CN219098725U - Nuclide split charging system - Google Patents
Nuclide split charging system Download PDFInfo
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- CN219098725U CN219098725U CN202223212721.8U CN202223212721U CN219098725U CN 219098725 U CN219098725 U CN 219098725U CN 202223212721 U CN202223212721 U CN 202223212721U CN 219098725 U CN219098725 U CN 219098725U
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E30/00—Energy generation of nuclear origin
- Y02E30/30—Nuclear fission reactors
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
The utility model discloses a nuclide split charging system, which comprises: the first multi-way valve is provided with a first connecting port, a second connecting port, a third connecting port and a fourth connecting port, wherein the first connecting port is selectively communicated with the second connecting port or the third connecting port, the fourth connecting port is selectively communicated with the second connecting port or the third connecting port, and the fourth connecting port is also selectively communicated with the gas storage bottle; the sample injector is communicated with the first connecting port; a second multi-way valve having an inlet and a plurality of outlets, the inlet selectively communicating with one of the plurality of outlets and the inlet communicating with the third connection port. From this, through first multiport valve, injector and second multiport valve cooperation work, can be voluntarily with in the nuclide partial shipment reagent bottle, compare with prior art, reduced operating personnel contact radionuclide time, reduced the radiation dose and infected, reduce the radionuclide and cause the radioactive injury to operating personnel to, can improve nuclide partial shipment efficiency.
Description
Technical Field
The utility model relates to the field of split charging equipment, in particular to a nuclide split charging system.
Background
In recent years, drugs for tumor diagnosis and treatment have been rapidly developed, and radiopharmaceuticals are growing, which means a special type of drugs that contain radionuclides and are used for medical diagnosis and treatment. A compound or biological agent containing a radionuclide label for use in medical diagnosis or therapy in vivo. These radionuclides can subject the operator to high radiation due to the high penetration photons emitted by them.
In the related art, radiopharmaceuticals are widely used in clinic at present, and most of radioactive nuclides are manually packaged in hospital institutions and radioactive drug synthesis institutions, but the operation wastes a great deal of time and has lower working efficiency. Meanwhile, operators are in contact with the radionuclide for a long time in operation, so that radiation dose infection is increased, and radioactive injury is easily caused to the operators.
Disclosure of Invention
The present utility model aims to solve at least one of the technical problems existing in the prior art. Therefore, an object of the present utility model is to provide a nuclide split charging system, which can automatically split nuclides into reagent bottles, reduce the radioactive injury of the nuclides to operators, and improve the nuclide split charging efficiency.
The nuclide split charging system according to the present utility model comprises:
a first multi-way valve having a first connection port selectively communicating with the second connection port or the third connection port, a second connection port selectively communicating with the second connection port or the third connection port, a third connection port selectively communicating with a gas storage bottle, and a fourth connection port selectively communicating with a nuclide storage bottle, the second connection port being adapted to communicate with a nuclide storage bottle;
the sample injector is communicated with the first connecting port;
a second multi-way valve having an inlet selectively in communication with one of a plurality of said outlets and said inlet in communication with said third connection port, and a plurality of outlets, each of said outlets being adapted to communicate with a reagent bottle.
According to the nuclide split charging system, the first multi-way valve, the sample injector and the second multi-way valve are matched to work, nuclides can be automatically split charged into the reagent bottles, compared with the prior art, the time for operators to contact with radionuclides is reduced, radiation dose infection is reduced, the radioactive injury of the nuclides to the operators is reduced, and the nuclide split charging efficiency can be improved.
In some examples of the present utility model, the nuclide dispensing system further comprises: and an opening and closing valve having an air inlet and an air outlet, the air outlet being in communication with the fourth connection port, the air inlet being adapted to communicate with a gas storage bottle.
In some examples of the present utility model, the nuclide dispensing system further comprises: the detection piece is used for detecting the nuclear element activity in the nuclide storage bottle.
In some examples of the utility model, the sample injector comprises: the sample injector comprises a sample injector body and a piston, wherein the sample injector body is limited to be communicated with a storage groove communicated with the first connecting port, the piston is arranged in the storage groove, and the piston is movable relative to the sample injector body along the depth direction of the storage groove.
In some examples of the present utility model, the nuclide dispensing system further comprises: the driving mechanism is in transmission connection with the piston and is used for driving the piston to move along the depth direction of the storage groove.
