CN219376935U

CN219376935U - Reagent mixing device

Info

Publication number: CN219376935U
Application number: CN202320485118.2U
Authority: CN
Inventors: 孟刚; 梁艳伟; 高春海
Original assignee: Beijing Baiyin Biotechnology Co ltd
Current assignee: Beijing Baiyin Biotechnology Co ltd
Priority date: 2023-03-14
Filing date: 2023-03-14
Publication date: 2023-07-21
Anticipated expiration: 2033-03-14

Abstract

The utility model provides a reagent mixing device, which comprises a first reagent disk and a first driving component, wherein the first driving component drives the first reagent disk to rotate; the first mixing component is rotationally connected with the first reagent disk; the second driving assembly is used for driving the first mixing assembly to rotate relative to the first reagent disk; the second mixing device comprises a second reagent disk nested with the first reagent disk; a third driving assembly for driving the second reagent disk to rotate; the second mixing component is rotationally connected with the second reagent disk; and a fourth driving component for driving the second mixing component to rotate relative to the second reagent disk. By adopting the nested arrangement of the first mixing device and the second mixing device, the two reagent trays are mutually independent and can rotate relatively, and the limited space is fully utilized, so that the quantity of the reagent boxes which can be placed under the same volume can be increased by at least 50 percent compared with the prior art.

Description

Reagent mixing device

Technical Field

The utility model relates to the technical field of analytical instruments, in particular to a reagent mixing device.

Background

Currently, for some in vitro diagnostic projects, solid phase-containing reagents are required, and the solid phase-containing reagents can be used in a uniform state, which requires that the reagent bottle must be in continuous motion when the reagent mixing device is used in a medical analyzer. Along with the continuous development of technology, the instrument test flux is higher and higher, the types of test items are also greatly increased, the requirement on the storage quantity of the reagent mixing device of the instrument is higher and higher, and in a limited space, how to increase the storage quantity of the reagent mixing device is a problem facing each design manufacturer.

In the prior art, the storage module of the reagent mixing device is designed in a single circle, namely, only one circle of reagent mixing device can be placed, if the storage quantity of the reagent mixing device is required to be increased, the volume of the storage device of the reagent mixing device can only be increased, or two storage devices of the reagent mixing device are designed on an instrument, so that the storage quantity of the reagent mixing device is increased, but the volume ratio is greatly increased, the space utilization rate is not high, and the manufacturing cost is greatly increased by designing two storage devices of the reagent mixing device on one instrument.

Disclosure of Invention

In view of the above, it is an object of one or more embodiments of the present utility model to provide a reagent mixing apparatus for improving the defoaming effect of a cleaning liquid.

In a first aspect, there is provided a reagent mixing device comprising:

the first mixing device comprises a first reagent disk and a first driving component for driving the first reagent disk to rotate; the first mixing assembly is rotationally connected with the first reagent disk; the second driving assembly is used for driving the first mixing assembly to rotate relative to the first reagent disk;

a second mixing device comprising a second reagent disk nested with the first reagent disk; a third driving assembly for driving the second reagent disk to rotate; the second mixing assembly is rotationally connected with the second reagent disk; and a fourth driving assembly for driving the second mixing assembly to rotate relative to the second reagent disk.

In the technical scheme, the first mixing device and the second mixing device are nested, the two reagent trays are mutually independent and can rotate relatively, the limited space is fully utilized, and compared with the prior art, the quantity of the reagent boxes which can be placed under the same volume can be increased by at least 50%.

In a specific embodiment, the device further comprises a support plate; the first reagent disk and the second reagent disk are respectively connected with the supporting disk in a rotating way.

In a specific embodiment, the first driving assembly comprises a first driving motor fixed on the supporting disc, a first belt pulley coaxially fixed with an output shaft of the first driving motor, and a second belt pulley coaxially arranged with the first reagent disc; and the transmission belt is sleeved on the first belt pulley and the second belt pulley.

In a specific embodiment, the second drive assembly comprises: the first fixed gear is fixedly connected with the supporting disc, and is coaxially arranged with the first planetary gear of the first uniform mixing assembly; the first fixed gear is meshed with the first planetary gear; wherein,,

the first fixed gear is coaxially arranged with the first reagent disk.

