CN219842305U - Monitoring and controlling means of particulate matter concentration and particle diameter when electron cigarette mouth and nose exposes - Google Patents
Monitoring and controlling means of particulate matter concentration and particle diameter when electron cigarette mouth and nose exposes Download PDFInfo
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- CN219842305U CN219842305U CN202222335496.0U CN202222335496U CN219842305U CN 219842305 U CN219842305 U CN 219842305U CN 202222335496 U CN202222335496 U CN 202222335496U CN 219842305 U CN219842305 U CN 219842305U
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- 239000002245 particle Substances 0.000 title claims abstract description 126
- 238000012544 monitoring process Methods 0.000 title claims abstract description 40
- 239000013618 particulate matter Substances 0.000 title claims abstract description 25
- 235000019504 cigarettes Nutrition 0.000 title claims abstract description 8
- 239000003571 electronic cigarette Substances 0.000 claims abstract description 110
- 239000000779 smoke Substances 0.000 claims abstract description 32
- 238000012806 monitoring device Methods 0.000 claims abstract description 20
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000003546 flue gas Substances 0.000 claims abstract description 17
- 238000005070 sampling Methods 0.000 claims abstract description 8
- 230000000391 smoking effect Effects 0.000 claims description 28
- 241001465754 Metazoa Species 0.000 claims description 21
- 239000007789 gas Substances 0.000 claims description 13
- 238000001514 detection method Methods 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 238000007599 discharging Methods 0.000 claims description 3
- 238000004949 mass spectrometry Methods 0.000 claims description 3
- 230000001276 controlling effect Effects 0.000 description 13
- 238000000034 method Methods 0.000 description 10
- 230000004071 biological effect Effects 0.000 description 6
- 238000011160 research Methods 0.000 description 6
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 5
- 241000700159 Rattus Species 0.000 description 5
- 229960002715 nicotine Drugs 0.000 description 5
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 5
- 241000283984 Rodentia Species 0.000 description 4
- 239000000443 aerosol Substances 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 231100000824 inhalation exposure Toxicity 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
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- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 231100001252 long-term toxicity Toxicity 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000222 OECD 412 Subacute Inhalation Toxicity: 28-Day Study Toxicity 0.000 description 1
- 231100000447 OECD 413 Subchronic Inhalation Toxicity: 90-day Study Toxicity 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 231100000045 chemical toxicity Toxicity 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
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- 238000005516 engineering process Methods 0.000 description 1
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- 238000002474 experimental method Methods 0.000 description 1
- 238000002290 gas chromatography-mass spectrometry Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
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- 230000008520 organization Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000001603 reducing effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000019505 tobacco product Nutrition 0.000 description 1
- 231100000048 toxicity data Toxicity 0.000 description 1
- 231100000041 toxicology testing Toxicity 0.000 description 1
- 239000012855 volatile organic compound Substances 0.000 description 1
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- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
A monitoring and controlling device for particle concentration and particle size of an electronic cigarette during oral and nasal exposure. Monitoring devices of particulate matter concentration and particle diameter when electron cigarette mouth and nose exposes includes: an oronasal exposure system defining an inner cylinder chamber and an outer cylinder chamber; the sampler is arranged in the inner cylinder cavity and is used for sampling smoke in the inner cylinder cavity; the particle size spectrometer is connected with the sampler and is used for detecting the particle size of the particles of the flue gas collected by the sampler; and the mass concentration meter is connected with the sampler and is used for detecting the mass concentration of particles in the smoke acquired by the sampler. The monitoring and controlling device for the concentration and the particle size of the particles during the exposure of the mouth and the nose of the electronic cigarette can detect the particle size of the particles through a particle size spectrometer, and can detect the mass concentration of the particles through a mass concentration meter.
Description
Technical Field
The utility model relates to the field of biotechnology application, in particular to a device for monitoring and controlling the concentration and the particle size of particulate matters in the process of exposing an electronic cigarette mouth and a nose.
