CN218687090U

CN218687090U - Exosome purification device

Info

Publication number: CN218687090U
Application number: CN202222935864.5U
Authority: CN
Inventors: 李立; 吴笛笛; 刘丕菊; 陈佳佳; 高强; 甘宁; 张静; 袁敏; 高小艳
Original assignee: Dolaimi Biotechnology Wuhan Co ltd
Current assignee: Dolaimi Biotechnology Wuhan Co ltd
Priority date: 2022-11-04
Filing date: 2022-11-04
Publication date: 2023-03-24
Anticipated expiration: 2032-11-04

Abstract

The utility model provides an exosome purification device, which comprises a tank body, the top fixed mounting of the jar body has the transmission case, the bottom fixed mounting of the inboard of the jar body has the fixed disk, the filter is installed to the spacing rotation in fixed disk top, through the regulation of hand wheel, screw rod, belt pulley mechanism, gear, outer clearance cover and interior clearance cover, outer clearance cover can slide in the inside of last fixed cover and rotatory cover with interior clearance cover, thereby through outer clearance cover, interior clearance cover and brush clear up the internal surface of external filter membrane, the internal and external surface of filter membrane, and easy operation, it is convenient follow-up to continue purification operation to the exosome, the filter comprises last fixed cover and rotatory cover two parts, do not exert an influence to last fixed cover when rotatory, rotatory cover can aim at the delivery pipe with the through-hole when rotatory, thereby conveniently discharge the material of separation, and the practicality is high.

Description

Exosome purification device

Technical Field

The utility model relates to an exosome separation and purification technical field specifically is an exosome purification device.

Background

The patent of Chinese utility model with publication number CN217247301U proposes an exosome separation and purification device, which comprises a separation tank with a hollow inside and an open top and a cover body arranged above the separation tank, wherein the separation tank is rotatably connected with a filter, a plurality of annular filter membranes arranged on central axes are arranged in the filter, the central axes on the upper end surface of the filter are fixedly provided with connecting shafts, the connecting shafts penetrate through the cover body and extend to the upper part of the cover body, a driving motor is arranged on the cover body, and the driving motor is in transmission connection with the connecting shafts through a speed reducer. Purify the exosome through multilayer filter membrane among this technical scheme, but when clearing up the purification device after the purification, need take out whole filter, install the inside at the knockout drum again after the sanitization, the operation is more complicated to the separator is monolithic structure, can not be with its sanitization completely, and the practicality is low.

Therefore, the utility model provides an exosome purification device.

SUMMERY OF THE UTILITY MODEL

Not enough to prior art exists, the utility model aims at providing an exosome purification device to solve the problem that proposes in the above-mentioned background art, the utility model discloses a screw rod, outer clearance cover, interior clearance cover's regulation can clear up easy operation, convenient to use to the surface of filter membrane and outer filter membrane.

In order to achieve the above purpose, the present invention is realized by the following technical solution: the utility model provides an exosome purification device, includes a jar body, the top fixed mounting of the jar body has the transmission case, the bottom fixed mounting of the inboard of the jar body has the fixed disk, the filter is installed in the spacing rotation in fixed disk top, the filter includes fixed cover, go up the central point department of putting at the inboard top of the jar body of fixed cover through dead lever fixed mounting, go up between fixed cover and the fixed disk spacing rotation and install rotatory cover, the inside fixed mounting of rotatory cover has the filter membrane.

Furthermore, an outer filter membrane is fixedly mounted on the inner wall of the rotating cover, the central axes of the outer filter membrane and the filter membrane are on the same straight line, and the filter membrane is annular.

Furthermore, the corresponding position department of the inside of transmission case rotates and installs the screw rod, the quantity of screw rod is three, the lower extreme movable mounting of screw rod is in the inside of last fixed cover.

Further, two outsides have outer clearance cover through screw movable mounting on the screw rod, outer clearance cover movable mounting is in the inside of last fixed cover, outer clearance cover's shape is the annular.

Furthermore, an inner cleaning cover is movably mounted on the other screw rod through a screw hole, and brushes are fixedly arranged on the outer walls of the inner cleaning cover and the outer cleaning cover.

Furthermore, the bottom of rotatory cover corresponds position department and has seted up the through-hole, the quantity of through-hole is two sets of, the both sides of the inside of fixed disk correspond position department and have seted up the delivery pipe, the central point of the bottom of fixed disk puts fixed mounting and has servo motor, servo motor's output shaft and the bottom of rotatory cover are fixed continuous.

Further, adjacent two the top fixed mounting of screw rod has the gear, the quantity of gear is two, two the gear intermeshing sets up, adjacent two in addition fixed mounting has a belt pulley mechanism between the screw rod, the right side the top fixed mounting of screw rod has the hand wheel, hand wheel movable mounting is at the top of transmission case.