In a specific embodiment, the first planetary gear and the first mixing assembly are arranged on opposite sides of the first reagent disk.

In a specific embodiment, the number of the first planetary gears is plural, and plural first planetary gears are disposed around the first fixed gear.

In a specific embodiment, the third driving assembly comprises a second driving motor fixed on the supporting disc, a driving gear connected with an output shaft of the second driving motor, and a driving gear ring coaxially and fixedly connected with the second reagent disc; the drive gear is meshed with the drive gear ring.

In a specific embodiment, the drive ring gear is disposed on an outer sidewall of the second reagent disk.

In a specific embodiment, the fourth drive assembly comprises: the second fixed gear is fixedly connected with the supporting disc, and is coaxially fixed with the second uniform mixing assembly; the second fixed gear is meshed with the second planetary gear; wherein,,

the second fixed gear is coaxially arranged with the second reagent disk.

In a specific embodiment, the number of the second planetary gears is plural, and plural second planetary gears are disposed around the second fixed gear.

Drawings

For a clearer description of one or more embodiments of the present utility model or of the solutions of the prior art, the following description will briefly explain one or more embodiments of the present utility model, and it is obvious to those skilled in the art that other drawings can be obtained according to these drawings without inventive effort.

FIG. 1 is a schematic diagram of a reagent mixing apparatus according to an embodiment of the present utility model;

fig. 2 is a schematic structural diagram of a first mixing device according to an embodiment of the present utility model;

fig. 3 is a schematic structural diagram of a second mixing device according to an embodiment of the present utility model;

FIG. 4 is a schematic diagram illustrating the cooperation between a kit component and a first mixing component according to an embodiment of the present utility model;

fig. 5 is a schematic structural diagram of a first mixing component according to an embodiment of the present utility model;

fig. 6 is a cross-sectional view of a magnetic bead bottle according to an embodiment of the present utility model.

Detailed Description

In order to make the objects, technical solutions and advantages of the present utility model more apparent, the technical solutions of the present utility model will be further described in detail below with reference to specific embodiments and with reference to the accompanying drawings.

Further details are provided below by way of the figures and examples. The features and advantages of the present utility model will become more apparent from the description.

The word "exemplary" is used herein to mean "serving as an example, embodiment, or illustration. Any embodiment described herein as "exemplary" is not necessarily to be construed as preferred or advantageous over other embodiments. Although various aspects of the embodiments are illustrated in the accompanying drawings, the drawings are not necessarily drawn to scale unless specifically indicated.

In addition, the technical features described below in the different embodiments of the present application may be combined with each other as long as they do not collide with each other.

In order to facilitate understanding of the reagent mixing device provided in the embodiments of the present application, first, an application scenario thereof will be described. The reagent mixing device provided by the embodiment of the application is used for in-vitro diagnosis projects, and the reagent mixing device is convenient to detect because the reagent containing solid phase is required to be mixed evenly. The existing reagent mixing device has less storage quantity for reagent mixing, and the whole device is complex. For this purpose, the embodiment of the present application provides a reagent mixing device, and the following details are described with reference to specific drawings and examples.

Referring to fig. 1, a schematic structural diagram of a reagent mixing device according to an embodiment of the present application is provided. The reagent mixing device comprises two reagent disc mixing devices which are nested. For convenience of description, the reagent disk mixing apparatus located at the inner ring is named as a first mixing apparatus 100, and the reagent disk mixing apparatus located at the outer ring is named as a second mixing apparatus 200. When carrying the kit 400, the first mixing device 100 and the second mixing device 200 can each carry the kit 400. The first mixing device 100 and the second mixing device 200 will be described in detail below with reference to the drawings.

Referring to fig. 2, fig. 2 shows a first mixing device 100, the first mixing device 100 comprising a first reagent disk 140, and a first driving assembly 110 driving the first reagent disk 140 in rotation. The first reagent disk 140 has a circular structure and is used for carrying the reagent kit 400. In a specific arrangement, the first reagent disk 140 is provided with a plurality of positioning structures around its axis for positioning and fixing with the reagent cartridge 400. So that the reagent cartridge 400 is placed around the axis of the first reagent disk 140 when being placed on the first reagent disk 140, increasing the number of places of the reagent cartridge 400.

