CN219764237U - Intracoronary thrombolysis drug delivery system - Google Patents
Intracoronary thrombolysis drug delivery system Download PDFInfo
- Publication number
- CN219764237U CN219764237U CN202222708805.4U CN202222708805U CN219764237U CN 219764237 U CN219764237 U CN 219764237U CN 202222708805 U CN202222708805 U CN 202222708805U CN 219764237 U CN219764237 U CN 219764237U
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- China
- Prior art keywords
- catheter
- threaded
- drug delivery
- delivery system
- guide wire
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- 238000012377 drug delivery Methods 0.000 title claims abstract description 24
- 230000002537 thrombolytic effect Effects 0.000 title claims abstract description 17
- 230000000149 penetrating effect Effects 0.000 claims abstract description 4
- 239000003527 fibrinolytic agent Substances 0.000 claims description 22
- 239000002872 contrast media Substances 0.000 claims description 5
- 239000011248 coating agent Substances 0.000 claims description 3
- 238000000576 coating method Methods 0.000 claims description 3
- 239000003814 drug Substances 0.000 abstract description 15
- 239000003146 anticoagulant agent Substances 0.000 abstract description 9
- 229940079593 drug Drugs 0.000 abstract description 8
- 208000007536 Thrombosis Diseases 0.000 abstract description 5
- 210000004204 blood vessel Anatomy 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 2
- 210000004351 coronary vessel Anatomy 0.000 description 5
- 238000002347 injection Methods 0.000 description 5
- 239000007924 injection Substances 0.000 description 5
- 238000001647 drug administration Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 description 2
- 239000000006 Nitroglycerin Substances 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 229960003711 glyceryl trinitrate Drugs 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- COKMIXFXJJXBQG-NRFANRHFSA-N tirofiban Chemical compound C1=CC(C[C@H](NS(=O)(=O)CCCC)C(O)=O)=CC=C1OCCCCC1CCNCC1 COKMIXFXJJXBQG-NRFANRHFSA-N 0.000 description 2
- 229960003425 tirofiban Drugs 0.000 description 2
- 206010061216 Infarction Diseases 0.000 description 1
- 206010063385 Intellectualisation Diseases 0.000 description 1
- 238000002583 angiography Methods 0.000 description 1
- 210000000709 aorta Anatomy 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000002059 diagnostic imaging Methods 0.000 description 1
- 230000007574 infarction Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000005693 optoelectronics Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000013022 venting Methods 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
Landscapes
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The utility model discloses an intracoronary thrombolysis drug delivery system, which comprises a guide wire, a catheter, a connecting piece and a threaded injector, wherein the guide wire is arranged on the catheter in a penetrating way, when the system is used, the guide wire is required to be firstly stretched into a blood vessel, and then the catheter can be advanced forwards along the guide wire, so that thrombolysis drugs or other drugs can be released along a developing head of the guide wire which moves back and forth in thrombus. The pipe is communicated with one end of the connecting piece, the other end of the connecting piece is communicated with the threaded syringe, and the tail part of the connecting piece is provided with threads, so that the threaded syringe or the three-way adapter can be conveniently connected. The utility model has simple structure and low cost, and solves the problem of reducing thrombolytic treatment effect in the prior art due to inconvenient real-time forward and backward drug delivery.
Description
Technical Field
The utility model relates to the technical field of medical supplies, in particular to an intracoronary thrombolytic drug delivery system.
Background
The first method is to administer the drug through a guiding catheter, which can be considered to be adopted by patients with right coronary infarction, but since the guiding catheter is positioned at the opening of the coronary artery, the drug can not completely enter the right coronary vessel during injection, so that part of thrombolytic drug falls into the ascending aorta to be lost. Therefore, if the anterior descending branch or the circumflex branch is blocked, the guiding catheter is not recommended for thrombolysis. In this case, the method may be performed by using a microcatheter or a puncture balloon. However, since the puncture of the balloon to push the medicine is relatively difficult, unlike the micro-catheter, the puncture of the balloon is convenient and easy to operate, the puncture of the balloon is difficult although the puncture of the balloon can be used, and the puncture of the balloon in the operation is performed through the common syringe needle, so that the defects of difficult balloon exhaust and the like exist. It is therefore also suggested, according to routine experience, to use microcatheters or thromboaspiration catheters, which are easier to handle and also facilitate the application of contrast agents or thrombolytic drugs. In particular, in the left coronary system, when the heart peduncles of the front wall are faced, the medicine is expected to fully enter the anterior descending branch system, so that the targeted thrombolytic therapy is emphasized, and a microcatheter or a thrombus aspiration catheter can be used for directly delivering the thrombolytic medicine into the anterior descending branch for thrombolysis, instead of allowing the medicine to enter the coronary artery through the guiding catheter, so that at least half of the medicine can enter the circumflex branch. Therefore, the microcatheter approach is also most recommended.