Background
The smoke of the electronic cigarette is a mixture containing particles, volatile organic compounds and gases. The electronic cigarette is manufactured by heating tobacco products to a certain temperature so as to release volatile compounds (including nicotine) to become inhalable aerosol, and the electronic cigarette does not burn, so that the amount of harmful substances generated by burning is reduced compared with the traditional cigarette. However, no definite evidence exists in the current scientific research to prove that the harm of the electronic cigarette is smaller than that of the traditional cigarette, so that the harm reducing effect of the electronic cigarette needs to be identified by utilizing an animal model experiment. The current oral-nasal exposure system is the primary means of electronic cigarette biological effect research, and is the primary means of rodent acute, subacute and subacute inhalation exposure.
Most of the current long-term toxicity studies of electronic cigarettes are mainly based on chemical toxicity test guidelines (OECD 412, 413 and the like) published by the regulatory organization, and most of the current long-term toxicity studies of electronic cigarettes are based on toxicity studies conforming to GLP (Good Laboratory Practice, drug non-clinical research quality management standard) of electronic cigarettes by rodents (including rats), and the positive and negative deviations of the mass concentration of particles in the oral and nasal exposure process of rats are not more than 20% of the mean value, and the median aerodynamic mass particle diameter (MMAD) is less than 2 mu m, so that the aerosol mass concentration and the MMAD of an oral and nasal exposure system need to be monitored to achieve the aim, and devices capable of monitoring the mass concentration of smoke and the MMAD in the process are absent in the related art. And the data is important to the research of the biological effect of the electronic cigarette smoke, because the concentration and the particle size distribution characteristics of the particles of the electronic cigarette in the animal exposure process directly determine the deposition dosage and the deposition position of the smoke in the animal lung and also determine the relative biological effect and metabolic pathways of the organism on the components in the electronic cigarette.
Disclosure of Invention
The present utility model has been made in view of the above-mentioned problems, and has as its object to provide a device for monitoring and controlling the concentration and the particle size of particulate matter when exposed to the mouth and nose of an electronic cigarette which overcomes or at least partially solves the above-mentioned problems.
According to a first aspect of the present utility model, there is provided a device for monitoring the concentration and particle size of particulate matter when exposed to the mouth and nose of an electronic cigarette, comprising: the oral-nasal exposure system is used for limiting an inner cylinder cavity and an outer cylinder cavity, an air inlet of the inner cylinder cavity is used for receiving smoke of the electronic cigarette, an air outlet of the inner cylinder cavity is communicated with an animal fixing cylinder used for fixing an animal, the animal is used for sucking the smoke exhausted by the inner cylinder cavity, the animal fixing cylinder is communicated with the outer cylinder cavity, and the outer cylinder cavity is at least used for receiving exhaled air of the animal; the sampler is arranged in the inner cylinder cavity and is used for sampling smoke in the inner cylinder cavity; the particle size spectrometer is connected with the sampler and is used for detecting the particle size of the particles of the flue gas collected by the sampler; and the mass concentration meter is connected with the sampler and is used for detecting the mass concentration of particles in the smoke acquired by the sampler.
Optionally, the device for monitoring the concentration and the particle size of the particulate matters when the electronic cigarette is exposed to the mouth and the nose further comprises: and the electronic cigarette smoking machine is connected with the oral-nasal exposure system and is used for placing the electronic cigarette and enabling the electronic cigarette to generate smoke.
Optionally, the device for monitoring the concentration and the particle size of the particulate matters when the electronic cigarette is exposed to the mouth and the nose further comprises: and the outlet of the air compressor is connected with the oral-nasal exposure system, and the air compressor is used for mixing air with the flue gas so that the flue gas and the air enter the inner cylinder cavity after being mixed.
Optionally, the device for monitoring the concentration and the particle size of the particulate matters when the electronic cigarette is exposed to the mouth and the nose further comprises: and the outlet of the air compressor is connected with the oral-nasal exposure system through the flow controller, and the flow controller is used for controlling the flow of air mixed with the smoke.
Optionally, the device for monitoring the concentration and the particle size of the particulate matters when the electronic cigarette is exposed to the mouth and the nose further comprises: and the first filter is arranged between the air compressor and the flow controller and is used for filtering the passing air.