The first reagent disk 140 may be driven by the first driving assembly 110 while being driven to rotate. Referring to fig. 1 and 2 together, the reagent mixing apparatus further comprises a support plate 300, and the support plate 300 is used for supporting the first reagent plate 140 to rotate. When assembled, the first reagent disk 140 is rotatably coupled to the support disk 300. The support plate 300 serves as a support structure that faces away from the first reagent plate 140 for supporting the reagent cartridge 400, so as to avoid that the arranged support plate 300 influences the effect of the first reagent plate 140 on supporting the reagent cartridge 400.

When the first reagent disk 140 is driven, the first driving assembly 110 drives the first reagent disk 140 to rotate relative to the support disk 300. Illustratively, the first drive assembly 110 drives the first reagent disk 140 in rotation via a pulley assembly. When specifically provided, the first drive assembly 110 includes a first drive motor, a first pulley, a second pulley, and a drive belt. The first driving motor is fixed on the support plate 300, for example, by a threaded connection (a bolt or a screw) on a side of the support plate 300 facing away from the first reagent plate 140. The first belt pulley is coaxially fixed with the output shaft of the first driving motor, the second belt pulley is coaxially arranged with the first real disc assembly, and the transmission belt is sleeved on the first belt pulley and the second belt pulley for transmission. When the first driving motor rotates, the first belt pulley drives the second belt pulley to rotate, and then drives the first reagent disk 140 to rotate.

When the kit 400 is placed on the first reagent disk 140, it is necessary to mix the reagents contained in the kit 400 uniformly. Accordingly, the first mixing device 100 further comprises a first mixing assembly 120. The first mixing component 120 is rotatably connected with the first reagent disk 140, and drives the magnetic bead bottle 410 in the reagent kit 400 to rotate, so as to mix the reagents in the magnetic bead bottle 410 uniformly.

When the kit 400 is arranged on the first reagent disk 140 in a surrounding manner, the kit 400 can be correspondingly mixed by the first mixing components 120.

When the first mixing assembly 120 drives the magnetic bead bottle 410 of the kit 400 to rotate, the magnetic bead bottle 410 in the kit 400 is driven by the second driving assembly 130, and the second driving assembly 130 is used for driving the first mixing assembly 120 to rotate relative to the first reagent disk 140 so as to drive the magnetic bead bottle 410 in the kit 400 to rotate.

When specifically provided, the second driving assembly 130 includes a first fixed gear 131 and a first planetary gear 132 that are engaged with each other. The first fixed gear 131 is fixedly connected with the support plate 300, and the first fixed gear 131 is coaxially disposed with the first reagent plate 140. The first planetary gear 132 is coaxially disposed with the first mixing assembly 120, and fixedly connected thereto. Wherein the first fixed gear 131 is engaged with the first planetary gear 132 such that the first planetary gear 132 can rotate with respect to the first fixed gear 131 when the first reagent disk 140 rotates with respect to the support disk 300.

When the first mixing device is arranged, the number of the first planetary gears 132 is a plurality of, and the plurality of first planetary gears 132 are in one-to-one correspondence with the plurality of first mixing components 120. When the plurality of first planetary gears 132 are engaged with the first fixed gear 131, the plurality of first planetary gears 132 are disposed around the first fixed gear 131, so that the plurality of first planetary gears 132 can be rotated around the first fixed gear 131 and can be rotated around the own axis when the first reagent disk 140 is rotated.

It should be appreciated that when the first planetary gears 132 are specifically configured, the first planetary gears 132 and the first mixing assembly 120 are arranged on opposite sides of the first reagent disk 140. The first mixing assembly 120 is fixedly connected to the first planetary gear 132 through a rotating shaft, which is disposed on the first reagent disk 140 and can rotate relative to the first reagent disk 140. One end of the rotating shaft exposed out of the first reagent disk 140 is fixedly connected with the first mixing assembly 120, and the other end of the rotating shaft exposed out of the first reagent disk 140 is fixedly connected with the first planetary gears 132, so that the first mixing assembly 120 and the first planetary gears 132 are respectively arranged on two opposite sides of the first reagent disk 140.

