CN219302089U - Biological sample mixing device for pathogen nucleic acid detection - Google Patents
Biological sample mixing device for pathogen nucleic acid detection Download PDFInfo
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- CN219302089U CN219302089U CN202222023261.8U CN202222023261U CN219302089U CN 219302089 U CN219302089 U CN 219302089U CN 202222023261 U CN202222023261 U CN 202222023261U CN 219302089 U CN219302089 U CN 219302089U
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract
A biological sample mixing device for pathogen nucleic acid detection relates to the technical field of pathogen detection; the device comprises a machine base, a driving device, a transmission device and a clamping device, wherein the driving device is arranged inside the machine base and is connected with the transmission device, the transmission device comprises a rotating mechanism and an eccentric wheel sliding groove mechanism, and the output end of the transmission device penetrates through the outer wall of the machine base and is connected with the clamping device. According to the biological sample mixing device for pathogen nucleic acid detection, the rotation mechanism and the eccentric wheel sliding groove mechanism enable the sampling tube to conduct rotation and swing, so that efficient inversion mixing of the sampling tube is achieved, labor cost is reduced, operation difficulty is reduced, product quality is guaranteed, operation time is saved, and detection efficiency is improved.
Description
Technical Field
The utility model belongs to the technical field of pathogen detection, and particularly relates to a biological sample mixing device for pathogen nucleic acid detection.
Background
Pathogen nucleic acid testing is a procedure for searching a patient sample of a patient for the presence of nucleic acid from a foreign invading pathogen to determine whether the patient is infected, and is typically performed by sampling blood, secretions and feces from a test sample, such as EBV, HBV, HCV, HPV.
In blood sampling in modern medicine, a vacuum sampling tube is generally adopted to realize quantitative blood sampling and is matched with a venous blood taking needle for use, and an additive is generally required to be added into the vacuum sampling tube to keep the performance of the blood sample, so that after the blood sample is collected again by medical staff, the sampling tube is required to be reversely and uniformly mixed. On the one hand, because the shaking of the sampling tube needs to consume a certain time, if continuous multi-bottle sampling is needed, the residual blood in the venous blood taking needle can be blocked due to the coagulation phenomenon, and the blood taking needle needs to be replaced to prick again to draw blood again, so that time and materials are consumed, and more pain is brought to a patient. On the other hand, the manual shaking has certain professional and skill requirements on operators, too severe shaking can lead to cell wall breaking and hemolysis, and if shaking is insufficient, insufficient mixing of blood and additives can be caused, the accuracy of subsequent detection is affected, and the detection efficiency is low. Aiming at the problems of high labor cost and high professional and skill requirements for operators when shaking biological samples by hands, an automatic biological sample mixing device is necessary to replace manual shaking operation, but the conventional biological sample mixing device moves singly and only performs simple swinging motion on the samples, and the mixing effect of the samples is far lower than that of the manual shaking during low-frequency swinging, so that the working time is longer; when the sample is swayed at high frequency, the cell wall is broken easily, hemolysis is caused, and the sample cells are destroyed. Therefore, there is a need for a device for mixing biological samples with multidirectional motion, which can better replace hands to perform shaking operation, and has higher mixing efficiency without damaging sample cells.
Disclosure of Invention
In order to overcome the defects of the prior art, the utility model aims to provide a biological sample mixing device for pathogen nucleic acid detection, which realizes automatic shaking of a sampling tube, improves the detection efficiency and ensures the quality of blood samples.
The utility model adopts the following technical scheme:
a biological sample mixing device for pathogen nucleic acid detection, includes frame, drive arrangement, transmission and clamping device, drive arrangement installs inside the frame, drive arrangement is connected with transmission, transmission includes rotary mechanism and eccentric wheel slide groove mechanism, transmission's output passes the frame outer wall and is connected with clamping device.
Further, the rotating mechanism comprises a first gear, a second gear and a control shaft, the first gear is connected with the output end of the driving device, the first gear is meshed with the second gear, the second gear is fixedly connected with the control shaft, and the end part of the control shaft is connected with the clamping device.
Further, an eccentric wheel sliding groove mechanism is arranged in the control shaft and is connected with the clamping device.
Further, eccentric wheel slide groove mechanism includes eccentric wheel and movable block, transmission still includes third gear, fourth gear and transfer line, the third gear with drive arrangement is connected, third gear and fourth gear engagement, the fourth gear with transfer line fixed connection, the transfer line with eccentric wheel fixed connection, the inside spout that is equipped with of movable block, the eccentric wheel with movable block sliding connection, the movable block is located on the control shaft and both rotate and connect, the movable block with clamping device connects.
Further, the clamping device comprises two symmetrical clamping jaws, and an arc-shaped groove is formed in the inner side of each clamping jaw.
Further, a bearing block for loading the sampling tube is arranged at the bottom of the clamping device.
Further, the device also comprises a control system for controlling the driving device, and a sensing device of the control system is positioned inside the bearing block.
Further, the machine base is also provided with a storage rack, and a plurality of storage grooves are formed in the storage rack.