Optionally, the device for monitoring the concentration and the particle size of the particulate matters when the electronic cigarette is exposed to the mouth and the nose further comprises: and the gas chromatograph-mass spectrometer is connected with the sampler and is used for carrying out gas-phase mass spectrometry on the flue gas acquired by the sampler.
Optionally, the device for monitoring the concentration and the particle size of the particulate matters when the electronic cigarette is exposed to the mouth and the nose further comprises: and the air inlet of the air pump is connected with the outer cylinder cavity and is used for discharging the air in the outer cylinder cavity.
Optionally, the device for monitoring the concentration and the particle size of the particulate matters when the electronic cigarette is exposed to the mouth and the nose further comprises: the second filter is arranged between the air inlet of the air pump and the outer cylinder cavity and is used for filtering the passing gas.
Optionally, the device for monitoring the concentration and the particle size of the particulate matters when the electronic cigarette is exposed to the mouth and the nose further comprises: the environment monitoring device is used for monitoring the air quality of the environment corresponding to the monitoring device for the concentration and the particle size of the particulate matters when the electronic cigarette mouth and nose are exposed.
According to a second aspect of the present utility model, there is provided a device for controlling the concentration and particle size of particulate matter when an e-cigarette is exposed to the mouth and nose, comprising: the monitoring device for the concentration and the particle size of the particles when the electronic cigarette nose and the mouth are exposed; and the controller is connected with the particle size spectrometer, the mass concentration meter, the electronic cigarette smoking machine and the flow controller of the monitoring device for the concentration and the particle size of the particles when the electronic cigarette mouth and the nose are exposed, and is used for controlling the electronic cigarette smoking machine and the flow controller according to the detection results of the particle size spectrometer and the mass concentration meter.
Compared with the prior art, the monitoring and controlling device for the concentration and the particle size of the particles in the exposure process of the electronic cigarette mouth and nose can detect the particle size of the particles through the particle size spectrometer, and can detect the mass concentration of the particles through the mass concentration meter, so that the aim that the positive and negative deviation of the mass concentration of the particles in the exposure process of the mouth and nose is not more than 20% of the mean value and the median aerodynamic mass particle size (MMAD) is less than 2 mu m is fulfilled, and data which are vital for the biological effect research of the smoke of the electronic cigarette are obtained.
Drawings
Other objects and advantages of the present utility model will become apparent from the following description of the utility model with reference to the accompanying drawings, which provide a thorough understanding of the present utility model.
FIG. 1 is a block diagram of a device for monitoring particulate concentration and particle size of an e-cigarette during oral-nasal exposure according to some embodiments of the present utility model;
fig. 2 is a block diagram of a control device for particulate concentration and particle size at the time of oral-nasal exposure of an electronic cigarette according to some embodiments of the present utility model.
It should be noted that the drawings are not necessarily drawn to scale, but are shown in a schematic manner which does not detract from the reader's understanding
In the figure, 10 is a control device for particle concentration and particle diameter during exposure of an electronic cigarette mouth and nose, 100 is a monitoring device for particle concentration and particle diameter during exposure of an electronic cigarette mouth and nose, 110 is an oral-nasal exposure system, 120 is a sampler, 130 is a particle diameter spectrometer, 140 is a mass concentration meter, 150 is an electronic cigarette smoking machine, 161 is an air compressor, 162 is a flow controller, 163 is a first filter, 170 is a gas chromatograph, 181 is an air pump, 182 is a second filter, 183 is an environment monitoring device, and 200 is a controller.
Detailed Description
In order to make the objects, technical solutions and advantages of the present utility model more apparent, the technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present utility model. It will be apparent that the described embodiments are one embodiment, but not all embodiments, of the present utility model. All other embodiments, which can be made by a person skilled in the art without creative efforts, based on the described embodiments of the present utility model fall within the protection scope of the present utility model.
Unless defined otherwise, technical or scientific terms used herein should be given the ordinary meaning as understood by one of ordinary skill in the art to which this utility model belongs.
