CN220411311U

CN220411311U - RNA early diagnosis detection device for non-small cell lung cancer circulating tumor

Info

Publication number: CN220411311U
Application number: CN202321788764.2U
Authority: CN
Inventors: 王钊哲; 宫鹏娟; 朱克森
Original assignee: Henan Ruiying Biotechnology Co ltd
Current assignee: Henan Ruiying Biotechnology Co ltd
Priority date: 2023-07-10
Filing date: 2023-07-10
Publication date: 2024-01-30
Anticipated expiration: 2033-07-10

Abstract

The utility model discloses an early diagnosis detection device for non-small cell lung cancer circulating tumor RNA, which belongs to the technical field of biomedical equipment.

Description

RNA early diagnosis detection device for non-small cell lung cancer circulating tumor

Technical Field

The utility model relates to the technical field of biomedical equipment, in particular to a non-small cell lung cancer circulating tumor RNA early diagnosis detection device.

Background

Prior to the day, a recent study demonstrated that lung cancer can be diagnosed by detecting tumor RNA absorbed in circulating platelets. Since platelet cells have no nuclei, all of the RNA found in platelets is either from megakaryocytes (cells that form platelets in bone marrow) or from RNA absorbed by platelets as they circulate in the blood, and in order to detect RNA that originates from tumor cells and is eventually absorbed by platelets, researchers have found that they can diagnose non-small cell lung cancer by detecting tumor RNA absorbed by circulating platelets (also known as thrombotic cells), with a diagnostic accuracy of approximately 90%.

When detecting, need use patient blood sample, after medical personnel generally take blood sample, pour into the test tube to paste the label on the test tube wall, then place in the kit one by one, but when detecting quantity (test tube quantity) more, the rear side test tube will be shielded, and medical personnel can't clear see the label information on the rear side test tube wall, can't be accurate take out required test tube, need one by one discrimination, comparatively troublesome.

Therefore, the utility model provides a non-small cell lung cancer circulating tumor RNA early diagnosis detection device, which solves the problem that medical staff is inconvenient to observe rear side test tube label information when more test tubes are arranged in a kit.

Disclosure of Invention

The utility model aims to solve the problems in the prior art, and provides a non-small cell lung cancer circulating tumor RNA early diagnosis detection device.

In order to achieve the above purpose, the present utility model adopts the following technical scheme:

the utility model provides a non-small cell lung cancer circulating tumor RNA early diagnosis detection device, a serial communication port, including upper end open-ended box body, the interval is equipped with multiunit test-tube rack around in the box body, the support bar is installed in the equal rotation of front side test-tube rack left and right sides wall, rear side test-tube rack left and right sides wall all is equipped with the slide rail, all be equipped with on two support bars with the inserted bar that corresponds sideslip rail one-to-one, box body upper end left and right sides all is equipped with the spout of fore-and-aft direction, all slidable mounting has the slider in two spouts, fixed mounting has the end cover between two sliders, two spouts rear end all rotate and install the swivel, the outer disc of swivel is equipped with the draw-in groove that corresponds with the slider, two swivel are all connected with the support bar of corresponding side through belt drive, be equipped with the brake mechanism of swivel on the box body, prevent that the swivel from passively deflecting.

Preferably, the braking mechanism comprises a ratchet wheel fixed on the outer wall of the swivel, the ratchet wheel is meshed with a pawl rotatably installed on the side wall of the box body, an elastic piece is arranged between the pawl and the box body, a deflector rod is rotatably installed on the side wall of the box body, a straight groove is formed in the lower end of the deflector rod, a push rod is inserted into the straight groove, and the push rod is fixed on the side wall of the pawl.

Preferably, the box body has no front side wall, the front side of the box body is rotatably provided with a closing cover, the upper end of the closing cover is provided with a base, the front side of the surface of the end cover is provided with a support corresponding to the base, and a fastener is connected between the base and the support.

Preferably, the base and the support are provided with a plurality of groups, and a fastener is arranged between each group of base and the support.

