CN219398655U - Drug eluting balloon catheter system - Google Patents
Drug eluting balloon catheter system Download PDFInfo
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- CN219398655U CN219398655U CN202223358005.0U CN202223358005U CN219398655U CN 219398655 U CN219398655 U CN 219398655U CN 202223358005 U CN202223358005 U CN 202223358005U CN 219398655 U CN219398655 U CN 219398655U
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- inner tube
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Abstract
The application discloses a drug eluting balloon catheter system comprising: the outer surface of the balloon is coated with a drug coating; the outer tube is connected to one end of the balloon; one end of the inner tube is positioned in the outer tube, and the other end of the inner tube penetrates through the balloon and is connected with one end, far away from the outer tube, of the balloon; a filling and discharging channel communicated with the interior of the balloon is formed between the inner tube and the outer tube so as to fill gas or liquid into the interior of the balloon; the drug eluting balloon catheter system also comprises an ultrasonic transducer, wherein the ultrasonic transducer is arranged in the balloon and sleeved on the inner tube; the balloon comprises a balloon body and a woven mesh, wherein the woven mesh is arranged in the balloon body, and at least part of the woven mesh extends to be in contact with the inner tube so as to transmit the vibration of the inner tube to the balloon. The beneficial point of the application lies in: a drug eluting balloon catheter system is provided that is connected to an inner tube through a portion of the braid inside the balloon to directly transmit high frequency vibrations to the balloon to improve the drug transfer efficiency of the balloon.
Description
Technical Field
The present application relates to the field of medical devices, and in particular, to a drug eluting balloon catheter system.
Background
Cardiovascular stenosis is one of the main causes of coronary heart disease, and interventional therapy (Percutaneous CoronaryIntervention, PCI) is an important means for treating cardiovascular stenosis. Interventional therapy is an effective treatment method for vascular diseases such as coronary artery diseases, peripheral artery diseases, intracranial artery diseases and the like. In recent years, a new technology for preventing restenosis of blood vessel after interventional therapy, namely a drug coating balloon, has appeared, and the basic principle is that specific drugs are coated on the surface of the balloon body, the balloon body is conveyed to a focus through a guide catheter and a guide wire and positioned, the balloon body is mechanically expanded by pressurization, and the drug coating on the surface of the balloon body is tightly contacted with the blood vessel wall of the focus, so that the drugs are rapidly released and absorbed by the blood vessel wall of the focus, thereby achieving the effect of treating vascular diseases.
Since the drug-coated balloon blocks blood flow when in an inflated state, how to increase the drug absorption effect is critical and necessary for drug-coated balloon therapy.
Patent application No. 201810219993.X discloses a drug eluting balloon catheter system with vibration comprising an elongate member and an inflatable balloon; the balloon is hollow and provided with a vibration structure unit, the outer surface of the balloon is covered with a medicine, when the balloon is inflated, the medicine covered on the surface is contacted with the blood vessel wall, and the balloon enters a vibration state; the elongate member has a lumen therein that is in communication with the interior of the balloon and is filled with a gas or liquid. After the balloon body is expanded, the drug coating on the surface of the balloon body is closely contacted with the wall of a focus blood vessel, and the balloon is excited to vibrate by the ultrasonic transducer, so that the drug on the surface is accelerated to permeate the inner surface of the lesion, and the absorption effect of the drug is improved.
The disadvantages of the above patents are: because ultrasonic transducer is located the sacculus inside and not contacted with the sacculus, ultrasonic transducer corresponds the middle part position that sets up at the sacculus in addition for the effect that sacculus axial direction's different positions received the ultrasonic wave is not the same, and the medicine transfer efficiency at sacculus both ends can obviously be less than the middle part, leads to the holistic release of sacculus and transfer effect not ideal.
Disclosure of Invention
The content of the present application is intended to introduce concepts in a simplified form that are further described below in the detailed description. The section of this application is not intended to identify key features or essential features of the claimed subject matter, nor is it intended to be used to limit the scope of the claimed subject matter.
To address the technical problems noted in the background section above, some embodiments of the present application provide a drug eluting balloon catheter system comprising: the outer surface of the balloon is coated with a drug coating; the outer tube is connected to one end of the balloon; one end of the inner tube is positioned in the outer tube, and the other end of the inner tube penetrates through the balloon and is connected with one end, far away from the outer tube, of the balloon; a filling and discharging channel communicated with the interior of the balloon is formed between the inner tube and the outer tube so as to fill gas or liquid into the interior of the balloon; the drug eluting balloon catheter system also comprises an ultrasonic transducer, wherein the ultrasonic transducer is arranged in the balloon and sleeved on the inner tube; the balloon comprises a balloon body and a woven mesh, wherein the woven mesh is arranged in the balloon body, and at least part of the woven mesh extends to be in contact with the inner tube so as to transmit the vibration of the inner tube to the balloon.