Referring to fig. 1 and 3 together, fig. 3 shows a schematic configuration of a second mixing device 200. The first mixing device 100 includes a second reagent disk 240 nested with the first reagent disk 140, and a third driving assembly 210 for driving the second reagent disk 240 to rotate. The second reagent disk 240 has a ring structure, and is sleeved on the outer side of the first reagent disk 140. When carrying the kit 400, the second reagent disk 240 is provided with a plurality of positioning structures around its axis, which are used for positioning and fixing with the kit 400. So that the kit 400 is placed around the axis of the second reagent disk 240 when being placed on the second reagent disk 240, increasing the number of places for the kit 400. As can be seen from the above description, the reagent mixing device provided in the embodiments of the present application can increase the number of the carrying reagent boxes 400 as much as possible, for example, at least 50% of the reagent boxes 400 can be increased by two reagent boxes that are nested.

The second reagent disk 240 may be driven by the third driving assembly 210 while being driven to rotate. Referring to fig. 1 and 3 together, the reagent mixing apparatus further comprises a supporting plate 300, and the supporting plate 300 is used for simultaneously supporting the first reagent plate 140 and the second reagent plate 240 to rotate. The second reagent disk 240 is rotatably coupled to the support disk 300 during assembly. The support plate 300 acts as a support structure facing away from the side of the second reagent plate 240 for supporting the reagent cartridge 400, so as to avoid that the arranged support plate 300 influences the effect of the second reagent plate 240 on supporting the reagent cartridge 400.

When the second reagent disk 240 is driven to rotate, the second reagent disk 240 may be driven to rotate relative to the support disk 300 by the third driving assembly 210. As an example, the third driving assembly 210 rotates the second reagent disk 240 through a gear assembly. Specifically, the third driving assembly 210 includes a second driving motor 211, which is fixed to the support plate 300, an output shaft of the second driving motor 211 is connected to a driving gear 212, and in addition, a driving gear ring 213 is coaxially and fixedly connected to the second reagent plate 240, and the driving gear 212 is meshed with the driving gear ring 213. When the second reagent disk 240 is driven to rotate, the output shaft of the second driving motor 211 drives the driving gear 212 to rotate, and the driving gear 212 drives the driving gear ring 213 to rotate, so as to drive the second reagent disk 240 to rotate.

When the second driving motor 211 is specifically provided, the second driving motor 211 may be fixed to the support plate 300 through a screw connection (a bolt or a screw), wherein the body of the second driving motor 211 is provided at a side of the support plate 300 facing away from the second reagent disk 240. And the output shaft of the second driving motor 211 is exposed through the supporting plate 300, and the driving gear 212 is fixed at the end of the output shaft exposed at the supporting plate 300.

When the driving ring gear 213 is provided, the driving ring gear 213 may be integrally formed with the second reagent disk 240. Illustratively, the drive ring gear 213 is disposed on an outer sidewall of the second reagent disk 240. That is, teeth are directly prepared on the outer side wall of the second reagent disk 240 to form an annular gear ring, thereby securing the connection strength of the annular gear ring with the second reagent disk 240.

When the kit 400 is placed on the second reagent disk 240, it is necessary to mix the reagents contained in the kit 400 uniformly. Accordingly, the second mixing device 200 further comprises a second mixing assembly 220. The second mixing component 220 is rotatably connected with the second reagent disk 240, and drives the magnetic bead bottle in the kit 400 to rotate, so as to mix the reagents in the magnetic bead bottle uniformly.

When the kit 400 is arranged on the second reagent disk 240 in a surrounding manner, the kit 400 can be correspondingly mixed by the second mixing components 220.

When the second mixing assembly 220 drives the magnetic bead bottle of the kit 400 to rotate, the magnetic bead bottle is driven by the fourth driving assembly 230, and the fourth driving assembly 230 is used for driving the second mixing assembly 220 to rotate relative to the second reagent disk 240 so as to drive the magnetic bead bottle in the kit 400 to rotate.