Preferably, a storage cabinet is arranged on the inner wall of the closing cover, a plurality of storage cavities are arranged in the storage cabinet, and a sealing cover is slidably arranged on the storage cabinet.

Preferably, the test tube rack at the forefront side is fixedly connected with the box body, and the rest test tube racks are vertically and slidably connected with the box body.

Compared with the prior art, the utility model provides the RNA early diagnosis detection device for the circulating tumor of the non-small cell lung cancer, which has the following beneficial effects.

1. When the test tube rack is used, the slide plate is pushed backwards to be inserted into the swivel, then the end cover is placed, the end cover deflects to drive the support rod to deflect through belt transmission, and the support rod jacks up the test tube rack at the rear side through the cooperation between the ejector rod and the slide rail and is distributed in a step mode, so that all the test tube labels at the rear side are exposed, and the test tube rack is convenient to observe and use.

2. According to the utility model, the rotating ring braking mechanism is arranged on the box body, so that after the end cover deflects, the test tube rack cannot fall back due to dead weight, and the stability of the test tube rack is ensured.

3. According to the utility model, the box body is provided with no front side wall, the front side of the box body is rotatably provided with the closing cover, the closing cover is connected with the end cover through the fastener, the inner wall of the closing cover is provided with the storage cabinet, the storage cabinet is internally provided with storage cavities with different specifications and sizes for storing different articles, the space utilization rate is improved, and after the end cover is opened, the closing cover deflects and is horizontally spread on the placing surface, so that the front side of the box body is free from shielding, and the placing of test tubes of the front test tube rack is facilitated.

Additional advantages, objects, and features of the utility model will be set forth in part in the description which follows; and will be apparent to those skilled in the art in part based upon a review of the following; alternatively, the teachings may be directed to practice of the present utility model.

Drawings

Fig. 1 is a schematic diagram of a closure state of a case according to the present utility model.

Fig. 2 is a schematic view of the case of the present utility model in an unfolded state.

Fig. 3 is a schematic perspective view of the utility model with the left side wall of the box body of fig. 2 broken away.

FIG. 4 is a schematic view of a locker and seal cap of the present utility model.

Fig. 5 is a partial schematic view of the utility model at a in fig. 1.

Fig. 6 is a schematic view showing the lifting of the test tube rack after removing the cartridge of fig. 2 according to the present utility model.

Fig. 7 is a partial schematic view of the utility model at B in fig. 6.

Fig. 8 is a schematic view of a braking mechanism of the swivel of fig. 7 in accordance with the utility model.

Fig. 9 is a partial schematic view of the utility model at C in fig. 6.

Fig. 10 is a schematic view of the swivel state (left) when the end cap of the present utility model is closed and the swivel state (right) when the end cap is opened.

In the figure: 1. a case body; 2. a test tube rack; 3. a support rod; 4. a chute; 5. an end cap; 6. a swivel; 7. a drive gear; 8. a driven gear; 9. a slide rail; 10. a ratchet wheel; 11. a pawl; 12. a deflector rod; 13. closing the cover; 14. a base; 15. a support; 16. a fastener; 17. and (5) storing a cabinet.

Detailed Description

The technical solutions of the embodiments of the present utility model will be clearly and completely described below with reference to fig. 1 to 10 of the embodiments of the present utility model, and it is obvious that the described embodiments are only some embodiments of the present utility model, but not all embodiments.