The embodiment first provides a device 100 for monitoring the concentration and the particle size of particles when an electronic cigarette is exposed to the mouth and the nose, and fig. 1 is a block diagram of the device 100 for monitoring the concentration and the particle size of particles when the electronic cigarette is exposed to the mouth and the nose according to some embodiments of the present utility model.
The monitoring device 100 for particle concentration and particle size during exposure of the electronic cigarette mouth and nose comprises an oral-nasal exposure system 110, a sampler 120, a particle size spectrometer 130 and a mass concentration meter 140.
The oral-nasal exposure system 110 defines an inner cylinder chamber and an outer cylinder chamber, wherein an air inlet of the inner cylinder chamber is used for receiving flue gas of the electronic cigarette, an air outlet of the inner cylinder chamber is communicated with an animal fixing cylinder used for fixing animals, the animals are used for sucking the flue gas exhausted from the inner cylinder chamber, the animal fixing cylinder is communicated with the outer cylinder chamber, and the outer cylinder chamber is at least used for receiving exhaled air of the animals. The sampler 120 (may be a Cambridge filter sampler 120) is disposed in the inner cylinder cavity, and is configured to sample smoke in the inner cylinder cavity. The particle size spectrometer 130 is connected to the sampler 120, and is used for detecting the particle size of the particles of the flue gas collected by the sampler 120. The mass concentration meter 140 is connected to the sampler 120, and is configured to detect the mass concentration of particles in the flue gas collected by the sampler 120.
The particle size of the particles can be detected by the particle size spectrometer 130 through the particle size control device 10 during the exposure of the mouth and nose of the electronic cigarette, and the mass concentration of the particles can be detected by the mass concentration meter 140, so that the aim that the positive and negative deviation of the mass concentration of the particles in the mouth and nose exposure process is not more than 20% of the mean value is fulfilled, and the aerodynamic mass median diameter (MMAD) is smaller than 2 mu m is fulfilled, so that data which are vital to the biological effect research of the smoke of the electronic cigarette are obtained.
Specifically, the mass concentration meter 140 may be a real-time dust monitor from CASELLA Inc. of England, model CEL-712Microdust Pro. Particle size spectrometer 130 may employ a model 3321 of TSI or model 3839 of TSI in the united states.
After the electronic cigarette smoke enters the inner cylinder cavity of the nose-nose exposure system 110, after the nicotine concentration, the particulate matter concentration and the MMAD of the electronic cigarette reach the set targets and are stable, the rodent is fixed on the animal fixing cylinder to inhale smoke, and the residual tail gas (animal exhale gas and residual electronic smoke) enters the outer cylinder cavity. Wherein oxygen concentration, carbon dioxide, temperature and humidity can also be monitored in real time.
In some embodiments, the device 100 for monitoring the concentration and the particle size of the particulate matter when the electronic cigarette is exposed to the mouth and nose may further include an electronic cigarette smoking machine 150 (may be a single-channel electronic cigarette smoking machine 150), where the electronic cigarette smoking machine 150 is connected to the mouth and nose exposure system 110, and is used for placing the electronic cigarette and making the electronic cigarette generate smoke. Therefore, the whole device is high in automation degree, wherein the electronic cigarette smoking machine 150 can adopt the HRH-SM120 electronic cigarette smoking machine 150 of Beijing Hui Rong and technology limited company. That is, the e-cigarette smoke is generated by the e-cigarette smoking machine 150, specifically, the smoking frequency is 30-60s, the smoking duration of each cigarette is 2-5s, the smoking capacity is 70ml/3s, the smoking time is 128s, and the number of smoking ports is 16.
The device 100 for monitoring the concentration and the particle size of the particulate matters when the electronic cigarette nose and the mouth are exposed can further comprise an air compressor 161, an outlet of the air compressor 161 is connected with the nose and mouth exposure system 110, and the air compressor 161 is used for mixing air with the flue gas so that the flue gas enters the inner cylinder cavity after being mixed with the air.
The monitoring device 100 for particle concentration and particle size of the electronic cigarette during oral-nasal exposure may further comprise a flow controller 162, wherein the outlet of the air compressor 161 is connected with the oral-nasal exposure system 110 through the flow controller 162, and the flow controller 162 is used for controlling the flow of air mixed with the flue gas.