In some examples of the present utility model, the nuclide dispensing system further comprises: the shell, first multiport valve, the injector, the second multiport valve all are located in the shell.
In some examples of the utility model, the housing has a visual window disposed in correspondence with the injector.
In some examples of the present utility model, the nuclide dispensing system further comprises: the storage rack is arranged in the assembly space and used for placing the gas storage bottle and/or the nuclide storage bottle and/or the reagent bottle.
In some examples of the utility model, the shelf has at least one placement slot.
In some examples of the utility model, the housing has a plurality of tube perforations through which the communication tube passes.
In some examples of the utility model, the housing has at least one heat sink.
In some examples of the present utility model, the nuclide dispensing system further comprises: and the synthesis device is used for synthesizing nuclides and is suitable for synthesizing the nuclides after split charging into radiopharmaceuticals.
Additional aspects and advantages of the utility model will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the utility model.
Drawings
The foregoing and/or additional aspects and advantages of the utility model will become apparent and may be better understood from the following description of embodiments taken in conjunction with the accompanying drawings in which:
FIG. 1 is a schematic diagram of a nuclide dispensing system in accordance with an embodiment of the present utility model;
FIG. 2 is an assembled schematic view of a first multi-way valve, injector, second multi-way valve, on-off valve, and drive mechanism of a nuclide dispensing system according to an embodiment of the present utility model;
FIG. 3 is a top view of a nuclide dispensing system according to an embodiment of the present utility model;
fig. 4 is a schematic diagram of the internal structure of a nuclide dispensing system in accordance with an embodiment of the present utility model.
Reference numerals:
a nuclide dispensing system 100;
a first multi-way valve 10; a first connection port 11; a second connection port 12; a third connection port 13; a fourth connection port 14;
a sample injector 20; a sample injector body 21; a piston 22;
a second multi-way valve 30; an inlet 31; an outlet 32;
an opening/closing valve 40; an air inlet 41; an air outlet 42;
a detecting member 50; a drive mechanism 60;
a housing 70; a visual window 71; an assembly space 72; a pipe perforation 73; a heat radiation hole 74;
a shelf 80; a placement groove 81;
the nuclide storage bottle 300.
Detailed Description
Embodiments of the present utility model are described in detail below, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to like or similar elements or elements having like or similar functions throughout. The embodiments described below by referring to the drawings are illustrative only and are not to be construed as limiting the utility model.
A nuclide dispensing system 100 according to an embodiment of the present utility model is described below with reference to fig. 1-4, where the nuclide dispensing system 100 is used to dispense nuclides, which may be liquid nuclides, and the present application is described with reference to the nuclide dispensing system 100 being used to dispense radionuclides. The nuclide dispensing system 100 may also be used to dilute a nuclide solution, and the nuclide dispensing system 100 may also dispense other substances including drugs, as illustrated herein by the nuclide dispensing system 100 being used to dispense radionuclides.
As shown in fig. 1 to 4, the nuclide dispensing system 100 according to the embodiment of the present utility model includes: a first multi-way valve 10, a sample injector 20 and a second multi-way valve 30. The first multi-way valve 10 may be a four-way valve. The first multi-way valve 10 has a first connection port 11, a second connection port 12, a third connection port 13, and a fourth connection port 14, the first connection port 11 selectively communicates with the second connection port 12 or the third connection port 13, that is, the first connection port 11 may selectively communicate with the second connection port 12, the first connection port 11 may selectively communicate with the third connection port 13, and when the first multi-way valve 10 is closed, the first connection port 11 may not communicate with both the second connection port 12 and the third connection port 13. The fourth connection port 14 selectively communicates with the second connection port 12 or the third connection port 13, that is, the fourth connection port 14 selectively communicates with the second connection port 12, the fourth connection port 14 may selectively communicate with the third connection port 13, and when the first multi-way valve 10 is closed, the fourth connection port 14 may not communicate with both the second connection port 12 and the third connection port 13. The fourth connection port 14 is also selectively in communication with a gas storage bottle, that is, the fourth connection port 14 may be in communication with a gas storage bottle, or the fourth connection port 14 may not be in communication with a gas storage bottle, in which a gas may be stored, for example: the gas storage bottle can store gas such as nitrogen. The second connection port 12 is adapted to communicate with the nuclide storage bottle 300, the nuclide storage bottle 300 stores therein nuclides to be dispensed, and the second connection port 12 may communicate with the nuclide storage bottle 300 through a pipeline.
