-08-28 | 2023-08-28 | Buffer solution conveying and cleaning pipeline system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220817457U true CN220817457U (en) | 2024-04-19 |
Family
ID=90675046
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202322323024.8U Active CN220817457U (en) | 2023-08-28 | 2023-08-28 | Buffer solution conveying and cleaning pipeline system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220817457U (en) |
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2023
- 2023-08-28 CN CN202322323024.8U patent/CN220817457U/en active Active
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