In order to solve the problems existing in the prior art, the embodiment provides a non-small cell lung cancer circulating tumor RNA early diagnosis detection device, which comprises a box body 1 with an opening at the upper end, wherein a plurality of groups of test tube racks 2 are arranged in the box body 1 at intervals from front to back, the front-most test tube rack 2 is fixedly connected with the box body 1, the rest of test tube racks 2 are vertically and slidingly connected with the box body 1, the left side wall and the right side wall of the front-most test tube rack 2 are respectively provided with a support rod 3 in a rotating way, the left side wall and the right side wall of the rear-side test tube rack 2 are respectively provided with a slide rail 9, the two support rods 3 are respectively provided with inserted bars corresponding to the slide rails 9 at the corresponding sides, the left side and the right side of the upper end of the box body 1 are respectively provided with a slide groove 4 in the front-back direction, the sliding blocks are slidably arranged in the two sliding grooves 4, an end cover 5 is fixedly arranged between the two sliding blocks, the width of the sliding grooves 4 is smaller than the thickness of the side wall of the box body 1, the side wall of the end cover 5 can be attached to the upper end face of the box body 1, the rear ends of the two sliding grooves 4 are rotatably provided with rotating rings 6, the outer circular surfaces of the rotating rings 6 are provided with clamping grooves corresponding to the sliding blocks, the two rotating rings 6 are positioned at the rear side wall of the box body 1 where the sliding grooves 4 extend, the two rotating rings 6 are connected with a driving gear 7 rotatably arranged on the side wall of the box body 1 through belt transmission, the driving gear 7 is meshed with a driven gear 8 rotatably arranged on the box body 1, and the driven gear 8 is coaxially connected with a supporting rod 3 at the corresponding side;

one of them swivel 6 stretches out and is fixed with ratchet 10 on the outer wall of spout 4 one side that deviates from box body 1 central line, ratchet 10 meshing has the pawl 11 of rotation installation on box body 1 lateral wall, be equipped with the elastic component between pawl 11 and the box body 1, make pawl 11 always tend to ratchet 10, keep the stability of pawl 11 and ratchet 10 meshing, box body 1 lateral wall rotates installs driving lever 12, be equipped with the torsional spring between driving lever 12 and the box body 1 rotation position, after making stirring driving lever 12, driving lever 12 can automatic re-setting, driving lever 12 lower extreme is equipped with the straight flute, the straight flute inslot has been inserted the ejector pin, the ejector pin is fixed on the lateral wall that pawl 11 is close to ratchet 10 one end.

In this embodiment, the box body 1 has no front side wall, the front side of the box body 1 is rotatably provided with a closing cover 13, the upper end of the closing cover 13 is provided with a plurality of groups of bases 14, the front side of the surface of the end cover 5 is provided with supports 15 corresponding to the bases 14 one by one, each group of bases 14 and each support 15 is connected with a fastener 16, each fastener 16 comprises a screw rod and a nut, the inner wall of the closing cover 13 is provided with a storage cabinet 17, a plurality of storage cavities are arranged in the storage cabinet 17, the storage cavities have different specification and dimensions and are used for placing different objects, the storage cavities can also be provided with a frame body with a special placing groove and are used for storing objects such as droppers and medicament bottles which need to be fixed in a clamping position, and the storage cabinet 17 is provided with a sealing cover in a sliding manner so as to avoid the objects from leaking.

In this embodiment, the box body 1 is provided with a lifting measure, which can be any one of a handle and a lifting rope, when the box body is a handle, the handle is in an inverted U shape, the cantilevers at two ends of the handle are respectively fixed at the upper ends of the two sliding grooves 4, the distance between the handle and the sliding grooves 4 is greater than the height of the support 15, and the box body 1 can be lifted and transferred by holding the handle at the moment; when the lifting rope is lifted, the two ends of the lifting rope are respectively fixed at the upper ends of the two sliding grooves 4, and the box body 1 can be moved by holding the lifting rope or carrying the lifting rope on shoulders.

In this embodiment, the rear ends of two sliding grooves 4 are fixed with the gag lever post between swivel 6 and rearmost test-tube rack 2, and gag lever post diapire is laminated with end cover 5 upper surface, and the rear end is not supported spacing and is easy the perk when avoiding end cover 5 to fold, the compactness when guaranteeing end cover 5 to fold.