The monitoring device 100 for particle concentration and particle size of the electronic cigarette during oral-nasal exposure may further include a first filter 163, where the first filter 163 is disposed between the air compressor 161 and the flow controller 162, for filtering the air passing therethrough.
The flow controller 162 may be a precise flow controller, the flow controller 162 controls air to flow out according to a set flow, and the electronic cigarette smoke is diluted and mixed with 30.0L/min clean air (air is filtered by 3-level HEPA efficiently) and then enters the nose exposure system 110.
The monitoring device 100 for the concentration and the particle size of the particulate matters when the electronic cigarette nose and the mouth are exposed can further comprise a gas chromatograph-mass spectrometer 170, wherein the gas chromatograph-mass spectrometer 170 is connected with the sampler 120 and is used for performing gas-phase mass spectrometry on the flue gas collected by the sampler 120. Specifically, the gas chromatograph 170 may employ an Agilent model GC7890 instrument.
The device 100 for monitoring the concentration and the particle size of the particulate matters when the electronic cigarette nose is exposed can further comprise an air pump 181, wherein an air inlet of the air pump 181 is connected with the outer cylinder cavity and used for discharging the air in the outer cylinder cavity.
The device 100 for monitoring the concentration and the particle size of the particulate matters when the electronic cigarette nose is exposed may further include a second filter 182, where the second filter 182 is disposed between the air inlet of the air pump 181 and the outer cylinder cavity, and is used for filtering the passing gas. Specifically, the pumping flow of 32.0L/min is filtered and discharged through the air pump 181, and the negative pressure state of the outer cylinder is maintained.
The device 100 for monitoring the concentration and the particle size of the particulate matters in the exposure of the electronic cigarette mouth and nose can further comprise an environment monitoring device 183, wherein the environment monitoring device 183 is used for monitoring the air quality of the environment corresponding to the device 100 for monitoring the concentration and the particle size of the particulate matters in the exposure of the electronic cigarette mouth and nose.
The present embodiment also provides a device 10 for controlling the concentration and the particle size of the particulate matter when the electronic cigarette is exposed, and fig. 2 is a block diagram of the device 10 for controlling the concentration and the particle size of the particulate matter when the electronic cigarette is exposed according to some embodiments of the present utility model.
The device 10 for controlling the concentration and the particle size of the particulate matters in the exposure of the electronic cigarette mouth and nose comprises any one of the above-mentioned monitoring device 100 and the controller 200 for monitoring the concentration and the particle size of the particulate matters in the exposure of the electronic cigarette mouth and nose, wherein the controller 200 is connected with the particle size spectrometer 130, the mass concentration meter 140, the electronic cigarette smoking machine 150 and the flow controller 162 of the monitoring device 100 for monitoring the concentration and the particle size of the particulate matters in the exposure of the electronic cigarette mouth and nose, and is used for controlling the electronic cigarette smoking machine 150 and the flow controller 162 according to the detection results of the particle size spectrometer 130 and the mass concentration meter 140. The controller 200 may be the small animal mouth and nose exposure control software V3.4 of beijing hui honor.
It will be appreciated that the sampler 120 may be a low-flow (1L/min) sampling device, so as to sample the smoke in the inner cylinder cavity of the oral-nasal exposure system 110 in real time, and detect the particulate matter mass concentration and MMAD value by using the particulate matter real-time mass concentration meter 140 and the particle size spectrometer 130, and transmit the detection result to the controller 200, and the controller 200 determines whether the current particulate matter mass concentration deviates from the set value ±20% and the MMAD is less than 2 μm, and if any index deviation occurs, the controller 200 directly adjusts the electronic cigarette smoking machine 150, adjusts the smoking capacity and the smoking time, and adjusts the dilution flow, thereby controlling the particulate matter mass concentration and the MMAD value to reach the set value and the allowable deviation degree.