Further, the drug eluting balloon catheter system further comprises a pair of electrode plates, wherein the electrode plates are respectively connected to two ends of the ultrasonic transducer, and are connected with an external power supply through wires so as to transmit voltage generated by the external power supply to the ultrasonic transducer, and the electrode plates are fixed on the surface of the inner tube.
Further, the drug eluting balloon catheter system further comprises an ultrasonic controller, wherein the ultrasonic controller is electrically connected with the electrode plates, and the ultrasonic controller controls the generation power of ultrasonic waves generated by the ultrasonic transducer by changing the input voltage value of the ultrasonic transducer.
Further, the woven mesh comprises a plurality of conductive wires, the conductive wires are arranged at intervals in the circumferential direction, and two ends of the conductive wires respectively penetrate out of the bag body and are connected with the inner tube.
Further, the balloon surface is formed with a plurality of medicine storage grooves which are arranged at intervals in the axial direction to form groove groups, and the groove groups are arranged at intervals in the circumferential direction.
Further, the depth of the medicine storage groove along the radial direction is 10 to 60 percent of the wall thickness of the balloon.
Further, the conductive filaments are located at the same circumferential position as at least a portion of the drug storage slot.
Further, the woven mesh comprises a plurality of structural wires and a plurality of connecting wires, wherein the structural wires are arranged at intervals in the circumferential direction and are positioned at different circumferential positions with the conducting wires; the connecting wires are positioned between the structural wires and the conducting wires and are respectively connected with the structural wires and the conducting wires.
Further, the structural wires circumferentially correspond to at least part of the drug storage slots.
Further, two adjacent connection wires in the circumferential direction are arranged in a V shape.
The beneficial effects of this application lie in: a drug eluting balloon catheter system is provided that is connected to an inner tube through a portion of the braid inside the balloon to directly transmit high frequency vibrations to the balloon to improve the drug transfer efficiency of the balloon.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this application, are included to provide a further understanding of the application and to provide a further understanding of the application with regard to the other features, objects and advantages of the application. The drawings of the illustrative embodiments of the present application and their descriptions are for the purpose of illustrating the present application and are not to be construed as unduly limiting the present application.
In addition, the same or similar reference numerals denote the same or similar elements throughout the drawings. It should be understood that the figures are schematic and that elements and components are not necessarily drawn to scale.
In the drawings:
FIG. 1 is an overall schematic of a drug eluting balloon catheter system according to one embodiment of the present application;
FIG. 2 is a schematic view of the internal structure of a portion of the drug eluting balloon catheter system shown in FIG. 1;
FIG. 3 is a schematic perspective view of a portion of the drug eluting balloon catheter system shown in FIG. 1;
FIG. 4 is a structural cross-sectional view of a portion of the drug eluting balloon catheter system shown in FIG. 3;
FIG. 5 is a schematic view of the structure of a woven mesh of a balloon in the drug eluting balloon catheter system shown in FIG. 1;
the meaning of the reference numerals in the figures is:
100. a drug eluting balloon catheter system;
110. a balloon; 111. a bladder; 112. a woven mesh;
1121. a conductive wire; 1122. a structural wire; 1123. a connecting wire;
110a, a medicine storage tank;
121. an inner tube; 122. an outer tube; 123. a tube seat;
131. an ultrasonic transducer; 132. an electrode sheet; 133. an ultrasonic controller; 134. a wire;
141. and a developing ring.
Detailed Description
Embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. While certain embodiments of the present disclosure are shown in the drawings, it should be understood that the present disclosure may be embodied in various forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete. It should be understood that the drawings and embodiments of the present disclosure are for illustration purposes only and are not intended to limit the scope of the present disclosure.
It should be noted that, for convenience of description, only the portions relevant to the present application are shown in the drawings. Embodiments of the present disclosure and features of embodiments may be combined with each other without conflict.
