CN219229846U - Bimodal living body imaging system - Google Patents
Bimodal living body imaging system Download PDFInfo
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- CN219229846U CN219229846U CN202222963051.7U CN202222963051U CN219229846U CN 219229846 U CN219229846 U CN 219229846U CN 202222963051 U CN202222963051 U CN 202222963051U CN 219229846 U CN219229846 U CN 219229846U
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Abstract
The utility model relates to the field of living body imaging technology, and provides a bimodal living body imaging system, which comprises: the device comprises an excitation light source, a short-wave infrared sensor, a dichroic mirror, a reflecting mirror and an infrared thermal imaging device; the excitation light source and the short-wave infrared sensor are respectively arranged at two opposite sides of the dichroic mirror, the reflecting mirror is arranged in the infrared radiation range of the experimental animal, and the infrared thermal imaging device is arranged at one side of the reflecting mirror close to the short-wave infrared sensor; after the laser emitted by the excitation light source passes through the dichroic mirror, the nanometer fluorescent probe in the animal body is excited to emit fluorescence; the short-wave infrared sensor receives laser emitted by the nano fluorescent probe and forwarded by the dichroic mirror; the infrared thermal imaging device receives the infrared radiation energy of the experimental animal forwarded by the reflector and converts the infrared radiation energy into an electric signal. Short-wave infrared fluorescence imaging and thermal imaging are built into the same system, so that real-time dynamic changes of temperature of a corresponding region and nano probe targeting substance imaging of experimental animals at the same time point are realized.
Description
Technical Field
The utility model relates to the technical field of living body imaging, in particular to a bimodal living body imaging system.
Background
In the process of fight against diseases of human beings, the accurate early diagnosis and treatment of the diseases still remains a great challenge, and generally, in vivo animal experiments are performed to study and observe the diseases, and then the results of the animal experiments are used for guiding the diagnosis and treatment of the diseases of human beings.
Because the conventional detection method such as EL I SA and blood conventional plasma medical detection method cannot observe in vivo conditions in real time and has certain hysteresis, imaging detection such as CT and MRI generally lacks targeting of specific substances, sensitivity and specificity cannot be guaranteed, accurate development cannot be performed on the bodies of experimental animals, objective and accurate real-time quantitative data are difficult to obtain, and high-quality preclinical researches cannot be performed. Therefore, it is needed to design a multifunctional imaging system for animal experiment research, so as to solve the key technical problem of real-time 'seeing' the space-time variation process of a specific object in a target area in animal experiments.
The short-wave infrared fluorescence imaging development technology is a research hot spot in the biomedical development field in recent years, mainly depends on a fluorescent probe marking technology to track and observe the change information of a region of interest in biological tissues and cells, and has the advantages of rapidness, simplicity, convenience, no radiation loss, non-invasiveness, high sensitivity, capability of penetrating soft tissues to a large extent to realize deep tissue development, realization of early diagnosis of pathological tissues, real-time imaging and the like. In recent decades, research in the visible region (400-700 nm) and in the short-wave infrared (700-900 nm) imaging has been dominant, making a great contribution to the development and advancement of biomedicine. The thermal imaging technology mainly relies on temperature sensor to observe temperature change information of a region of interest in biological tissues and cells, has the advantages of high precision, high sensitivity, no invasiveness, capability of observing small temperature change of a target region in real time and the like, and has great application prospect in the biomedical field along with the continuous development of the technologies such as the precision of the sensor and the like.
In the prior art, a living animal is imaged by a simple short-wave infrared fluorescence imaging technology, or the temperature of the living animal is observed in real time by a simple thermal imaging technology. The single short wave infrared imaging technology or the single thermal imaging technology cannot complete the real-time dynamic change of the nano probe targeting substance in the experimental animal and the bimodal observation of the real-time temperature of the corresponding area of the experimental animal at the same time point. In medical research, the fields such as pathogen infection-immunization and treatment by using different temperatures are continuously studied, the change of a specific object in animal tissues and the change of regional temperature become one of hot spots for research, the real-time change of the two are generally in corresponding relation under different physiological or pathological states of experimental animals, and if two devices are combined together without an effective device, the real-time monitoring of multiple dimensions of the same animal cannot be realized.