The injector 20 is communicated with the first connection port 11, and the injector 20 can be injectors 20 with different specifications, for example, the injector 20 is an injector 20 with the volume of 1.25mL, 2.5mL, 5mL, etc. The second multi-way valve 30 has an inlet 31 and a plurality of outlets 32, the inlet 31 being in selective communication with one of the plurality of outlets 32, and the inlet 31 being in communication with the third connection port 13, each outlet 32 being adapted to be in communication with a reagent bottle in which a nuclear species may be stored in a sub-package. For ease of understanding, the plurality of outlets 32 may be labeled A1, A2, A3, A4, A5, A6, A7 to An, respectively. The second multi-way valve 30 may be a multi-way valve such as a two-way valve, a three-way valve, a four-way valve, a five-way valve, a six-way valve, or a seven-way valve, and the second multi-way valve 30 is described as an example. The second multi-way valve 30 has one inlet 31 and six outlets 32, the inlet 31 being in selective communication with any one outlet 32 of the plurality of outlets 32, the plurality of outlets 32 being capable of communicating with different types of reagent bottles, respectively, the six outlets 32 being capable of being labeled A1, A2, A3, A4, A5, A6, respectively.
When the nuclide split charging system 100 is used for split charging nuclide, the second connection port 12 is communicated with the nuclide storage bottle 300, the first multi-way valve 10 is controlled to enable the first connection port 11 to be communicated with the second connection port 12, the injector 20 works to extract nuclide from the nuclide storage bottle 300, the nuclide flows into the injector 20 from the nuclide storage bottle 300 along the second connection port 12 and the first connection port 11, the first multi-way valve 10 is controlled to enable the first connection port 11 to be communicated with the third connection port 13, the second multi-way valve 30 is controlled to enable the inlet 31 to be communicated with the outlet 32 communicated with the corresponding reagent bottle, for example: when the nuclide needs to be split-charged into the reagent bottle communicated with the outlet 32 marked as A1, the second multi-way valve 30 is controlled to enable the inlet 31 to be communicated with the outlet 32 marked as A1, the injector 20 works, and the nuclide in the injector 20 flows into the corresponding reagent bottle along the first connecting port 11, the third connecting port 13, the inlet 31 and the outlet 32 marked as A1, so that the split charging of the nuclide is completed. Through the cooperation work of first multiport valve 10, injector 20 and second multiport valve 30, can be automatic in the corresponding reagent bottle of nuclide partial shipment, compare with prior art, reduced operating personnel contact radionuclide time, reduced the radiation dose and infected, reduced the radionuclide and to the radioactive injury that operating personnel caused to, and, can save partial shipment nuclide time, can improve nuclide partial shipment efficiency. If the nuclide needs to be filled into different reagent bottles, the nuclide can be filled into different reagent bottles by controlling the inlet 31 to be communicated with the different outlets 32.
By using the nuclide split charging system 100 of the present application to split the nuclide, post-dilution repacking of the nuclide may be achieved. For example: the reagent bottle communicating with the outlet 32 labeled A1 may contain a nuclide (initially, 30mCi, 100uL of 89Zr nuclide) and the reagent bottle communicating with the outlet 32 labeled A2 may contain an acetic acid/sodium acetate buffer solution. The first multi-way valve 10 is controlled to communicate the first connection port 11 with the third connection port 13, the second multi-way valve 30 is controlled to communicate the inlet 31 with the outlet 32 marked as A2, the injector 20 extracts acetic acid/sodium acetate buffer solution in the reagent bottle communicating with the outlet 32 marked as A2, then the second multi-way valve 30 is controlled to communicate the inlet 31 with the outlet 32 marked as A1, the injector 20 injects acetic acid/sodium acetate buffer solution into the reagent bottle communicating with the outlet 32 marked as A1, then the injector 20 extracts nuclide from the reagent bottle communicating with the outlet 32 marked as A1, the first multi-way valve 10 is controlled to communicate the first connection port 11 with the second connection port 12, the injector 20 injects nuclide into the nuclide storage bottle 300 through the second connection port 12, then the fourth connection port 14 can be controlled to communicate with the gas storage bottle, the gas in the gas storage bottle flows to the second connection port 12 along the fourth connection port 14, residual nuclide in the gas flow process pipeline is prevented from being blown into the connection port 300.