In the description of the present application, it should be noted that, if the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," "outer," and the like indicate an azimuth or a positional relationship based on that shown in the drawings, or an azimuth or a positional relationship that a product of the application conventionally puts in use, it is merely for convenience of describing the present application and simplifying the description, and does not indicate or imply that the device or element to be referred to must have a specific azimuth, be configured and operated in a specific azimuth, and thus should not be construed as limiting the present application. Furthermore, the terms "first," "second," and the like in the description of the present application, if any, are used for distinguishing between the descriptions and not necessarily for indicating or implying a relative importance.
In the description of the present application, it should also be noted that, unless explicitly stated and limited otherwise, the terms "disposed," "mounted," "connected," and "connected" should be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the terms in this application will be understood by those of ordinary skill in the art in a specific context.
It should be noted that references to "one" or "a plurality" in this application are intended to be illustrative rather than limiting, and those of ordinary skill in the art will appreciate that "one or more" is intended to be interpreted as "one or more" unless the context clearly indicates otherwise.
The present disclosure will be described in detail below with reference to the accompanying drawings in conjunction with embodiments.
As shown in fig. 1-3, a drug eluting balloon catheter system 100 of the present application includes: balloon 110, inner tube 121 and outer tube 122.
Specifically, the outer surface of balloon 110 is pre-coated with a drug coating, including self-paclitaxel, rapamycin, and the like. The medicines such as paclitaxel and the like are prepared by adopting an ultrasonic spraying process, so that the compactness and firmness of a medicine coating are ensured, the loss in the conveying process is reduced, and the medicine content is ensured. In addition, the application adopts nano and needle crystal medicines, improves the transfer rate in blood vessels and ensures the blood concentration.
Specifically, the outer tube 122 is connected to one end of the balloon 110, and one end of the outer tube 122 away from the balloon 110 is connected to the tube seat 123; one end of the inner tube 121 is positioned in the outer tube 122, and the other end penetrates the balloon 110 and is connected to one end of the balloon 110 far away from the outer tube 122; in specific use, the end of the balloon 110 is inserted into a blood vessel, and the doctor holds the tube seat 123 by hand, so that the balloon 110 and the medicine on the surface of the balloon 110 are pushed to the deep part of the blood vessel until the balloon 110 reaches the lesion part of the blood vessel. An inflation/deflation passage communicating with the interior of the balloon 110 is formed between the inner tube 121 and the outer tube 122 to fill the interior of the balloon 110 with an inflation medium (gas or liquid) to thereby switch the balloon 110 between an inflated state and a deflated state; when the balloon 110 is inflated, the surface drug will be in close contact with the vessel wall, thereby releasing the drug to the vessel wall.
As a specific aspect, the drug eluting balloon catheter system 100 of the present application further comprises: an ultrasonic transducer 131 and an electrode sheet 132; the ultrasonic transducer 131 is mounted inside the balloon 110 and sleeved on the inner tube 121, and is used for converting electric energy into ultrasonic vibration. The ultrasonic waves generated by the ultrasonic transducer 131 are transmitted to the saccule 110 through filling media, so that the dynamic force of the medicine entering the vascular wall or other tissues through the administration hole can be further provided, the transfer rate of the medicine at the target position is increased, and the blood concentration is improved; the instantaneous pressure generated by cavitation of ultrasonic wave can increase the gap between cells, which is beneficial to the drug entering the vascular wall or other tissues and improves the absorption effect of the drug.
The electrode plates 132 are provided with a pair, and are respectively connected to the electrode plates 132 at the two ends of the ultrasonic transducer 131 in a specific connection mode of spot welding with the ultrasonic transducer 131; the electrode sheet 132 is connected to an external power source through a wire 134 to transmit a voltage generated by the external power source to the ultrasonic transducer 131; the electrode plate 132 is fixed on the surface of the inner tube 121, so as to avoid the influence on the electrical contact stability with the ultrasonic transducer 131 caused by the movement of the electrode plate relative to the inner tube 121 under the action of ultrasonic waves.
In consideration of accurately adjusting the generation power of the ultrasonic transducer 131 to ensure the operation requirement and patient safety, the drug eluting balloon catheter system 100 further includes an ultrasonic controller 133, the ultrasonic controller 133 being electrically connected with the electrode sheet 132, the ultrasonic controller 133 controlling the generation power of the ultrasonic waves generated by the ultrasonic transducer 131 by changing the input voltage value of the ultrasonic transducer 131, and controlling the vibration frequency and the vibration time of the balloon 110 so that the surface of the balloon 110 vibrates at a small amplitude and a high frequency.