When the control device 10 for particle concentration and particle size of the electronic cigarette during the exposure of the mouth and nose of the electronic cigarette works, the electronic cigarette is placed on an electronic smoking machine to generate electronic smoke; the air outlet of the air compressor is connected with a high-efficiency filter, air flow generated by the air compressor is filtered by a high-efficiency HEPA filter device, and is connected with a precise flow controller 162 after reaching the clean air standard, the flow controller 162 is connected with a computer control system, flows out according to the set flow of the controller 200, is mixed and diluted with smoke vortex generated by the electronic cigarette smoking machine 150, and is connected with an oral-nasal exposure system 110, an oral-nasal inhalation exposure system inner cylinder, rodent inhalation and residual tail gas (animal exhaled air and residual electronic smoke) are filtered and discharged by an air pump 181; and meanwhile, the low-flow sampling device is utilized to sample and detect the mass concentration of the particulate matters and the MMAD value of the internal cylinder aerosol in the oral-nasal exposure system 110 in real time, the real-time concentration monitor of the particulate matters and the particle size spectrometer 130 are respectively connected with a computer control system and timely fed back to the computer control system, the computer control system judges whether the current mass concentration of the particulate matters deviates from a set value +/-20% and whether the MMAD value is smaller than 2 mu m, if the current mass concentration deviates from the set value, the control system directly adjusts the electronic cigarette smoking machine 150, controls a smoking interval and a smoking mode, and then adjusts the dilution flow, so that the mass concentration of the particulate matters and the MMAD value are controlled to reach the set value. In addition, the oral-nasal exposure system 110 is connected to a low flow sampler 120 that samples particles of electronic smoke periodically on a Cambridge filter for GCMS analysis.
The embodiment provides a control device 10 for particle concentration and particle diameter of an electronic cigarette when the mouth and nose of the electronic cigarette are exposed, which meets the requirements of OECD test guidelines, and aims to provide a control device for stable supply of the exposure concentration and particle diameter of the electronic cigarette. The real-time online monitoring and nicotine concentration detection and control device for the aerosol mass concentration and particle size characteristic analysis during the inhalation and exposure of the mouth and nose of the rat of the electronic cigarette is established, is a detection method for judging the stability of the electronic cigarette, and ensures the accuracy and repeatability of experimental results. The method is reasonable in design, the particle concentration and MMAD of the electronic cigarette are monitored in real time by adopting low-flow sampling in the oral and nasal exposure process of the rat, the nicotine concentration is detected by regular sampling, and the diluted air flow and the occurrence parameters of the electronic cigarette are automatically regulated and controlled by a real-time feedback system, so that the particle concentration and the MMAD of the electronic cigarette are dynamically regulated and controlled, the particle concentration and the MMAD setting range of the electronic cigarette are achieved, the problem that the positive and negative deviations of the mass concentration in an OECD test guide rule are not more than 20% in the oral and nasal inhalation exposure process of the rat for 28 days and 90 days cannot be met, the MMAD is less than 2 mu m, meanwhile, the regular automatic sampling of nicotine is realized, the manual operation and complicated parameter adjustment are reduced, the labor intensity is reduced, exposure data is provided for evaluating the toxicity of different types of electronic cigarettes, the toxicity data conforming to the OECD technical requirements is provided for accurately evaluating the biological effect, and the scientificity and the accuracy of the toxicity evaluation of the electronic cigarette are promoted.
It should also be noted that, in the embodiments of the present utility model, the features of the embodiments of the present utility model and the features of the embodiments of the present utility model may be combined with each other to obtain new embodiments without conflict.
The present utility model is not limited to the above embodiments, but the scope of the utility model is defined by the claims.
Claims (10)
1. Monitoring devices of particulate matter concentration and particle diameter when electron cigarette mouth and nose exposes, its characterized in that includes:
the oral-nasal exposure system is used for limiting an inner cylinder cavity and an outer cylinder cavity, an air inlet of the inner cylinder cavity is used for receiving smoke of the electronic cigarette, an air outlet of the inner cylinder cavity is communicated with an animal fixing cylinder used for fixing an animal, the animal is used for sucking the smoke exhausted by the inner cylinder cavity, the animal fixing cylinder is communicated with the outer cylinder cavity, and the outer cylinder cavity is at least used for receiving exhaled air of the animal;
the sampler is arranged in the inner cylinder cavity and is used for sampling smoke in the inner cylinder cavity;
the particle size spectrometer is connected with the sampler and is used for detecting the particle size of the particles of the flue gas collected by the sampler;
and the mass concentration meter is connected with the sampler and is used for detecting the mass concentration of particles in the smoke acquired by the sampler.