The specific operation steps are as follows:
a. switching the second multi-way valve 30 to the inlet 31 to communicate with the outlet 32 marked as A2, switching the first multi-way valve 10 to the first connection port 11 to communicate with the third connection port 13, and extracting 2.9mL of acetic acid/sodium acetate buffer solution in the reagent bottle communicated with the outlet 32 marked as A2 by the injector 20;
b. switching the second multi-way valve 30 to the inlet 31 in communication with the outlet 32 labeled A1, and transferring all of the acetic acid/sodium acetate buffer solution in the sample injector 20 into a reagent bottle in communication with the outlet 32 labeled A1;
c. the injector 20 then extracts the species from the reagent bottle in communication with the outlet 32 labeled A1, for example: the injector 20 again withdraws 1mL of nuclide from the reagent bottle in communication with the outlet 32 labeled A1;
d. the first multi-way valve 10 is switched to communicate with the first connection port 11 and the second connection port 12, the nuclide in the injector 20 is transferred into the nuclide storage bottle 300 communicated with the second connection port 12,
e. the first multi-way valve 10 is switched to the communication between the fourth connecting port 14 and the second connecting port 12, the fourth connecting port 14 is controlled to be communicated with the gas storage bottle, gas in the gas storage bottle flows to the second connecting port 12 along the fourth connecting port 14, and residual nuclide in the pipeline is blown into the nuclide storage bottle 300 in the gas flowing process, so that the nuclide is prevented from remaining in the pipeline. At this time, a nuclide with an activity of 10mCi can be obtained.
The flow paths are connected between the first connection port 11 and the second connection port 12, between the first connection port 11 and the third connection port 13, between the fourth connection port 14 and the second connection port 12, and between the fourth connection port 14 and the third connection port 13, and between the inlet 31 and the plurality of outlets 32, and between the inlet 31 and the third connection port 13, pipes may be connected. When the nuclide split charging system 100 split charges different nuclides, nuclides may remain in the flow channel, and if the flow channel is not cleaned, cross interference among the different nuclides may be caused, so that adverse effects are caused on the production quality of the different nuclides.
The nuclide split charging system 100 of the present application can clean a flow channel, one outlet 32 of a plurality of outlets 32 of a second multi-way valve 30 can be connected with a reagent bottle containing 75% ethanol, and the other outlet 32 of the plurality of outlets 32 of the second multi-way valve 30 can be connected with a reagent bottle containing sterilized water for injection, and the present application describes taking an example in which an outlet 32 marked as A3 is connected with a reagent bottle containing 75% ethanol, and an outlet 32 marked as A4 is connected with a reagent bottle containing sterilized water for injection. The flow path between the inlet 31 and the outlet 32 denoted as A5, the flow path between the inlet 31 and the outlet 32 denoted as A6, the piping between the inlet 31 and the third connection port 13, the flow path between the first connection port 11 and the third connection port 13, and the cleaning of the sample injector 20 will be described as examples.
When the flow channel between the inlet 31 and the outlet 32 marked as A5 is cleaned, the second multi-way valve 30 is controlled to be switched to be communicated with the inlet 31 and the outlet 32 marked as A3, the first multi-way valve 10 is switched to be communicated with the first connecting port 11 and the third connecting port 13, the injector 20 is operated to extract 75 percent of ethanol from the reagent bottle communicated with the outlet 32 marked as A3, the second multi-way valve 30 is controlled to be switched to be communicated with the inlet 31 and the outlet 32 marked as A5, and the injector 20 is controlled to discharge 75 percent of ethanol to enable the 75 percent of ethanol to flow into the corresponding reagent bottle along the pipeline between the inlet 31 and the third connecting port 13 and the flow channel between the inlet 31 and the outlet 32 marked as A5, and the operation is repeated for example twice. The second multi-way valve 30 is controlled to be switched to be communicated with the inlet 31 and the outlet 32 marked as A4, the first multi-way valve 10 is switched to be communicated with the first connecting port 11 and the third connecting port 13, the injector 20 is controlled to work to extract sterilization injection water from a reagent bottle communicated with the outlet 32 marked as A4, the second multi-way valve 30 is controlled to be switched to be communicated with the inlet 31 and the outlet 32 marked as A5, the injector 20 is controlled to discharge the sterilization injection water, the sterilization injection water flows into the corresponding reagent bottle along a pipeline between the inlet 31 and the third connecting port 13 and a pipeline between the inlet 31 and the outlet 32 marked as A5, a pipeline between the inlet 31 and the third connecting port 13 and a pipeline between the first connecting port 11 and the third connecting port 13, and cleaning of the injector 20 are realized repeatedly for a plurality of times, for example, twice. The first multi-way valve 10 is switched to the third connecting port 13 to be communicated with the fourth connecting port 14, and the fourth connecting port 14 is controlled to be communicated with a gas storage bottle, gas in the gas storage bottle flows into a flow passage between the third connecting port 13 and the fourth connecting port 14, a pipeline between the inlet 31 and the third connecting port 13, a flow passage between the inlet 31 and an outlet 32 marked as A5, and the gas blows the flow passage between the inlet 31 and the third connecting port 13, the pipeline between the inlet 31 and the outlet 32 marked as A5.