As a preferred aspect, the drug eluting balloon catheter system 100 of the present application further includes a temperature sensor for detecting the temperature of the ultrasound transducer 131, the temperature sensor being electrically connected to the ultrasound controller 133 to feed back the temperature of the ultrasound transducer 131 to be within a preset range, the preset temperature range being 37 ℃ to 44 ℃.
Based on the above scheme, because the ultrasonic transducer 131 is located inside the balloon 110 and is not in contact with the balloon 110, in addition, the ultrasonic transducer 131 is correspondingly arranged at the middle position of the balloon 110, so that the effect of the ultrasonic waves on different positions of the balloon 110 in the axial direction is not the same, the drug transfer efficiency at two ends of the balloon 110 is obviously lower than that at the middle part, and the overall release and transfer effects of the balloon 110 are not ideal.
In addition, considering that the ultrasonic transducer 131 is sleeved on the inner tube 121, the generated vibration is also transmitted to the inner tube 121; as a preferred solution, the balloon 110 of the present application includes a balloon body 111 and a mesh grid 112, the mesh grid 112 is embedded in the balloon body 111, and at least part of the mesh grid 112 extends to contact with the inner tube 121 to transmit the vibration of the inner tube 121 to the balloon 110. In this way, a part of the ultrasonic waves can be transmitted to the balloon 110 along the path of the inner tube 121 and the mesh 112, and the ultrasonic waves can be uniformly transmitted to each part of the balloon 110 through the mesh 112, thereby improving the drug transfer efficiency of the balloon 110.
Specifically, the woven mesh 112 includes conductive filaments 1121, structural filaments 1122, and connecting filaments 1123; the plurality of conductive wires 1121 are arranged, the conductive wires 1121 are arranged at intervals in the circumferential direction, and two ends of the conductive wires 1121 respectively penetrate out of the bag body 111 and are connected with the inner tube 121; the conductive filaments 1121 transmit the vibrations of the catheter to the mesh grid 112. The structural wires 1122 are circumferentially spaced apart and located at different circumferential positions from the conductive wires 1121, and the structural wires 1122 and the conductive wires 1121 together constitute the main structure of the braid; the connecting wires 1123 are positioned between the structural wires 1122 and the conductive wires 1121 and are respectively connected with the structural wires 1122 and the structural wires 1122 so as to realize vibration transmission between the conductive wires 1121 and the structural wires 1122; two connection wires 1123 adjacent in the circumferential direction are arranged in a "V" shape. With such an arrangement, the burst pressure of the balloon 110 is ensured while the ultrasonic vibration conduction is improved.
If the drug is only coated on the outer surface of the balloon 110, a large amount of the drug is lost due to falling off during the process of delivering the balloon 110 to the lesion, resulting in inaccurate dosage. Preferably, the surface of the balloon 110 is formed with a plurality of medicine storage grooves 110a, the plurality of medicine storage grooves 110a are arranged at intervals in the axial direction to constitute groove groups, and some groove groups are arranged at intervals in the circumferential direction so that the medicine storage grooves 110a are uniformly distributed on the outer surface of the balloon 110. By arranging the medicine storage groove 110a to contain medicine, the medicine is prevented from falling off in the process of being conveyed to the target lesion, and the dosage is accurately controlled.
As a specific scheme, the depth of the drug storage groove 110a along the radial direction is 10% to 60% of the wall thickness of the balloon 110, so that the balloon 110 can meet certain physical performance requirements, such as radial extrusion resistance, over-expansion performance or axial retraction capability of the balloon 110, while the drug loading is ensured, and corresponding medical instrument standards are required to be met. If the depth of the medicine storage groove 110a is larger than the wall thickness of the balloon 110, the wall thickness of the balloon 110 becomes thinner at the medicine storage groove 110a and is easily broken. Through rationally setting up the degree of depth of medicine storage groove 110a for sacculus 110 main part can satisfy the physical properties requirement, provides sufficient holding power, can provide better adhesion condition for the medicine again, improves the adhesion effect of medicine.
Preferably, the conductive filaments 1121 are located at the same circumferential position as at least a portion of the drug storage groove 110a, and the structural filaments 1122 circumferentially correspond to at least a portion of the drug storage groove 110 a. In this way, vibration of the conductive filaments 1121 and the structural filaments 1122 can directly act on the drug storage groove 110a, and the release efficiency of the drug in the drug storage groove 110a can be improved.
As a preferred solution, the drug eluting balloon catheter system 100 of the present application further comprises a developing ring 141, the developing ring 141 is sleeved on the inner tube and located inside the balloon, the developing ring is used for developing imaging, and can display the position of the balloon, so that the medical staff can perform the operation conveniently.