Disclosure of Invention
Aiming at the problems, the utility model aims to provide a bimodal living body imaging system, which is used for realizing the imaging of a nano probe targeting substance of an experimental animal at the same time point and the monitoring of the real-time dynamic change of the temperature of a corresponding area by setting up short-wave infrared fluorescence imaging and thermal imaging into the same system, and dynamically tracing the change of various substances including cells, collagen and pathogens and the body surface temperature of a specific biological cluster of the specific area of the experimental animal, so that the research of the corresponding field can be more accurate and scientific.
The above object of the present utility model is achieved by the following technical solutions:
a bimodal in vivo imaging system comprising: the device comprises an excitation light source, a short-wave infrared sensor, a dichroic mirror, a reflecting mirror and an infrared thermal imaging device;
the excitation light source and the short-wave infrared sensor are respectively arranged at two opposite sides of the dichroic mirror, the reflecting mirror is arranged in the infrared radiation range of the experimental animal, and the infrared thermal imaging device is arranged in the reflecting range of the reflecting mirror;
the excitation light source is configured to emit laser, and after the laser passes through the dichroic mirror, the nano fluorescent probe arranged in the experimental animal body is excited to emit fluorescence;
the short-wave infrared sensor is configured to receive the laser light emitted by the nano fluorescent probe forwarded by the dichroic mirror;
the infrared thermal imaging device is configured to receive infrared radiant energy of the laboratory animal forwarded by the reflector, convert the infrared radiant energy into an electrical signal, and amplify the electrical signal.
Further, the bimodal in vivo imaging system further comprises: the laser beam expander is arranged between the dichroic mirror and the excitation light source;
the laser beam expander is configured to constrain an irradiation range of the laser light and to uniformly irradiate the intensity of the laser light within the irradiation range.
Further, the bimodal in vivo imaging system further comprises: the light filtering device is arranged between the dichroic mirror and the short-wave infrared sensor;
the filtering device is configured to filter light rays in a wavelength band outside the observation requirement of the short-wave infrared sensor.
Further, the bimodal living body imaging system, the optical filtering device comprises: a filter and a filter wheel;
the optical filter is configured to filter light rays in a wave band outside the observation requirement of the short-wave infrared sensor;
the filter wheel is configured to replace the filter to account for the replacement of the filter when different types of band observation requirements.
Further, the short wave infrared sensor includes: a lens and a detector;
the lens is configured to collect the fluorescence;
the detector is configured to acquire a component of the fluorescent medium short wave infrared band.
Further, the bimodal in vivo imaging system further comprises: a lifting developing table arranged below the dichroic mirror;
the lifting developing station is configured to place the laboratory animal.
Further, the bimodal living body imaging system, the elevating developing station, comprises: a developing bottom plate and a light-blocking plate;
the developing base plate is configured to hold the laboratory animal;
the light-blocking baffle is arranged around the developing bottom plate and is configured to block light except the laser.
Further, the bimodal in vivo imaging system further comprises: the processing display device is respectively connected with the short-wave infrared sensor and the infrared thermal imaging device;
the processing display device is configured to receive the light fed back by the short-wave infrared sensor and convert the light into image display, receive the electric signal fed back by the infrared thermal imaging device and convert the electric signal into a video signal to display a thermal image of the experimental animal.
Further, the bimodal living body imaging system also comprises an animal gas anesthesia machine, an animal anesthesia induction box, an animal various disease model making operation table and animal living body developing operation related equipment including a gas conveying pipeline for continuous anesthesia of animals.
Compared with the prior art, the utility model has the following beneficial effects:
by providing a bimodal in vivo imaging system comprising: the device comprises an excitation light source, a short-wave infrared sensor, a dichroic mirror, a reflecting mirror and an infrared thermal imaging device; the excitation light source and the short-wave infrared sensor are respectively arranged at two opposite sides of the dichroic mirror, the reflecting mirror is arranged in the infrared radiation range of the experimental animal, and the infrared thermal imaging device is arranged in the reflecting range of the reflecting mirror; the excitation light source is configured to emit laser, and after the laser passes through the dichroic mirror, the nano fluorescent probe arranged in the experimental animal body is excited to emit fluorescence; the short-wave infrared sensor is configured to receive the laser light emitted by the nano fluorescent probe forwarded by the dichroic mirror; the infrared thermal imaging device is configured to receive infrared radiant energy of the laboratory animal forwarded by the reflector, convert the infrared radiant energy into an electrical signal, and amplify the electrical signal. According to the technical scheme, the short-wave infrared fluorescence imaging and the thermal imaging are built into the same system, the real-time dynamic change of the temperature of the corresponding region and the nano probe targeting substance imaging of the experimental animal at the same time point are realized, the specific biological clusters of the specific region of the experimental animal including the change of various substances including cells, collagen and pathogens and the body surface temperature of the specific region are dynamically tracked, and therefore the research of the experimental animal in various fields can be more accurate and scientific.
Drawings
FIG. 1 is a schematic diagram of the overall structure of a bimodal in-vivo imaging system in accordance with the present utility model;
FIG. 2 is a schematic view of a lifting developing station according to the present utility model.
Reference numerals
1: an excitation light source; 2: a short wave infrared sensor; 3: an optical path forwarding device; 4: an infrared thermal imaging device; 5: a laser beam expander; 6: a light filtering device; 7: lifting the developing table; 8, processing the display device; 9: an experimental animal;
21: a lens; 22: a detector;
31: a dichroic mirror; 32: a reflecting mirror;
61: a light filter; 62: a filter wheel;
71: a developing base plate; 72: and a light-blocking plate.
Detailed Description
For the purposes of making the objects, technical solutions and advantages of the embodiments of the present application more clear, the technical solutions of the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is apparent that the described embodiments are some embodiments of the present application, but not all embodiments. All other embodiments, which can be made by one of ordinary skill in the art without undue burden from the present disclosure, are within the scope of the present disclosure.
As used herein, the singular forms "a", "an", "the" and "the" are intended to include the plural forms as well, unless expressly stated otherwise, as understood by those skilled in the art. It will be further understood that the terms "comprises" and/or "comprising," when used in this specification, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof.
Examples
As shown in fig. 1, the present embodiment provides a bimodal living body imaging system, comprising: an excitation light source 1, a short-wave infrared sensor 2, an optical path forwarding device 3 (comprising a dichroic mirror 31 and a reflecting mirror 32), an infrared thermal imaging device 4; the excitation light source 1 and the short-wave infrared sensor 2 are respectively arranged at two opposite sides of the dichroic mirror 31, the reflecting mirror 32 is arranged in the infrared radiation range of the experimental animal, and the infrared thermal imaging device 4 is arranged in the reflecting range of the reflecting mirror 32.
The excitation light source 1 is configured to emit laser light, and after the laser light passes through the dichroic mirror 31, the nano fluorescent probe arranged in the experimental animal body is excited to emit fluorescence; the short-wave infrared sensor 2 is configured to receive the laser light emitted by the nano-fluorescent probe forwarded by the dichroic mirror 31; the infrared thermal imaging device 4 is configured to receive the infrared radiant energy of the laboratory animal forwarded by the mirror 32, collect the infrared radiant energy by the photosensitive elements in the infrared thermal imaging device 4, convert the infrared radiant energy into an electrical signal, and amplify the electrical signal.
Specifically, the bimodal living body imaging system built by the technical point of the utility model can simultaneously adopt the short wave infrared fluorescence imaging and thermal imaging technology in one system, and when an animal experiment is carried out, the nanometer fluorescent probe (a fluorescent molecule with characteristic fluorescence in ultraviolet-visible-short wave infrared region and the fluorescence property of which can sensitively change along with the change of the property of the environment, such as polarity, refractive index, viscosity and the like) in the animal body can be simultaneously carried out at the same time point, and the targeted substance is imaged by crosslinking and the real-time change of the body surface temperature of the corresponding region is monitored in real time, so that the specific biological cluster of the specific region of the experimental animal, including the change of cells, collagen and pathogens and the body surface temperature are tracked, and the research of the corresponding field can be more accurate and scientific.
Further, the bimodal living body imaging system of the present embodiment further includes: a laser beam expander 5, wherein the laser beam expander 5 is arranged between the dichroic mirror 31 and the excitation light source 1; the laser beam expander 5 is configured to restrict an irradiation range of the laser light and to uniformly irradiate the intensity of the laser light within the irradiation range. By arranging the laser beam expander 5 between the dichroic mirror 31 and the laser light source 1, the laser beam is shaped by the laser beam expander 5 before entering the dichroic mirror 31, and the beam directed to the dichroic mirror 31 is within a certain range without scattering and uniformly emits light.
Further, the bimodal living body imaging system of the present embodiment further includes: a light filtering device 6, wherein the light filtering device 6 is arranged between the dichroic mirror 31 and the short-wave infrared sensor 2;
the filtering means 6 are configured to filter light rays in a wavelength band outside the observation requirement of the short-wave infrared sensor 2. Specifically, for the short-wave infrared sensor 2, the imaging of the nano fluorescence target substance needs to be observed in a specified wave band, the filtering device 6 has the function of filtering the light except the specified wave band, and the fluorescence only keeps the wave band required to be observed by the short-wave infrared sensor 2 after passing through the filtering device 6.
More specifically, the filtering device 6 further includes: a filter 61 and a filter wheel 62; the optical filter 61 is configured to filter light in a wavelength band outside the observation requirement of the short-wave infrared sensor 2; the filter wheel 62 is configured to replace the filter 61 to cope with the replacement of the filter 61 when a different kind of band observation is required. Since the wavelength band designated by the short-wave infrared sensor 2 is not necessarily the same in each observation, a filter wheel 62 is added to the filter device 6 for replacing the filter 61 when the wavelength band needs to be replaced.
Further, the short-wave infrared sensor 2 specifically includes: a lens 21 and a detector 22; the lens 21 is configured to collect the fluorescence; the detector 22 is configured to acquire components of the fluorescent medium short wave infrared band. The lens 31 and the detector 22 may be integrated together or may be separate devices, which is not limited in this embodiment.
Further, the bimodal living body imaging system of the present embodiment further includes: a lifting developing table 7 provided below the dichroic mirror 31; the lifting developing station 7 is configured to place the laboratory animal.
More specifically, the lifting developing station 7, as shown in fig. 2, includes: a developing bottom plate 71 and a light blocking plate 72;
the developing bottom plate 71 is configured to hold the laboratory animal; the light blocking plate 72 is disposed around the developing bottom plate 71 and configured to block light other than the laser light.
Further, the bimodal living body imaging system of the present embodiment further includes: the processing display device 8 is respectively connected with the short-wave infrared sensor 2 and the infrared thermal imaging device 4; the processing display device 8 is configured to receive the light fed back by the short-wave infrared sensor 2 and convert the light into image for display, and receive the electric signal fed back by the infrared thermal imaging device 4 and convert the electric signal into a video signal for displaying the thermal image of the experimental animal. The processing display device 8 may be a computer integrated with short-wave infrared image acquisition software and image processing software.
Further, the bimodal living body imaging system of the embodiment also comprises animal living body developing operation related equipment including an animal gas anesthesia machine, an animal anesthesia induction box, an animal various disease model manufacturing operation table and a gas conveying pipeline for continuous anesthesia of animals.
It should be noted that the present utility model is mainly directed to the connection relationship between devices in a bimodal imaging system, and aims to build a system capable of performing short-wave infrared imaging and thermal imaging at the same time. The structure of each device in the system can be a self-developed device or a device existing in the prior art, and the specific device selection is not specifically described in this embodiment.
For example, a 808nm fiber laser of model BOT808-10W-GQ produced by co-dimensional electronics may be used for the excitation light source 1, or a 850nm laser of model ZLM1200AD850-22FGD produced by Zhonglai laser may be used. For the short-wave infrared sensor 2, a short-wave infrared sensor manufactured by Al l ied v i s i on company, model Go l dye, may be used, which integrates a lens and a detector. For the infrared thermal imaging device 4, a thermal infrared imager of the type AT600 manufactured by arii photo electricity may be used. For the laser beam expander 5, a beam expander of the model BOT600D manufactured by co-dimensional electronics may be used. For the filter 61, a filter manufactured by CHROM A and having a model MV1650/60 may be used. For the dichroic mirror 31, a dichroic mirror of model dml p1000 l manufactured by tho l abs can be used. For the lifting developing stage 7, an imaging stage of GCM series produced by large constant photoelectric production can be used. The above is merely illustrative of specific devices included in the system of the present utility model and is not intended to limit the use of the devices of the present utility model. The concept of constructing a system capable of simultaneously carrying out short wave infrared imaging and thermal imaging at the same time point is included in the utility model. Through the integration and construction of the two systems, the method can help us to realize the imaging of the short-wave infrared fluorescent nano probe for simultaneously displaying the experimental animal and the thermal imaging of the corresponding area. The system can accurately analyze degradation speed and metabolic pathways in repairing various losses in animal bodies, and provides a high-precision, visual and convenient developing means for relevant basic research.
The above description is only a preferred embodiment of the present utility model, and the protection scope of the present utility model is not limited to the above examples, and all technical solutions belonging to the concept of the present utility model belong to the protection scope of the present utility model. It should be noted that modifications and adaptations to the present utility model may occur to one skilled in the art without departing from the principles of the present utility model and are intended to be within the scope of the present utility model.
The technical features of the above-described embodiments may be arbitrarily combined, and all possible combinations of the technical features in the above-described embodiments are not described for brevity of description, however, as long as there is no contradiction between the combinations of the technical features, they should be considered as the scope of the description.
It should be noted that the above embodiments can be freely combined as needed. The foregoing is merely a preferred embodiment of the present utility model and it should be noted that modifications and adaptations to those skilled in the art may be made without departing from the principles of the present utility model, which are intended to be comprehended within the scope of the present utility model.
Claims (9)
1. A bimodal in vivo imaging system, comprising: the device comprises an excitation light source, a short-wave infrared sensor, a dichroic mirror, a reflecting mirror and an infrared thermal imaging device;
the excitation light source and the short-wave infrared sensor are respectively arranged at two opposite sides of the dichroic mirror, the reflecting mirror is arranged in the infrared radiation range of the experimental animal, and the infrared thermal imaging device is arranged in the reflecting range of the reflecting mirror;
the excitation light source is configured to emit laser, and after the laser passes through the dichroic mirror, the nano fluorescent probe arranged in the experimental animal body is excited to emit fluorescence;
the short-wave infrared sensor is configured to receive the laser light emitted by the nano fluorescent probe forwarded by the dichroic mirror;
the infrared thermal imaging device is configured to receive infrared radiant energy of the laboratory animal forwarded by the reflector, convert the infrared radiant energy into an electrical signal, and amplify the electrical signal.
2. The dual modality in vivo imaging system of claim 1, further comprising: the laser beam expander is arranged between the dichroic mirror and the excitation light source;
the laser beam expander is configured to constrain an irradiation range of the laser light and to uniformly irradiate the intensity of the laser light within the irradiation range.
3. The dual modality in vivo imaging system of claim 1, further comprising: the light filtering device is arranged between the dichroic mirror and the short-wave infrared sensor;
the filtering device is configured to filter light rays in a wavelength band outside the observation requirement of the short-wave infrared sensor.
4. The bimodal in vivo imaging system as defined in claim 3 wherein said filtering means comprises: a filter and a filter wheel;
the optical filter is configured to filter light rays in a wave band outside the observation requirement of the short-wave infrared sensor;
the filter wheel is configured to replace the filter to account for the replacement of the filter when different types of band observation requirements.
5. The dual modality in vivo imaging system as defined in claim 1 wherein said short wave infrared sensor comprises: a lens and a detector;
the lens is configured to collect the fluorescence;
the detector is configured to acquire a component of the fluorescent medium short wave infrared band.
6. The dual modality in vivo imaging system of claim 1, further comprising: a lifting developing table arranged below the dichroic mirror;
the lifting developing station is configured to place the laboratory animal.
7. The dual modality in vivo imaging system of claim 6 wherein said lift development station comprises: a developing bottom plate and a light-blocking plate;
the developing base plate is configured to hold the laboratory animal;
the light-blocking baffle is arranged around the developing bottom plate and is configured to block light except the laser.
8. The dual modality in vivo imaging system of claim 1, further comprising: the processing display device is respectively connected with the short-wave infrared sensor and the infrared thermal imaging device;
the processing display device is configured to receive the light fed back by the short-wave infrared sensor and convert the light into image display, receive the electric signal fed back by the infrared thermal imaging device and convert the electric signal into a video signal to display a thermal image of the experimental animal.
9. The dual modality in vivo imaging system of claim 1 further comprising equipment associated with the in vivo development of animals including an animal gas anesthesia machine, an animal anesthesia induction box, an animal model making station for various diseases, and a gas delivery conduit for continuous anesthesia of animals.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202222963051.7U CN219229846U (en) | 2022-11-08 | 2022-11-08 | Bimodal living body imaging system |
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| CN202222963051.7U CN219229846U (en) | 2022-11-08 | 2022-11-08 | Bimodal living body imaging system |
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| CN219229846U true CN219229846U (en) | 2023-06-23 |
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