CN220276123U - Combined microneedle - Google Patents
Combined microneedle Download PDFInfo
- Publication number
- CN220276123U CN220276123U CN202321527245.0U CN202321527245U CN220276123U CN 220276123 U CN220276123 U CN 220276123U CN 202321527245 U CN202321527245 U CN 202321527245U CN 220276123 U CN220276123 U CN 220276123U
- Authority
- CN
- China
- Prior art keywords
- needle body
- needle
- microneedle
- modular
- back plate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 210000002615 epidermis Anatomy 0.000 claims abstract description 7
- 239000007788 liquid Substances 0.000 claims description 14
- 210000003491 skin Anatomy 0.000 claims description 14
- 238000003860 storage Methods 0.000 claims description 10
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 3
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 3
- 229920002307 Dextran Polymers 0.000 claims description 3
- 239000004696 Poly ether ether ketone Substances 0.000 claims description 3
- 239000004952 Polyamide Substances 0.000 claims description 3
- 239000004743 Polypropylene Substances 0.000 claims description 3
- 239000004793 Polystyrene Substances 0.000 claims description 3
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 3
- 229920001577 copolymer Polymers 0.000 claims description 3
- 229960002086 dextran Drugs 0.000 claims description 3
- 229920002674 hyaluronan Polymers 0.000 claims description 3
- 229960003160 hyaluronic acid Drugs 0.000 claims description 3
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 claims description 3
- 239000002184 metal Substances 0.000 claims description 3
- 229910052751 metal Inorganic materials 0.000 claims description 3
- 229920000747 poly(lactic acid) Polymers 0.000 claims description 3
- 229920002647 polyamide Polymers 0.000 claims description 3
- 229920000515 polycarbonate Polymers 0.000 claims description 3
- 239000004417 polycarbonate Substances 0.000 claims description 3
- 229920002530 polyetherether ketone Polymers 0.000 claims description 3
- 239000004626 polylactic acid Substances 0.000 claims description 3
- -1 polypropylene Polymers 0.000 claims description 3
- 229920001155 polypropylene Polymers 0.000 claims description 3
- 229920002223 polystyrene Polymers 0.000 claims description 3
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 3
- 229920000915 polyvinyl chloride Polymers 0.000 claims description 3
- 239000004800 polyvinyl chloride Substances 0.000 claims description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 3
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 3
- 239000010703 silicon Substances 0.000 claims description 3
- 229910052710 silicon Inorganic materials 0.000 claims description 3
- 235000010413 sodium alginate Nutrition 0.000 claims description 3
- 239000000661 sodium alginate Substances 0.000 claims description 3
- 229940005550 sodium alginate Drugs 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 abstract description 13
- 239000002699 waste material Substances 0.000 abstract description 5
- 239000000463 material Substances 0.000 description 11
- 210000004207 dermis Anatomy 0.000 description 6
- 230000007547 defect Effects 0.000 description 4
- 230000000875 corresponding effect Effects 0.000 description 3
- 239000002537 cosmetic Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 210000000434 stratum corneum Anatomy 0.000 description 2
- 230000001960 triggered effect Effects 0.000 description 2
- 239000013543 active substance Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
Landscapes
- Media Introduction/Drainage Providing Device (AREA)
Abstract
The utility model discloses a combined type micro-needle, which comprises a back plate and a needle body arranged on the back plate, wherein the needle body comprises a first needle body fixed on the back plate and a second needle body connected with the first needle body, and the height of the first needle body is not lower than the thickness of a epidermis layer. The combined type microneedle has good mechanical properties, and meanwhile, the waste of effective preparations can be effectively reduced.
Description
Technical Field
The utility model relates to the field of cosmetics, in particular to a combined microneedle.
Background
Microneedles (MN) are a novel physical penetration technique consisting of a plurality of micro-sized fine needle tips connected to a base in an array. The microneedles can be oriented to penetrate the stratum corneum to create a mechanical channel of micron size, and the drug can be placed directly in the epidermis or upper dermis to participate in microcirculation without passing through the stratum corneum, exerting pharmacological responses. In the prior art, the microneedles are all made of non-degradable materials or are made of degradable materials in an integrated structure, and the microneedles made of the non-degradable materials have good mechanical properties, but when in use, the corresponding effective preparations are required to be injected into the skin; while the micro needle prepared from the degradable material can carry the effective preparation to be directly dissolved in the skin, the mechanical property is poor, and the effective preparation in the epidermis layer cannot be effectively absorbed, so that the waste of the effective preparation is caused.
Disclosure of Invention
In order to overcome the defects in the prior art, the utility model aims to provide a combined type microneedle which has good mechanical properties and can effectively reduce the waste of effective preparations.
In order to solve the problems, the technical scheme adopted by the utility model is as follows:
the combined type micro needle comprises a back plate and a needle body arranged on the back plate, wherein the needle body comprises a first needle body fixed on the back plate and a second needle body connected with the first needle body, and the height of the first needle body is not lower than the thickness of a epidermis layer.
