CN220284030U - Liquid drop detection box for digital PCR - Google Patents
Liquid drop detection box for digital PCR Download PDFInfo
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- CN220284030U CN220284030U CN202321432634.5U CN202321432634U CN220284030U CN 220284030 U CN220284030 U CN 220284030U CN 202321432634 U CN202321432634 U CN 202321432634U CN 220284030 U CN220284030 U CN 220284030U
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- 238000001514 detection method Methods 0.000 title claims abstract description 29
- 238000007847 digital PCR Methods 0.000 title claims abstract description 13
- 239000007788 liquid Substances 0.000 title abstract description 14
- 230000007246 mechanism Effects 0.000 claims abstract description 11
- 239000000428 dust Substances 0.000 abstract description 10
- 238000000034 method Methods 0.000 description 6
- 230000009471 action Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 2
- 230000004543 DNA replication Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000003752 polymerase chain reaction Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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Abstract
The utility model relates to the technical field of biomedicine, and discloses a liquid drop detection box for digital PCR, which comprises the following components: the dustproof mechanism comprises a main body and a dustproof mechanism, wherein the dustproof mechanism is arranged in the main body, a fixing plate is fixedly arranged in the main body, the dustproof plate is movably connected in the main body, sliding grooves are formed in two ends of the dustproof plate, the dustproof plate slides on the surface of the fixing plate, a limiting hole I is formed in the right end of the main body, and a limiting mechanism is arranged at the right end of the main body. According to the utility model, the second square rod moves in the first square rod through the tension spring, so that the limiting block moves the front end of the second limiting hole, then the tension is canceled, the spring is reset, and the limiting block enters into the second limiting hole during resetting, so that the limiting plate limits the dust-proof plate, and finally, dust is prevented from entering into the hole groove and affecting the next detection while the dust-proof plate is stored for a long time.
Description
Technical Field
The utility model relates to the technical field of biomedicine, in particular to a liquid drop detection box for digital PCR.
Background
In the field of biotechnology, PCR is particularly popular, namely polymerase chain reaction, which is a molecular biology technology for amplifying specific DNA fragments, and can be regarded as special DNA replication outside a living body, the largest feature of PCR is that a trace amount of DNA can be greatly increased, in order to obtain the number of DNA molecules, PCR droplets are required to be detected, the prior art is to drop the droplets into a hole groove in a detection box, then put the detection box into a detection instrument for detection, after detection is completed, the detection box needs to be stored, dust in air may enter the detection box in the process of long-time storage, and even if the detection box is cleaned, a small amount of dust is still produced in the hole groove, so that the analysis result is affected.
Disclosure of Invention
In order to overcome the defects in the prior art, the utility model provides a liquid drop detection box for digital PCR, which has the advantage of preventing dust from entering the detection box.
In order to achieve the above purpose, the present utility model provides the following technical solutions: a drop detection cartridge for digital PCR, comprising:
the main body is provided with a plurality of grooves,
a dust-proof mechanism arranged in the main body,
wherein the inside of the main body is fixedly provided with a fixed plate, the inside of the main body is movably connected with a dustproof plate, two ends of the dustproof plate are provided with sliding grooves, the dustproof plate slides on the surface of the fixed plate,
a first limiting hole which is arranged at the right end of the main body,
a limiting mechanism arranged at the right end of the main body,
the limiting mechanism comprises a limiting plate, the limiting plate is located at the right end of the main body, the main body and the limiting plate are hinged through a hinge chain, a fixing block is fixedly arranged at the top end of the limiting plate, a limiting hole II is formed in the front end of the fixing block, a fixing rod is fixedly arranged at the right end of the main body, a square rod I is rotationally connected to the surface of the fixing rod, a square rod II is movably connected to the surface of the square rod I, a telescopic rod is fixedly arranged at the bottom end of the inside of the square rod I, a spring is movably connected to the surface of the telescopic rod, and a limiting block is fixedly arranged at the bottom end of the square rod II.
As a preferable technical scheme of the utility model, the bottom end of the main body is provided with the hole grooves, the shape of the bottom end of the hole groove is a cone, and the number of the hole grooves is twenty-five.
As a preferable technical scheme of the utility model, the other end of the telescopic rod is fixedly connected with the rear end of the square rod II, and the springs are fixedly connected with the square rod II and the square rod I.
As a preferable technical scheme of the utility model, the shape of the limiting block is L-shaped, and the rear end of the limiting block is positioned in the second limiting hole.
As a preferable technical scheme of the utility model, the fixing plates are symmetrically arranged around the main body.
As a preferable technical scheme of the utility model, the top end of the dustproof plate is fixedly provided with a semicircular plate, and the semicircular plate is positioned in the first limiting hole.
Compared with the prior art, the utility model has the following beneficial effects:
1. according to the utility model, the dustproof plate is inserted into the first limiting hole, then the dustproof plate is supported through the fixing plate, then the limiting plate is rotated, the left end of the limiting plate is attached to the right end of the main body, then the first square rod is rotated, the second square rod is driven to move by the first square rod, the second square rod is driven to move by the second square rod, the second square rod is driven to move in the first square rod while rotating, the front end of the second limiting hole is moved by the limiting block, then the stretching is canceled, the spring is reset, and the limiting block enters the second limiting hole while resetting, so that the limiting plate limits the dustproof plate, and finally dust is prevented from entering a hole groove while storing for a long time, and the next detection is affected.