However, at present, the clinical microcatheter is mostly a single lumen, needs to be penetrated along a guide wire, and needs to be withdrawn after reaching a thrombolytic target point, and then is connected with a syringe to inject thrombolytic drugs, so that the current microcatheter is inconvenient to advance and retreat in real time for drug delivery, and brings a certain influence to thrombolytic treatment.
Disclosure of Invention
Therefore, the utility model provides a coronary thrombolytic drug delivery system, which solves the problem that the thrombolytic therapeutic effect is reduced due to inconvenient real-time forward and backward drug delivery in the prior art.
In order to achieve the above object, the present utility model provides the following technical solutions:
the utility model discloses an intracoronary thrombolysis drug delivery system, which comprises a guide wire, a catheter, a connecting piece and a threaded injector, wherein the guide wire is arranged on the catheter in a penetrating way, the catheter is communicated with one end of the connecting piece, and the other end of the connecting piece is communicated with the threaded injector.
Further, the catheter comprises a developing head, a guiding side hole, a tube body and a rubber sleeve, wherein the developing head is integrally communicated with one end of the tube body, the other end of the tube body is communicated with the rubber sleeve, the bottom of the developing head is provided with the guiding side hole, and a guide wire is arranged in the guiding side hole in a penetrating mode.
Further, the developing head comprises a size mark, a catheter head and a drug administration hole, the catheter body is integrally connected with the catheter head, a plurality of drug administration holes are formed in the catheter head, contrast agent is contained in the catheter head, and the outer side of the catheter head is provided with the size mark with the length of 10 mm.
Further, the tube body is coated with a hydrophilic coating.
Further, the connecting piece comprises a joint, a threaded pipe and a rotating handle, wherein the joint is inserted into the rubber sleeve, the joint is integrally connected with one end of the threaded pipe, and the rotating handle is arranged on the outer side of the threaded pipe.
Further, the threaded injector comprises a threaded joint, an injection tube and a piston, wherein the other end of the threaded tube is in threaded connection with the threaded joint, the threaded joint is arranged at the end part of the injection tube, and the piston is inserted into the injection tube.
The utility model has the following advantages:
the utility model has simple structure and low cost, and the size mark is arranged on the catheter head containing the contrast agent so as to be developed under a DSA machine, confirm the position of the catheter head end in real time, facilitate fixed-point administration and solve the problem that the thrombolytic treatment effect is reduced due to inconvenient real-time forward and backward administration in the prior art.
Drawings
In order to more clearly illustrate the embodiments of the present utility model or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below. It will be apparent to those of ordinary skill in the art that the drawings in the following description are exemplary only and that other implementations can be obtained from the extensions of the drawings provided without inventive effort.
The structures, proportions, sizes, etc. shown in the present specification are shown only for the purposes of illustration and description, and are not intended to limit the scope of the utility model, which is defined by the claims, so that any structural modifications, changes in proportions, or adjustments of sizes, which do not affect the efficacy or the achievement of the present utility model, should fall within the ambit of the technical disclosure.
FIG. 1 is a perspective view of an intracoronary thrombolytic drug delivery system provided by the present utility model;
FIG. 2 is a perspective view of a connector of an intracoronary thrombolytic drug delivery system according to the present utility model;
FIG. 3 is a perspective view of a threaded syringe of an intracoronary thrombolytic drug delivery system according to the present utility model;
FIG. 4 is a perspective view of a developing head of an intracoronary thrombolytic drug delivery system according to the present utility model;
FIG. 5 is a perspective view of a catheter of an intracoronary thrombolytic drug delivery system according to the present utility model;
in the figure: 1, a guide wire; 2 a conduit; a developing head 21; 211 size marking; 212 a catheter head; 213 drug administration wells; 22 guiding side holes; 23 pipe bodies; 24 rubber sleeves; 3 a connecting piece; 31 linker; 32 threaded pipes; 33 rotating handles; a 4-thread syringe; a 41-thread joint; 42 syringes; 43 pistons.
Detailed Description
Other advantages and advantages of the present utility model will become apparent to those skilled in the art from the following detailed description, which, by way of illustration, is to be read in connection with certain specific embodiments, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the utility model without making any inventive effort, are intended to be within the scope of the utility model.
It should be noted that DAS is a new technology of medical imaging that appears after CT in the 80 th century, and is produced by the development of television technology, image enhancement technology, digital electronic technology, optoelectronics technology, electronics, computer technology, image processing technology, and the like. Is an imaging technique for highlighting blood vessels by eliminating bone and soft tissue images on blood vessel images by a computer. The development of DSA devices has been advanced toward integration, programming, automation, intellectualization, and the like.
1-5, the present utility model discloses an intracoronary thrombolytic drug delivery system comprising a guidewire 1, a catheter 2, a connector 3 and a threaded syringe 4, the guidewire 1 being threaded over the catheter 2, in use, the guidewire 1 being required to be first advanced into a vessel and then the catheter 2 being allowed to advance along the guidewire 1 to facilitate release of thrombolytic or other drugs (e.g., tirofiban, nitroglycerin, etc.) along a developing head 21 of the guidewire 1 that moves back and forth within a thrombus. The catheter 2 is communicated with one end of the connecting piece 3, the other end of the connecting piece 3 is communicated with the threaded injector 4, the tail of the connecting piece 3 is provided with threads, and the tail of the connecting piece 3 is provided with threads, so that the threaded injector or the three-way adapter can be conveniently connected.
According to one embodiment of the utility model, the catheter 2 comprises a developing head 21, a guiding side hole 22, a tube body 23 and a rubber sleeve 24, as shown in fig. 5, the developing head 21 is integrally communicated with one end of the tube body 23, the other end of the tube body 23 is communicated with the rubber sleeve 24, the bottom of the developing head 21 is provided with the guiding side hole 22, and a guide wire 1 is penetrated in the guiding side hole 22. Thereby, the threaded syringe 4 can inject the drug into the developing head 21 through the tube 23 and release the thrombolytic drug through the developing head 21 to the lesion.
According to one embodiment of the present disclosure, the developing head 21 includes a size mark 211, a catheter head 212, and an administration hole 213, as shown in fig. 2, the catheter body 23 is integrally connected to the catheter head 212, and the catheter head 212 is provided with a plurality of administration holes 213, so that the medicine is released from the administration holes 213, as shown in fig. 4. The catheter head 212 contains contrast medium, and the outer side of the catheter head 212 is provided with a size mark 211 with the length of 10mm, so that the catheter head 212 can be developed under a DSA (digital subtraction angiography) machine, and the position of the catheter head 212 is confirmed in real time, thereby facilitating fixed-point administration.
According to one embodiment of the present disclosure, the tube 23 is coated with a hydrophilic coating to improve drug deliverability thereof.
According to one embodiment of the present utility model, the connector 3 comprises a joint 31, a threaded tube 32 and a rotating handle 33, wherein the joint 31 is inserted into the rubber sleeve 24, as shown in fig. 2, the joint 31 is integrally connected with one end of the threaded tube 32, the rotating handle 33 is arranged outside the threaded tube 32, and the threaded tube 32 can be in threaded connection with the threaded joint 41 by rotating the rotating handle 33, so that the problem that the threaded syringe 4 and the catheter 2 are separated is prevented.
According to one embodiment of the present utility model, the threaded injector 4 comprises a threaded joint 41, a syringe 42 and a piston 43, wherein the other end of the threaded tube 32 is in threaded connection with the threaded joint 41, the threaded joint 41 is arranged at the end of the syringe 42, the piston 43 is inserted into the syringe 42, a scale (not shown in the drawing) for indicating the dosage is arranged on the outer wall of the syringe 42, the syringe 42 contains thrombolytic medicine, and the piston 43 is pushed when in use.
The application process of the embodiment of the utility model is as follows:
the utility model discloses a thrombolytic drug delivery system in coronary artery, when in use, a threaded injector 4 is firstly pumped with thrombolytic drug and connected with the tail end of a threaded tube 32 of a catheter. Following the venting operation, the catheter 2 is evacuated of air by pushing on the plunger 43 to fill the catheter 2 with thrombolytic drug. The delivery system is then connected to the guidewire 1 through the pilot side hole 22. The delivery catheter is then advanced along the guidewire 1 into the coronary artery, and the imaging head 21 is advanced into the target thrombus according to the DSA fluoroscopic catheter tip visualization. Then the thrombolytic drug in the syringe is injected by pushing, and can move back and forth along the guide wire 1 in the thrombus, the thrombolytic drug or other drugs (such as tirofiban, nitroglycerin, etc.) are released through the drug administration hole 213, and after the injection is completed, the tube body 23 can be withdrawn, thus completing one coronary administration.
While the utility model has been described in detail in the foregoing general description and specific examples, it will be apparent to those skilled in the art that modifications and improvements can be made thereto. Accordingly, such modifications or improvements may be made without departing from the spirit of the utility model and are intended to be within the scope of the utility model as claimed.
Claims (6)
1. The coronary thrombolysis drug delivery system is characterized by comprising a guide wire (1), a catheter (2), a connecting piece (3) and a threaded injector (4), wherein the guide wire (1) is arranged on the catheter (2) in a penetrating mode, the catheter (2) is communicated with one end of the connecting piece (3), and the other end of the connecting piece (3) is communicated with the threaded injector (4).
2. The intracoronary thrombolytic drug delivery system according to claim 1, wherein the catheter (2) comprises a developing head (21), a guiding side hole (22), a tube body (23) and a rubber sleeve (24), the developing head (21) is integrally communicated with one end of the tube body (23), the other end of the tube body (23) is communicated with the rubber sleeve (24), the guiding side hole (22) is arranged at the bottom of the developing head (21), and the guiding side hole (22) is internally penetrated with the guide wire (1).
3. An intracoronary thrombolytic drug delivery system according to claim 2, wherein the developing head (21) comprises a size mark (211), a catheter head (212) and a drug delivery hole (213), the catheter body (23) is integrally connected with the catheter head (212), the catheter head (212) is provided with a plurality of drug delivery holes (213), the catheter head (212) contains a contrast medium, and the outer side of the catheter head (212) is provided with the size mark (211) with a length of 10 mm.
4. An intracoronary thrombolytic drug delivery system as defined in claim 2 wherein said tube (23) is coated with a hydrophilic coating.
5. An intracoronary thrombolytic drug delivery system according to claim 2, wherein said connector (3) comprises a joint (31), a threaded tube (32) and a stem (33), said rubber sleeve (24) is internally provided with the joint (31), said joint (31) is integrally connected to one end of the threaded tube (32), and the stem (33) is provided outside said threaded tube (32).
6. An intracoronary thrombolytic drug delivery system according to claim 5, wherein said threaded injector (4) comprises a threaded joint (41), a syringe (42) and a piston (43), said threaded tube (32) being in threaded connection with said threaded joint (41) at the other end, said threaded joint (41) being provided at the end of said syringe (42), said syringe (42) being internally provided with a piston (43).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222708805.4U CN219764237U (en) | 2022-10-14 | 2022-10-14 | Intracoronary thrombolysis drug delivery system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202222708805.4U CN219764237U (en) | 2022-10-14 | 2022-10-14 | Intracoronary thrombolysis drug delivery system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN219764237U true CN219764237U (en) | 2023-09-29 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202222708805.4U Active CN219764237U (en) | 2022-10-14 | 2022-10-14 | Intracoronary thrombolysis drug delivery system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN219764237U (en) |
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2022
- 2022-10-14 CN CN202222708805.4U patent/CN219764237U/en active Active
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