In this embodiment, a semiconductor refrigeration sheet is disposed in the box 1 (the semiconductor refrigeration sheet uses peltier effect, that is, when there is a loop formed by different conductors through which current flows, besides irreversible joule heat is generated, heat absorption and heat release phenomena occur at joints of different conductors respectively along with different current directions), so that the storage of a sample is facilitated, a power supply electrically connected with the semiconductor refrigeration sheet is disposed in a gap of the box 1, the power supply is a rechargeable storage battery and can be used in a rechargeable and reciprocating manner, a controller is electrically connected to the power supply, the controller is embedded in the outer side wall of the box 1, and the controller can control the opening and closing of the semiconductor refrigeration sheet and the temperature control; the heat preservation has been laid to box body 1 inner wall, closes and has laid the heat preservation between lid 13 inner wall and the box body 1 diapire, closes and is equipped with sealing means, such as magnetic seal strip or rubber circle between lid 13 inner wall left and right sides and end cover 5 diapire and the box body 1 upper end, avoids the air conditioning to spill over from gap department.

In this embodiment, friction damping is provided between the rotation connection portion of the swivel 6 and the chute 4, the rotation portion of the lever 12 and the box body 1, and the rotation connection portion of the closing cover 13 and the box body 1, so as to increase the rotation resistance and avoid the deflection of the component in the non-autonomous driving state.

In this embodiment, the left and right sides of the box body 1 are all provided with shields, which cover the brake mechanism, the driving gear 7, the driven gear 8 and the belt transmission mechanism, and only the upper end of the deflector rod 12 is leaked, so that the user is prevented from being injured by the component clamp, and the influence on the use caused by the fact that external foreign matters block the transmission part is avoided.

The specific implementation process of the utility model comprises the following steps:

when in use, the fastener 16 is screwed, so that the support 15 is separated from the base 14, namely, the braking limit of the end cover 5 is released, then the end cover 5 is pushed and pulled backwards until the sliding block enters the clamping groove of the swivel 6, at the moment, the front end of the end cover 5 passes through the limiting rod and is positioned at the rear side of the limiting rod, the end cover 5 is completely separated from the upper end face of the box body 1, the end cover 5 is put down, the end cover 5 deflects, as shown in figure 2, the end cover 5 deflects to drive the swivel 6 to rotate anticlockwise, the swivel 6 drives the driving gear 7 to rotate anticlockwise through belt transmission, the driving gear 7 drives the driven gear 8 to rotate clockwise, the driven gear 8 drives the supporting rod 3 to rotate clockwise, the supporting rod 3 rotates clockwise, the test tube rack 2 at the rear side is jacked up through the ejector rod and is in a step shape, as shown in figure 2, test tube labels at the rear side can be exposed, the inquiry, the picking and placing of medical staff are facilitated, in the anticlockwise rotation process of the swivel 6, the ratchet 10 rotates along with the swivel 6, the top end of the pawl 11 is attached to the tooth surface of the ratchet 10 to slide until the swivel 6 stops rotating, the pawl 11 is propped against the tooth root of the ratchet 10 again, the swivel 6 is braked, the end cover 5 is braked along with the swivel 6, the supporting rod 3 is braked through belt transmission, the driving gear 7 and the driven gear 8, the test tube rack 2 keeps stable in lifting state and cannot slide down due to gravity, after the test tube rack 2 is separated from the base 14, the closing cover 13 is also lost to limit, the closing cover 13 is opened, the front side of the box body 1 leaks out, the forefront test tube rack 2 is convenient to observe, the box body 1 has no front side wall, when the test tube is placed on the forefront test tube rack 2, no side wall shields an arm, the arm can naturally drop down to place, the test tube placing action is more convenient and natural, after the closing cover 13 is opened, the storage cabinet 17 leaks out, the sealing cover is opened, and articles can be used, the inner space of the box body 1 is reasonably utilized, and the space utilization rate is improved.

After the use is finished, the end cover 5 is supported by one hand, the deflector rod 12 is stirred by the other hand, the deflector rod 12 deflects to drive the pawl 11 to deflect, so that the pawl 11 is separated from the ratchet 10, the rotating ring 6 loses the brake, the end cover 5 loses the limit, the end cover 5 is lifted, the upper end of the end cover 5 is leveled with the upper end of the box body 1, in the process, the end cover 5 drives the rotating ring 6 to rotate clockwise, the rotating ring 6 drives the driving gear 7 to rotate clockwise through belt transmission, the driving gear 7 drives the driven gear 8 to rotate anticlockwise, the driven gear 8 drives the supporting rod 3 to rotate anticlockwise, the test tube rack 2 at the rear side is gradually lowered to reset, the inside of the box body 1 is contracted, the end cover 5 is pulled, the end cover 5 is moved forwards along the chute 4 until the box body 1 is closed, the closing cover 13 is closed, the support 15 is connected with the base 14 through the fastener 16, at the moment, the box body 1 is resealed, the object transfer can be realized, and convenience and practicability are realized.