In a specific arrangement, the fourth drive assembly 230 includes a second fixed gear 231 and a second planetary gear 232. The second fixed gear 231 is fixedly connected with the support plate 300, and the second fixed gear 231 is coaxially disposed with the second reagent plate 240. And the second planetary gear 232 is coaxially disposed with the second mixing assembly 220 and fixedly connected thereto. Wherein the second fixed gear 231 is engaged with the second planetary gear 232 such that the second planetary gear 232 can rotate with respect to the second fixed gear 231 when the second reagent disk 240 rotates with respect to the support disk 300.

In a specific embodiment, the second fixed gear 231 is located on the same surface of the support plate 300 as the second driving gear 212, and the second fixed gear 231 is nested with the second driving gear 212.

For convenience of understanding the cooperation between the first mixing component 120 and the second mixing component 220 and the kit 400 provided in the embodiments of the present application, the cooperation between the first mixing component 120 and the kit 400 will be described by taking the structure of the first mixing component 120 and the structure of the second mixing component as an example.

Referring to fig. 4, fig. 4 is a schematic diagram illustrating the cooperation of the first mixing component 120 and the kit 400 according to the embodiment of the present application. The kit 400 includes a reagent bottle sleeve 320 and a magnetic bead bottle 410 disposed within the reagent bottle sleeve 320. Wherein the magnetic bead bottle 410 is rotatably connected with the reagent bottle cap 320.

Referring to fig. 5 and 6, the engagement structure of the magnetic bead bottle 410 includes a first engagement structure 411 and a second engagement structure 412 when engaged with the reagent disk. The first engaging structure 411 and the second engaging structure 412 are located at one end of the magnetic bead bottle 410 facing the reagent disk, so as to ensure that the magnetic bead bottle 410 can be matched with the reagent disk.

When the first engaging structure 411 and the second engaging structure 412 are specifically disposed, the first engaging structure 411 and the second engaging structure 412 are arranged at intervals, and the first engaging structure 411 and the second engaging structure 412 are arranged on both sides of the axis of the magnetic bead bottle 410. In addition, the first engaging structure 411 and the second engaging structure 412 are provided at different heights. For example, the height of the first engaging structure 411 is H1, and the height of the second engaging structure 412 is H2, then: h1 > H2, or H1 < H2. When the heights of the first clamping structure 411 and the second clamping structure 412 are different, the first clamping structure 411 and the second clamping structure 412 are convenient to collide with the first mixing component 120 on the reagent disk when being inserted into the driving structure on the reagent disk, and the first clamping structure 411 and the second clamping structure 412 are convenient to cooperate with the first mixing component 120 on the reagent disk.

Referring to fig. 4 and 6, the first mixing assembly 120 on the reagent disk includes a driving column 122 and two driving columns 121 disposed on the driving column 122, when the magnetic bead bottle 410 is matched with the first mixing assembly 120, the driving column 122 is inserted between the first engaging structure 411 and the second engaging structure 412, and when the driving column 122 rotates, the two driving columns 121 are respectively pressed against the first engaging structure 411 and the second engaging structure 412 in a one-to-one correspondence manner, so as to drive the magnetic bead bottle 410 to rotate. When the magnetic bead bottle 410 is inserted into the first mixing component 120, since the first engaging structure 411 and the second engaging structure 412 have different heights, if there is a collision between the transmission column 121 and one of the engaging structures, only one engaging structure collides with the other engaging structure, and at this time, the magnetic bead bottle 410 can be relatively rotated to complete the assembly, so that the difficulty in the assembly can be reduced.

As an alternative, when the first engaging structure 411 and the second engaging structure 412 are specifically arranged, a first conical guiding structure is arranged at one end of the first engaging structure 411 away from the magnetic bead bottle 410; and/or, a second conical guiding structure is disposed at an end of the second engaging structure 412 away from the magnetic bead bottle 410. When the first taper guiding structure and the second taper guiding structure are arranged, the first taper guiding structure and the second taper guiding structure are respectively arranged at one end of the first clamping structure 411 and one end of the second clamping structure 412, which face the reagent disk. As an example, only the first engagement 411 may be provided with a first tapered guide structure; alternatively, only the second engaging structure 412 may be provided with a second tapered guiding structure; alternatively, the first engagement structure 411 and the second engagement structure 412 are provided with a first tapered guide structure and a second tapered guide structure, respectively.