2. According to the utility model, twenty-five liquid drops are dripped into the hole groove, then the liquid drops can diffuse in the hole groove, then the main body filled with the liquid drops is put into the detection instrument for detection, and meanwhile, the bottom end of the hole groove is in a conical design, so that the liquid drops in the hole groove can move to the middle part, the phenomenon that the liquid drops cling to the edge of the inside of the hole groove and the liquid drops are vacant in the middle part of the hole groove is prevented, and the detection instrument cannot accurately identify the hole groove, so that the analysis result is influenced.
Drawings
FIG. 1 is a schematic diagram of the structure of the present utility model;
FIG. 2 is a schematic right-side view of the structure of the present utility model;
FIG. 3 is a schematic view showing a dust-proof plate according to the present utility model;
FIG. 4 is a schematic cross-sectional view of the structure of the present utility model;
fig. 5 is an enlarged schematic view of the structure of fig. 2 at a.
In the figure: 1. a main body; 2. a hole groove; 3. a fixing plate; 4. a dust-proof plate; 5. a sliding groove; 6. a first limiting hole; 7. a limiting plate; 8. a hinged chain; 9. a fixed block; 10. a limiting hole II; 11. a fixed rod; 12. square bar I; 13. square bar II; 14. a telescopic rod; 15. a spring; 16. a limiting block; 17. a semicircular plate.
Detailed Description
The following description of the embodiments of the present utility model will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present utility model, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
As shown in fig. 1 to 5, the present utility model provides a droplet detection cartridge for digital PCR, comprising:
the body 1 is provided with a plurality of grooves,
a dust-proof mechanism provided inside the main body 1,
wherein, the fixing plate 3 is fixedly arranged in the main body 1, the dustproof plate 4 is movably connected in the main body 1, the two ends of the dustproof plate 4 are provided with sliding grooves 5, the dustproof plate 4 slides on the surface of the fixing plate 3,
a first limiting hole 6 which is arranged at the right end of the main body 1,
a limiting mechanism arranged at the right end of the main body 1,
wherein, stop gear is including limiting plate 7, limiting plate 7 is located the right-hand member of main part 1, main part 1 and limiting plate 7 are articulated through articulated chain 8, limiting plate 7's top fixed mounting has fixed block 9, spacing hole two 10 have been seted up to the front end of fixed block 9, main part 1's right-hand member fixed mounting has dead lever 11, the surface rotation of dead lever 11 is connected with square pole one 12, square pole one 12's inside swing joint has square pole two 13, square pole one 12 inside bottom fixed mounting has telescopic link 14, telescopic link 14's surface swing joint has spring 15.
After the detection of the operator is finished, when the main body 1 needs to be stored for a long time, the dust-proof plate 4 is inserted into the first limit hole 6, then the sliding groove 5 moves on the surface of the fixed plate 3, so that the fixed plate 3 supports the sliding groove 5, because the main body 1 and the limit plate 7 are hinged through the hinge chain 8, the limit plate 7 is rotated, the left end of the limit plate 7 is contacted with the right end of the main body 1, then the bottom end of the second square rod 13 is contacted with the top end of the fixed block 9 through rotating the first square rod 12, the second square rod 13 is moved towards the front end of the fixed block 9 through the tension spring 15 in rotating the first square rod 12, the second square rod 13 drives the limit block 16 to move, the limit block 16 is far away from the front end of the fixed block 9, then the tension is cancelled, then the limit block 16 is moved backwards by the elasticity of the spring 15, the limit block 16 enters the second limit hole 10, so that the limit plate 7 is limited, the limit plate 7 is limited to the limit the dust-proof plate 4 inside the limit hole 6, so that the main body 1 is in a closed state, and dust is prevented from falling into the inside the hole 2.
Wherein, hole groove 2 has been seted up to the bottom of main part 1, and the shape of hole groove 2 bottom is "circular cone" type, and the quantity of hole groove 2 is twenty-five.
Through the design of hole groove 2, can drip the liquid droplet that needs to detect into hole groove 2, can put into hole groove 2 next, then put into detecting instrument with hole groove 2 that is equipped with the liquid droplet through operating personnel, then in the in-process that detects, because hole groove 2's shape is the toper, and then the liquid droplet in the hole groove 2 can gather to the center, has increased detection efficiency.
The other end of the telescopic rod 14 is fixedly connected with the rear end of the square rod II 13, and the springs 15 are fixedly connected with the square rod II 13 and the square rod I12.
Through the design of telescopic link 14 and spring 15, can make square pole two 13 can remove in square pole one 12's inside in the extension spring 15, make stopper 16 more stable carry out the spacing to limiting plate 7 simultaneously.
The shape of the limiting block 16 is an L shape, and the rear end of the limiting block 16 is located in the second limiting hole 10.