Further, the inside fixed mounting of dead lever has the inlet pipe, the inlet pipe passes the transmission case and sets up the top at the transmission case, the observation window has been opened to the front side of the jar body, the bottom symmetry fixed mounting of the jar body has the landing leg, one side fixed mounting of the bottom of the jar body has the delivery pipe, correspond position department fixed mounting on the delivery pipe and have the solenoid valve.

The utility model has the advantages that: the utility model relates to an exosome purification device passes through the hand wheel, the screw rod, belt pulley mechanism, the gear, the regulation of outer clearance cover and interior clearance cover, outer clearance cover can slide in the inside of last fixed cover and rotatory cover with interior clearance cover, thereby through outer clearance cover, interior clearance cover and the internal surface of brush to the external filter membrane, the internal and external surface of filter membrane is cleared up, and the operation is thus simple, convenient follow-up purification operation continues to the exosome, the filter comprises last fixed cover and rotatory cover two parts, do not exert an influence to last fixed cover when rotatory cover is rotatory, rotatory cover can be when rotatory with the through-hole alignment delivery pipe, thereby conveniently discharge the material of separation out, the practicality is high.

Drawings

FIG. 1 is a schematic diagram of an exosome purification apparatus of the present invention;

FIG. 2 is a cross-sectional view of an exosome purification device of the present invention;

FIG. 3 is an enlarged view of the exosome purification device of the present invention at A in FIG. 2;

FIG. 4 is an enlarged view of the exosome purification device of the present invention at B in FIG. 2;

FIG. 5 is a bottom view of a rotating cover of an exosome purification device of the present invention;

FIG. 6 is a structure diagram of a fixing disc of the exosome purifying device of the present invention;

in the figure: 1. a tank body; 2. an observation window; 3. a support leg; 4. a transmission case; 5. a feed pipe; 6. a hand wheel; 7. an upper fixing cover; 8. a rotating cover; 9. filtering the membrane; 10. fixing the disc; 11. a servo motor; 12. a discharge pipe; 13. a screw; 14. an inner cleaning cover; 15. an outer cleaning cover; 16. a gear; 17. a belt pulley mechanism; 18. and a through hole.

Detailed Description

In order to make the technical means, creation features, achievement purposes and functions of the present invention easy to understand, the present invention is further described below with reference to the following embodiments.

Referring to fig. 1 to 6, the present invention provides a technical solution: the utility model provides an exosome purification device, includes a jar body 1, the top fixed mounting of the jar body 1 has transmission case 4, the bottom fixed mounting of the inboard of the jar body 1 has fixed disk 10, the filter is installed in the spacing rotation in fixed disk 10 top, the filter includes fixed cover 7, go up fixed cover 7 and put the department through the central point at the inboard top of the jar body 1 of dead lever fixed mounting, it installs rotatory cover 8 to go up spacing rotation between fixed cover 7 and the fixed disk 10, the inside fixed mounting of rotatory cover 8 has filter membrane 9, and the internal surface of the interior external surface of filter membrane 9 and external filter membrane is cleared up through setting up of outer clearance cover 15 and interior clearance cover 14 conveniently, and easy operation can improve cleaning efficiency.

In this embodiment, an outer filter membrane is fixedly mounted on the inner wall of the rotating cover 8, the central axes of the outer filter membrane and the filter membrane 9 are on the same straight line, the filter membrane 9 is annular, a screw 13 is rotatably mounted at a corresponding position inside the transmission case 4, the number of the screws 13 is three, the lower end of the screw 13 is movably mounted inside the upper fixing cover 7, outer cleaning covers 15 are movably mounted on the screws 13 at two outer sides through screw holes, the outer cleaning covers 15 are movably mounted inside the upper fixing cover 7, the outer cleaning covers 15 are annular, an inner cleaning cover 14 is movably mounted on another screw 13 through screw holes, brushes are fixedly arranged on the outer walls of the inner cleaning cover 14 and the outer cleaning cover 15, adjacent two the top fixed mounting of screw rod 13 has gear 16, the quantity of gear 16 is two, two gear 16 intermeshing sets up, adjacent two in addition fixed mounting has belt pulley mechanism 17 between the screw rod 13, the right side the top fixed mounting of screw rod 13 has hand wheel 6, hand wheel 6 movable mounting is at the top of transmission case 4, and when hand wheel 6 drove screw rod 13 rotatory, can be through gear 16 and belt pulley mechanism 17 two other screw rod simultaneous rotations, and screw rod 13 drove outer clearance cover 15 and interior clearance cover 14 and slides and descend in the inside of last fixed cover 7 to drive the brush through outer clearance cover 5 and interior clearance cover 14 and clear up the internal surface of the interior external surface of filter membrane 9 and the internal surface of external filter membrane, convenient to use.