Similarly, when the flow channel between the inlet 31 and the outlet 32 marked as A6 is cleaned, the second multi-way valve 30 is controlled to be switched to be communicated with the inlet 31 and the outlet 32 marked as A3, the first multi-way valve 10 is switched to be communicated with the first connecting port 11 and the third connecting port 13, the injector 20 is operated to extract 75% ethanol from the reagent bottle communicated with the outlet 32 marked as A3, the second multi-way valve 30 is controlled to be switched to be communicated with the inlet 31 and the outlet 32 marked as A6, and the injector 20 is controlled to discharge 75% ethanol to enable the 75% ethanol to flow into the corresponding reagent bottle along the flow channel between the first connecting port 11 and the third connecting port 13, the pipeline between the inlet 31 and the third connecting port 13, and the flow channel between the inlet 31 and the outlet 32 marked as A6, for example, the operation is repeated for two times. The second multi-way valve 30 is controlled to be switched to be communicated with the inlet 31 and the outlet 32 marked as A4, the first multi-way valve 10 is switched to be communicated with the first connecting port 11 and the third connecting port 13, the injector 20 is controlled to work to extract sterilization injection water from a reagent bottle communicated with the outlet 32 marked as A4, the second multi-way valve 30 is controlled to be switched to be communicated with the inlet 31 and the outlet 32 marked as A6, the injector 20 is controlled to discharge the sterilization injection water, the sterilization injection water flows into the corresponding reagent bottle along a pipeline between the inlet 31 and the third connecting port 13 and a pipeline between the inlet 31 and the outlet 32 marked as A6, a pipeline between the inlet 31 and the third connecting port 13 and a pipeline between the first connecting port 11 and the third connecting port 13, and cleaning of the injector 20 is realized repeatedly for a plurality of times, for example, twice. The first multi-way valve 10 is switched to the third connecting port 13 to be communicated with the fourth connecting port 14, and the fourth connecting port 14 is controlled to be communicated with a gas storage bottle, gas in the gas storage bottle flows into a flow passage between the third connecting port 13 and the fourth connecting port 14, a pipeline between the inlet 31 and the third connecting port 13, a flow passage between the inlet 31 and an outlet 32 marked as A6, and the gas blows the flow passage between the inlet 31 and the third connecting port 13, the pipeline between the inlet 31 and the outlet 32 marked as A6. Therefore, the flow channel flowing through the nuclide can be cleaned, cross interference among different nuclides is avoided, the quality of the nuclide is ensured, the cleaning process is fully-automatic operation, and the artificial contact nuclide is reduced.
In the same way, the cleaning of each flow passage and the first and second multi-way valves 10 and 30 can be achieved by adjusting the communication direction of the first and second multi-way valves 10 and 30.
From this, through first multiport valve 10, injector 20 and second multiport valve 30 cooperation work, can be voluntarily with the nuclide partial shipment in the reagent bottle, compare with prior art, reduced operating personnel contact radionuclide time, reduced the radiation dose and infected, reduce the radionuclide and to the radioactive injury that operating personnel caused, and, can improve nuclide partial shipment efficiency, in addition, can wash the runner of flow nuclide, avoid different nuclides cross interference, thereby guarantee the quality of nuclide, the cleaning work is full automatization operation, reduce artificial contact nuclide.
It should be noted that the nuclide dispensing system 100 may dispense a plurality of nuclides, for example: such as 177 Lu、 68 Ga、 89 Zr, etc. The nuclide dispensing system 100 may enable automated dispensing of nuclides into a plurality of reagent bottles,
in some embodiments of the present utility model, as shown in FIG. 1, the nuclide dispensing system 100 may further include: the shell 70, the first multi-way valve 10, the injector 20 and the second multi-way valve 30 are all arranged in the shell 70, the shell 70 can protect the first multi-way valve 10, the injector 20 and the second multi-way valve 30, and the risk that the first multi-way valve 10, the injector 20 and the second multi-way valve 30 are damaged by external objects can be reduced.