2. The device for monitoring the concentration and the particle size of particulate matter when the electronic cigarette mouth and nose are exposed according to claim 1, further comprising:
and the electronic cigarette smoking machine is connected with the oral-nasal exposure system and is used for placing the electronic cigarette and enabling the electronic cigarette to generate smoke.
3. The device for monitoring the concentration and the particle size of particulate matter when the electronic cigarette mouth and nose are exposed according to claim 2, further comprising:
and the outlet of the air compressor is connected with the oral-nasal exposure system, and the air compressor is used for mixing air with the flue gas so that the flue gas and the air enter the inner cylinder cavity after being mixed.
4. The device for monitoring the concentration and the particle size of particulate matter when the electronic cigarette mouth and nose are exposed according to claim 3, further comprising:
and the outlet of the air compressor is connected with the oral-nasal exposure system through the flow controller, and the flow controller is used for controlling the flow of air mixed with the smoke.
5. The device for monitoring the concentration and the particle size of particulate matter when the electronic cigarette mouth and nose are exposed according to claim 4, further comprising:
and the first filter is arranged between the air compressor and the flow controller and is used for filtering the passing air.
6. The device for monitoring the concentration and the particle size of particulate matter when the electronic cigarette mouth and nose are exposed according to claim 5, further comprising:
and the gas chromatograph-mass spectrometer is connected with the sampler and is used for carrying out gas-phase mass spectrometry on the flue gas acquired by the sampler.
7. The device for monitoring the concentration and the particle size of particulate matter when the electronic cigarette mouth and nose are exposed according to claim 6, further comprising:
and the air inlet of the air pump is connected with the outer cylinder cavity and is used for discharging the air in the outer cylinder cavity.
8. The device for monitoring the concentration and the particle size of particulate matter when the electronic cigarette mouth and nose are exposed according to claim 7, further comprising:
the second filter is arranged between the air inlet of the air pump and the outer cylinder cavity and is used for filtering the passing gas.
9. The device for monitoring the concentration and the particle size of particulate matter when the electronic cigarette mouth and nose are exposed according to claim 8, further comprising:
the environment monitoring device is used for monitoring the air quality of the environment corresponding to the monitoring device for the concentration and the particle size of the particulate matters when the electronic cigarette mouth and nose are exposed.
10. The utility model provides a controlling means of particulate matter concentration and particle diameter when electron cigarette mouth and nose exposes which characterized in that includes:
the monitoring device of particulate matter concentration and particle size at the time of exposure of the e-cigarette mouth and nose according to any one of claims 4 to 9;
and the controller is connected with the particle size spectrometer, the mass concentration meter, the electronic cigarette smoking machine and the flow controller of the monitoring device for the concentration and the particle size of the particles when the electronic cigarette mouth and the nose are exposed, and is used for controlling the electronic cigarette smoking machine and the flow controller according to the detection results of the particle size spectrometer and the mass concentration meter.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222335496.0U CN219842305U (en) | 2022-09-02 | 2022-09-02 | Monitoring and controlling means of particulate matter concentration and particle diameter when electron cigarette mouth and nose exposes |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222335496.0U CN219842305U (en) | 2022-09-02 | 2022-09-02 | Monitoring and controlling means of particulate matter concentration and particle diameter when electron cigarette mouth and nose exposes |
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| Publication Number | Publication Date |
|---|---|
| CN219842305U true CN219842305U (en) | 2023-10-17 |
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| CN202222335496.0U Active CN219842305U (en) | 2022-09-02 | 2022-09-02 | Monitoring and controlling means of particulate matter concentration and particle diameter when electron cigarette mouth and nose exposes |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN219842305U (en) |
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2022
- 2022-09-02 CN CN202222335496.0U patent/CN219842305U/en active Active
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