This embodiment, the bottom of rotatory cover 8 corresponds position department and has seted up through-hole 18, the quantity of through-hole 18 is two sets of, delivery pipe 12 has been seted up to the both sides of the inside of fixed disk 10 corresponding position department, the central point of the bottom of fixed disk 10 puts fixed mounting and has servo motor 11, servo motor 11's output shaft links to each other with the bottom of rotatory cover 8 is fixed, the inside fixed mounting of dead lever has inlet pipe 5, inlet pipe 5 passes transmission case 4 and sets up the top at transmission case 4, the front side of the jar body 1 is seted up and is equipped with observation window 2, the bottom symmetry fixed mounting of the jar body 1 has landing leg 3, one side fixed mounting of the bottom of the jar body 1 has delivery pipe 12, corresponding position department fixed mounting has the solenoid valve on delivery pipe 12, and servo motor 11 drives rotatory cover 8 and rotates to make the exosome separate under the effect of centrifugal force, and discharge through delivery pipe 12.

When using this exosome purification device, belt pulley mechanism 17 is the prior art belt promptly, the drive mechanism of belt pulley, through the hand wheel 6, screw rod 13, belt pulley mechanism 17, the gear, the regulation of outer clearance cover 15 and interior clearance cover 14, outer clearance cover 15 and interior clearance cover 14 can slide in the inside of last fixed cover 7 and rotatory cover 8, thereby through outer clearance cover 15, interior clearance cover 14 and brush are to the internal surface of external filtration membrane, the interior external surface of filtration membrane 9 is cleared up, the operation is simple, it is convenient follow-up to continue to carry out purification operation to the exosome, the filter comprises last fixed cover 7 and rotatory cover 8 two parts, do not exert an influence to last fixed cover 7 when rotatory cover 8 is rotatory, rotatory cover 8 can aim at discharge pipe 12 with through-hole 18 when rotatory, thereby conveniently discharge the material of separation, and the practicality is high.

Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.

Claims

1. The utility model provides an exosome purification device, includes a jar body (1), its characterized in that, the top fixed mounting of the jar body (1) has transmission case (4), the bottom fixed mounting of the inboard of the jar body (1) has fixed disk (10), the filter is installed in the spacing rotation in fixed disk (10) top, the filter is including fixed cover (7), go up fixed cover (7) and put the department through the central point at the top of the inboard of the jar body (1) of dead lever fixed mounting, it installs rotatory cover (8) to go up spacing rotation between fixed cover (7) and fixed disk (10), the inside fixed mounting of rotatory cover (8) has filter membrane (9).

2. An exosome purification device according to claim 1, characterised in that: an outer filter membrane is fixedly mounted on the inner wall of the rotating cover (8), the central axes of the outer filter membrane and the filter membrane (9) are on the same straight line, and the filter membrane (9) is annular.

3. An exosome purification device according to claim 2, characterised in that: the screw rod (13) is rotatably installed at the corresponding position in the transmission case (4), the number of the screw rods (13) is three, and the lower end of each screw rod (13) is movably installed in the upper fixing cover (7).

4. An exosome purification device according to claim 3, characterised in that: two outsides there are outer clearance cover (15) through screw movable mounting on screw (13), outer clearance cover (15) movable mounting is in the inside of last fixed cover (7), the shape of outer clearance cover (15) is the annular.

5. An exosome purification device according to claim 4, characterised in that: an inner cleaning cover (14) is movably arranged on the other screw rod (13) through a screw hole, and brushes are fixedly arranged on the outer walls of the inner cleaning cover (14) and the outer cleaning cover (15).

6. An exosome purification device according to claim 1, characterised in that: through-hole (18) have been seted up to the bottom of rotatory cover (8) corresponding position department, the quantity of through-hole (18) is two sets of, delivery pipe (12) have been seted up to the both sides of the inside of fixed disk (10) corresponding position department, the central point of the bottom of fixed disk (10) puts fixed mounting has servo motor (11), the output shaft of servo motor (11) links to each other with the bottom of rotatory cover (8) is fixed.

7. An exosome purification device according to claim 5, characterised in that: adjacent two the top fixed mounting of screw rod (13) has gear (16), the quantity of gear (16) is two, two gear (16) intermeshing sets up, adjacent two in addition fixed mounting has belt pulley mechanism (17), right side between screw rod (13) the top fixed mounting of screw rod (13) has hand wheel (6), hand wheel (6) movable mounting is at the top of transmission case (4).

8. An exosome purification device according to claim 6, characterised in that: the inside fixed mounting of dead lever has inlet pipe (5), inlet pipe (5) pass transmission case (4) and set up the top at transmission case (4), observation window (2) have been seted up to the front side of the jar body (1), the bottom symmetry fixed mounting of the jar body (1) has landing leg (3), one side fixed mounting of the bottom of the jar body (1) has delivery pipe (12), it has the solenoid valve to correspond position department fixed mounting on delivery pipe (12).