Through the design of stopper 16, when extension spring 15 makes square pole two 13 remove, square pole two 13 also can drive stopper 16 and remove, makes the rear end of stopper 16 be located the front end of spacing hole two 10, then through the elasticity of spring 15, makes stopper 16 get into the inside of spacing hole two 10, carries out spacingly to limiting plate 7, prevents that dust guard 4 from coming off in spacing hole one 6.
Wherein the fixing plate 3 is disposed symmetrically in front and rear with respect to the main body 1.
Through the design of fixed plate 3, when dust guard 4 inserts spacing hole one 6, can be steady support dust guard 4, prevent that dust guard 4 from inclining to one end.
The top end of the dust-proof plate 4 is fixedly provided with a semicircular plate 17, and the semicircular plate 17 is positioned in the first limiting hole 6.
By the design of the semicircular plate 17, when the dustproof plate 4 needs to be taken out of the first limiting hole 6, the dustproof plate 4 can be taken out of the first limiting hole 6 quickly by pressing the semicircular plate 17 to exert force through the gap of the first limiting hole 6.
The working principle and the using flow of the utility model are as follows:
after twenty-five drops are dropped into the hole groove 2 by an operator, then the main body 1 filled with the drops is placed into a detection instrument for detection, and meanwhile, the bottom end of the hole groove 2 is in a conical design, so that the drops in the hole groove 2 can move towards the middle part, the detection efficiency is improved, after detection work is finished, when the drops are required to be stored for a long time, the dust-proof plate 4 is inserted into the limit hole I6, then the dust-proof plate 4 is supported by the fixing plate 3, then the limit plate 7 is rotated, the left end of the limit plate 7 is attached to the right end of the main body 1, then the square rod I12 is rotated, the square rod I12 drives the square rod II 13 to move, the square rod II 13 drives the limit block 16 to move, the extension spring 15 enables the square rod II 13 to move in the square rod I12, the front end of the limit block 16 moves to the limit hole II 10, then the extension spring 15 is canceled, and the limit block 16 enters the interior of the limit hole II 10 when the detection work is finished, so that the limit plate 7 limits the dust-proof plate 4, and finally, the operation flow of the device is finished.
It is noted that relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present utility model have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the utility model, the scope of which is defined in the appended claims and their equivalents.
Claims (6)
1. A drop detection cartridge for digital PCR, characterized by: comprises the following steps:
a main body (1),
a dust-proof mechanism arranged inside the main body (1),
wherein the inside of the main body (1) is fixedly provided with a fixed plate (3), the inside of the main body (1) is movably connected with a dust-proof plate (4), two ends of the dust-proof plate (4) are provided with sliding grooves (5), the dust-proof plate (4) slides on the surface of the fixed plate (3),
a first limiting hole (6) which is arranged at the right end of the main body (1),
the limiting mechanism is arranged at the right end of the main body (1),
wherein, stop gear is including limiting plate (7), limiting plate (7) are located the right-hand member of main part (1), main part (1) and limiting plate (7) are articulated through articulated chain (8), top fixed mounting of limiting plate (7) has fixed block (9), spacing hole two (10) have been seted up to the front end of fixed block (9), the right-hand member fixed mounting of main part (1) has dead lever (11), the surface rotation of dead lever (11) is connected with square pole one (12), the inside swing joint of square pole one (12) has square pole two (13), the inside bottom fixed mounting of square pole one (12) has telescopic link (14), the surface swing joint of telescopic link (14) has spring (15), the bottom fixed mounting of square pole two (13) has stopper (16).
2. A drop test cartridge for digital PCR as in claim 1, wherein: the bottom of the main body (1) is provided with hole grooves (2), the shape of the bottom of the hole grooves (2) is conical, and the number of the hole grooves (2) is twenty-five.
3. A drop test cartridge for digital PCR as in claim 1, wherein: the other end of the telescopic rod (14) is fixedly connected with the rear end of the square rod II (13), and the springs (15) are fixedly connected with the square rod II (13) and the square rod I (12).
4. A drop test cartridge for digital PCR as in claim 1, wherein: the shape of the limiting block (16) is L-shaped, and the rear end of the limiting block (16) is positioned in the second limiting hole (10).
5. A drop test cartridge for digital PCR as in claim 1, wherein: the fixing plates (3) are symmetrically arranged around the main body (1).
6. A drop test cartridge for digital PCR as in claim 1, wherein: the top of the dustproof plate (4) is fixedly provided with a semicircular plate (17), and the semicircular plate (17) is positioned in the first limiting hole (6).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321432634.5U CN220284030U (en) | 2023-06-07 | 2023-06-07 | Liquid drop detection box for digital PCR |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321432634.5U CN220284030U (en) | 2023-06-07 | 2023-06-07 | Liquid drop detection box for digital PCR |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220284030U true CN220284030U (en) | 2024-01-02 |
Family
ID=89339730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202321432634.5U Active CN220284030U (en) | 2023-06-07 | 2023-06-07 | Liquid drop detection box for digital PCR |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220284030U (en) |
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2023
- 2023-06-07 CN CN202321432634.5U patent/CN220284030U/en active Active
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