Further, a plurality of storage tanks are arranged at equal intervals.
Further, a storage groove is formed in the machine base, and the storage groove is used for storing the storage rack.
Compared with the prior art, the utility model has the beneficial effects that:
according to the biological sample mixing device for pathogen nucleic acid detection, the rotation mechanism and the eccentric wheel sliding groove mechanism enable the sampling tube to conduct rotation and swing, so that efficient inversion mixing of the sampling tube is achieved, labor cost is reduced, operation difficulty is reduced, product quality is guaranteed, operation time is saved, and detection efficiency is improved.
Drawings
FIG. 1 is a perspective view of a biological sample homogenization device for pathogen nucleic acid detection of the present utility model.
FIG. 2 is a cross-sectional view of the biological sample homogenization device for pathogen nucleic acid detection of the present utility model of FIG. 1.
FIG. 3 is a schematic structural view of an eccentric wheel chute mechanism of a biological sample mixing device for pathogen nucleic acid detection according to the present utility model.
Wherein, 1, the frame; 11. a storage groove; 2. a transmission device; 21. a first gear; 22. a second gear; 23. a third gear; 24. a fourth gear; 25. a control shaft; 26. a transmission rod; 27. an eccentric wheel; 28. a movable block; 281. a chute; 3. a clamping device; 31. a support block; 4. a storage rack; 5. a driving device.
Detailed Description
The present utility model will be further described with reference to the following specific embodiments, and it should be noted that, on the premise of no conflict, new embodiments may be formed by any combination of the embodiments or technical features described below.
A biological sample mixing device for pathogen nucleic acid detection, includes frame 1, drive arrangement 5, transmission 2 and clamping device 3, drive arrangement 5 installs inside frame 1, drive arrangement 5 is connected with transmission 2, the output of transmission 2 passes frame 1 outer wall and is connected with clamping device 3.
The transmission device 2 comprises a rotating mechanism and an eccentric wheel 27 sliding groove 281 mechanism, and is used for performing rotating motion and swinging motion on the sampling tube; the rotating mechanism comprises a first gear 21, a second gear 22 and a control shaft 25, wherein the first gear 21 is connected with the output end of the driving device 5, the first gear 21 is meshed with the second gear 22, the second gear 22 is fixedly connected with the control shaft 25, and the end part of the control shaft 25 is connected with the clamping device 3; meanwhile, an eccentric wheel 27 sliding groove 281 mechanism is arranged in the control shaft 25, and the eccentric wheel 27 sliding groove 281 mechanism is connected with the clamping device 3;
specifically, the transmission device 2 further comprises a third gear 23, a fourth gear 24 and a transmission rod 26, the sliding groove 281 mechanism of the eccentric wheel 27 comprises an eccentric wheel 27 and a movable block 28, the third gear 23 is connected with the driving device 5, the third gear 23 is meshed with the fourth gear 24, the fourth gear 24 is fixedly connected with the transmission rod 26, the transmission rod 26 is fixedly connected with the eccentric wheel 27, the sliding groove 281 is arranged in the movable block 28, the sliding groove 281 is preferably in a flat and oblong shape, the eccentric wheel 27 is in sliding connection with the movable block 28, irregular swinging of the movable block 28 is realized through rotation of the eccentric wheel 27, the movable block 28 is positioned on the control shaft 25 and is in rotational connection with the control shaft, and the movable block 28 is connected with the clamping device 3.
The clamping device 3 comprises two symmetrical clamping jaws, an arc-shaped groove is formed in the inner sides of the clamping jaws, and a bearing block 31 for loading a sampling tube is arranged at the bottom of the clamping device 3; any mechanism for moving two symmetrical jaws toward each other may be used in this embodiment, including but not limited to driving the two jaws toward each other by an air cylinder.
The biological sample mixing device of this embodiment further includes a control system for controlling the driving device 5, the sensing device of the control system is located inside the supporting block 31, the sensing device may be any device such as an infrared sensor, a point touch sensor, etc. that senses that a foreign matter exists in the supporting block 31 and triggers and sends a signal, when the sensing device triggers, the signal is sent to the controller, the controller controls the clamping device 3 to clamp the sampling tube, then the driving device 5 is started, the driving device 5 of this embodiment is a motor, parameters such as time and rotation speed of the motor can be set in advance in the controller as required to adjust and achieve the best effect, for example, the time is 10s, and the rotation speed is 200rpm.
Further, the machine base 1 is further provided with a storage rack 4, and a plurality of storage grooves are formed in the storage rack 4; the arrangement in the embodiment is that the storage tanks are equidistantly arranged according to the specification of 2 multiplied by 7; the inside storage tank 11 that is equipped with of frame 1, storage tank 11 is used for accomodating storage rack 4, be equipped with the slide rail between storage rack 4 and the storage tank 11, make storage rack 4 free activity in storage tank 11.