Preferably, the first needle body includes a base portion, and the height of the base portion is not lower than the thickness of the skin layer.
Preferably, the base part is cylindrical or frustum-shaped.
Preferably, the first needle body further comprises a needle portion and a connecting portion connected between the base portion and the needle portion.
Preferably, the connecting part is positioned in the middle of the needle body.
Preferably, the connecting part is positioned at the outer edge of the needle body.
Preferably, the needle portion is tapered.
Preferably, the needle comprises a needle body, a needle cover and a liquid storage bag, wherein the liquid storage bag is arranged on the back plate and is positioned at one side of the back plate far away from the needle body; and liquid guide holes which are communicated with the liquid storage bag and the second needle body are formed in the back plate and the first needle body.
Preferably, the first needle body is made of polyvinyl chloride, polyamide, polycarbonate, polyether ether ketone, polystyrene, polypropylene, metal or silicon.
Preferably, the second needle body is made of polyvinyl alcohol, polyvinylpyrrolidone, hyaluronic acid, dextran, sodium alginate, polylactic acid or polylactic acid-glycolic acid copolymer.
Compared with the prior art, the utility model has the beneficial effects that: in the utility model, the first needle body is made of a non-degradable material with good mechanical property, and the second needle body is made of a degradable material matched with an effective preparation; the first needle body has a height not lower than the thickness of the skin layer of the application site. After the needle body penetrates into the skin, the second needle body in the epidermis layer completely enters the dermis layer and is thoroughly absorbed in the dermis layer, so that the waste of the effective preparation is avoided. .
Drawings
FIG. 1 is a schematic diagram of a combined microneedle according to the present utility model;
FIG. 2 is a schematic diagram of a combined microneedle structure according to a first embodiment;
FIG. 3 is a schematic view of the needle structure of FIG. 2;
FIG. 4 is a schematic view of the structure of a needle body in a second embodiment;
FIG. 5 is a schematic view of a combined microneedle structure according to a third embodiment;
FIG. 6 is a schematic view of the needle structure of FIG. 5;
FIG. 7 is a schematic view of the structure of a needle in a fourth embodiment;
FIG. 8 is a schematic view of a combined microneedle structure according to a fifth embodiment;
FIG. 9 is a schematic view of the needle structure of FIG. 8;
FIG. 10 is a schematic view of a needle structure in a sixth embodiment;
wherein 1 is a back plate, 10 is a liquid guide hole, 2 is a needle body, 21 is a first needle body, 211 is a base part, 212 is a connecting part, 213 is a needle head part, 22 is a second needle body, and 3 is a liquid storage bag.
Detailed Description
The utility model is described in further detail below with reference to the drawings and the detailed description.
Referring to fig. 1 to 3, in a first embodiment of the present utility model, a combined type microneedle comprises a back plate 1 and a plurality of needle bodies 2 arranged on the back plate 1, wherein the needle bodies 2 comprise a first needle body 21 fixed on the back plate 1 and a second needle body 22 connected with the first needle body 21, the first needle body 21 is made of a non-degradable material with good mechanical properties, and the second needle body 22 is made of a degradable material matched with an effective preparation; the height of the first needle 21 is not lower than the thickness of the skin layer of the application site. After the needle body 2 penetrates the skin, the second needle body 22 in the epidermis layer completely enters the dermis layer and is thoroughly absorbed in the dermis layer, so that the waste of the effective preparation is avoided.
Specifically, the first needle body 21 includes a base portion 211, the base portion 211 is in a frustum shape, the second needle body 22 is in a cone shape, and is disposed below the first needle body 21, and the two needle bodies are combined to form a cone shape; the height of the base portion 211 is not lower than the thickness of the skin layer.
Referring to fig. 4, in the combined type microneedle structure according to the second embodiment, unlike the first embodiment, the base portion 211 has a cylindrical shape, so that the use of the material of the first microneedle 21 is reduced, and the production cost is reduced.
Referring to fig. 5 to 10, the first needle body 21 includes a base portion 211, and further includes a needle portion 213 and a connection portion 212 connected between the base portion 211 and the needle portion 213. The connecting portion 212 can provide better mechanical properties for the needle body 2, overcomes the defects of poor mechanical properties, poor rigidity and easy breakage of the second needle body 22, and the needle head 213 is preferably in a conical structure, so as to be convenient for penetrating the skin, and overcomes the defect of poor needling effect of the second needle body 22.
Referring to fig. 5 and 6, in the combined type microneedle structure of the third embodiment, unlike the first embodiment, the first needle body 21 further includes a needle portion 213 and a connection portion 212 connected between the base portion 211 and the needle portion 213. The connecting part 212 can provide better mechanical performance for the needle body 2, and overcomes the defects of poor mechanical performance, poor rigidity and easy breakage of the second needle body 22; the tip portion 213 compensates for the disadvantage of the poor mechanical properties of the second needle body 22 and the poor needling effect.