When setting up above-mentioned guide structure, can be in the transmission post 121 when collision appears in two block structures, lead the direction of inserting of magnetic bead bottle 410 through toper guide structure, improve the reliability of correct connection between the transmission structure on magnetic bead bottle 410 and the reagent dish by a wide margin, effectively avoided the condition that both are mutually collided.

In the description of the present application, it should be noted that, the azimuth or positional relationship indicated by the terms "upper", "lower", "inner", "outer", "front", "rear", "left", "right", etc. are based on the azimuth or positional relationship in the working state of the present application, and are merely for convenience of description and simplification of the description, and are not indicative or implying that the apparatus or element in question must have a specific azimuth, be configured and operated in a specific azimuth, and that the relative positional relationship may be changed correspondingly when the absolute position of the object to be described is changed.

It is to be noted that unless otherwise defined, technical or scientific terms used in one or more embodiments of the present utility model should be taken in a general sense as understood by one of ordinary skill in the art to which the present utility model belongs. The use of the terms "first," "second," and the like in one or more embodiments of the present utility model does not denote any order, quantity, or importance, but rather are used to distinguish one element from another. The word "comprising" or "comprises", and the like, means that elements or items preceding the word are included in the element or item listed thereafter and equivalents thereof without precluding other elements or items. The terms "connected" or "connected," and the like, are not limited to physical or mechanical connections, but may include electrical connections, whether direct or indirect.

In the description of the present utility model, it should be noted that the terms "mounted," "connected," and "connected" are to be construed broadly, unless otherwise specifically defined and limited. The specific meaning of the above terms in the present utility model will be understood in specific cases by those of ordinary skill in the art.

The technical solutions of the present utility model have been described above in connection with preferred embodiments, but these embodiments are merely exemplary and serve only for illustrative purposes. On this basis, various substitutions and modifications can be made to the embodiments, which fall within the scope of the present utility model.

Claims

1. A reagent mixing device, comprising:

2. The reagent mixing apparatus of claim 1, further comprising a support tray; the first reagent disk and the second reagent disk are respectively connected with the supporting disk in a rotating way.

3. The reagent mixing apparatus of claim 2, wherein the first driving assembly comprises a first driving motor fixed on the supporting plate, a first belt pulley coaxially fixed with an output shaft of the first driving motor, and a second belt pulley coaxially arranged with the first reagent plate; and the transmission belt is sleeved on the first belt pulley and the second belt pulley.

4. The reagent mixing apparatus of claim 3, wherein the second drive assembly comprises: the first fixed gear is fixedly connected with the supporting disc, and is coaxially arranged with the first planetary gear of the first uniform mixing assembly; the first fixed gear is meshed with the first planetary gear; wherein,,

the first fixed gear is coaxially arranged with the first reagent disk.

5. The reagent mixing apparatus of claim 4, wherein the first planetary gear and the first mixing assembly are arranged on opposite sides of the first reagent disk.

6. The reagent mixing apparatus according to claim 4, wherein the number of the first planetary gears is plural, and the plural first planetary gears are disposed around the first fixed gear.

7. The reagent mixing apparatus according to any one of claims 2 to 6, wherein the third driving assembly comprises a second driving motor fixed on the supporting plate, a driving gear connected with an output shaft of the second driving motor, and a driving gear ring coaxially and fixedly connected with the second reagent plate; the drive gear is meshed with the drive gear ring.

8. The reagent mixing apparatus of claim 7, wherein the drive ring gear is disposed on an outer sidewall of the second reagent disk.

9. The reagent mixing apparatus of claim 8, wherein the fourth drive assembly comprises: the second fixed gear is fixedly connected with the supporting disc, and is coaxially fixed with the second uniform mixing assembly; the second fixed gear is meshed with the second planetary gear; wherein,,

the second fixed gear is coaxially arranged with the second reagent disk.

10. The reagent mixing apparatus of claim 9, wherein the number of the second planetary gears is plural, and the plural second planetary gears are disposed around the second fixed gear.