The foregoing description is only of the preferred embodiments of the present disclosure and description of the principles of the technology being employed. It will be appreciated by those skilled in the art that the scope of the utility model in the embodiments of the present disclosure is not limited to the specific combination of the above technical features, but encompasses other technical features formed by any combination of the above technical features or their equivalents without departing from the spirit of the utility model. Such as the above-described features, are mutually substituted with (but not limited to) the features having similar functions disclosed in the embodiments of the present disclosure.
Claims (10)
1. A drug eluting balloon catheter system comprising a balloon, an inner tube and an outer tube, the outer surface of the balloon being coated with a drug coating; the outer tube is connected to one end of the balloon; one end of the inner tube is positioned in the outer tube, and the other end of the inner tube penetrates through the balloon and is connected with one end, far away from the outer tube, of the balloon; a filling and discharging channel communicated with the interior of the balloon is formed between the inner tube and the outer tube so as to fill gas or liquid into the interior of the balloon;
the method is characterized in that:
the drug eluting balloon catheter system further comprises an ultrasonic transducer, wherein the ultrasonic transducer is arranged in the balloon and sleeved on the inner tube;
the balloon comprises a balloon body and a woven mesh, wherein the woven mesh is arranged in the balloon body, and at least part of the woven mesh extends to be in contact with the inner tube so as to transfer the vibration of the inner tube to the balloon.
2. The drug eluting balloon catheter system according to claim 1, wherein:
the drug eluting balloon catheter system further comprises a pair of electrode plates, wherein the electrode plates are respectively connected to two ends of the ultrasonic transducer, are connected with an external power supply through wires to transmit voltage generated by the external power supply to the ultrasonic transducer, and are fixed on the surface of the inner tube.
3. The drug eluting balloon catheter system according to claim 2, wherein:
the drug eluting balloon catheter system further comprises an ultrasonic controller, wherein the ultrasonic controller is electrically connected with the electrode plates, and the ultrasonic controller controls the generation power of ultrasonic waves generated by the ultrasonic transducer by changing the input voltage value of the ultrasonic transducer.
4. The drug eluting balloon catheter system according to claim 1, wherein:
the woven mesh comprises a plurality of conductive wires, the conductive wires are arranged at intervals in the circumferential direction, and two ends of the conductive wires respectively penetrate out of the bag body and are connected with the inner tube.
5. The drug eluting balloon catheter system according to claim 4, wherein:
the surface of the balloon is provided with a plurality of medicine storage grooves which are axially arranged at intervals to form groove groups, and the groove groups are circumferentially arranged at intervals.
6. The drug eluting balloon catheter system according to claim 5, wherein:
the depth of the medicine storage groove along the radial direction is 10 to 60 percent of the wall thickness of the balloon.
7. The drug eluting balloon catheter system according to claim 5, wherein:
the conductive filaments are located at the same circumferential position as at least a portion of the drug storage groove.
8. The drug eluting balloon catheter system according to claim 5, wherein:
the woven mesh comprises a plurality of structural wires and a plurality of connecting wires, wherein the structural wires are arranged at intervals in the circumferential direction and are positioned at different circumferential positions with the conducting wires; the connecting wires are positioned between the structural wires and the conducting wires and are respectively connected with the structural wires and the conducting wires.
9. The drug eluting balloon catheter system according to claim 8, wherein:
the structural wires circumferentially correspond to at least part of the drug storage grooves.
10. The drug eluting balloon catheter system according to claim 8, wherein:
two adjacent connecting wires in the circumferential direction are arranged in a V shape.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202223358005.0U CN219398655U (en) | 2022-12-13 | 2022-12-13 | Drug eluting balloon catheter system |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202223358005.0U CN219398655U (en) | 2022-12-13 | 2022-12-13 | Drug eluting balloon catheter system |
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| CN219398655U true CN219398655U (en) | 2023-07-25 |
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| CN202223358005.0U Active CN219398655U (en) | 2022-12-13 | 2022-12-13 | Drug eluting balloon catheter system |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108371745A (en) * | 2018-03-16 | 2018-08-07 | 上海心至医疗科技有限公司 | A kind of medicine eluting balloon catheter system of band vibration |
-
2022
- 2022-12-13 CN CN202223358005.0U patent/CN219398655U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108371745A (en) * | 2018-03-16 | 2018-08-07 | 上海心至医疗科技有限公司 | A kind of medicine eluting balloon catheter system of band vibration |
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