Specifically, the connecting portion 212 is located at the outer edge of the needle body 2, may be located at one side of the needle body 2 as shown in fig. 5 and 6, or may be distributed in a curtain-like manner in the circumferential direction of the needle body 2 (not shown). Tip segment 213 is preferably tapered to facilitate penetration into the skin.
Referring to fig. 7, in the combined type microneedle structure according to the fourth embodiment, unlike the third embodiment, the base portion 211 of the first needle body 21 has a cylindrical shape, so that the use of the material of the first needle body 21 is reduced, and the production cost is reduced.
Referring to fig. 8 and 9, in the fifth embodiment, unlike the third embodiment, the connection portion 212 is located at the middle of the needle body 2, and may be cylindrical as shown in fig. 9, prismatic, or a structure in which a plurality of facets are distributed on a cylinder or a prism.
Referring to fig. 10, in the combined type microneedle structure of the sixth embodiment, unlike the fifth embodiment, the base portion 211 of the first needle body 21 has a cylindrical shape, and the use of the material of the first needle body 21 is reduced.
The microneedle structure in the above embodiment can directly act on the skin without using a trigger, and the second needle 22 with the active agent combined in the dermis layer is directly absorbed, thereby achieving the corresponding effect.
Further, when the microneedle structure needs to be triggered by a trigger in use, referring to fig. 2, 5 and 8 again, the combined microneedle structure further includes a liquid storage bag 3, the liquid storage bag 3 contains the trigger (solution), and the liquid storage bag 3 is disposed on the back plate 1 and is located at a side of the back plate 1 far from the needle body 2; the back plate 1 and the first needle body 21 are internally provided with a liquid guide hole 10 which is communicated with the liquid storage bag 3 and the second needle body 22. When the microneedle structure is used, after being pressed on the surface of skin, the trigger (solution) in the microneedle structure is conveyed to the second needle body 22 by extruding the liquid storage bag 3, so that the effective preparation in the second needle body 22 is triggered to be absorbed by the skin after being changed, and the corresponding efficacy is realized.
Specifically, in the above embodiments, the effective preparation may be a pharmaceutical or cosmetic preparation. The first needle 21 is preferably made of polyvinyl chloride, polyamide, polycarbonate, polyetheretherketone, polystyrene, polypropylene, metal or silicon. The second needle 22 is preferably made from polyvinyl alcohol, polyvinylpyrrolidone, hyaluronic acid, dextran, sodium alginate, polylactic acid or polylactic acid-glycolic acid copolymer mixed with an effective formulation.
It will be apparent to those skilled in the art from this disclosure that various other changes and modifications can be made which are within the scope of the utility model as defined in the appended claims.
Claims (10)
1. The combined type micro needle is characterized by comprising a back plate and a needle body arranged on the back plate, wherein the needle body comprises a first needle body fixed on the back plate and a second needle body connected with the first needle body, and the height of the first needle body is not lower than the thickness of a epidermis layer.
2. The modular microneedle of claim 1 wherein said first needle comprises a base portion having a height not less than the thickness of the skin layer.
3. The modular microneedle of claim 2 wherein said base portion is cylindrical or frustoconical.
4. The modular microneedle of claim 3 wherein said first needle further comprises a needle portion and a connecting portion connected between the base portion and the needle portion.
5. The modular microneedle of claim 4 wherein said connector is located in the middle of the needle body.
6. The modular microneedle of claim 4 wherein said connector is located at the outer edge of the needle body.
7. The modular microneedle of claim 4 wherein said needle portion is tapered.
8. The modular microneedle of any one of claims 1-7, further comprising a reservoir disposed on the backing plate on a side of the backing plate remote from the needle body; and liquid guide holes which are communicated with the liquid storage bag and the second needle body are formed in the back plate and the first needle body.
9. The combination microneedle of any one of claims 1-7, wherein said first needle body is made of polyvinyl chloride, polyamide, polycarbonate, polyetheretherketone, polystyrene, polypropylene, metal or silicon.
10. The combination microneedle of any one of claims 1-7, wherein the second needle is made of polyvinyl alcohol, polyvinylpyrrolidone, hyaluronic acid, dextran, sodium alginate, polylactic acid, or a polylactic acid-glycolic acid copolymer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321527245.0U CN220276123U (en) | 2023-06-15 | 2023-06-15 | Combined microneedle |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202321527245.0U CN220276123U (en) | 2023-06-15 | 2023-06-15 | Combined microneedle |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220276123U true CN220276123U (en) | 2024-01-02 |
Family
ID=89328725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202321527245.0U Active CN220276123U (en) | 2023-06-15 | 2023-06-15 | Combined microneedle |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220276123U (en) |
-
2023
- 2023-06-15 CN CN202321527245.0U patent/CN220276123U/en active Active
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| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant |