CN219481318U - Signal synchronization device, nerve stimulation device and nerve stimulation system - Google Patents
Signal synchronization device, nerve stimulation device and nerve stimulation system Download PDFInfo
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Abstract
The application provides a signal synchronization device, nerve stimulation apparatus and nerve stimulation system, the signal synchronization device includes: the device comprises a signal acquisition module, a preprocessing module, a communication module and a stimulation module; the signal acquisition module is used for receiving bioelectric signals acquired by the sensing electrodes and outputting the bioelectric signals; the preprocessing module is used for preprocessing and outputting bioelectric signals; the communication module is respectively connected with the signal acquisition module, the preprocessing module, the stimulation module and the upper computer in a communication way, and is used for sending the preprocessed bioelectric signals to the upper computer, receiving the stimulation control instruction sent by the upper computer and outputting the stimulation control instruction; the stimulation module is used for receiving the stimulation control instruction and outputting a stimulation pulse signal to one or more stimulation electrodes so that each stimulation electrode releases electric stimulation energy. On the premise of meeting multiple functions, the whole signal synchronization device is simpler and more compact in structure.
Description
The present application claims priority to chinese patent application No. 202220957914.7 filed 24 at 2022, 4, which is incorporated by reference in its entirety.
Technical Field
The application relates to the technical field of bioelectric signal acquisition, in particular to signal synchronization equipment, a nerve stimulation device and a nerve stimulation system.
Background
Active cells or tissues (e.g., human, animal tissue), whether in a resting state or an active state, produce a regular electrical phenomenon that is closely related to a living state, known as bioelectricity. Bioelectric signals include resting and action potentials, which are essentially transmembrane flows of ions. In modern biology and medicine, there are various devices for acquiring bioelectric signals, such as electroencephalogram, myoelectricity, electrooculogram, and electrocardiographic acquisition devices.
In order to solve the limitations of bioelectric signals, multi-mode bioelectric signals are commonly subjected to joint analysis, and because the devices for acquiring the bioelectric signals come from different manufacturers, the devices respectively use different special systems, so that synchronization among a plurality of signals cannot be ensured.
Patent CN108433729a discloses a multi-signal acquisition and synchronization system for human sensory-motor control studies, comprising: the device comprises an upper computer, a signal acquisition module, a stimulation input device and a signal synchronous acquisition processor; the signal acquisition module is arranged on a human body and used for acquiring biomechanical parameters and bioelectric signals of the human body, and the output of the signal acquisition module is connected to the input end of the signal synchronous acquisition processor; the input of the stimulation input device is connected with the upper computer, and the output of the stimulation input device is connected with the human body and is used for outputting stimulation to the human body according to the instruction of the upper computer; the output end of the signal synchronous acquisition processor is connected with the upper computer and used for transmitting the synchronous acquisition signals to the upper computer. The technology is characterized in that three devices, namely a signal acquisition module, a stimulation input device and a signal synchronous acquisition processor, are arranged, the three devices are used for respectively realizing the functions of signal acquisition, stimulation provision and signal synchronization, an upper computer is required to be in communication connection with the two devices, namely the stimulation input device and the signal synchronous acquisition processor, and the whole signal acquisition and synchronization system comprises a plurality of devices, so that the structure is complex.
Patent CN111973874a discloses a photoelectric combined stimulation device and method, which adopts a multi-sensing fusion photoelectric combined stimulation mode to simultaneously collect movement intention signals of brain and spinal cord in different movement states aiming at a patient with movement function loss or partial loss caused by spinal cord injury. The difference of the brain electrical signals and the spinal cord electrical signals under different motion states is compared and discussed, the high signal-to-noise ratio accurate acquisition of the motion intention signals is realized through signal fusion and preprocessing, the motion intention signals are finally converted into high-precision issuing command signals, and the target nerve is stimulated and activated by utilizing the nerve selectivity of subthreshold electrical stimulation and optical stimulation. The technology utilizes the electroencephalogram electrode module and the spinal cord electrode module to collect electroencephalogram signals and spinal cord signals simultaneously and send the electroencephalogram signals and the spinal cord signals to the processor, the processor and the upper computer are communicated so that the upper computer can set parameters of the processor to realize adjustment of the stimulation device, however, the whole photoelectric combined stimulation device not only comprises the electroencephalogram electrode module, the pulse generator and the photoelectric combined stimulation electrode, but also needs to be independently provided with the processor integrated device to realize communication with the upper computer, and the structure is complex.
Therefore, it is desirable to provide a signal synchronization device, a neural stimulation device and a neural stimulation system, which solve the problem of complex structure of the synchronization system in the prior art.
Disclosure of Invention
An object of the present application is to provide a signal synchronization device, a nerve stimulation apparatus and a nerve stimulation system, which solve the problem of complex structure of the synchronization system in the prior art.
The purpose of the application is realized by adopting the following technical scheme:
in a first aspect, the present application provides a signal synchronization device, comprising: the device comprises a signal acquisition module, a preprocessing module, a communication module and a stimulation module;
the signal acquisition module is used for receiving bioelectric signals acquired by the sensing electrodes and outputting the bioelectric signals;
the preprocessing module is in communication connection with the signal acquisition module and is used for preprocessing and outputting the bioelectric signals;
the communication module is respectively connected with the signal acquisition module, the preprocessing module, the stimulation module and the upper computer in a communication way, and is used for sending the preprocessed bioelectric signals to the upper computer, receiving the stimulation control instruction sent by the upper computer and outputting the stimulation control instruction;
the stimulation module is used for receiving the stimulation control instructions and outputting stimulation pulse signals to one or more stimulation electrodes so that each stimulation electrode releases electric stimulation energy.
The beneficial effect of this technical scheme lies in: the signal acquisition module receives the bioelectric signals acquired by the sensing electrodes and outputs the bioelectric signals to the preprocessing module, the preprocessing module preprocesses the bioelectric signals and outputs the bioelectric signals to the communication module, the communication module sends the preprocessed bioelectric signals to the upper computer, the communication module sends a stimulation control instruction of the upper computer to the stimulation module, and the stimulation module receives the stimulation control instruction and outputs stimulation pulse signals to one or more stimulation electrodes so that each stimulation electrode releases electric stimulation energy.
On one hand, the signal synchronization device can receive bioelectric signals acquired by a plurality of sensing electrodes, and solves the problem of data flow synchronization during the acquisition and uploading of the independent sensing electrodes; on the other hand, the signal synchronization equipment can realize the collection and synchronization of bioelectric signals, and can also control the stimulation electrodes to release electric stimulation energy through the stimulation module.
In some alternative embodiments, the sensing electrode comprises one or more of the following: an intracranial sensing electrode, a scalp brain electrical sensing electrode, a cortical brain electrical sensing electrode, a myoelectric sensing electrode, an oculogram sensing electrode and a cardiac sensing electrode.
The beneficial effect of this technical scheme lies in: in general, different kinds of sensing electrodes have respective advantages and limitations, and bioelectric signals acquired at different spatial positions have respective electrophysiological characteristics, such as scalp brain electrical sensing electrodes, myoelectric sensing electrodes, electro-oculogram sensing electrodes and non-implantable noninvasive sensing electrodes, which have small damage to patients, while the spatial resolutions and signal-to-noise ratios of the skull electrical sensing electrodes and the cortex brain electrical sensing electrodes are relatively high.
In some alternative embodiments, the preprocessing module includes one or more of the following: a pre-amplifying unit, a high-pass filtering unit, a low-pass filtering unit and a post-amplifying unit.
The beneficial effect of this technical scheme lies in: the bioelectric signals can be filtered by using a high-pass filtering unit or a low-pass filtering unit, so that power frequency interference and direct current bias are eliminated; the bioelectric signal may be amplified by a pre-amplification unit or a post-amplification unit.
In some alternative embodiments, the stimulation module includes a controller and a stimulation chip;
the controller is used for receiving the stimulation control instruction and outputting a stimulation control signal;
the stimulation chip is communicatively connected with the controller and is used for receiving the stimulation control signals and outputting the stimulation pulse signals to one or more stimulation electrodes so that each stimulation electrode releases electric stimulation energy.
The beneficial effect of this technical scheme lies in: the stimulation chip and the controller are independently arranged, wherein the controller is responsible for carrying out data interaction with external equipment, for example, the controller obtains a stimulation control instruction of the upper computer through the communication module, analyzes stimulation parameter information obtained by the controller and outputs a stimulation control signal, so that the stimulation chip and the upper computer have no direct data interaction, the output of the stimulation chip is prevented from being interfered by external electromagnetic waves, and the anti-interference performance is strong.
In some alternative embodiments, the signal synchronization device is disposed within or outside the patient.
The beneficial effect of this technical scheme lies in: when the signal synchronization device is arranged outside the patient, the doctor can conveniently carry out temporary diagnosis or temporary use before implantation operation, and when the signal synchronization device is arranged in the patient, the patient can conveniently carry about the signal synchronization device.
In some alternative embodiments, the signal synchronization device is disposed in the patient, the signal acquisition module is communicatively connected to the sensing electrode disposed in the patient in a wired or wireless communication manner, and the signal acquisition module is communicatively connected to the sensing electrode disposed outside the patient in a wireless communication manner.
The beneficial effect of this technical scheme lies in: when the signal synchronization device is arranged in a patient, on one hand, the signal synchronization device can be communicably connected with sensing electrodes (such as a cranio-electric sensing electrode and a cortical brain electric sensing electrode) arranged in the patient in a wired communication or wireless communication mode, the wired communication mode is stable, the reliability is high, the transmission rate is high, the communication distance of the wireless communication mode is long, the wireless communication device is not limited by wires, the signal synchronization device has certain mobility, and can communicate through wireless connection in a moving state, so that the cost is low; on the other hand, the signal synchronization device may be communicatively connected in wireless communication with sensing electrodes (e.g., scalp brain, muscle, eye and heart sensing electrodes) disposed outside the patient's body.
In some alternative embodiments, the signal synchronization device is disposed outside the patient's body, and the signal acquisition module is communicatively coupled to the sensing electrode in a wired or wireless communication.
The beneficial effect of this technical scheme lies in: when the signal synchronization device is arranged outside a patient, the signal synchronization device can be connected with the sensing electrode in a wired communication or wireless communication mode according to actual needs, the wired communication mode is stable, the reliability is high, the transmission rate is high, the communication distance of the wireless communication mode is long, the signal synchronization device is not limited by wires, the signal synchronization device has certain mobility, can communicate through wireless connection in a moving state, and is low in cost.
In some alternative embodiments, the signal acquisition module and the stimulation module are integrated control chips, and the control chips are respectively electrically connected with the preprocessing module and the communication module.
In some alternative embodiments, the first to fourth pulse signal outputs have first to fourth pulse signal inputs;
the first stimulation pulse signal output end is electrically connected with the first stimulation pulse signal input end, the second stimulation pulse signal output end is electrically connected with the second stimulation pulse signal input end, the third stimulation pulse signal output end is electrically connected with the third stimulation pulse signal input end, and the fourth stimulation pulse signal output end is electrically connected with the fourth stimulation pulse signal input end;
each stimulation pulse signal output end is used for outputting the stimulation pulse signals to one or more stimulation electrodes so that each stimulation electrode releases electric stimulation energy.
In some optional embodiments, the main control chip further has an EL0 signal transmission end, an EL2 signal transmission end, an LFP1 signal transmission end and an LFP2 signal transmission end, the communication chip has an LFP1 signal transmission end and an LFP2 signal transmission end, and the preprocessing module has an EL0 signal transmission end, an EL2 signal transmission end and an LFP2 signal transmission end;
the EL0 signal transmission end of the main control chip is electrically connected with the EL0 signal transmission end of the preprocessing module, the EL2 signal transmission end of the main control chip is electrically connected with the EL2 signal transmission end of the preprocessing module, the LFP1 signal transmission end of the main control chip is electrically connected with the LFP1 signal transmission end of the communication chip, and the LFP2 signal transmission end of the main control chip is respectively electrically connected with the LFP2 signal transmission end of the communication chip and the LFP2 signal transmission end of the preprocessing module; the EL0 signal transmission end is used for receiving and outputting bioelectric signals acquired by the sensing electrode.
In a second aspect, the present application provides a neural stimulation device comprising a sensing electrode, a stimulation electrode, an extension lead, and any one of the signal synchronization apparatuses described above;
the extension lead is electrically connected with the sensing electrode, the stimulation electrode and the signal synchronization device respectively.
In some alternative embodiments, the sensing electrode comprises one or more of the following: an intracranial sensing electrode, a scalp brain electrical sensing electrode, a cortical brain electrical sensing electrode, a myoelectric sensing electrode, an oculogram sensing electrode and a cardiac sensing electrode.
In a third aspect, the present application provides a neural stimulation system, the system comprising a host computer and any one of the neural stimulation devices described above;
the upper computer is communicatively connected with the nerve stimulation device.
Drawings
The present application is further described below with reference to the drawings and examples.
Fig. 1 is a block diagram of a signal synchronization device according to an embodiment of the present application.
Fig. 2 is a block diagram of a preprocessing module according to an embodiment of the present application.
Fig. 3 is a block diagram of a stimulation module according to an embodiment of the present application.
Fig. 4 is a block diagram of a neural stimulation device according to an embodiment of the present application.
Fig. 5 is a block diagram of a neural stimulation system according to an embodiment of the present application.
Fig. 6 is a schematic structural diagram of a main control chip according to an embodiment of the present application.
Fig. 7 is a schematic structural diagram of a communication chip according to an embodiment of the present application.
Fig. 8 is a schematic structural diagram of a preprocessing module according to an embodiment of the present application.
Fig. 9 is a schematic structural diagram of a first AD conversion chip according to an embodiment of the present application.
Fig. 10 is a schematic structural diagram of a second AD conversion chip according to an embodiment of the present application.
Fig. 11 is a schematic structural diagram of a third AD conversion chip according to an embodiment of the present application.
Fig. 12 is a schematic structural diagram of a fourth AD conversion chip according to an embodiment of the present application.
Fig. 13 is a schematic structural diagram of a multiplexing switch chip according to an embodiment of the present application.
Detailed Description
The present application will be further described with reference to the drawings and detailed description, which should be understood that, on the premise of no conflict, the following embodiments or technical features may be arbitrarily combined to form new embodiments.
First, the application field of the present application will be briefly described.