In some embodiments of the present utility model, the nuclide dispensing system 100 may further include a first rotating electric machine in driving communication with the first multi-way valve 10, the first rotating electric machine may drive the first multi-way valve 10 to switch the corresponding connection port to communicate, and a second rotating electric machine in driving communication with the second multi-way valve 30, the second rotating electric machine may drive the second multi-way valve 30 to switch the inlet 31 to communicate with the corresponding outlet 32.
In some embodiments of the present utility model, as shown in fig. 2, the nuclide dispensing system 100 may further include: the opening/closing valve 40, the opening/closing valve 40 may be provided to the housing 70, for example: the on-off valve 40 may be provided in the housing 70, the on-off valve 40 may be a solenoid valve, the on-off valve 40 may be a two-way valve, the on-off valve 40 has an air inlet 41 and an air outlet 42, the air outlet 42 communicates with the fourth connection port 14, and the air inlet 41 is adapted to communicate with a gas storage bottle. The first pipeline is connected between the air outlet 42 and the fourth connecting port 14, the first pipeline is communicated with the air outlet 42 and the fourth connecting port 14, the second pipeline is connected between the air inlet 41 and the gas storage bottle, and the second pipeline is communicated with the air inlet 41 and the gas storage bottle. The effect of selectively communicating the fourth connection port 14 with the gas storage bottle is achieved by controlling the opening or closing of the opening/closing valve 40. Further, the on-off valve 40 may be communicatively coupled to a controller of the nuclide dispensing system 100, which may control the on-off valve 40 to open or close.
In some embodiments of the present utility model, as shown in fig. 3 and 4, the nuclide dispensing system 100 may further include: the detecting member 50, the detecting member 50 is used for detecting the nuclear activity in the nuclear storage bottle 300, and the detecting member 50 may be disposed on the housing 70. Further, the sensing element 50 may be a radioactive probe, and the sensing element 50 may be disposed adjacent to the nuclear storage bottle 300 so that the sensing element 50 senses nuclear activity within the nuclear storage bottle 300. The sensing element 50 may be communicatively coupled to a controller of the nuclide dispensing system 100.
When the nuclide split charging system 100 is used for split charging nuclide, the second connecting port 12 is communicated with the nuclide storage bottle 300 through a third pipeline, the third pipeline can be inserted into the bottom wall of the nuclide storage bottle 300, the first multi-way valve 10 is controlled to enable the first connecting port 11 to be communicated with the second connecting port 12, the injector 20 works to extract nuclide with a certain volume from the nuclide storage bottle 300, the nuclide flows into the injector 20 from the nuclide storage bottle 300 along the second connecting port 12 and the first connecting port 11, the radioactive probe detects the activity reduction amount of the nuclide in the nuclide storage bottle 300, the concentration of the radioactive nuclide of the original nuclide can be automatically calculated through the ratio of the activity reduction amount to the reduced volume, and the total volume of the original nuclide can be calculated according to the concentration and the total dosage of the radioactive probe at the beginning. The sub-packaging can be performed subsequently according to radioactivity or volume. The first multi-way valve 10 is controlled to enable the first connecting port 11 to be communicated with the third connecting port 13, the second multi-way valve 30 is controlled to enable the inlet 31 to be communicated with the outlet 32 communicated with the corresponding reagent bottle, and according to the required activity, the required volume can be calculated to be automatically split into the corresponding reagent bottle, so that the effect of split charging according to the activity or split charging according to the volume into the corresponding reagent bottle is achieved.
In some embodiments of the present utility model, as shown in fig. 2, the injector 20 may include: the injector body 21 defines a storage tank communicating with the first connection port 11, and a piston 22 is provided in the storage tank, and the piston 22 is movable relative to the injector body 21 in a depth direction of the storage tank. Wherein, the bottom wall of the storage tank may be provided with a through hole, the through hole is communicated with the first connection port 11 through a fourth pipeline, along the depth direction of the storage tank, the opposite end of the storage tank and the bottom wall of the storage tank are opened, the side wall of the piston 22 may contact with the inner side wall of the storage tank, the piston 22 may extract nuclide when moving towards the direction far away from the bottom wall of the storage tank, and the piston 22 may push the nuclide of the storage tank out of the injector 20 when moving towards the direction far away from the bottom wall of the storage tank.
In some embodiments of the present utility model, as shown in fig. 2, the nuclide dispensing system 100 may further include: the driving mechanism 60, the driving mechanism 60 may be disposed in the housing 70, the driving mechanism 60 is in transmission connection with the piston 22, and the driving mechanism 60 is used for driving the piston 22 to move along the depth direction of the storage groove. Further, the driving mechanism 60 may include a driving motor, a screw and a driving block, where the driving motor is fixedly installed on the housing 70, the driving block is sleeved outside the screw and is in threaded connection with the screw, the driving block is fixedly connected with the piston 22, the driving motor is in transmission connection with the screw to drive the screw to rotate, and the driving motor drives the screw to rotate so as to move the driving block along the axial direction of the screw, thereby realizing the effect of moving the driving piston 22 along the depth direction of the storage tank. However, the present utility model is not limited thereto, and the driving mechanism 60 may be provided in other configurations as long as the driving mechanism 60 can drive the piston 22 to move in the depth direction of the storage tank, and is not particularly limited thereto.
In some embodiments of the present utility model, as shown in fig. 1, the housing 70 may have a visual window 71 provided corresponding to the sample injector 20, and an operator may observe the sample in and out of the sample injector 20 through the visual window 71. Further, the visual window 71 may be provided with a transparent member, such as: the transparent member is glass or transparent plastic member, and the transparent member can shield the visual window 71, and prevent the outside of the housing 70 from entering the housing 70 from the visual window 71.
In some embodiments of the present utility model, as shown in FIG. 1, the nuclide dispensing system 100 may further include: the housing 70 has an assembly space 72 recessed toward the interior of the housing 70, the housing 80 is disposed in the assembly space 72, the housing 80 is used for placing a gas storage bottle and/or a nuclide storage bottle 300 and/or a reagent bottle, and it is also understood that the housing 80 is used for placing at least one of the gas storage bottle, the nuclide storage bottle 300, and the reagent bottle, for example: the rack 80 is used to house a nuclide storage bottle 300 and a reagent bottle. When placed, the nuclide storage bottle 300 to be measured for activity needs to be provided in correspondence with the detecting member 50 so as to be able to detect activity. Wherein, supporter 80 fixed mounting is in assembly space 72, through placing at least one in gas storage bottle, nuclide storage bottle 300, reagent bottle in supporter 80, can make gas storage bottle, nuclide storage bottle 300, reagent bottle put in order on shell 70, avoid putting gas storage bottle, nuclide storage bottle 300, reagent bottle at will to gas storage bottle, nuclide storage bottle 300, reagent bottle are located assembly space 72, avoid the external object to scrape and bump gas storage bottle, nuclide storage bottle 300, reagent bottle.
In some embodiments of the present utility model, as shown in FIG. 1, the shelf 80 has at least one placement slot 81, such as: the commodity shelf 80 has a plurality of standing grooves 81, can install in every standing groove 81 and place a bottle, through placing at least one in gas storage bottle, nuclide storage bottle 300, the reagent bottle in the standing groove 81, can install gas storage bottle, nuclide storage bottle 300, reagent bottle firmly in commodity shelf 80, avoid gas storage bottle, nuclide storage bottle 300, reagent bottle to empty.
In some embodiments of the present utility model, as shown in fig. 1, the housing 70 has a plurality of pipe perforations 73 through which the communication pipe passes, and the pipe perforations 73 may be provided in plurality. The pipe perforations may be provided on the front or rear side and the left and right sides of the housing 70. Taking the example of the pipeline perforation on the front side and the rear side. The second line between the gas inlet 41 and the gas storage bottle, the third line between the second connection port 12 and the nuclide storage bottle 300, the outlet 32 of the second multi-way valve 30, and the line between the reagent bottles may pass through the line perforations 73, respectively. The air inlet 41 is communicated with a second pipeline, the second pipeline passes through a pipeline perforation 73 on the rear side surface, so that the second pipeline is communicated with the gas storage bottle, the second connection port 12 is communicated with a third pipeline, the third pipeline passes through a pipeline perforation 73 corresponding to the front side surface, so that the third pipeline is communicated with the nuclide storage bottle 300, the pipeline between the outlet 32 of the second multi-way valve 30 and the reagent bottle passes through the pipeline perforation 73 on the front side surface, and the pipeline between the outlet 32 of the second multi-way valve 30 and the reagent bottle is communicated with the reagent bottle.
In some embodiments of the present utility model, as shown in fig. 1, the housing 70 has at least one heat sink 74, and heat within the housing 70 may be dissipated outside the nuclide dispensing system 100 through the heat sink 74, reducing the risk of overheating the nuclide dispensing system 100.
In some embodiments of the present utility model, the nuclide dispensing system 100 may further include a synthesizer for synthesizing a drug (e.g., a radiopharmaceutical), the synthesizer being adapted to synthesize the dispensed nuclide into a radiopharmaceutical, the nuclide dispensing system 100 dispensing the nuclide as desired, the dispensed nuclide optionally being delivered to the synthesizer via a reagent bottle or directly connected to a sample inlet of the synthesizer.
The specific structure of the synthesizing device is not particularly limited as long as the synthesizing of the drug can be achieved. The nuclide split charging system 100 can greatly reduce the radiation dose of an operator in the nuclide synthesis process, and realize the automatic synthesis of medical nuclide liquid medicine.
In the description of the present specification, reference to the terms "one embodiment," "some embodiments," "illustrative embodiments," "examples," "specific examples," or "some examples," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the utility model. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiments or examples. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
While embodiments of the present utility model have been shown and described, it will be understood by those of ordinary skill in the art that: many changes, modifications, substitutions and variations may be made to the embodiments without departing from the spirit and principles of the utility model, the scope of which is defined by the claims and their equivalents.
Claims (12)
1. A nuclide dispensing system, comprising:
a first multi-way valve having a first connection port selectively communicating with the second connection port or the third connection port, a second connection port selectively communicating with the second connection port or the third connection port, a third connection port selectively communicating with a gas storage bottle, and a fourth connection port selectively communicating with a nuclide storage bottle, the second connection port being adapted to communicate with a nuclide storage bottle;
the sample injector is communicated with the first connecting port;
a second multi-way valve having an inlet selectively in communication with one of a plurality of said outlets and said inlet in communication with said third connection port, and a plurality of outlets, each of said outlets being adapted to communicate with a reagent bottle.
2. The nuclide dispensing system of claim 1, further comprising: and an opening and closing valve having an air inlet and an air outlet, the air outlet being in communication with the fourth connection port, the air inlet being adapted to communicate with a gas storage bottle.
3. The nuclide dispensing system of claim 1, further comprising: the detection piece is used for detecting the nuclear element activity in the nuclide storage bottle.
4. The nuclear species dispensing system of claim 1 wherein the sample injector comprises: the sample injector comprises a sample injector body and a piston, wherein the sample injector body is limited to be communicated with a storage groove communicated with the first connecting port, the piston is arranged in the storage groove, and the piston is movable relative to the sample injector body along the depth direction of the storage groove.
5. The nuclide dispensing system of claim 4, further comprising: the driving mechanism is in transmission connection with the piston and is used for driving the piston to move along the depth direction of the storage groove.
6. The nuclear species dispensing system of any one of claims 1 to 5, further comprising: the shell, first multiport valve, the injector, the second multiport valve all are located in the shell.
7. The nuclide dispensing system of claim 6, wherein the housing has a visual window disposed in correspondence with the injector.
8. The nuclear species dispensing system of claim 6 further comprising: the storage rack is arranged in the assembly space and used for placing the gas storage bottle and/or the nuclide storage bottle and/or the reagent bottle.
9. The nuclide dispensing system of claim 8, wherein the rack has at least one placement slot.
10. The nuclide dispensing system of claim 6, wherein the housing has a plurality of tube perforations through which the communication tube passes.
11. The nuclide dispensing system of claim 6, wherein the housing has at least one heat sink.
12. The nuclide dispensing system of claim 1, further comprising: and the synthesis device is used for synthesizing the medicines and is suitable for synthesizing the nuclides after split charging into the radiopharmaceuticals.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202223212721.8U CN219098725U (en) | 2022-11-30 | 2022-11-30 | Nuclide split charging system |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202223212721.8U CN219098725U (en) | 2022-11-30 | 2022-11-30 | Nuclide split charging system |
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| Publication Number | Publication Date |
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| CN219098725U true CN219098725U (en) | 2023-05-30 |
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|---|---|---|---|
| CN202223212721.8U Active CN219098725U (en) | 2022-11-30 | 2022-11-30 | Nuclide split charging system |
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| CN (1) | CN219098725U (en) |
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2022
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