The present utility model is not limited to the above-mentioned embodiments, and any person skilled in the art, based on the technical solution of the present utility model and the inventive concept thereof, can be replaced or changed within the scope of the present utility model.

In the description of the present specification, a description referring to terms "one embodiment," "some embodiments," "examples," "specific examples," or "some examples," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present utility model. In this specification, schematic representations of the above terms are not necessarily directed to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, the different embodiments or examples described in this specification and the features of the different embodiments or examples may be combined and combined by those skilled in the art without contradiction.

While embodiments of the present utility model have been shown and described above, it will be understood that the above embodiments are illustrative and not to be construed as limiting the utility model, and that variations, modifications, alternatives and variations may be made to the above embodiments by one of ordinary skill in the art within the scope of the utility model.

Claims

1. The utility model provides a detection device is diagnosed early to non-small cell lung cancer circulation tumour RNA, a serial communication port, including upper end open-ended box body (1), the interval is equipped with multiunit test-tube rack (2) around in box body (1), support bar (3) are all installed in front side test-tube rack (2) left and right sides wall rotation, rear side test-tube rack (2) left and right sides wall all is equipped with slide rail (9), all be equipped with on two support bars (3) with correspond the inserted bar of side slide rail (9) one-to-one, all be equipped with spout (4) of fore-and-aft direction in box body (1) upper end left and right sides, all slidable mounting has the slider in two spouts (4), fixed mounting has end cover (5) between two sliders, swivel (6) are all installed in the rotation of two spout (4) rear end, swivel (6) outer disc is equipped with the draw-in groove that corresponds with the slider, two swivel (6) all are connected through band drive and support bar (3) of corresponding side, be equipped with the brake mechanism of swivel (6) on box body (1), prevent that swivel (6) from passively deflecting.

2. The device for early diagnosis of non-small cell lung cancer circulating tumor RNA (ribonucleic acid) according to claim 1, wherein the braking mechanism comprises a ratchet wheel (10) fixed on the outer wall of a swivel (6), the ratchet wheel (10) is meshed with a pawl (11) rotatably installed on the side wall of the box body (1), an elastic piece is arranged between the pawl (11) and the box body (1), a deflector rod (12) is rotatably installed on the side wall of the box body (1), a straight groove is formed in the lower end of the deflector rod (12), a push rod is inserted into the straight groove, and the push rod is fixed on the side wall of the pawl (11).

3. The non-small cell lung cancer circulating tumor RNA early diagnosis detection device according to claim 1, wherein the box body (1) has no front side wall, the front side of the box body (1) is rotatably provided with a closing cover (13), the upper end of the closing cover (13) is provided with a base (14), the front side of the surface of the end cover (5) is provided with a support (15) corresponding to the base (14), and a fastener (16) is connected between the base (14) and the support (15).

4. The non-small cell lung cancer circulating tumor RNA early diagnosis detection device according to claim 3, wherein the base (14) and the support (15) are provided with a plurality of groups, and a fastener (16) is arranged between each group of base (14) and the support (15).

5. The device for early diagnosis of non-small cell lung cancer circulating tumor RNA according to claim 3, wherein a storage cabinet (17) is arranged on the inner wall of the closing cover (13), a plurality of storage cavities are arranged in the storage cabinet (17), and a sealing cover is slidably arranged on the storage cabinet (17).

6. The non-small cell lung cancer circulating tumor RNA early diagnosis detection device according to claim 1, wherein the forefront test tube rack (2) is fixedly connected with the box body (1), and the rest test tube racks (2) are vertically and slidably connected with the box body (1).