The implantable medical device is an implantable programmable multi-program medical device, and can be any one of an implantable nerve electrical stimulation device, an implantable cardiac electrical stimulation system (also called a cardiac pacemaker), an implantable drug infusion device (Implantable Drug Delivery System, abbreviated as I DDS) and a lead switching device. The implantable nerve electrical stimulation device is, for example, a deep brain electrical stimulation system (Deep Brain Stimulation, abbreviated as DBS), an implantable brain cortex stimulation system (Cortical Nerve Stimulation, abbreviated as CNS), an implantable spinal cord electrical stimulation system (Spinal Cord Stimulation, abbreviated as SCS), an implantable sacral nerve electrical stimulation system (Sacral Nerve Stimulation, abbreviated as SNS), an implantable vagal nerve electrical stimulation system (Vagus Nerve Stimulation, abbreviated as VNS), or the like. The implantable medical device is, for example, a stimulator comprising an IPG, an extension lead and an electrode lead, the IPG (implantable pulse generator ) being arranged in the patient, controllable electrical pulse stimulation being provided by means of a sealed battery and electrical circuitry, one or two controllable specific electrical pulse stimuli being provided by means of the implanted extension lead and electrode lead to specific areas of biological tissue. The extension lead is used in combination with the IPG as a pulse transmission medium to transmit the stimulation pulse generated by the IPG to the electrode lead. The electrode lead transmits the electrical stimulation generated by the IPG to a specific area of the organism tissue through a plurality of electrode contacts; the implantable medical device has one or more electrode leads on one side or both sides, on which a plurality of electrode contacts are provided, which may be uniformly or non-uniformly arranged in the circumferential direction of the electrode leads, for example, the electrode contacts are arranged in an array of 4 rows and 3 columns (12 electrode contacts in total) in the circumferential direction of the electrode leads.
In one embodiment of the present application, the stimulated biological tissue may be brain tissue of a patient, the stimulated site may be a specific site of brain tissue, the stimulated site is generally different when the type of disease of the patient is different, the number of stimulation contacts (single or multi-source) used, the application of one or more (single or multi-channel) specific electrical pulse stimulation, and the stimulation parameter data are also different. The type of disease to which the present application is applicable is not limited, and may be a type of disease to which Deep Brain Stimulation (DBS), spinal Cord Stimulation (SCS), pelvic stimulation, gastric stimulation, peripheral nerve stimulation, functional electrical stimulation are applicable. Among the types of diseases that DBS may be used to treat or manage include, but are not limited to: spasticity (e.g., epilepsy), pain, migraine, psychotic disorders (e.g., major Depressive Disorder (MDD)), bipolar disorder, anxiety, post-traumatic stress disorder, depression, obsessive Compulsive Disorder (OCD), behavioral disorders, mood disorders, memory disorders, mental state disorders, movement disorders (e.g., essential tremor or parkinson's disease), huntington's disease, alzheimer's disease, drug addiction, autism, or other neurological or psychiatric disorders and impairments.
Referring to fig. 1, an embodiment of the present application provides a signal synchronization apparatus 100, including: a signal acquisition module 110, a preprocessing module 120, a communication module 130, and a stimulation module 140;
the signal acquisition module 110 is configured to receive and output bioelectric signals acquired by the plurality of sensing electrodes 400;
the preprocessing module 120 is communicatively connected with the signal acquisition module 110, and the preprocessing module 120 is used for preprocessing and outputting the bioelectric signals;
the communication module 130 is respectively and communicatively connected to the signal acquisition module 110, the preprocessing module 120, the stimulation module 140 and the upper computer 200, and the communication module 130 is configured to send the preprocessed bioelectric signal to the upper computer 200, and receive and output a stimulation control command sent by the upper computer 200;
the stimulation module 140 is configured to receive the stimulation control instructions and output stimulation pulse signals to one or more stimulation electrodes 500, such that each of the stimulation electrodes 500 releases electrical stimulation energy.
Therefore, when the bioelectric signals are collected, the communication module 130 is responsible for interaction with the upper computer 200, the communication module 130 acquires and outputs the collection instruction of the upper computer 200, the signal collection module 110 receives the bioelectric signals collected by the corresponding sensing electrodes 400 according to the collection instruction and outputs the bioelectric signals to the preprocessing module 120, the preprocessing module 120 preprocesses the bioelectric signals and outputs the bioelectric signals to the communication module 130, the communication module 130 sends the preprocessed bioelectric signals to the upper computer 200, and the upper computer 200 can perform research and analysis on the collected electroencephalogram signals and electrophysiological biomarkers matched with disease symptoms to judge the disease symptoms of a patient so as to output corresponding stimulation control instructions, so that the self-adaptive regulation and control function is realized. Specifically, the stimulation control command of the host computer 200 is sent to the stimulation module 140 through the communication module 130, and the stimulation module 140 receives the stimulation control command and outputs a stimulation pulse signal to one or more stimulation electrodes 500, so that each stimulation electrode 500 releases electrical stimulation energy.
On the one hand, the signal synchronization device 100 of the present application can receive bioelectric signals collected by a plurality of sensing electrodes 400, so as to solve the problem of data flow synchronization when the individual sensing electrodes collect and upload; on the other hand, the signal synchronization device 100 can not only collect and synchronize bioelectric signals, but also control the stimulating electrode 500 to release electric stimulation energy through the stimulating module 140, and compared with the prior art, the whole signal synchronization device 100 has simpler and more compact structure on the premise of meeting multiple functions.
In some embodiments, the bioelectric signal collected by the sensing electrode may be a single cell bioelectric signal, a nuclear mass localized bioelectric signal, or a neuronal bioelectric signal.
In some embodiments, the communication module 130 may include a wired communication component or a wireless communication component.
The wired communication component may include one or more of the following communication units: optical fiber communication unit, coaxial cable communication unit, open wire communication unit, waveguide communication unit and photoelectric communication unit.
The wireless communication component may include one or more of the following communication units: bluetooth communication units, 4G communication units, 5G communication units, WIFI communication units, near field communication units, wiGig communication units, and ZigBee communication units.
In some embodiments, the upper computer 200 may interact with the server 300.
The server 300 is one type of computer, and the server 300 provides computing or application services to other clients (e.g., terminals such as PCs, smartphones, ATM, etc., and even large devices such as train systems) in a network. The server 300 has high-speed CPU operation capability, long-time reliable operation, strong I/O external data throughput capability, and better expandability.
The upper computer 200 is a computer that can directly send out control commands, and various signal changes (such as hydraulic pressure, water level, temperature, etc.) are displayed on the screen of the upper computer 200. The lower computer is a computer for directly controlling equipment to acquire equipment conditions, and is generally a PLC or a singlechip and the like. The command sent by the upper computer 200 is firstly sent to the lower computer, and the lower computer is then interpreted into a corresponding time sequence signal according to the command to directly control the corresponding equipment. The lower computer reads the device status data (generally, analog quantity) from time to time, converts the device status data into a digital signal, and feeds the digital signal back to the upper computer 200.
In some alternative embodiments, the sense electrode 400 includes one or more of the following: an intracranial sensing electrode, a scalp brain electrical sensing electrode, a cortical brain electrical sensing electrode, a myoelectric sensing electrode, an oculogram sensing electrode and a cardiac sensing electrode.
The system comprises an electroencephalogram sensing electrode, a scalp electroencephalogram sensing electrode, a cortex electroencephalogram sensing electrode, a myoelectricity sensing electrode and an electrocardio sensing electrode, wherein the intracranial sensing electrode is used for collecting intracranial electroencephalogram signals of a patient, the scalp electroencephalogram sensing electrode is used for collecting scalp electroencephalogram signals of the patient, the cortex electroencephalogram sensing electrode is used for collecting cortex electroencephalogram signals of the patient, the myoelectricity sensing electrode is used for collecting myoelectricity signals of the patient, the electrooculogram sensing electrode is used for collecting electrooculogram signals of the patient.
Thus, in general, the different types of sensing electrodes 400 have respective advantages and limitations, and the bioelectric signals acquired at different spatial locations have respective electrophysiological characteristics, such as scalp electroencephalographic sensing electrodes, myoelectric sensing electrodes, electro-oculographic sensing electrodes and cardiac sensing electrodes, which are non-implantable, non-invasive sensing electrodes, with less damage to the patient, while the spatial resolutions and signal-to-noise ratios of the craniocerebral sensing electrodes and cortical electroencephalographic sensing electrodes are relatively high, the signal synchronization device 100 of the present application can select one or more types of bioelectric signals acquired from the patient according to actual needs, for example, multiple sensing electrodes 400 can be utilized to acquire multi-mode bioelectric signals for joint analysis.
In some embodiments, the sensing electrode 400 may include an intracranial sensing electrode, a scalp brain electrical sensing electrode, and a cortical brain electrical sensing electrode.
By integrating the invasive and non-invasive brain sensing electrode 400, the problems of lower spatial resolution of the signal and lower signal-to-noise ratio are solved.
The scalp cerebral inductance electrode can be an electrode cap, and the cortex cerebral inductance electrode can be a medical standard cortex electrode array.
In some embodiments, the sensing electrode 400 and the stimulation electrode 500 may be the same electrode lead.
Therefore, the electrode lead has both stimulation and perception functions, and provides convenience for clinical disease treatment and closed-loop regulation and control research.
In other embodiments, the sensing electrode 400 and the stimulating electrode 500 may be two electrode leads provided separately.
In some alternative embodiments, the preprocessing module 120 includes one or more of the following: a pre-amplification unit 121, a high-pass filtering unit 122, a low-pass filtering unit 123, and a post-amplification unit 124.
Thus, the bioelectric signal can be filtered by the high-pass filtering unit 122 or the low-pass filtering unit 123, so that power frequency interference and direct current bias are eliminated; the bioelectric signal may be amplified by the pre-amplification unit 121 or the post-amplification unit 124 by the pre-processing module 120.
Referring to fig. 2, fig. 2 shows a block diagram of a preprocessing module 120 according to an embodiment of the present application.
In some embodiments, the preprocessing module 120 may include: a pre-amplification unit 121, a high-pass filtering unit 122, a low-pass filtering unit 123, and a post-amplification unit 124.
Referring to fig. 3, fig. 3 shows a block diagram of a stimulation module 140 according to an embodiment of the present application.
In some alternative embodiments, the stimulation module 140 includes a controller and a stimulation chip;
the controller is used for receiving the stimulation control instruction and outputting a stimulation control signal;
the stimulation chip is communicatively connected to the controller, and is configured to receive the stimulation control signals and output the stimulation pulse signals to one or more of the stimulation electrodes 500, such that each of the stimulation electrodes 500 releases electrical stimulation energy.
Among them, the control function of the controller may be realized by an MPU (microprocessor), MCU, DSP, FPGA, or any combination thereof.
Therefore, the stimulation chip and the controller are separately arranged, wherein the controller is responsible for data interaction with external equipment, for example, the controller obtains a stimulation control instruction of the upper computer 200 through the communication module 130, analyzes stimulation parameter information obtained in the stimulation control instruction and outputs a stimulation control signal, so that the stimulation chip and the upper computer 200 have no direct data interaction, the output of the stimulation chip is prevented from being interfered by external electromagnetic waves, and the anti-interference performance is strong.
In some embodiments, the stimulation chip may be fabricated using a 0.35um CMOS process.
In some embodiments, the stimulation module 140 employs a control chip configured to:
receiving the stimulation control command and outputting a stimulation control signal;
receives the stimulation control signals and outputs the stimulation pulse signals to one or more of the stimulation electrodes 500 to cause each of the stimulation electrodes 500 to release electrical stimulation energy.
In some alternative embodiments, the signal synchronization device 100 is disposed inside or outside the patient.
Therefore, when the signal synchronization device 100 is arranged outside the patient, the doctor can conveniently perform temporary diagnosis or temporarily use the signal synchronization device before implantation operation, and when the signal synchronization device 100 is arranged in the patient, the patient can conveniently use the signal synchronization device with the patient.
In some alternative embodiments, the signal synchronization device 100 is disposed within the patient, the signal acquisition module 110 is communicatively coupled to the sensing electrode 400 disposed within the patient in wired or wireless communication, and the signal acquisition module is communicatively coupled to the sensing electrode disposed outside the patient in wireless communication.
Thus, when the signal synchronization device 100 is disposed in the patient, on one hand, the signal synchronization device 100 can be communicably connected with the sensing electrode 400 (e.g., the cranio-electric sensing electrode and the cortical brain electric sensing electrode) disposed in the patient in a wired communication or wireless communication manner, the wired communication manner is relatively stable, the reliability is high, the transmission rate is high, the communication distance of the wireless communication manner is long, and the wireless communication device is not limited by wires, has a certain mobility, can communicate through wireless connection in a moving state, and has lower cost; on the other hand, the signal synchronization device 100 may be communicatively connected in wireless communication with sensing electrodes 400 (e.g., scalp brain, muscle, eye, and heart sensing electrodes) disposed outside the patient's body.
In some alternative embodiments, the signal synchronization device 100 is disposed outside the patient's body, and the signal acquisition module 110 is communicatively coupled to the sensing electrode 400 in a wired or wireless communication manner.
Therefore, when the signal synchronization device 100 is disposed outside the patient, it can be communicably connected with the sensing electrode 400 by wired communication or wireless communication according to actual needs, the wired communication is stable, the reliability is high, the transmission rate is high, the communication distance of the wireless communication is long, and the wireless communication device is not limited by wires, has certain mobility, can communicate through wireless connection in a moving state, and has low cost.
Referring to fig. 4, fig. 4 shows a block diagram of a neural stimulation device 700 according to an embodiment of the present application.
The present application also provides a nerve stimulation device 700, the nerve stimulation device 700 comprising a sensing electrode 400, a stimulation electrode 500, an extension lead 600, and any of the signal synchronization apparatuses 100 described above;
the extension wires 600 are electrically connected to the sensing electrode 400, the stimulating electrode 500, and the signal synchronization device 100, respectively.
In some alternative embodiments, the sense electrode 400 includes one or more of the following: an intracranial sensing electrode, a scalp brain electrical sensing electrode, a cortical brain electrical sensing electrode, a myoelectric sensing electrode, an oculogram sensing electrode and a cardiac sensing electrode.
Referring to fig. 5, fig. 5 shows a block diagram of a neural stimulation system 800 provided in an embodiment of the present application.
The application also provides a nerve stimulation system 800, which comprises a host computer 200 and any one of the nerve stimulation devices 700;
the upper computer 200 is communicatively coupled to the nerve stimulation device 700.
In some alternative embodiments, the signal acquisition module and the stimulation module are integrated control chips, and the control chips are respectively electrically connected with the preprocessing module and the communication module.
The embodiment of the application does not limit the control chip and the communication module, the control chip can be a dual-source acquisition chip, and the communication module can be a communication chip.
Referring to fig. 6 and 7, in some alternative embodiments, the control chip has first to fourth pulse signal outputs, and the communication module has first to fourth pulse signal inputs;
the first stimulation pulse signal output end of the control chip is electrically connected with the first stimulation pulse signal input end of the communication module, the second stimulation pulse signal output end of the control chip is electrically connected with the second stimulation pulse signal input end of the communication module, the third stimulation pulse signal output end of the control chip is electrically connected with the third stimulation pulse signal input end of the communication module, and the fourth stimulation pulse signal output end of the control chip is electrically connected with the fourth stimulation pulse signal input end of the communication module;
each stimulation pulse signal output end is used for outputting the stimulation pulse signals to one or more stimulation electrodes so that each stimulation electrode releases electric stimulation energy.
The network label (netlabel) is an electrical connection point, generally composed of letters, symbols, numbers, etc., and the electrical connection lines, pins and networks with the same network label are connected together, and the network labels are not connected.
The setting of the network labels is not limited in this embodiment, the network labels of the first stimulation pulse signal output end and the first stimulation pulse signal input end are, for example, stim_pulsea1, the network labels of the second stimulation pulse signal output end and the second stimulation pulse signal input end are, for example, stim_pulsea2, the network labels of the third stimulation pulse signal output end and the third stimulation pulse signal input end are, for example, stim_pulsea3, and the network labels of the fourth stimulation pulse signal output end and the fourth stimulation pulse signal input end are, for example, stim_pulsea4.
Referring to fig. 6 to 8, in some alternative embodiments, the control chip further has an EL0 signal transmission end, an EL2 signal transmission end, an LFP1 signal transmission end, and an LFP2 signal transmission end, the communication module has an LFP1 signal transmission end and an LFP2 signal transmission end, and the preprocessing module has an EL0 signal transmission end, an EL2 signal transmission end, and an LFP2 signal transmission end;
the EL0 signal transmission end of the control chip is electrically connected with the EL0 signal transmission end of the preprocessing module, the EL2 signal transmission end of the control chip is electrically connected with the EL2 signal transmission end of the preprocessing module, the LFP1 signal transmission end of the control chip is electrically connected with the LFP1 signal transmission end of the communication module, and the LFP2 signal transmission end of the control chip is respectively electrically connected with the LFP2 signal transmission end of the communication module and the LFP2 signal transmission end of the preprocessing module; the EL0 signal transmission end is used for receiving and outputting bioelectric signals acquired by the sensing electrode.
The network label of the EL0 signal transmission end is, for example, EL0, the network label of the EL2 signal transmission end is, for example, EL2, the network label of the LFP1 signal transmission end is, for example, adc_lfp1, and the network label of the LFP2 signal transmission end is, for example, adc_lfp2.
Referring to fig. 8, in some alternative embodiments, the preprocessing module includes a pre-amplifying unit, a low-pass filtering unit, and a post-amplifying unit, which are sequentially connected.
The pre-amplifying unit comprises an instrument amplifier, wherein an EL0 signal transmission end of the pre-processing module is connected to the-IN end of the instrument amplifier through a capacitor and a resistor, and an EL2 signal transmission end of the pre-processing module is connected to the-IN end of the instrument amplifier through a capacitor and a resistor;
the post-amplifying unit comprises a precision amplifier, and the LFP2 signal transmission end of the preprocessing module is connected to the output end of the precision amplifier through a capacitor.
With continued reference to fig. 6 and 7, in some alternative embodiments, the control chip further has an ADC voltage control terminal, a first pulse signal transmission terminal, a second pulse signal transmission terminal, a data input terminal, a control line signal control terminal, a clock signal control terminal, a first control line transmission terminal, a second control line transmission terminal, a first data output terminal, a second data output terminal, and a serial signal transmission terminal;
correspondingly, the communication module is also provided with an ADC voltage control end, a first pulse signal transmission end, a second pulse signal transmission end, a data input end, a control line signal control end, a clock signal control end, a first control line transmission end, a second control line transmission end, a first data output end, a second data output end and a serial signal transmission end;
the ADC voltage control terminal is, for example, adc_vcomp, the first pulse signal transmission terminal is, for example, adc_vpulse_1, the second pulse signal transmission terminal is, for example, adc_vpulse_2, the data input terminal is, for example, stim_da_in, the control line signal control terminal is, for example, sw24_cs_n, the clock signal control terminal is, for example, sti_sclk, the first control line transmission terminal is, for example, stim_cs1_n, the second control line transmission terminal is, for example, stim_cs2_n, the first data output terminal is, for example, stim_da_out_1, the second data output terminal is, for example, stim_da_out_2, and the serial signal transmission terminal is, for example, sw_sdata OUT.
Referring to fig. 9 to 12, in some alternative embodiments, the signal synchronization device further includes first to fourth AD conversion chips, the control chip further includes first to eighth stimulus measurement terminals, and the communication module further includes an AD conversion pulse signal transmission terminal, first to fourth enable control terminals;
the first stimulation measuring end is electrically connected with the IN+ end of the first AD conversion chip, the second stimulation measuring end is electrically connected with the IN-end of the first AD conversion chip, and the first enabling control end is electrically connected with the EN end of the first AD conversion chip; the third stimulus measurement end is electrically connected with the IN+ end of the second AD conversion chip, the fourth stimulus measurement end is electrically connected with the IN-end of the second AD conversion chip, and the second enabling control end is electrically connected with the EN end of the second AD conversion chip; the fifth stimulus measurement end is electrically connected with the IN+ end of the third AD conversion chip, the sixth stimulus measurement end is electrically connected with the IN-end of the third AD conversion chip, and the third enabling control end is electrically connected with the EN end of the third AD conversion chip; the seventh stimulus measurement end is electrically connected with the IN+ end of the fourth AD conversion chip, the eighth stimulus measurement end is electrically connected with the IN-end of the fourth AD conversion chip, and the fourth enable control end is electrically connected with the EN end of the fourth AD conversion chip. The AD conversion pulse signal transmission terminals are electrically connected with the OUT terminals of the first AD conversion chip to the fourth AD conversion chip, respectively.
The network labels of the first stimulus measuring end are exemplified by bcap_p_1, the network labels of the second stimulus measuring end are exemplified by bcap_p_2, the network labels of the third stimulus measuring end are exemplified by bcap_m_1, the network labels of the fourth stimulus measuring end are exemplified by bcap_m_2, the network labels of the fifth stimulus measuring end are exemplified by acap_p_1, the network labels of the sixth stimulus measuring end are exemplified by acap_p_2, the network labels of the seventh stimulus measuring end are exemplified by acap_m_1, the network labels of the eighth stimulus measuring end are exemplified by acap_m_2, the network labels of the first enabling control end are exemplified by IPULSE1a_en, the network labels of the second enabling control end are exemplified by IPULSE2a_en, the network labels of the third enabling control end are exemplified by IPULSE1b_en, the network labels of the fourth enabling control end are exemplified by IPULSE2 b_b_en, and the network labels of the AD converted pulse signal transmitting end are exemplified by adc_ipulse_ipulse.
Referring to fig. 13, in some alternative embodiments, the signal synchronization device further includes a multiplexing switch chip, the wireless charging circuit further has a charging detection terminal, and the communication module further has a first selection loop control terminal, a second selection loop control terminal, a VT control terminal, and a fifth enable control terminal;
the charging detection end of the wireless charging circuit is electrically connected with the S1 end of the multiplexing switch chip, the first selection loop control end of the communication module is electrically connected with the A0 end of the multiplexing switch chip, the second selection loop control end of the communication module is electrically connected with the A1 end of the multiplexing switch chip, the VT control end of the communication module is electrically connected with the D end of the multiplexing switch chip, and the fifth enabling control end of the communication module is electrically connected with the EN end of the multiplexing switch chip.
The present application is directed to functional enhancement and use elements, which are emphasized by the patent laws, such as the description and drawings, of the present application, but are not limited to the preferred embodiments of the present application, and therefore, all equivalents and modifications, equivalents, and modifications, etc. of the structures, devices, features, etc. of the present application are included in the scope of the present application.
Claims (10)
1. A signal synchronization device, comprising: the device comprises a signal acquisition module, a preprocessing module, a communication module and a stimulation module;
the signal acquisition module is used for receiving bioelectric signals acquired by the sensing electrodes and outputting the bioelectric signals;
the preprocessing module is in communication connection with the signal acquisition module and is used for preprocessing and outputting the bioelectric signals;
the communication module is respectively connected with the signal acquisition module, the preprocessing module, the stimulation module and the upper computer in a communication way, and is used for sending the preprocessed bioelectric signals to the upper computer, receiving the stimulation control instruction sent by the upper computer and outputting the stimulation control instruction;
the stimulation module is used for receiving the stimulation control instructions and outputting stimulation pulse signals to one or more stimulation electrodes so that each stimulation electrode releases electric stimulation energy.
2. The signal synchronization device of claim 1, wherein the sensing electrode comprises one or more of: an intracranial sensing electrode, a scalp brain electrical sensing electrode, a cortical brain electrical sensing electrode, a myoelectric sensing electrode, an oculogram sensing electrode and a cardiac sensing electrode.
3. The signal synchronization device of claim 1, wherein the preprocessing module comprises one or more of: a pre-amplifying unit, a high-pass filtering unit, a low-pass filtering unit and a post-amplifying unit.
4. The signal synchronization device of claim 1, wherein the stimulation module comprises a controller and a stimulation chip;
the controller is used for receiving the stimulation control instruction and outputting a stimulation control signal;
the stimulation chip is communicatively connected with the controller and is used for receiving the stimulation control signals and outputting the stimulation pulse signals to one or more stimulation electrodes so that each stimulation electrode releases electric stimulation energy.
5. The signal synchronization device of claim 1, wherein the signal synchronization device is disposed within or outside of a patient.
6. The signal synchronization device of claim 5, wherein the signal synchronization device is disposed within the patient, the signal acquisition module is communicatively coupled to the sensing electrode disposed within the patient in wired or wireless communication, and the signal acquisition module is communicatively coupled to the sensing electrode disposed outside the patient in wireless communication.
7. The signal synchronization device of claim 5, wherein the signal synchronization device is disposed outside the patient's body, and wherein the signal acquisition module is communicatively coupled to the sensing electrode in a wired or wireless communication.
8. A neurostimulation device, characterized in that it comprises a sensing electrode, a stimulation electrode, an extension lead and a signal synchronization device according to any of claims 1-7;
the extension lead is electrically connected with the sensing electrode, the stimulation electrode and the signal synchronization device respectively.
9. The neurostimulation device of claim 8, wherein the sensing electrode comprises one or more of: an intracranial sensing electrode, a scalp brain electrical sensing electrode, a cortical brain electrical sensing electrode, a myoelectric sensing electrode, an oculogram sensing electrode and a cardiac sensing electrode.
10. A neurostimulation system, characterized in that it comprises a host computer and a neurostimulation device according to any of claims 8 or 9;
the upper computer is communicatively connected with the nerve stimulation device.
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| CN202220957914 | 2022-04-24 | ||
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