The action principle of the embodiment is as follows:
in the moving state, the clamping device 3 moves in opposite directions to clamp and fix the sampling tube, the driving device 5 is started to drive the first gear 21 to move, the second gear 22 is rotated through the first gear 21, and the control shaft 25 is rotated through the second gear 22; meanwhile, the driving device 5 drives the third gear 23 to move, the fourth gear 24 is rotated through the third gear 23, the transmission rod 26 is rotated through the fourth gear 24, the transmission rod 26 drives the eccentric wheel 27 to rotate, the movable block 28 swings in the control shaft 25 through interaction of the sliding groove 281 of the movable block 28 and the eccentric wheel 27, and the movable block 28 is connected with the clamping device 3, so that the sampling tube continuously and repeatedly swings in rotation, and blood and additives in the sampling tube swing reversely and uniformly.
According to the biological sample mixing device for pathogen nucleic acid detection, the rotation mechanism and the eccentric wheel 27 sliding groove 281 mechanism enable the sampling tube to conduct rotation motion and swing motion, so that efficient inversion mixing of the sampling tube is achieved, labor cost is reduced, operation difficulty is reduced, product quality is guaranteed, operation time is saved, and detection efficiency is improved.
The above embodiments are only preferred embodiments of the present utility model, and the scope of the present utility model is not limited thereto, but any insubstantial changes and substitutions made by those skilled in the art on the basis of the present utility model are intended to be within the scope of the present utility model as claimed.
Claims (10)
1. The biological sample mixing device for pathogen nucleic acid detection is characterized by comprising a machine base, a driving device, a transmission device and a clamping device, wherein the driving device is arranged inside the machine base and is connected with the transmission device, the transmission device comprises a rotating mechanism and an eccentric pulley groove mechanism, and the output end of the transmission device penetrates through the outer wall of the machine base and is connected with the clamping device.
2. The biological sample homogenization apparatus for pathogen nucleic acid detection of claim 1, wherein: the rotary mechanism comprises a first gear, a second gear and a control shaft, wherein the first gear is connected with the output end of the driving device, the first gear is meshed with the second gear, the second gear is fixedly connected with the control shaft, and the end part of the control shaft is connected with the clamping device.
3. The biological sample homogenization apparatus for pathogen nucleic acid detection of claim 2, wherein: and an eccentric wheel sliding groove mechanism is arranged in the control shaft and is connected with the clamping device.
4. The biological sample homogenization apparatus for pathogen nucleic acid detection of claim 3, wherein: the eccentric wheel sliding groove mechanism comprises an eccentric wheel and a movable block, the transmission device further comprises a third gear, a fourth gear and a transmission rod, the third gear is connected with the driving device, the third gear is meshed with the fourth gear, the fourth gear is fixedly connected with the transmission rod, the transmission rod is fixedly connected with the eccentric wheel, a sliding groove is formed in the movable block, the eccentric wheel is in sliding connection with the movable block, the movable block is located on the control shaft and is in rotary connection with the control shaft, and the movable block is connected with the clamping device.
5. The biological sample homogenization apparatus for pathogen nucleic acid detection of claim 1, wherein: the clamping device comprises two symmetrical clamping jaws, and arc-shaped grooves are formed in the inner sides of the clamping jaws.
6. The biological sample homogenization apparatus for pathogen nucleic acid detection of claim 5, wherein: the bottom of the clamping device is provided with a bearing block for loading the sampling tube.
7. The biological sample homogenization apparatus for pathogen nucleic acid detection of claim 6, wherein: the device also comprises a control system for controlling the driving device, and a sensing device of the control system is positioned inside the bearing block.
8. The biological sample homogenization apparatus for pathogen nucleic acid detection of claim 1, wherein: the machine base is also provided with a storage rack, and a plurality of storage grooves are formed in the storage rack.
9. The biological sample homogenization apparatus for pathogen nucleic acid detection of claim 8, wherein: the storage tanks are equidistantly arranged.
10. The biological sample homogenization apparatus for pathogen nucleic acid detection of claim 8, wherein: the inside storage groove that is equipped with of frame, the storage groove is used for accomodating the storage rack.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202222023261.8U CN219302089U (en) | 2022-08-01 | 2022-08-01 | Biological sample mixing device for pathogen nucleic acid detection |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202222023261.8U CN219302089U (en) | 2022-08-01 | 2022-08-01 | Biological sample mixing device for pathogen nucleic acid detection |
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| CN219302089U true CN219302089U (en) | 2023-07-04 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115322883A (en) * | 2022-08-09 | 2022-11-11 | 苏州海苗生物科技有限公司 | Totally-enclosed multi-target nucleic acid isothermal amplification detection device |
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- 2022-08-01 CN CN202222023261.8U patent/CN219302089U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115322883A (en) * | 2022-08-09 | 2022-11-11 | 苏州海苗生物科技有限公司 | Totally-enclosed multi-target nucleic acid isothermal amplification detection device |
| CN115322883B (en) * | 2022-08-09 | 2024-03-01 | 苏州海苗生物科技有限公司 | Totally-enclosed multi-target nucleic acid isothermal amplification detection device |
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